Tspan33 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tspan33
Entrez Gene ID	232670
Full Name	tetraspanin 33
Synonyms	1300010A20Rik,Pen
General protein information	Preferred Names tetraspanin 33 Names tetraspanin-33 penumbra proerythroblast new membrane
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 A3.3
Summary	This gene encodes a member of the tetraspanin family which typically have four transmembrane domains. The encoded protein may be involved in the regulation of erythropoiesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001301407.1	NP_001288336.1	tetraspanin-33 isoform 2
NM_146173.3	NP_666285.1	tetraspanin-33 isoform 1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	tspan33	NP_001002617.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002257	XP_307926.5
Xenopus tropicalis (tropical clawed frog)	tspan33	XP_002931890.1
	TSPAN33	XP_001091336.2
Bos taurus (cattle)	TSPAN33	NP_001029844.1
Mus musculus (house mouse)	Tspan33	NP_666285.1
Homo sapiens (human)	TSPAN33	NP_848657.1
Drosophila melanogaster (fruit fly)	Tsp86D	NP_001262468.1
Pan troglodytes (chimpanzee)	TSPAN33	XP_001155179.1
Canis lupus familiaris (dog)	TSPAN33	XP_532430.2
Rattus norvegicus (Norway rat)	Tspan33	NP_001102697.1
Drosophila melanogaster (fruit fly)	Tsp3A	NP_001245504.1

Gene Ontology
Bibliography

Related articles in PubMed

The Tetraspanin TSPAN33 Controls TLR-Triggered Macrophage Activation through Modulation of NOTCH Signaling.
Ruiz-Garc?a A, L?pez-L?pez S, Garc?a-Ram?rez JJ, Baladr?n V, Ruiz-Hidalgo MJ, L?pez-Sanz L, Ballesteros ?, Laborda J, Monsalve EM, D?az-Guerra MJ
Journal of immunology (Baltimore, Md. : 1950)197(8)3371-3381(2016 Oct)

The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression.
Haining EJ, Yang J, Bailey RL, Khan K, Collier R, Tsai S, Watson SP, Frampton J, Garcia P, Tomlinson MG
The Journal of biological chemistry287(47)39753-65(2012 Nov)

Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H
BMC genomics9511(2008 Oct)

Appearance of new tetraspanin genes during vertebrate evolution.
Garcia-Espa?a A, Chung PJ, Sarkar IN, Stiner E, Sun TT, Desalle R
Genomics91(4)326-34(2008 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results suggest that TSPAN33 represents a new control element in the development of inflammation by macrophages that could constitute a potential therapeutic target.
Title: The Tetraspanin TSPAN33 Controls TLR-Triggered Macrophage Activation through Modulation of NOTCH Signaling.

Penumbra has a positive function in erythropoiesis and its deletion or mutation may result in anemia.
Title: Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis.

The following Tspan33 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tspan33 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12286	NM_146173.3 Latest version!	Mus musculus tetraspanin 33 (Tspan33), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu73621	NM_001301407.1 Latest version!	Mus musculus tetraspanin 33 (Tspan33), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tspan33 ( NM_146173.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_666285.1 Mus musculus tetraspanin 33 (Tspan33), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu12286
Clone ID Related Accession (Same CDS sequence)	NM_146173.3
Accession Version	NM_146173.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Mus musculus(house mouse)
Product	tetraspanin-33 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF460925.1, AK004954.1, BE861472.1, AC069469.5 and BE949216.1. On Aug 19, 2014 this sequence version replaced NM_146173.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC024685.1, AF276890.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCGGA GACCTGGCGT GCCGGCTGCC TACGGGGACG AGTTCTCCTT CGTCAGCCCG 
CTGGTGAAAT ACCTGCTCTT CTTCTTCAAC ATGCTCTTCT GGGTAATCTC CATGGTCATG 
GTGGCCGTGG GTGTCTATGC CAGGCTAATG AAGCACGCAG AAGCAGCCTT GGCTTGTCTG 
GCGGTGGACC CTGCTATCCT GCTGATCGTG GTGGGCGTCC TCATGTTCCT GCTCACCTTC 
TGCGGCTGTA TCGGATCCCT TCGGGAGAAC ATCTGCCTTC TGCAGACGTT CTCCCTCTGC 
CTCACCATCG TGTTCCTGCT GCAGCTGGCT GCTGGCATCC TGGGCTTCGT CTTCTCAGAC 
AAGGCTCGGG GGAAAGTGAG CGAGATCATC AACAATGCTA TCGTGCATTA TCGAGATGAC 
CTGGATCTGC AGAACCTCAT CGACTTTGGC CAGAAGAAGT TCAGCTGCTG TGGAGGGATC 
TCCTACAGAG ACTGGTCTCA GAATATGTAC TTCAACTGCT CGGAGGACAA CCCTAGCCGG 
GAGCGCTGCT CTGTGCCTTA TTCCTGTTGC TTGCCCACCC CCAACCAGGC AGTGATCAAC 
ACGATGTGTG GCCAAGGTAT GCAGGCTCTG GACTACTTGG AAGCTAGTAA GGTCATCTAC 
ACCAATGGCT GTATTGACAA GTTGGTCAAC TGGATACACA GCAACCTGTT CCTGCTTGGT 
GGTGTGGCAC TAGGCCTGGC CATCCCCCAG CTGGTGGGAA TCCTGCTATC CCAGGTCCTC 
GTGAATCAAA TAAAAGATCA GATCAAGCTA CAGCTCTACA ACCAACAGCA CCGAGCTGAC 
CCGTGGTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_666285.1
CDS	230..1081
Translation	MARRPGVPAAYGDEFSFVSPLVKYLLFFFNMLFWVISMVMVAVGVYARLMKHAEAALACLAVDPAILLIVVGVLMFLLTFCGCIGSLRENICLLQTFSLCLTIVFLLQLAAGILGFVFSDKARGKVSEIINNAIVHYRDDLDLQNLIDFGQKKFSCCGGISYRDWSQNMYFNCSEDNPSRERCSVPYSCCLPTPNQAVINTMCGQGMQALDYLEASKVIYTNGCIDKLVNWIHSNLFLLGGVALGLAIPQLVGILLSQVLVNQIKDQIKLQLYNQQHRADPWY

