Mark4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mark4
Entrez Gene ID	232944
Full Name	MAP/microtubule affinity regulating kinase 4
Synonyms	2410090P21Rik,C79806,Markl1
General protein information	Preferred Names MAP/microtubule affinity regulating kinase 4 Names MAP/microtubule affinity-regulating kinase 4 MAP/microtubule affinity-regulating kinase 4L MARK4 serine/threonine protein kinase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001368427.1	NP_001355356.1	MAP/microtubule affinity-regulating kinase 4 isoform 2
XM_030242436.1	XP_030098296.1	MAP/microtubule affinity-regulating kinase 4 isoform X2
XM_006539829.3	XP_006539892.1	MAP/microtubule affinity-regulating kinase 4 isoform X1
XM_011250513.2	XP_011248815.1	MAP/microtubule affinity-regulating kinase 4 isoform X2
XM_011250513.3	XP_011248815.1	MAP/microtubule affinity-regulating kinase 4 isoform X1
NM_172279.1	NP_758483.1	MAP/microtubule affinity-regulating kinase 4
NM_172279.2	NP_758483.1	MAP/microtubule affinity-regulating kinase 4 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MARK4	XP_541564.4
Danio rerio (zebrafish)	mark4a	XP_005165425.1
Danio rerio (zebrafish)	si:dkey-31m14.7	XP_005157656.1
Homo sapiens (human)	MARK4	NP_001186796.1
	MARK4	XP_001105523.2
Xenopus tropicalis (tropical clawed frog)	mark4	XP_002932682.1
Pan troglodytes (chimpanzee)	MARK4	XP_512745.3
Mus musculus (house mouse)	Mark4	NP_758483.1
Rattus norvegicus (Norway rat)	Mark4	NP_001178000.1
Bos taurus (cattle)	MARK4	NP_001030436.1

Gene Ontology
Bibliography

Related articles in PubMed

MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism.
Li X, Thome S, Ma X, Amrute-Nayak M, Finigan A, Kitt L, Masters L, James JR, Shi Y, Meng G, Mallat Z
Nature communications815986(2017 Jun)

Mark4 promotes oxidative stress and inflammation via binding to PPAR? and activating NF-?B pathway in mice adipocytes.
Liu Z, Gan L, Chen Y, Luo D, Zhang Z, Cao W, Zhou Z, Lin X, Sun C
Scientific reports621382(2016 Feb)

The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis.
Kuhns S, Schmidt KN, Reymann J, Gilbert DF, Neuner A, Hub B, Carvalho R, Wiedemann P, Zentgraf H, Erfle H, Klingm?ller U, Boutros M, Pereira G
The Journal of cell biology200(4)505-22(2013 Feb)

Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin hypersensitivity and resistance to diet-induced obesity.
Sun C, Tian L, Nie J, Zhang H, Han X, Shi Y
The Journal of biological chemistry287(45)38305-15(2012 Nov)

Differential signature of the centrosomal MARK4 isoforms in glioma.
Magnani I, Novielli C, Fontana L, Tabano S, Rovina D, Moroni RF, Bauer D, Mazzoleni S, Colombo EA, Tedeschi G, Monti L, Porta G, Bosari S, Frassoni C, Galli R, Bello L, Larizza L
Analytical cellular pathology (Amsterdam)34(6)319-38(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PPARgamma interacted with Mark4 and inhibited the stimulating effect of Mark4 on oxidative stress and inflammation.
Title: Mark4 promotes oxidative stress and inflammation via binding to PPAR? and activating NF-?B pathway in mice adipocytes.

MARK4 is a critical positive regulator of early steps in ciliogenesis.
Title: The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis.

data indicate a key role of MARK4 in energy metabolism, implicating the kinase as a novel drug target for the treatment of obesity and type 2 diabetes.
Title: Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin hypersensitivity and resistance to diet-induced obesity.

The balance between the MARK4 isoforms is carefully guarded during neural differentiation but may be subverted in gliomagenesis.
Title: Differential signature of the centrosomal MARK4 isoforms in glioma.

MARK4 is a functional protein kinase which specifically phosphorylates a cognate peptide substrate for the AMP-kinase family. On overexpression in heterologous cells functional wild-type protein, but not its kinase-dead mutant, decreased cell viability
Title: Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4.

The following Mark4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mark4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu03296	NM_172279.2 Latest version!	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$440.30 $629.00
OMu38178	NM_001368427.1 Latest version!	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OMu38178	XM_006539829.3 Latest version!	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OMu73636	XM_011250513.3 Latest version!	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OMu89434	XM_030242436.1 Latest version!	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OMu73636	XM_011250513.2	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu03296	NM_172279.1	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$440.30 $629.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mark4 ( XM_011250513.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011248815.1 Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu73636
Clone ID Related Accession (Same CDS sequence)	XM_011250513.2 , XM_011250513.3
Accession Version	XM_011250513.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	MAP/microtubule affinity-regulating kinase 4 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011250513.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGGAC TCAACCACCC CAACATCGTG AAGCTTTTTG AGGTGATAGA GACGGAGAAG 
ACGCTATACC TGGTGATGGA ATACGCTAGC GCAGGAGAAG TGTTTGACTA CCTCGTGTCG 
CACGGCCGCA TGAAGGAGAA GGAGGCTCGA GCCAAGTTCC GGCAGATCGT GTCAGCCGTG 
CACTACTGTC ATCAGAAGAA CATTGTACAC AGGGATCTAA AGGCTGAAAA CCTGTTGCTG 
GATGCCGAGG CCAACATCAA AATCGCCGAC TTCGGCTTCA GCAATGAGTT CACGCTGGGC 
TCCAAGCTGG ACACCTTCTG TGGGAGCCCC CCATACGCCG CCCCAGAGCT GTTCCAGGGC 
AAGAAGTATG ATGGGCCAGA GGTGGACATC TGGAGCCTGG GTGTCATCCT GTACACGCTG 
GTCAGCGGCT CCCTGCCCTT CGATGGGCAC AACCTCAAGG AGCTGCGGGA GCGAGTCCTC 
AGAGGAAAGT ACCGGGTCCC CTTCTACATG TCTACAGACT GCGAGAGCAT TCTGCGGAGA 
TTTCTGGTGC TGAACCCCGC AAAACGCTGT ACTCTGGAGC AAATCATGAA AGACAAATGG 
ATCAACATCG GCTATGAGGG TGAGGAGCTG AAGCCATACA CGGAGCCTGA GGAGGACTTC 
GGGGACACCA AGAGAATTGA GGTGATGGTG GGTATGGGCT ACACACGGGA AGAAATCAAA 
GAGGCCTTGA CCAACCAGAA GTACAACGAG GTGACCGCCA CCTACCTCCT GCTGGGCAGG 
AAGACTGAGG AGGGTGGGGA CCGGGGTGCC CCAGGGCTGG CCCTGGCACG GGTGCGGGCG 
CCCAGCGACA CCACCAACGG GACAAGCTCC AGCAAAGGCA GCAGCCACAA CAAAGGGCAA 
CGGGCTTCTT CCTCCACCTA CCACCGCCAG CGCCGTCACA GTGACTTCTG TGGCCCGTCC 
CCTGCCCCGC TGCACCCGAA GCGCAGCCCA ACCAGCACGG GAGACACGGA GCTCAAAGAA 
GAGCGGATGC CGGGTCGGAA AGCGAGCTGC AGTGCAGTGG GCAGTGGAAG TCGAGGCTTG 
CCCCCCTCCA GCCCCATGGT CAGCAGTGCC CACAACCCCA ATAAGGCAGA GATCCCTGAG 
CGGCGGAAGG ACAGCACTAG CACCCCTAAC AACCTCCCCC CCAGCATGAT GACCCGAAGA 
AACACCTATG TGTGCACAGA GCGACCAGGA TCTGAACGCC CGTCCTTGTT GCCAAATGGC 
AAAGAAAATA GCTCCGGTAC CTCGCGGGTG CCCCCTGCCT CGCCTTCCAG TCATAGCCTG 
GCTCCCCCGT CAGGCGAGCG GAGCCGCCTG GCTCGGGGCT CCACCATCCG CAGCACCTTC 
CATGGGGGCC AGGTCCGAGA CCGGCGGGCA GGGAGCGGGA GTGGCGGGGG TGTGCAGAAT 
GGACCCCCAG CCTCACCCAC GCTTGCCCAC GAGGCCGCAC CCCTGCCCTC CGGGCGGCCT 
CGCCCCACCA CCAACCTCTT CACCAAGCTG ACCTCCAAAC TGACCCGAAG GGTCACAGAC 
GAACCTGAGA GAATCGGGGG ACCTGAGGTC ACAAGTTGCC ATCTACCTTG GGATAAAACG 
GAAACCGCCC CCAGGCTGCT CCGATTCCCC TGGAGTGTGA AGCTGACCAG CTCGCGACCT 
CCTGAGGCCC TGATGGCTGC CCTGCGACAG GCCACAGCGG CCGCCCGCTG CCGGTGCCGC 
CAGCCGCAGC CGTTCCTGCT GGCCTGCCTG CACGGGGGTG CGGGCGGGCC CGAGCCCCTG 
TCCCATTTCG AAGTGGAGGT GTGCCAGCTG CCCCGGCCCG GCCTCAGGGG CGTCCTCTTC 
CGCCGTGTGG CGGGCACCGC CCTGGCCTTC CGCACCCTCG TCACCCGCAT CTCCAACGAC 
CTCGAACTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011248815.1
CDS	772..2703
Translation	MKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKEALTNQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGSSHNKGQRASSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGDTELKEERMPGRKASCSAVGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGSERPSLLPNGKENSSGTSRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGSGSGGGVQNGPPASPTLAHEAAPLPSGRPRPTTNLFTKLTSKLTRRVTDEPERIGGPEVTSCHLPWDKTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL

