Cxcl17 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cxcl17
Entrez Gene ID	232983
Full Name	chemokine (C-X-C motif) ligand 17
Synonyms	VCC-1,Vcc1
General protein information	Preferred Names chemokine (C-X-C motif) ligand 17 Names C-X-C motif chemokine 17 13.6-kDa protein 6-Cys CXCL17 VEGF co-regulated chemokine 1 VEGF coregulated chemokine 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_153576.2	NP_705804.2	C-X-C motif chemokine 17 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CXCL17	NP_940879.1
Rattus norvegicus (Norway rat)	Cxcl17	NP_001100961.1
Bos taurus (cattle)	CXCL17	NP_001077268.1
Mus musculus (house mouse)	Cxcl17	NP_705804.2
Pan troglodytes (chimpanzee)	CXCL17	XP_001154726.1
	CXCL17	XP_001105835.1

Gene Ontology
Bibliography

Related articles in PubMed

CXCL17 Attenuates Imiquimod-Induced Psoriasis-like Skin Inflammation by Recruiting Myeloid-Derived Suppressor Cells and Regulatory T Cells.
Oka T, Sugaya M, Takahashi N, Takahashi T, Shibata S, Miyagaki T, Asano Y, Sato S
Journal of immunology (Baltimore, Md. : 1950)198(10)3897-3908(2017 May)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17.
Maravillas-Montero JL, Burkhardt AM, Hevezi PA, Carnevale CD, Smit MJ, Zlotnik A
Journal of immunology (Baltimore, Md. : 1950)194(1)29-33(2015 Jan)

CXCL17 is a major chemotactic factor for lung macrophages.
Burkhardt AM, Maravillas-Montero JL, Carnevale CD, Vilches-Cisneros N, Flores JP, Hevezi PA, Zlotnik A
Journal of immunology (Baltimore, Md. : 1950)193(3)1468-74(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CXCL17 attenuates Imiquimod -induced psoriasis-like skin inflammation by recruiting myeloid-derived suppressor cells and regulatory T cells , which may be important for regulating excessive inflammation in psoriasis skin.
Title: CXCL17 Attenuates Imiquimod-Induced Psoriasis-like Skin Inflammation by Recruiting Myeloid-Derived Suppressor Cells and Regulatory T Cells.

CXCL17 is a novel macrophage chemoattractant that operates in mucosal tissues as a major regulator of inflammatory responses.
Title: CXCL17 is a major chemotactic factor for lung macrophages.

These results suggest that aberrant expression of CXCL17 in tumor cells recruits immature myeloid-derived cells and promotes tumor progression through angiogenesis.
Title: CXCL17 expression by tumor cells recruits CD11b+Gr1 high F4/80- cells and promotes tumor progression.

VCC-1 plays a role in angiogenesis and possibly in the development of tumors in some tissue types[VCC-1]
Title: VCC-1, a novel chemokine, promotes tumor growth.

The following Cxcl17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cxcl17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02908	NM_153576.2 Latest version!	Mus musculus chemokine (C-X-C motif) ligand 17 (Cxcl17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cxcl17 ( NM_153576.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_705804.2 Mus musculus chemokine (C-X-C motif) ligand 17 (Cxcl17), mRNA.

Price & Availability↑

CloneID	OMu02908
Clone ID Related Accession (Same CDS sequence)	NM_153576.2
Accession Version	NM_153576.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	C-X-C motif chemokine 17 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY598463.1 and AC162443.3. On Mar 21, 2007 this sequence version replaced NM_153576.1. ##Evidence-Data-START## Transcript exon combination :: BC024561.1, DV047460.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849387 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCTTC TAGCCTCTCC CTTCCTTCTG TTGCTTCCAG TGATGCTCAT GTCCATGGTC 
TTCAGCAGCC CGAACCCAGG GGTCGCCAGA AGCCACGGGG ACCAACACCT GGCTCCTAGG 
AGGTGGCTCT TGGAAGGTGG CCAAGAATGT GAATGCAAAG ATTGGTTCCT GCAAGCCCCA 
AAGAGAAAAG CCACAGCAGT GCTGGGGCCA CCAAGGAAGC AGTGTCCCTG TGATCACGTC 
AAGGGCAGGG AGAAAAAAAA CAGACACCAA AAGCACCACA GGAAGTCGCA AAGACCCTCC 
AGAGCCTGCC AGCAATTTCT CAAACGATGT CACCTGGCAA GCTTTGCGCT GCCCTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_705804.2
CDS	107..466
Translation	MKLLASPFLLLLPVMLMSMVFSSPNPGVARSHGDQHLAPRRWLLEGGQECECKDWFLQAPKRKATAVLGPPRKQCPCDHVKGREKKNRHQKHHRKSQRPSRACQQFLKRCHLASFALPL

Target ORF information:

RefSeq Version	NM_153576.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus chemokine (C-X-C motif) ligand 17 (Cxcl17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153576.2

ORF Insert Sequence:

ATGAAGCTTC TAGCCTCTCC CTTCCTTCTG TTGCTTCCAG TGATGCTCAT GTCCATGGTC 
TTCAGCAGCC CGAACCCAGG GGTCGCCAGA AGCCACGGGG ACCAACACCT GGCTCCTAGG 
AGGTGGCTCT TGGAAGGTGG CCAAGAATGT GAATGCAAAG ATTGGTTCCT GCAAGCCCCA 
AAGAGAAAAG CCACAGCAGT GCTGGGGCCA CCAAGGAAGC AGTGTCCCTG TGATCACGTC 
AAGGGCAGGG AGAAAAAAAA CAGACACCAA AAGCACCACA GGAAGTCGCA AAGACCCTCC 
AGAGCCTGCC AGCAATTTCT CAAACGATGT CACCTGGCAA GCTTTGCGCT GCCCTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CXCL17 Attenuates Imiquimod-Induced Psoriasis-like Skin Inflammation by Recruiting Myeloid-Derived Suppressor Cells and Regulatory T Cells.
Journal of immunology (Baltimore, Md. : 1950)198(10)3897-3908(2017 May)
Oka T,Sugaya M,Takahashi N,Takahashi T,Shibata S,Miyagaki T,Asano Y,Sato S

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17.
Journal of immunology (Baltimore, Md. : 1950)194(1)29-33(2015 Jan)
Maravillas-Montero JL,Burkhardt AM,Hevezi PA,Carnevale CD,Smit MJ,Zlotnik A

CXCL17 is a major chemotactic factor for lung macrophages.
Journal of immunology (Baltimore, Md. : 1950)193(3)1468-74(2014 Aug)
Burkhardt AM,Maravillas-Montero JL,Carnevale CD,Vilches-Cisneros N,Flores JP,Hevezi PA,Zlotnik A

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Cxcl17 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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