Target ORF information:

RefSeq Version	NM_146173.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus tetraspanin 33 (Tspan33), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_146173.3

ORF Insert Sequence:

ATGGCGCGGA GACCTGGCGT GCCGGCTGCC TACGGGGACG AGTTCTCCTT CGTCAGCCCG 
CTGGTGAAAT ACCTGCTCTT CTTCTTCAAC ATGCTCTTCT GGGTAATCTC CATGGTCATG 
GTGGCCGTGG GTGTCTATGC CAGGCTAATG AAGCACGCAG AAGCAGCCTT GGCTTGTCTG 
GCGGTGGACC CTGCTATCCT GCTGATCGTG GTGGGCGTCC TCATGTTCCT GCTCACCTTC 
TGCGGCTGTA TCGGATCCCT TCGGGAGAAC ATCTGCCTTC TGCAGACGTT CTCCCTCTGC 
CTCACCATCG TGTTCCTGCT GCAGCTGGCT GCTGGCATCC TGGGCTTCGT CTTCTCAGAC 
AAGGCTCGGG GGAAAGTGAG CGAGATCATC AACAATGCTA TCGTGCATTA TCGAGATGAC 
CTGGATCTGC AGAACCTCAT CGACTTTGGC CAGAAGAAGT TCAGCTGCTG TGGAGGGATC 
TCCTACAGAG ACTGGTCTCA GAATATGTAC TTCAACTGCT CGGAGGACAA CCCTAGCCGG 
GAGCGCTGCT CTGTGCCTTA TTCCTGTTGC TTGCCCACCC CCAACCAGGC AGTGATCAAC 
ACGATGTGTG GCCAAGGTAT GCAGGCTCTG GACTACTTGG AAGCTAGTAA GGTCATCTAC 
ACCAATGGCT GTATTGACAA GTTGGTCAAC TGGATACACA GCAACCTGTT CCTGCTTGGT 
GGTGTGGCAC TAGGCCTGGC CATCCCCCAG CTGGTGGGAA TCCTGCTATC CCAGGTCCTC 
GTGAATCAAA TAAAAGATCA GATCAAGCTA CAGCTCTACA ACCAACAGCA CCGAGCTGAC 
CCGTGGTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tspan33 ( NM_001301407.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001288336.1 Mus musculus tetraspanin 33 (Tspan33), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu73621
Clone ID Related Accession (Same CDS sequence)	NM_001301407.1
Accession Version	NM_001301407.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Mus musculus(house mouse)
Product	tetraspanin-33 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF460925.1, CJ068126.1, BU054333.1, AK004954.1, AC069469.5 and BE949216.1. On Aug 19, 2014 this sequence version replaced XM_006505062.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK172176.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCGGA GACCTGGCGT GCCGGCTGCC TACGGGGACG AGTTCTCCTT CGTCAGCCCG 
CTGGTGAAAT ACCTGCTCTT CTTCTTCAAC ATGCTCTTCT GGGTAATCTC CATGGTCATG 
GTGGCCGTGG GTGTCTATGC CAGGCTAATG AAGCACGCAG CAGCCTTGGC TTGTCTGGCG 
GTGGACCCTG CTATCCTGCT GATCGTGGTG GGCGTCCTCA TGTTCCTGCT CACCTTCTGC 
GGCTGTATCG GATCCCTTCG GGAGAACATC TGCCTTCTGC AGACGTTCTC CCTCTGCCTC 
ACCATCGTGT TCCTGCTGCA GCTGGCTGCT GGCATCCTGG GCTTCGTCTT CTCAGACAAG 
GCTCGGGGGA AAGTGAGCGA GATCATCAAC AATGCTATCG TGCATTATCG AGATGACCTG 
GATCTGCAGA ACCTCATCGA CTTTGGCCAG AAGAAGTTCA GCTGCTGTGG AGGGATCTCC 
TACAGAGACT GGTCTCAGAA TATGTACTTC AACTGCTCGG AGGACAACCC TAGCCGGGAG 
CGCTGCTCTG TGCCTTATTC CTGTTGCTTG CCCACCCCCA ACCAGGCAGT GATCAACACG 
ATGTGTGGCC AAGGTATGCA GGCTCTGGAC TACTTGGAAG CTAGTAAGGT CATCTACACC 
AATGGCTGTA TTGACAAGTT GGTCAACTGG ATACACAGCA ACCTGTTCCT GCTTGGTGGT 
GTGGCACTAG GCCTGGCCAT CCCCCAGCTG GTGGGAATCC TGCTATCCCA GGTCCTCGTG 
AATCAAATAA AAGATCAGAT CAAGCTACAG CTCTACAACC AACAGCACCG AGCTGACCCG 
TGGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288336.1
CDS	230..1078
Translation	MARRPGVPAAYGDEFSFVSPLVKYLLFFFNMLFWVISMVMVAVGVYARLMKHAAALACLAVDPAILLIVVGVLMFLLTFCGCIGSLRENICLLQTFSLCLTIVFLLQLAAGILGFVFSDKARGKVSEIINNAIVHYRDDLDLQNLIDFGQKKFSCCGGISYRDWSQNMYFNCSEDNPSRERCSVPYSCCLPTPNQAVINTMCGQGMQALDYLEASKVIYTNGCIDKLVNWIHSNLFLLGGVALGLAIPQLVGILLSQVLVNQIKDQIKLQLYNQQHRADPWY