Target ORF information:

RefSeq Version	XM_011250513.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011250513.2

ORF Insert Sequence:

ATGAAGGGAC TCAACCACCC CAACATCGTG AAGCTTTTTG AGGTGATAGA GACGGAGAAG 
ACGCTATACC TGGTGATGGA ATACGCTAGC GCAGGAGAAG TGTTTGACTA CCTCGTGTCG 
CACGGCCGCA TGAAGGAGAA GGAGGCTCGA GCCAAGTTCC GGCAGATCGT GTCAGCCGTG 
CACTACTGTC ATCAGAAGAA CATTGTACAC AGGGATCTAA AGGCTGAAAA CCTGTTGCTG 
GATGCCGAGG CCAACATCAA AATCGCCGAC TTCGGCTTCA GCAATGAGTT CACGCTGGGC 
TCCAAGCTGG ACACCTTCTG TGGGAGCCCC CCATACGCCG CCCCAGAGCT GTTCCAGGGC 
AAGAAGTATG ATGGGCCAGA GGTGGACATC TGGAGCCTGG GTGTCATCCT GTACACGCTG 
GTCAGCGGCT CCCTGCCCTT CGATGGGCAC AACCTCAAGG AGCTGCGGGA GCGAGTCCTC 
AGAGGAAAGT ACCGGGTCCC CTTCTACATG TCTACAGACT GCGAGAGCAT TCTGCGGAGA 
TTTCTGGTGC TGAACCCCGC AAAACGCTGT ACTCTGGAGC AAATCATGAA AGACAAATGG 
ATCAACATCG GCTATGAGGG TGAGGAGCTG AAGCCATACA CGGAGCCTGA GGAGGACTTC 
GGGGACACCA AGAGAATTGA GGTGATGGTG GGTATGGGCT ACACACGGGA AGAAATCAAA 
GAGGCCTTGA CCAACCAGAA GTACAACGAG GTGACCGCCA CCTACCTCCT GCTGGGCAGG 
AAGACTGAGG AGGGTGGGGA CCGGGGTGCC CCAGGGCTGG CCCTGGCACG GGTGCGGGCG 
CCCAGCGACA CCACCAACGG GACAAGCTCC AGCAAAGGCA GCAGCCACAA CAAAGGGCAA 
CGGGCTTCTT CCTCCACCTA CCACCGCCAG CGCCGTCACA GTGACTTCTG TGGCCCGTCC 
CCTGCCCCGC TGCACCCGAA GCGCAGCCCA ACCAGCACGG GAGACACGGA GCTCAAAGAA 
GAGCGGATGC CGGGTCGGAA AGCGAGCTGC AGTGCAGTGG GCAGTGGAAG TCGAGGCTTG 
CCCCCCTCCA GCCCCATGGT CAGCAGTGCC CACAACCCCA ATAAGGCAGA GATCCCTGAG 
CGGCGGAAGG ACAGCACTAG CACCCCTAAC AACCTCCCCC CCAGCATGAT GACCCGAAGA 
AACACCTATG TGTGCACAGA GCGACCAGGA TCTGAACGCC CGTCCTTGTT GCCAAATGGC 
AAAGAAAATA GCTCCGGTAC CTCGCGGGTG CCCCCTGCCT CGCCTTCCAG TCATAGCCTG 
GCTCCCCCGT CAGGCGAGCG GAGCCGCCTG GCTCGGGGCT CCACCATCCG CAGCACCTTC 
CATGGGGGCC AGGTCCGAGA CCGGCGGGCA GGGAGCGGGA GTGGCGGGGG TGTGCAGAAT 
GGACCCCCAG CCTCACCCAC GCTTGCCCAC GAGGCCGCAC CCCTGCCCTC CGGGCGGCCT 
CGCCCCACCA CCAACCTCTT CACCAAGCTG ACCTCCAAAC TGACCCGAAG GGTCACAGAC 
GAACCTGAGA GAATCGGGGG ACCTGAGGTC ACAAGTTGCC ATCTACCTTG GGATAAAACG 
GAAACCGCCC CCAGGCTGCT CCGATTCCCC TGGAGTGTGA AGCTGACCAG CTCGCGACCT 
CCTGAGGCCC TGATGGCTGC CCTGCGACAG GCCACAGCGG CCGCCCGCTG CCGGTGCCGC 
CAGCCGCAGC CGTTCCTGCT GGCCTGCCTG CACGGGGGTG CGGGCGGGCC CGAGCCCCTG 
TCCCATTTCG AAGTGGAGGT GTGCCAGCTG CCCCGGCCCG GCCTCAGGGG CGTCCTCTTC 
CGCCGTGTGG CGGGCACCGC CCTGGCCTTC CGCACCCTCG TCACCCGCAT CTCCAACGAC 
CTCGAACTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mark4 ( NM_172279.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_758483.1 Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), mRNA.

Price & Availability↑

CloneID	OMu03296
Clone ID Related Accession (Same CDS sequence)	NM_172279.1 , NM_172279.2
Accession Version	NM_172279.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2259bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-22
Organism	Mus musculus(house mouse)
Product	MAP/microtubule affinity-regulating kinase 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY151083.1. ##Evidence-Data-START## Transcript exon combination :: AY151083.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164141 [ECO:0000348] ##Evidence-Data-END##

ATGTCTTCGA GGACGGCGCT GGCCCCGGGC AACGATCGAA ACTCGGACAC GCATGGCACA 
TTGGGCAGTG GACGATCTTC GGACAAAGGG CCGTCCTGGT CCAGCCGTTC CCTGGGTGCC 
CGTTGCCGGA ACTCTATCGC TTCCTGCCCT GAGGAACAAC CCCATGTGGG CAACTATAGG 
CTGCTAAGGA CCATCGGGAA GGGCAACTTC GCCAAAGTCA AGCTGGCTCG GCATATCCTC 
ACGGGCCGGG AGGTCGCTAT TAAGATCATT GATAAGACCC AGCTGAACCC CAGTAGCTTG 
CAGAAGCTGT TCAGAGAAGT CCGAATTATG AAGGGACTCA ACCACCCCAA CATCGTGAAG 
CTTTTTGAGG TGATAGAGAC GGAGAAGACG CTATACCTGG TGATGGAATA CGCTAGCGCA 
GGAGAAGTGT TTGACTACCT CGTGTCGCAC GGCCGCATGA AGGAGAAGGA GGCTCGAGCC 
AAGTTCCGGC AGATCGTGTC AGCCGTGCAC TACTGTCATC AGAAGAACAT TGTACACAGG 
GATCTAAAGG CTGAAAACCT GTTGCTGGAT GCCGAGGCCA ACATCAAAAT CGCCGACTTC 
GGCTTCAGCA ATGAGTTCAC GCTGGGCTCC AAGCTGGACA CCTTCTGTGG GAGCCCCCCA 
TACGCCGCCC CAGAGCTGTT CCAGGGCAAG AAGTATGATG GGCCAGAGGT GGACATCTGG 
AGCCTGGGTG TCATCCTGTA CACGCTGGTC AGCGGCTCCC TGCCCTTCGA TGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTCCTCAGA GGAAAGTACC GGGTCCCCTT CTACATGTCT 
ACAGACTGCG AGAGCATTCT GCGGAGATTT CTGGTGCTGA ACCCCGCAAA ACGCTGTACT 
CTGGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGCTGAAG 
CCATACACGG AGCCTGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG GCCTTGACCA ACCAGAAGTA CAACGAGGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGTGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGGAC AAGCTCCAGC 
AAAGGCAGCA GCCACAACAA AGGGCAACGG GCTTCTTCCT CCACCTACCA CCGCCAGCGC 
CGTCACAGTG ACTTCTGTGG CCCGTCCCCT GCCCCGCTGC ACCCGAAGCG CAGCCCAACC 
AGCACGGGAG ACACGGAGCT CAAAGAAGAG CGGATGCCGG GTCGGAAAGC GAGCTGCAGT 
GCAGTGGGCA GTGGAAGTCG AGGCTTGCCC CCCTCCAGCC CCATGGTCAG CAGTGCCCAC 
AACCCCAATA AGGCAGAGAT CCCTGAGCGG CGGAAGGACA GCACTAGCAC CCCTAACAAC 
CTCCCCCCCA GCATGATGAC CCGAAGAAAC ACCTATGTGT GCACAGAGCG ACCAGGATCT 
GAACGCCCGT CCTTGTTGCC AAATGGCAAA GAAAATAGCT CCGGTACCTC GCGGGTGCCC 
CCTGCCTCGC CTTCCAGTCA TAGCCTGGCT CCCCCGTCAG GCGAGCGGAG CCGCCTGGCT 
CGGGGCTCCA CCATCCGCAG CACCTTCCAT GGGGGCCAGG TCCGAGACCG GCGGGCAGGG 
AGCGGGAGTG GCGGGGGTGT GCAGAATGGA CCCCCAGCCT CACCCACGCT TGCCCACGAG 
GCCGCACCCC TGCCCTCCGG GCGGCCTCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT CACAGACGAA CCTGAGAGAA TCGGGGGACC TGAGGTCACA 
AGTTGCCATC TACCTTGGGA TAAAACGGAA ACCGCCCCCA GGCTGCTCCG ATTCCCCTGG 
AGTGTGAAGC TGACCAGCTC GCGACCTCCT GAGGCCCTGA TGGCTGCCCT GCGACAGGCC 
ACAGCGGCCG CCCGCTGCCG GTGCCGCCAG CCGCAGCCGT TCCTGCTGGC CTGCCTGCAC 
GGGGGTGCGG GCGGGCCCGA GCCCCTGTCC CATTTCGAAG TGGAGGTGTG CCAGCTGCCC 
CGGCCCGGCC TCAGGGGCGT CCTCTTCCGC CGTGTGGCGG GCACCGCCCT GGCCTTCCGC 
ACCCTCGTCA CCCGCATCTC CAACGACCTC GAACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758483.1
CDS	1..2259
Translation	MSSRTALAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKEALTNQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGSSHNKGQRASSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGDTELKEERMPGRKASCSAVGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGSERPSLLPNGKENSSGTSRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGSGSGGGVQNGPPASPTLAHEAAPLPSGRPRPTTNLFTKLTSKLTRRVTDEPERIGGPEVTSCHLPWDKTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL

Target ORF information:

RefSeq Version	NM_172279.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172279.1

ORF Insert Sequence:

ATGTCTTCGA GGACGGCGCT GGCCCCGGGC AACGATCGAA ACTCGGACAC GCATGGCACA 
TTGGGCAGTG GACGATCTTC GGACAAAGGG CCGTCCTGGT CCAGCCGTTC CCTGGGTGCC 
CGTTGCCGGA ACTCTATCGC TTCCTGCCCT GAGGAACAAC CCCATGTGGG CAACTATAGG 
CTGCTAAGGA CCATCGGGAA GGGCAACTTC GCCAAAGTCA AGCTGGCTCG GCATATCCTC 
ACGGGCCGGG AGGTCGCTAT TAAGATCATT GATAAGACCC AGCTGAACCC CAGTAGCTTG 
CAGAAGCTGT TCAGAGAAGT CCGAATTATG AAGGGACTCA ACCACCCCAA CATCGTGAAG 
CTTTTTGAGG TGATAGAGAC GGAGAAGACG CTATACCTGG TGATGGAATA CGCTAGCGCA 
GGAGAAGTGT TTGACTACCT CGTGTCGCAC GGCCGCATGA AGGAGAAGGA GGCTCGAGCC 
AAGTTCCGGC AGATCGTGTC AGCCGTGCAC TACTGTCATC AGAAGAACAT TGTACACAGG 
GATCTAAAGG CTGAAAACCT GTTGCTGGAT GCCGAGGCCA ACATCAAAAT CGCCGACTTC 
GGCTTCAGCA ATGAGTTCAC GCTGGGCTCC AAGCTGGACA CCTTCTGTGG GAGCCCCCCA 
TACGCCGCCC CAGAGCTGTT CCAGGGCAAG AAGTATGATG GGCCAGAGGT GGACATCTGG 
AGCCTGGGTG TCATCCTGTA CACGCTGGTC AGCGGCTCCC TGCCCTTCGA TGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTCCTCAGA GGAAAGTACC GGGTCCCCTT CTACATGTCT 
ACAGACTGCG AGAGCATTCT GCGGAGATTT CTGGTGCTGA ACCCCGCAAA ACGCTGTACT 
CTGGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGCTGAAG 
CCATACACGG AGCCTGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG GCCTTGACCA ACCAGAAGTA CAACGAGGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGTGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGGAC AAGCTCCAGC 
AAAGGCAGCA GCCACAACAA AGGGCAACGG GCTTCTTCCT CCACCTACCA CCGCCAGCGC 
CGTCACAGTG ACTTCTGTGG CCCGTCCCCT GCCCCGCTGC ACCCGAAGCG CAGCCCAACC 
AGCACGGGAG ACACGGAGCT CAAAGAAGAG CGGATGCCGG GTCGGAAAGC GAGCTGCAGT 
GCAGTGGGCA GTGGAAGTCG AGGCTTGCCC CCCTCCAGCC CCATGGTCAG CAGTGCCCAC 
AACCCCAATA AGGCAGAGAT CCCTGAGCGG CGGAAGGACA GCACTAGCAC CCCTAACAAC 
CTCCCCCCCA GCATGATGAC CCGAAGAAAC ACCTATGTGT GCACAGAGCG ACCAGGATCT 
GAACGCCCGT CCTTGTTGCC AAATGGCAAA GAAAATAGCT CCGGTACCTC GCGGGTGCCC 
CCTGCCTCGC CTTCCAGTCA TAGCCTGGCT CCCCCGTCAG GCGAGCGGAG CCGCCTGGCT 
CGGGGCTCCA CCATCCGCAG CACCTTCCAT GGGGGCCAGG TCCGAGACCG GCGGGCAGGG 
AGCGGGAGTG GCGGGGGTGT GCAGAATGGA CCCCCAGCCT CACCCACGCT TGCCCACGAG 
GCCGCACCCC TGCCCTCCGG GCGGCCTCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT CACAGACGAA CCTGAGAGAA TCGGGGGACC TGAGGTCACA 
AGTTGCCATC TACCTTGGGA TAAAACGGAA ACCGCCCCCA GGCTGCTCCG ATTCCCCTGG 
AGTGTGAAGC TGACCAGCTC GCGACCTCCT GAGGCCCTGA TGGCTGCCCT GCGACAGGCC 
ACAGCGGCCG CCCGCTGCCG GTGCCGCCAG CCGCAGCCGT TCCTGCTGGC CTGCCTGCAC 
GGGGGTGCGG GCGGGCCCGA GCCCCTGTCC CATTTCGAAG TGGAGGTGTG CCAGCTGCCC 
CGGCCCGGCC TCAGGGGCGT CCTCTTCCGC CGTGTGGCGG GCACCGCCCT GGCCTTCCGC 
ACCCTCGTCA CCCGCATCTC CAACGACCTC GAACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mark4 ( NM_172279.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_758483.1 Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant 1, mRNA.

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CloneID	OMu03296
Clone ID Related Accession (Same CDS sequence)	NM_172279.1 , NM_172279.2
Accession Version	NM_172279.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2259bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-06
Organism	Mus musculus(house mouse)
Product	MAP/microtubule affinity-regulating kinase 4 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC149052.3 and AC118017.15. On Feb 13, 2019 this sequence version replaced NM_172279.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.529839.1, SRR7345562.2284844.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164141 [ECO:0000348] ##Evidence-Data-END##

ATGTCTTCGA GGACGGCGCT GGCCCCGGGC AACGATCGAA ACTCGGACAC GCATGGCACA 
TTGGGCAGTG GACGATCTTC GGACAAAGGG CCGTCCTGGT CCAGCCGTTC CCTGGGTGCC 
CGTTGCCGGA ACTCTATCGC TTCCTGCCCT GAGGAACAAC CCCATGTGGG CAACTATAGG 
CTGCTAAGGA CCATCGGGAA GGGCAACTTC GCCAAAGTCA AGCTGGCTCG GCATATCCTC 
ACGGGCCGGG AGGTCGCTAT TAAGATCATT GATAAGACCC AGCTGAACCC CAGTAGCTTG 
CAGAAGCTGT TCAGAGAAGT CCGAATTATG AAGGGACTCA ACCACCCCAA CATCGTGAAG 
CTTTTTGAGG TGATAGAGAC GGAGAAGACG CTATACCTGG TGATGGAATA CGCTAGCGCA 
GGAGAAGTGT TTGACTACCT CGTGTCGCAC GGCCGCATGA AGGAGAAGGA GGCTCGAGCC 
AAGTTCCGGC AGATCGTGTC AGCCGTGCAC TACTGTCATC AGAAGAACAT TGTACACAGG 
GATCTAAAGG CTGAAAACCT GTTGCTGGAT GCCGAGGCCA ACATCAAAAT CGCCGACTTC 
GGCTTCAGCA ATGAGTTCAC GCTGGGCTCC AAGCTGGACA CCTTCTGTGG GAGCCCCCCA 
TACGCCGCCC CAGAGCTGTT CCAGGGCAAG AAGTATGATG GGCCAGAGGT GGACATCTGG 
AGCCTGGGTG TCATCCTGTA CACGCTGGTC AGCGGCTCCC TGCCCTTCGA TGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTCCTCAGA GGAAAGTACC GGGTCCCCTT CTACATGTCT 
ACAGACTGCG AGAGCATTCT GCGGAGATTT CTGGTGCTGA ACCCCGCAAA ACGCTGTACT 
CTGGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGCTGAAG 
CCATACACGG AGCCTGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG GCCTTGACCA ACCAGAAGTA CAACGAGGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGTGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGGAC AAGCTCCAGC 
AAAGGCAGCA GCCACAACAA AGGGCAACGG GCTTCTTCCT CCACCTACCA CCGCCAGCGC 
CGTCACAGTG ACTTCTGTGG CCCGTCCCCT GCCCCGCTGC ACCCGAAGCG CAGCCCAACC 
AGCACGGGAG ACACGGAGCT CAAAGAAGAG CGGATGCCGG GTCGGAAAGC GAGCTGCAGT 
GCAGTGGGCA GTGGAAGTCG AGGCTTGCCC CCCTCCAGCC CCATGGTCAG CAGTGCCCAC 
AACCCCAATA AGGCAGAGAT CCCTGAGCGG CGGAAGGACA GCACTAGCAC CCCTAACAAC 
CTCCCCCCCA GCATGATGAC CCGAAGAAAC ACCTATGTGT GCACAGAGCG ACCAGGATCT 
GAACGCCCGT CCTTGTTGCC AAATGGCAAA GAAAATAGCT CCGGTACCTC GCGGGTGCCC 
CCTGCCTCGC CTTCCAGTCA TAGCCTGGCT CCCCCGTCAG GCGAGCGGAG CCGCCTGGCT 
CGGGGCTCCA CCATCCGCAG CACCTTCCAT GGGGGCCAGG TCCGAGACCG GCGGGCAGGG 
AGCGGGAGTG GCGGGGGTGT GCAGAATGGA CCCCCAGCCT CACCCACGCT TGCCCACGAG 
GCCGCACCCC TGCCCTCCGG GCGGCCTCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT CACAGACGAA CCTGAGAGAA TCGGGGGACC TGAGGTCACA 
AGTTGCCATC TACCTTGGGA TAAAACGGAA ACCGCCCCCA GGCTGCTCCG ATTCCCCTGG 
AGTGTGAAGC TGACCAGCTC GCGACCTCCT GAGGCCCTGA TGGCTGCCCT GCGACAGGCC 
ACAGCGGCCG CCCGCTGCCG GTGCCGCCAG CCGCAGCCGT TCCTGCTGGC CTGCCTGCAC 
GGGGGTGCGG GCGGGCCCGA GCCCCTGTCC CATTTCGAAG TGGAGGTGTG CCAGCTGCCC 
CGGCCCGGCC TCAGGGGCGT CCTCTTCCGC CGTGTGGCGG GCACCGCCCT GGCCTTCCGC 
ACCCTCGTCA CCCGCATCTC CAACGACCTC GAACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758483.1
CDS	350..2608
Translation	MSSRTALAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKEALTNQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGSSHNKGQRASSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGDTELKEERMPGRKASCSAVGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGSERPSLLPNGKENSSGTSRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGSGSGGGVQNGPPASPTLAHEAAPLPSGRPRPTTNLFTKLTSKLTRRVTDEPERIGGPEVTSCHLPWDKTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL

Target ORF information:

RefSeq Version	NM_172279.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172279.2

ORF Insert Sequence:

ATGTCTTCGA GGACGGCGCT GGCCCCGGGC AACGATCGAA ACTCGGACAC GCATGGCACA 
TTGGGCAGTG GACGATCTTC GGACAAAGGG CCGTCCTGGT CCAGCCGTTC CCTGGGTGCC 
CGTTGCCGGA ACTCTATCGC TTCCTGCCCT GAGGAACAAC CCCATGTGGG CAACTATAGG 
CTGCTAAGGA CCATCGGGAA GGGCAACTTC GCCAAAGTCA AGCTGGCTCG GCATATCCTC 
ACGGGCCGGG AGGTCGCTAT TAAGATCATT GATAAGACCC AGCTGAACCC CAGTAGCTTG 
CAGAAGCTGT TCAGAGAAGT CCGAATTATG AAGGGACTCA ACCACCCCAA CATCGTGAAG 
CTTTTTGAGG TGATAGAGAC GGAGAAGACG CTATACCTGG TGATGGAATA CGCTAGCGCA 
GGAGAAGTGT TTGACTACCT CGTGTCGCAC GGCCGCATGA AGGAGAAGGA GGCTCGAGCC 
AAGTTCCGGC AGATCGTGTC AGCCGTGCAC TACTGTCATC AGAAGAACAT TGTACACAGG 
GATCTAAAGG CTGAAAACCT GTTGCTGGAT GCCGAGGCCA ACATCAAAAT CGCCGACTTC 
GGCTTCAGCA ATGAGTTCAC GCTGGGCTCC AAGCTGGACA CCTTCTGTGG GAGCCCCCCA 
TACGCCGCCC CAGAGCTGTT CCAGGGCAAG AAGTATGATG GGCCAGAGGT GGACATCTGG 
AGCCTGGGTG TCATCCTGTA CACGCTGGTC AGCGGCTCCC TGCCCTTCGA TGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTCCTCAGA GGAAAGTACC GGGTCCCCTT CTACATGTCT 
ACAGACTGCG AGAGCATTCT GCGGAGATTT CTGGTGCTGA ACCCCGCAAA ACGCTGTACT 
CTGGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGCTGAAG 
CCATACACGG AGCCTGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG GCCTTGACCA ACCAGAAGTA CAACGAGGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGTGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGGAC AAGCTCCAGC 
AAAGGCAGCA GCCACAACAA AGGGCAACGG GCTTCTTCCT CCACCTACCA CCGCCAGCGC 
CGTCACAGTG ACTTCTGTGG CCCGTCCCCT GCCCCGCTGC ACCCGAAGCG CAGCCCAACC 
AGCACGGGAG ACACGGAGCT CAAAGAAGAG CGGATGCCGG GTCGGAAAGC GAGCTGCAGT 
GCAGTGGGCA GTGGAAGTCG AGGCTTGCCC CCCTCCAGCC CCATGGTCAG CAGTGCCCAC 
AACCCCAATA AGGCAGAGAT CCCTGAGCGG CGGAAGGACA GCACTAGCAC CCCTAACAAC 
CTCCCCCCCA GCATGATGAC CCGAAGAAAC ACCTATGTGT GCACAGAGCG ACCAGGATCT 
GAACGCCCGT CCTTGTTGCC AAATGGCAAA GAAAATAGCT CCGGTACCTC GCGGGTGCCC 
CCTGCCTCGC CTTCCAGTCA TAGCCTGGCT CCCCCGTCAG GCGAGCGGAG CCGCCTGGCT 
CGGGGCTCCA CCATCCGCAG CACCTTCCAT GGGGGCCAGG TCCGAGACCG GCGGGCAGGG 
AGCGGGAGTG GCGGGGGTGT GCAGAATGGA CCCCCAGCCT CACCCACGCT TGCCCACGAG 
GCCGCACCCC TGCCCTCCGG GCGGCCTCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT CACAGACGAA CCTGAGAGAA TCGGGGGACC TGAGGTCACA 
AGTTGCCATC TACCTTGGGA TAAAACGGAA ACCGCCCCCA GGCTGCTCCG ATTCCCCTGG 
AGTGTGAAGC TGACCAGCTC GCGACCTCCT GAGGCCCTGA TGGCTGCCCT GCGACAGGCC 
ACAGCGGCCG CCCGCTGCCG GTGCCGCCAG CCGCAGCCGT TCCTGCTGGC CTGCCTGCAC 
GGGGGTGCGG GCGGGCCCGA GCCCCTGTCC CATTTCGAAG TGGAGGTGTG CCAGCTGCCC 
CGGCCCGGCC TCAGGGGCGT CCTCTTCCGC CGTGTGGCGG GCACCGCCCT GGCCTTCCGC 
ACCCTCGTCA CCCGCATCTC CAACGACCTC GAACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mark4 ( NM_001368427.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001355356.1 Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu38178
Clone ID Related Accession (Same CDS sequence)	NM_001368427.1 , XM_006539829.3
Accession Version	NM_001368427.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2067bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-06
Organism	Mus musculus(house mouse)
Product	MAP/microtubule affinity-regulating kinase 4 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC149052.3 and AC118017.15. On Feb 13, 2019 this sequence version replaced XM_006539829.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.691516.1, SRR7345562.1923176.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164141 [ECO:0000348] ##Evidence-Data-END##