Target ORF information:

RefSeq Version	NM_001301407.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus tetraspanin 33 (Tspan33), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301407.1

ORF Insert Sequence:

ATGGCGCGGA GACCTGGCGT GCCGGCTGCC TACGGGGACG AGTTCTCCTT CGTCAGCCCG 
CTGGTGAAAT ACCTGCTCTT CTTCTTCAAC ATGCTCTTCT GGGTAATCTC CATGGTCATG 
GTGGCCGTGG GTGTCTATGC CAGGCTAATG AAGCACGCAG CAGCCTTGGC TTGTCTGGCG 
GTGGACCCTG CTATCCTGCT GATCGTGGTG GGCGTCCTCA TGTTCCTGCT CACCTTCTGC 
GGCTGTATCG GATCCCTTCG GGAGAACATC TGCCTTCTGC AGACGTTCTC CCTCTGCCTC 
ACCATCGTGT TCCTGCTGCA GCTGGCTGCT GGCATCCTGG GCTTCGTCTT CTCAGACAAG 
GCTCGGGGGA AAGTGAGCGA GATCATCAAC AATGCTATCG TGCATTATCG AGATGACCTG 
GATCTGCAGA ACCTCATCGA CTTTGGCCAG AAGAAGTTCA GCTGCTGTGG AGGGATCTCC 
TACAGAGACT GGTCTCAGAA TATGTACTTC AACTGCTCGG AGGACAACCC TAGCCGGGAG 
CGCTGCTCTG TGCCTTATTC CTGTTGCTTG CCCACCCCCA ACCAGGCAGT GATCAACACG 
ATGTGTGGCC AAGGTATGCA GGCTCTGGAC TACTTGGAAG CTAGTAAGGT CATCTACACC 
AATGGCTGTA TTGACAAGTT GGTCAACTGG ATACACAGCA ACCTGTTCCT GCTTGGTGGT 
GTGGCACTAG GCCTGGCCAT CCCCCAGCTG GTGGGAATCC TGCTATCCCA GGTCCTCGTG 
AATCAAATAA AAGATCAGAT CAAGCTACAG CTCTACAACC AACAGCACCG AGCTGACCCG 
TGGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Tetraspanin TSPAN33 Controls TLR-Triggered Macrophage Activation through Modulation of NOTCH Signaling.
Journal of immunology (Baltimore, Md. : 1950)197(8)3371-3381(2016 Oct)
Ruiz-Garc?a A,L?pez-L?pez S,Garc?a-Ram?rez JJ,Baladr?n V,Ruiz-Hidalgo MJ,L?pez-Sanz L,Ballesteros ?,Laborda J,Monsalve EM,D?az-Guerra MJ

The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression.
The Journal of biological chemistry287(47)39753-65(2012 Nov)
Haining EJ,Yang J,Bailey RL,Khan K,Collier R,Tsai S,Watson SP,Frampton J,Garcia P,Tomlinson MG

Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
BMC genomics9511(2008 Oct)
Tamplin OJ,Kinzel D,Cox BJ,Bell CE,Rossant J,Lickert H

Appearance of new tetraspanin genes during vertebrate evolution.
Genomics91(4)326-34(2008 Apr)
Garcia-Espa?a A,Chung PJ,Sarkar IN,Stiner E,Sun TT,Desalle R

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Tspan33 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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