ATGTCTTCGA GGACGGCGCT GGCCCCGGGC AACGATCGAA ACTCGGACAC GCATGGCACA 
TTGGGCAGTG GACGATCTTC GGACAAAGGG CCGTCCTGGT CCAGCCGTTC CCTGGGTGCC 
CGTTGCCGGA ACTCTATCGC TTCCTGCCCT GAGGAACAAC CCCATGTGGG CAACTATAGG 
CTGCTAAGGA CCATCGGGAA GGGCAACTTC GCCAAAGTCA AGCTGGCTCG GCATATCCTC 
ACGGGCCGGG AGGTCGCTAT TAAGATCATT GATAAGACCC AGCTGAACCC CAGTAGCTTG 
CAGAAGCTGT TCAGAGAAGT CCGAATTATG AAGGGACTCA ACCACCCCAA CATCGTGAAG 
CTTTTTGAGG TGATAGAGAC GGAGAAGACG CTATACCTGG TGATGGAATA CGCTAGCGCA 
GGAGAAGTGT TTGACTACCT CGTGTCGCAC GGCCGCATGA AGGAGAAGGA GGCTCGAGCC 
AAGTTCCGGC AGATCGTGTC AGCCGTGCAC TACTGTCATC AGAAGAACAT TGTACACAGG 
GATCTAAAGG CTGAAAACCT GTTGCTGGAT GCCGAGGCCA ACATCAAAAT CGCCGACTTC 
GGCTTCAGCA ATGAGTTCAC GCTGGGCTCC AAGCTGGACA CCTTCTGTGG GAGCCCCCCA 
TACGCCGCCC CAGAGCTGTT CCAGGGCAAG AAGTATGATG GGCCAGAGGT GGACATCTGG 
AGCCTGGGTG TCATCCTGTA CACGCTGGTC AGCGGCTCCC TGCCCTTCGA TGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTCCTCAGA GGAAAGTACC GGGTCCCCTT CTACATGTCT 
ACAGACTGCG AGAGCATTCT GCGGAGATTT CTGGTGCTGA ACCCCGCAAA ACGCTGTACT 
CTGGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGCTGAAG 
CCATACACGG AGCCTGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG GCCTTGACCA ACCAGAAGTA CAACGAGGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGTGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGGAC AAGCTCCAGC 
AAAGGCAGCA GCCACAACAA AGGGCAACGG GCTTCTTCCT CCACCTACCA CCGCCAGCGC 
CGTCACAGTG ACTTCTGTGG CCCGTCCCCT GCCCCGCTGC ACCCGAAGCG CAGCCCAACC 
AGCACGGGAG ACACGGAGCT CAAAGAAGAG CGGATGCCGG GTCGGAAAGC GAGCTGCAGT 
GCAGTGGGCA GTGGAAGTCG AGGCTTGCCC CCCTCCAGCC CCATGGTCAG CAGTGCCCAC 
AACCCCAATA AGGCAGAGAT CCCTGAGCGG CGGAAGGACA GCACTAGCAC CCCTAACAAC 
CTCCCCCCCA GCATGATGAC CCGAAGAAAC ACCTATGTGT GCACAGAGCG ACCAGGATCT 
GAACGCCCGT CCTTGTTGCC AAATGGCAAA GAAAATAGCT CCGGTACCTC GCGGGTGCCC 
CCTGCCTCGC CTTCCAGTCA TAGCCTGGCT CCCCCGTCAG GCGAGCGGAG CCGCCTGGCT 
CGGGGCTCCA CCATCCGCAG CACCTTCCAT GGGGGCCAGG TCCGAGACCG GCGGGCAGGG 
AGCGGGAGTG GCGGGGGTGT GCAGAATGGA CCCCCAGCCT CACCCACGCT TGCCCACGAG 
GCCGCACCCC TGCCCTCCGG GCGGCCTCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT TACCCTCGAT CCCTCTAAAC GGCAGAACTC TAACCGCTGT 
GTCTCGGGCG CCTCTCTGCC CCAGGGATCC AAAATCAGGT CACAGACGAA CCTGAGAGAA 
TCGGGGGACC TGAGGTCACA AGTTGCCATC TACCTTGGGA TAAAACGGAA ACCGCCCCCA 
GGCTGCTCCG ATTCCCCTGG AGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001355356.1
CDS	350..2416
Translation	MSSRTALAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKEALTNQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGSSHNKGQRASSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGDTELKEERMPGRKASCSAVGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGSERPSLLPNGKENSSGTSRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGSGSGGGVQNGPPASPTLAHEAAPLPSGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRSQTNLRESGDLRSQVAIYLGIKRKPPPGCSDSPGV

Target ORF information:

RefSeq Version	NM_001368427.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001368427.1

ORF Insert Sequence:

ATGTCTTCGA GGACGGCGCT GGCCCCGGGC AACGATCGAA ACTCGGACAC GCATGGCACA 
TTGGGCAGTG GACGATCTTC GGACAAAGGG CCGTCCTGGT CCAGCCGTTC CCTGGGTGCC 
CGTTGCCGGA ACTCTATCGC TTCCTGCCCT GAGGAACAAC CCCATGTGGG CAACTATAGG 
CTGCTAAGGA CCATCGGGAA GGGCAACTTC GCCAAAGTCA AGCTGGCTCG GCATATCCTC 
ACGGGCCGGG AGGTCGCTAT TAAGATCATT GATAAGACCC AGCTGAACCC CAGTAGCTTG 
CAGAAGCTGT TCAGAGAAGT CCGAATTATG AAGGGACTCA ACCACCCCAA CATCGTGAAG 
CTTTTTGAGG TGATAGAGAC GGAGAAGACG CTATACCTGG TGATGGAATA CGCTAGCGCA 
GGAGAAGTGT TTGACTACCT CGTGTCGCAC GGCCGCATGA AGGAGAAGGA GGCTCGAGCC 
AAGTTCCGGC AGATCGTGTC AGCCGTGCAC TACTGTCATC AGAAGAACAT TGTACACAGG 
GATCTAAAGG CTGAAAACCT GTTGCTGGAT GCCGAGGCCA ACATCAAAAT CGCCGACTTC 
GGCTTCAGCA ATGAGTTCAC GCTGGGCTCC AAGCTGGACA CCTTCTGTGG GAGCCCCCCA 
TACGCCGCCC CAGAGCTGTT CCAGGGCAAG AAGTATGATG GGCCAGAGGT GGACATCTGG 
AGCCTGGGTG TCATCCTGTA CACGCTGGTC AGCGGCTCCC TGCCCTTCGA TGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTCCTCAGA GGAAAGTACC GGGTCCCCTT CTACATGTCT 
ACAGACTGCG AGAGCATTCT GCGGAGATTT CTGGTGCTGA ACCCCGCAAA ACGCTGTACT 
CTGGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGCTGAAG 
CCATACACGG AGCCTGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG GCCTTGACCA ACCAGAAGTA CAACGAGGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGTGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGGAC AAGCTCCAGC 
AAAGGCAGCA GCCACAACAA AGGGCAACGG GCTTCTTCCT CCACCTACCA CCGCCAGCGC 
CGTCACAGTG ACTTCTGTGG CCCGTCCCCT GCCCCGCTGC ACCCGAAGCG CAGCCCAACC 
AGCACGGGAG ACACGGAGCT CAAAGAAGAG CGGATGCCGG GTCGGAAAGC GAGCTGCAGT 
GCAGTGGGCA GTGGAAGTCG AGGCTTGCCC CCCTCCAGCC CCATGGTCAG CAGTGCCCAC 
AACCCCAATA AGGCAGAGAT CCCTGAGCGG CGGAAGGACA GCACTAGCAC CCCTAACAAC 
CTCCCCCCCA GCATGATGAC CCGAAGAAAC ACCTATGTGT GCACAGAGCG ACCAGGATCT 
GAACGCCCGT CCTTGTTGCC AAATGGCAAA GAAAATAGCT CCGGTACCTC GCGGGTGCCC 
CCTGCCTCGC CTTCCAGTCA TAGCCTGGCT CCCCCGTCAG GCGAGCGGAG CCGCCTGGCT 
CGGGGCTCCA CCATCCGCAG CACCTTCCAT GGGGGCCAGG TCCGAGACCG GCGGGCAGGG 
AGCGGGAGTG GCGGGGGTGT GCAGAATGGA CCCCCAGCCT CACCCACGCT TGCCCACGAG 
GCCGCACCCC TGCCCTCCGG GCGGCCTCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT TACCCTCGAT CCCTCTAAAC GGCAGAACTC TAACCGCTGT 
GTCTCGGGCG CCTCTCTGCC CCAGGGATCC AAAATCAGGT CACAGACGAA CCTGAGAGAA 
TCGGGGGACC TGAGGTCACA AGTTGCCATC TACCTTGGGA TAAAACGGAA ACCGCCCCCA 
GGCTGCTCCG ATTCCCCTGG AGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mark4 ( XM_006539829.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006539892.1 Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu38178
Clone ID Related Accession (Same CDS sequence)	NM_001368427.1 , XM_006539829.3
Accession Version	XM_006539829.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2067bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	MAP/microtubule affinity-regulating kinase 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006539829.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTTCGA GGACGGCGCT GGCCCCGGGC AACGATCGAA ACTCGGACAC GCATGGCACA 
TTGGGCAGTG GACGATCTTC GGACAAAGGG CCGTCCTGGT CCAGCCGTTC CCTGGGTGCC 
CGTTGCCGGA ACTCTATCGC TTCCTGCCCT GAGGAACAAC CCCATGTGGG CAACTATAGG 
CTGCTAAGGA CCATCGGGAA GGGCAACTTC GCCAAAGTCA AGCTGGCTCG GCATATCCTC 
ACGGGCCGGG AGGTCGCTAT TAAGATCATT GATAAGACCC AGCTGAACCC CAGTAGCTTG 
CAGAAGCTGT TCAGAGAAGT CCGAATTATG AAGGGACTCA ACCACCCCAA CATCGTGAAG 
CTTTTTGAGG TGATAGAGAC GGAGAAGACG CTATACCTGG TGATGGAATA CGCTAGCGCA 
GGAGAAGTGT TTGACTACCT CGTGTCGCAC GGCCGCATGA AGGAGAAGGA GGCTCGAGCC 
AAGTTCCGGC AGATCGTGTC AGCCGTGCAC TACTGTCATC AGAAGAACAT TGTACACAGG 
GATCTAAAGG CTGAAAACCT GTTGCTGGAT GCCGAGGCCA ACATCAAAAT CGCCGACTTC 
GGCTTCAGCA ATGAGTTCAC GCTGGGCTCC AAGCTGGACA CCTTCTGTGG GAGCCCCCCA 
TACGCCGCCC CAGAGCTGTT CCAGGGCAAG AAGTATGATG GGCCAGAGGT GGACATCTGG 
AGCCTGGGTG TCATCCTGTA CACGCTGGTC AGCGGCTCCC TGCCCTTCGA TGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTCCTCAGA GGAAAGTACC GGGTCCCCTT CTACATGTCT 
ACAGACTGCG AGAGCATTCT GCGGAGATTT CTGGTGCTGA ACCCCGCAAA ACGCTGTACT 
CTGGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGCTGAAG 
CCATACACGG AGCCTGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG GCCTTGACCA ACCAGAAGTA CAACGAGGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGTGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGGAC AAGCTCCAGC 
AAAGGCAGCA GCCACAACAA AGGGCAACGG GCTTCTTCCT CCACCTACCA CCGCCAGCGC 
CGTCACAGTG ACTTCTGTGG CCCGTCCCCT GCCCCGCTGC ACCCGAAGCG CAGCCCAACC 
AGCACGGGAG ACACGGAGCT CAAAGAAGAG CGGATGCCGG GTCGGAAAGC GAGCTGCAGT 
GCAGTGGGCA GTGGAAGTCG AGGCTTGCCC CCCTCCAGCC CCATGGTCAG CAGTGCCCAC 
AACCCCAATA AGGCAGAGAT CCCTGAGCGG CGGAAGGACA GCACTAGCAC CCCTAACAAC 
CTCCCCCCCA GCATGATGAC CCGAAGAAAC ACCTATGTGT GCACAGAGCG ACCAGGATCT 
GAACGCCCGT CCTTGTTGCC AAATGGCAAA GAAAATAGCT CCGGTACCTC GCGGGTGCCC 
CCTGCCTCGC CTTCCAGTCA TAGCCTGGCT CCCCCGTCAG GCGAGCGGAG CCGCCTGGCT 
CGGGGCTCCA CCATCCGCAG CACCTTCCAT GGGGGCCAGG TCCGAGACCG GCGGGCAGGG 
AGCGGGAGTG GCGGGGGTGT GCAGAATGGA CCCCCAGCCT CACCCACGCT TGCCCACGAG 
GCCGCACCCC TGCCCTCCGG GCGGCCTCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT TACCCTCGAT CCCTCTAAAC GGCAGAACTC TAACCGCTGT 
GTCTCGGGCG CCTCTCTGCC CCAGGGATCC AAAATCAGGT CACAGACGAA CCTGAGAGAA 
TCGGGGGACC TGAGGTCACA AGTTGCCATC TACCTTGGGA TAAAACGGAA ACCGCCCCCA 
GGCTGCTCCG ATTCCCCTGG AGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006539892.1
CDS	304..2370
Translation	MSSRTALAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKEALTNQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGSSHNKGQRASSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGDTELKEERMPGRKASCSAVGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGSERPSLLPNGKENSSGTSRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGSGSGGGVQNGPPASPTLAHEAAPLPSGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRSQTNLRESGDLRSQVAIYLGIKRKPPPGCSDSPGV

Target ORF information:

RefSeq Version	XM_006539829.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006539829.3

ORF Insert Sequence:

ATGTCTTCGA GGACGGCGCT GGCCCCGGGC AACGATCGAA ACTCGGACAC GCATGGCACA 
TTGGGCAGTG GACGATCTTC GGACAAAGGG CCGTCCTGGT CCAGCCGTTC CCTGGGTGCC 
CGTTGCCGGA ACTCTATCGC TTCCTGCCCT GAGGAACAAC CCCATGTGGG CAACTATAGG 
CTGCTAAGGA CCATCGGGAA GGGCAACTTC GCCAAAGTCA AGCTGGCTCG GCATATCCTC 
ACGGGCCGGG AGGTCGCTAT TAAGATCATT GATAAGACCC AGCTGAACCC CAGTAGCTTG 
CAGAAGCTGT TCAGAGAAGT CCGAATTATG AAGGGACTCA ACCACCCCAA CATCGTGAAG 
CTTTTTGAGG TGATAGAGAC GGAGAAGACG CTATACCTGG TGATGGAATA CGCTAGCGCA 
GGAGAAGTGT TTGACTACCT CGTGTCGCAC GGCCGCATGA AGGAGAAGGA GGCTCGAGCC 
AAGTTCCGGC AGATCGTGTC AGCCGTGCAC TACTGTCATC AGAAGAACAT TGTACACAGG 
GATCTAAAGG CTGAAAACCT GTTGCTGGAT GCCGAGGCCA ACATCAAAAT CGCCGACTTC 
GGCTTCAGCA ATGAGTTCAC GCTGGGCTCC AAGCTGGACA CCTTCTGTGG GAGCCCCCCA 
TACGCCGCCC CAGAGCTGTT CCAGGGCAAG AAGTATGATG GGCCAGAGGT GGACATCTGG 
AGCCTGGGTG TCATCCTGTA CACGCTGGTC AGCGGCTCCC TGCCCTTCGA TGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTCCTCAGA GGAAAGTACC GGGTCCCCTT CTACATGTCT 
ACAGACTGCG AGAGCATTCT GCGGAGATTT CTGGTGCTGA ACCCCGCAAA ACGCTGTACT 
CTGGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGCTGAAG 
CCATACACGG AGCCTGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG GCCTTGACCA ACCAGAAGTA CAACGAGGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGTGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGGAC AAGCTCCAGC 
AAAGGCAGCA GCCACAACAA AGGGCAACGG GCTTCTTCCT CCACCTACCA CCGCCAGCGC 
CGTCACAGTG ACTTCTGTGG CCCGTCCCCT GCCCCGCTGC ACCCGAAGCG CAGCCCAACC 
AGCACGGGAG ACACGGAGCT CAAAGAAGAG CGGATGCCGG GTCGGAAAGC GAGCTGCAGT 
GCAGTGGGCA GTGGAAGTCG AGGCTTGCCC CCCTCCAGCC CCATGGTCAG CAGTGCCCAC 
AACCCCAATA AGGCAGAGAT CCCTGAGCGG CGGAAGGACA GCACTAGCAC CCCTAACAAC 
CTCCCCCCCA GCATGATGAC CCGAAGAAAC ACCTATGTGT GCACAGAGCG ACCAGGATCT 
GAACGCCCGT CCTTGTTGCC AAATGGCAAA GAAAATAGCT CCGGTACCTC GCGGGTGCCC 
CCTGCCTCGC CTTCCAGTCA TAGCCTGGCT CCCCCGTCAG GCGAGCGGAG CCGCCTGGCT 
CGGGGCTCCA CCATCCGCAG CACCTTCCAT GGGGGCCAGG TCCGAGACCG GCGGGCAGGG 
AGCGGGAGTG GCGGGGGTGT GCAGAATGGA CCCCCAGCCT CACCCACGCT TGCCCACGAG 
GCCGCACCCC TGCCCTCCGG GCGGCCTCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT TACCCTCGAT CCCTCTAAAC GGCAGAACTC TAACCGCTGT 
GTCTCGGGCG CCTCTCTGCC CCAGGGATCC AAAATCAGGT CACAGACGAA CCTGAGAGAA 
TCGGGGGACC TGAGGTCACA AGTTGCCATC TACCTTGGGA TAAAACGGAA ACCGCCCCCA 
GGCTGCTCCG ATTCCCCTGG AGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mark4 ( XM_011250513.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011248815.1 Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu73636
Clone ID Related Accession (Same CDS sequence)	XM_011250513.2 , XM_011250513.3
Accession Version	XM_011250513.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	MAP/microtubule affinity-regulating kinase 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011250513.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGGAC TCAACCACCC CAACATCGTG AAGCTTTTTG AGGTGATAGA GACGGAGAAG 
ACGCTATACC TGGTGATGGA ATACGCTAGC GCAGGAGAAG TGTTTGACTA CCTCGTGTCG 
CACGGCCGCA TGAAGGAGAA GGAGGCTCGA GCCAAGTTCC GGCAGATCGT GTCAGCCGTG 
CACTACTGTC ATCAGAAGAA CATTGTACAC AGGGATCTAA AGGCTGAAAA CCTGTTGCTG 
GATGCCGAGG CCAACATCAA AATCGCCGAC TTCGGCTTCA GCAATGAGTT CACGCTGGGC 
TCCAAGCTGG ACACCTTCTG TGGGAGCCCC CCATACGCCG CCCCAGAGCT GTTCCAGGGC 
AAGAAGTATG ATGGGCCAGA GGTGGACATC TGGAGCCTGG GTGTCATCCT GTACACGCTG 
GTCAGCGGCT CCCTGCCCTT CGATGGGCAC AACCTCAAGG AGCTGCGGGA GCGAGTCCTC 
AGAGGAAAGT ACCGGGTCCC CTTCTACATG TCTACAGACT GCGAGAGCAT TCTGCGGAGA 
TTTCTGGTGC TGAACCCCGC AAAACGCTGT ACTCTGGAGC AAATCATGAA AGACAAATGG 
ATCAACATCG GCTATGAGGG TGAGGAGCTG AAGCCATACA CGGAGCCTGA GGAGGACTTC 
GGGGACACCA AGAGAATTGA GGTGATGGTG GGTATGGGCT ACACACGGGA AGAAATCAAA 
GAGGCCTTGA CCAACCAGAA GTACAACGAG GTGACCGCCA CCTACCTCCT GCTGGGCAGG 
AAGACTGAGG AGGGTGGGGA CCGGGGTGCC CCAGGGCTGG CCCTGGCACG GGTGCGGGCG 
CCCAGCGACA CCACCAACGG GACAAGCTCC AGCAAAGGCA GCAGCCACAA CAAAGGGCAA 
CGGGCTTCTT CCTCCACCTA CCACCGCCAG CGCCGTCACA GTGACTTCTG TGGCCCGTCC 
CCTGCCCCGC TGCACCCGAA GCGCAGCCCA ACCAGCACGG GAGACACGGA GCTCAAAGAA 
GAGCGGATGC CGGGTCGGAA AGCGAGCTGC AGTGCAGTGG GCAGTGGAAG TCGAGGCTTG 
CCCCCCTCCA GCCCCATGGT CAGCAGTGCC CACAACCCCA ATAAGGCAGA GATCCCTGAG 
CGGCGGAAGG ACAGCACTAG CACCCCTAAC AACCTCCCCC CCAGCATGAT GACCCGAAGA 
AACACCTATG TGTGCACAGA GCGACCAGGA TCTGAACGCC CGTCCTTGTT GCCAAATGGC 
AAAGAAAATA GCTCCGGTAC CTCGCGGGTG CCCCCTGCCT CGCCTTCCAG TCATAGCCTG 
GCTCCCCCGT CAGGCGAGCG GAGCCGCCTG GCTCGGGGCT CCACCATCCG CAGCACCTTC 
CATGGGGGCC AGGTCCGAGA CCGGCGGGCA GGGAGCGGGA GTGGCGGGGG TGTGCAGAAT 
GGACCCCCAG CCTCACCCAC GCTTGCCCAC GAGGCCGCAC CCCTGCCCTC CGGGCGGCCT 
CGCCCCACCA CCAACCTCTT CACCAAGCTG ACCTCCAAAC TGACCCGAAG GGTCACAGAC 
GAACCTGAGA GAATCGGGGG ACCTGAGGTC ACAAGTTGCC ATCTACCTTG GGATAAAACG 
GAAACCGCCC CCAGGCTGCT CCGATTCCCC TGGAGTGTGA AGCTGACCAG CTCGCGACCT 
CCTGAGGCCC TGATGGCTGC CCTGCGACAG GCCACAGCGG CCGCCCGCTG CCGGTGCCGC 
CAGCCGCAGC CGTTCCTGCT GGCCTGCCTG CACGGGGGTG CGGGCGGGCC CGAGCCCCTG 
TCCCATTTCG AAGTGGAGGT GTGCCAGCTG CCCCGGCCCG GCCTCAGGGG CGTCCTCTTC 
CGCCGTGTGG CGGGCACCGC CCTGGCCTTC CGCACCCTCG TCACCCGCAT CTCCAACGAC 
CTCGAACTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011248815.1
CDS	1307..3238
Translation	MKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKEALTNQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGSSHNKGQRASSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGDTELKEERMPGRKASCSAVGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGSERPSLLPNGKENSSGTSRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGSGSGGGVQNGPPASPTLAHEAAPLPSGRPRPTTNLFTKLTSKLTRRVTDEPERIGGPEVTSCHLPWDKTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL

Target ORF information:

RefSeq Version	XM_011250513.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011250513.3

ORF Insert Sequence:

ATGAAGGGAC TCAACCACCC CAACATCGTG AAGCTTTTTG AGGTGATAGA GACGGAGAAG 
ACGCTATACC TGGTGATGGA ATACGCTAGC GCAGGAGAAG TGTTTGACTA CCTCGTGTCG 
CACGGCCGCA TGAAGGAGAA GGAGGCTCGA GCCAAGTTCC GGCAGATCGT GTCAGCCGTG 
CACTACTGTC ATCAGAAGAA CATTGTACAC AGGGATCTAA AGGCTGAAAA CCTGTTGCTG 
GATGCCGAGG CCAACATCAA AATCGCCGAC TTCGGCTTCA GCAATGAGTT CACGCTGGGC 
TCCAAGCTGG ACACCTTCTG TGGGAGCCCC CCATACGCCG CCCCAGAGCT GTTCCAGGGC 
AAGAAGTATG ATGGGCCAGA GGTGGACATC TGGAGCCTGG GTGTCATCCT GTACACGCTG 
GTCAGCGGCT CCCTGCCCTT CGATGGGCAC AACCTCAAGG AGCTGCGGGA GCGAGTCCTC 
AGAGGAAAGT ACCGGGTCCC CTTCTACATG TCTACAGACT GCGAGAGCAT TCTGCGGAGA 
TTTCTGGTGC TGAACCCCGC AAAACGCTGT ACTCTGGAGC AAATCATGAA AGACAAATGG 
ATCAACATCG GCTATGAGGG TGAGGAGCTG AAGCCATACA CGGAGCCTGA GGAGGACTTC 
GGGGACACCA AGAGAATTGA GGTGATGGTG GGTATGGGCT ACACACGGGA AGAAATCAAA 
GAGGCCTTGA CCAACCAGAA GTACAACGAG GTGACCGCCA CCTACCTCCT GCTGGGCAGG 
AAGACTGAGG AGGGTGGGGA CCGGGGTGCC CCAGGGCTGG CCCTGGCACG GGTGCGGGCG 
CCCAGCGACA CCACCAACGG GACAAGCTCC AGCAAAGGCA GCAGCCACAA CAAAGGGCAA 
CGGGCTTCTT CCTCCACCTA CCACCGCCAG CGCCGTCACA GTGACTTCTG TGGCCCGTCC 
CCTGCCCCGC TGCACCCGAA GCGCAGCCCA ACCAGCACGG GAGACACGGA GCTCAAAGAA 
GAGCGGATGC CGGGTCGGAA AGCGAGCTGC AGTGCAGTGG GCAGTGGAAG TCGAGGCTTG 
CCCCCCTCCA GCCCCATGGT CAGCAGTGCC CACAACCCCA ATAAGGCAGA GATCCCTGAG 
CGGCGGAAGG ACAGCACTAG CACCCCTAAC AACCTCCCCC CCAGCATGAT GACCCGAAGA 
AACACCTATG TGTGCACAGA GCGACCAGGA TCTGAACGCC CGTCCTTGTT GCCAAATGGC 
AAAGAAAATA GCTCCGGTAC CTCGCGGGTG CCCCCTGCCT CGCCTTCCAG TCATAGCCTG 
GCTCCCCCGT CAGGCGAGCG GAGCCGCCTG GCTCGGGGCT CCACCATCCG CAGCACCTTC 
CATGGGGGCC AGGTCCGAGA CCGGCGGGCA GGGAGCGGGA GTGGCGGGGG TGTGCAGAAT 
GGACCCCCAG CCTCACCCAC GCTTGCCCAC GAGGCCGCAC CCCTGCCCTC CGGGCGGCCT 
CGCCCCACCA CCAACCTCTT CACCAAGCTG ACCTCCAAAC TGACCCGAAG GGTCACAGAC 
GAACCTGAGA GAATCGGGGG ACCTGAGGTC ACAAGTTGCC ATCTACCTTG GGATAAAACG 
GAAACCGCCC CCAGGCTGCT CCGATTCCCC TGGAGTGTGA AGCTGACCAG CTCGCGACCT 
CCTGAGGCCC TGATGGCTGC CCTGCGACAG GCCACAGCGG CCGCCCGCTG CCGGTGCCGC 
CAGCCGCAGC CGTTCCTGCT GGCCTGCCTG CACGGGGGTG CGGGCGGGCC CGAGCCCCTG 
TCCCATTTCG AAGTGGAGGT GTGCCAGCTG CCCCGGCCCG GCCTCAGGGG CGTCCTCTTC 
CGCCGTGTGG CGGGCACCGC CCTGGCCTTC CGCACCCTCG TCACCCGCAT CTCCAACGAC 
CTCGAACTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mark4 ( XM_030242436.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030098296.1 Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu89434
Clone ID Related Accession (Same CDS sequence)	XM_030242436.1
Accession Version	XM_030242436.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1740bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	MAP/microtubule affinity-regulating kinase 4 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGGAC TCAACCACCC CAACATCGTG AAGCTTTTTG AGGTGATAGA GACGGAGAAG 
ACGCTATACC TGGTGATGGA ATACGCTAGC GCAGGAGAAG TGTTTGACTA CCTCGTGTCG 
CACGGCCGCA TGAAGGAGAA GGAGGCTCGA GCCAAGTTCC GGCAGATCGT GTCAGCCGTG 
CACTACTGTC ATCAGAAGAA CATTGTACAC AGGGATCTAA AGGCTGAAAA CCTGTTGCTG 
GATGCCGAGG CCAACATCAA AATCGCCGAC TTCGGCTTCA GCAATGAGTT CACGCTGGGC 
TCCAAGCTGG ACACCTTCTG TGGGAGCCCC CCATACGCCG CCCCAGAGCT GTTCCAGGGC 
AAGAAGTATG ATGGGCCAGA GGTGGACATC TGGAGCCTGG GTGTCATCCT GTACACGCTG 
GTCAGCGGCT CCCTGCCCTT CGATGGGCAC AACCTCAAGG AGCTGCGGGA GCGAGTCCTC 
AGAGGAAAGT ACCGGGTCCC CTTCTACATG TCTACAGACT GCGAGAGCAT TCTGCGGAGA 
TTTCTGGTGC TGAACCCCGC AAAACGCTGT ACTCTGGAGC AAATCATGAA AGACAAATGG 
ATCAACATCG GCTATGAGGG TGAGGAGCTG AAGCCATACA CGGAGCCTGA GGAGGACTTC 
GGGGACACCA AGAGAATTGA GGTGATGGTG GGTATGGGCT ACACACGGGA AGAAATCAAA 
GAGGCCTTGA CCAACCAGAA GTACAACGAG GTGACCGCCA CCTACCTCCT GCTGGGCAGG 
AAGACTGAGG AGGGTGGGGA CCGGGGTGCC CCAGGGCTGG CCCTGGCACG GGTGCGGGCG 
CCCAGCGACA CCACCAACGG GACAAGCTCC AGCAAAGGCA GCAGCCACAA CAAAGGGCAA 
CGGGCTTCTT CCTCCACCTA CCACCGCCAG CGCCGTCACA GTGACTTCTG TGGCCCGTCC 
CCTGCCCCGC TGCACCCGAA GCGCAGCCCA ACCAGCACGG GAGACACGGA GCTCAAAGAA 
GAGCGGATGC CGGGTCGGAA AGCGAGCTGC AGTGCAGTGG GCAGTGGAAG TCGAGGCTTG 
CCCCCCTCCA GCCCCATGGT CAGCAGTGCC CACAACCCCA ATAAGGCAGA GATCCCTGAG 
CGGCGGAAGG ACAGCACTAG CACCCCTAAC AACCTCCCCC CCAGCATGAT GACCCGAAGA 
AACACCTATG TGTGCACAGA GCGACCAGGA TCTGAACGCC CGTCCTTGTT GCCAAATGGC 
AAAGAAAATA GCTCCGGTAC CTCGCGGGTG CCCCCTGCCT CGCCTTCCAG TCATAGCCTG 
GCTCCCCCGT CAGGCGAGCG GAGCCGCCTG GCTCGGGGCT CCACCATCCG CAGCACCTTC 
CATGGGGGCC AGGTCCGAGA CCGGCGGGCA GGGAGCGGGA GTGGCGGGGG TGTGCAGAAT 
GGACCCCCAG CCTCACCCAC GCTTGCCCAC GAGGCCGCAC CCCTGCCCTC CGGGCGGCCT 
CGCCCCACCA CCAACCTCTT CACCAAGCTG ACCTCCAAAC TGACCCGAAG GGTTACCCTC 
GATCCCTCTA AACGGCAGAA CTCTAACCGC TGTGTCTCGG GCGCCTCTCT GCCCCAGGGA 
TCCAAAATCA GGTCACAGAC GAACCTGAGA GAATCGGGGG ACCTGAGGTC ACAAGTTGCC 
ATCTACCTTG GGATAAAACG GAAACCGCCC CCAGGCTGCT CCGATTCCCC TGGAGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030098296.1
CDS	1307..3046
Translation	MKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKEALTNQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGSSHNKGQRASSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGDTELKEERMPGRKASCSAVGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGSERPSLLPNGKENSSGTSRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGSGSGGGVQNGPPASPTLAHEAAPLPSGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRSQTNLRESGDLRSQVAIYLGIKRKPPPGCSDSPGV

Target ORF information:

RefSeq Version	XM_030242436.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030242436.1

ORF Insert Sequence:

ATGAAGGGAC TCAACCACCC CAACATCGTG AAGCTTTTTG AGGTGATAGA GACGGAGAAG 
ACGCTATACC TGGTGATGGA ATACGCTAGC GCAGGAGAAG TGTTTGACTA CCTCGTGTCG 
CACGGCCGCA TGAAGGAGAA GGAGGCTCGA GCCAAGTTCC GGCAGATCGT GTCAGCCGTG 
CACTACTGTC ATCAGAAGAA CATTGTACAC AGGGATCTAA AGGCTGAAAA CCTGTTGCTG 
GATGCCGAGG CCAACATCAA AATCGCCGAC TTCGGCTTCA GCAATGAGTT CACGCTGGGC 
TCCAAGCTGG ACACCTTCTG TGGGAGCCCC CCATACGCCG CCCCAGAGCT GTTCCAGGGC 
AAGAAGTATG ATGGGCCAGA GGTGGACATC TGGAGCCTGG GTGTCATCCT GTACACGCTG 
GTCAGCGGCT CCCTGCCCTT CGATGGGCAC AACCTCAAGG AGCTGCGGGA GCGAGTCCTC 
AGAGGAAAGT ACCGGGTCCC CTTCTACATG TCTACAGACT GCGAGAGCAT TCTGCGGAGA 
TTTCTGGTGC TGAACCCCGC AAAACGCTGT ACTCTGGAGC AAATCATGAA AGACAAATGG 
ATCAACATCG GCTATGAGGG TGAGGAGCTG AAGCCATACA CGGAGCCTGA GGAGGACTTC 
GGGGACACCA AGAGAATTGA GGTGATGGTG GGTATGGGCT ACACACGGGA AGAAATCAAA 
GAGGCCTTGA CCAACCAGAA GTACAACGAG GTGACCGCCA CCTACCTCCT GCTGGGCAGG 
AAGACTGAGG AGGGTGGGGA CCGGGGTGCC CCAGGGCTGG CCCTGGCACG GGTGCGGGCG 
CCCAGCGACA CCACCAACGG GACAAGCTCC AGCAAAGGCA GCAGCCACAA CAAAGGGCAA 
CGGGCTTCTT CCTCCACCTA CCACCGCCAG CGCCGTCACA GTGACTTCTG TGGCCCGTCC 
CCTGCCCCGC TGCACCCGAA GCGCAGCCCA ACCAGCACGG GAGACACGGA GCTCAAAGAA 
GAGCGGATGC CGGGTCGGAA AGCGAGCTGC AGTGCAGTGG GCAGTGGAAG TCGAGGCTTG 
CCCCCCTCCA GCCCCATGGT CAGCAGTGCC CACAACCCCA ATAAGGCAGA GATCCCTGAG 
CGGCGGAAGG ACAGCACTAG CACCCCTAAC AACCTCCCCC CCAGCATGAT GACCCGAAGA 
AACACCTATG TGTGCACAGA GCGACCAGGA TCTGAACGCC CGTCCTTGTT GCCAAATGGC 
AAAGAAAATA GCTCCGGTAC CTCGCGGGTG CCCCCTGCCT CGCCTTCCAG TCATAGCCTG 
GCTCCCCCGT CAGGCGAGCG GAGCCGCCTG GCTCGGGGCT CCACCATCCG CAGCACCTTC 
CATGGGGGCC AGGTCCGAGA CCGGCGGGCA GGGAGCGGGA GTGGCGGGGG TGTGCAGAAT 
GGACCCCCAG CCTCACCCAC GCTTGCCCAC GAGGCCGCAC CCCTGCCCTC CGGGCGGCCT 
CGCCCCACCA CCAACCTCTT CACCAAGCTG ACCTCCAAAC TGACCCGAAG GGTTACCCTC 
GATCCCTCTA AACGGCAGAA CTCTAACCGC TGTGTCTCGG GCGCCTCTCT GCCCCAGGGA 
TCCAAAATCA GGTCACAGAC GAACCTGAGA GAATCGGGGG ACCTGAGGTC ACAAGTTGCC 
ATCTACCTTG GGATAAAACG GAAACCGCCC CCAGGCTGCT CCGATTCCCC TGGAGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism.
Nature communications815986(2017 Jun)
Li X,Thome S,Ma X,Amrute-Nayak M,Finigan A,Kitt L,Masters L,James JR,Shi Y,Meng G,Mallat Z

Mark4 promotes oxidative stress and inflammation via binding to PPAR? and activating NF-?B pathway in mice adipocytes.
Scientific reports621382(2016 Feb)
Liu Z,Gan L,Chen Y,Luo D,Zhang Z,Cao W,Zhou Z,Lin X,Sun C

The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis.
The Journal of cell biology200(4)505-22(2013 Feb)
Kuhns S,Schmidt KN,Reymann J,Gilbert DF,Neuner A,Hub B,Carvalho R,Wiedemann P,Zentgraf H,Erfle H,Klingm?ller U,Boutros M,Pereira G

Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin hypersensitivity and resistance to diet-induced obesity.
The Journal of biological chemistry287(45)38305-15(2012 Nov)
Sun C,Tian L,Nie J,Zhang H,Han X,Shi Y

Differential signature of the centrosomal MARK4 isoforms in glioma.
Analytical cellular pathology (Amsterdam)34(6)319-38(2011)
Magnani I,Novielli C,Fontana L,Tabano S,Rovina D,Moroni RF,Bauer D,Mazzoleni S,Colombo EA,Tedeschi G,Monti L,Porta G,Bosari S,Frassoni C,Galli R,Bello L,Larizza L

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Mark4 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

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Target ORF information:

ORF Insert Sequence:

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