Clec12a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Clec12a
Entrez Gene ID	232413
Full Name	C-type lectin domain family 12, member a
Synonyms	CLL-1,D230024O04,KLRL1,Micl
General protein information	Preferred Names C-type lectin domain family 12, member a Names C-type lectin domain family 12 member A C-type lectin-like molecule 1 myeloid inhibitory C-type lectin-like receptor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 F3

mRNA and Protein(s)

mRNA	Protein	Name
XM_011241323.1	XP_011239625.1	C-type lectin domain family 12 member A isoform X1
NM_177686.4	NP_808354.1	C-type lectin domain family 12 member A
XM_011241323.3	XP_011239625.1	C-type lectin domain family 12 member A isoform X1
XM_011241323.2	XP_011239625.1	C-type lectin domain family 12 member A isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Clec12a	NP_001128188.1
	LOC722319	XP_001118480.2
Canis lupus familiaris (dog)	CLEC12A	XP_534891.2
Mus musculus (house mouse)	Clec12a	NP_808354.1
Pan troglodytes (chimpanzee)	CLEC12A	XP_003313529.1
Bos taurus (cattle)	CLEC12A	NP_001098815.1
Homo sapiens (human)	CLEC12A	NP_001193939.1

Gene Ontology
Bibliography

Related articles in PubMed

Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity.
Sagar D, Singh NP, Ginwala R, Huang X, Philip R, Nagarkatti M, Nagarkatti P, Neumann K, Ruland J, Andrews AM, Ramirez SH, Khan ZK, Jain P
Scientific reports7(1)2707(2017 Jun)

Antibody-mediated targeting of antigen to C-type lectin-like receptors Clec9A and Clec12A elicits different vaccination outcomes.
Macri C, Dumont C, Panozza S, Lahoud MH, Caminschi I, Villadangos JA, Johnston AP, Mintern JD
Molecular immunology81143-150(2017 Jan)

MICL controls inflammation in rheumatoid arthritis.
Redelinghuys P, Whitehead L, Augello A, Drummond RA, Levesque JM, Vautier S, Reid DM, Kerscher B, Taylor JA, Nigrovic PA, Wright J, Murray GI, Willment JA, Hocking LJ, Fernandes MJ, De Bari C, Mcinnes IB, Brown GD
Annals of the rheumatic diseases75(7)1386-91(2016 Jul)

Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.
Begun J, Lassen KG, Jijon HB, Baxt LA, Goel G, Heath RJ, Ng A, Tam JM, Kuo SY, Villablanca EJ, Fagbami L, Oosting M, Kumar V, Schenone M, Carr SA, Joosten LA, Vyas JM, Daly MJ, Netea MG, Brown GD, Wijmenga C, Xavier RJ
Cell reports11(12)1905-18(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clec9A and Clec12A exhibit different intrinsic capacities to elicit MHC I and MHC II presentation following direct antigen targeting
Title: Antibody-mediated targeting of antigen to C-type lectin-like receptors Clec9A and Clec12A elicits different vaccination outcomes.

Clec12a(-/-) mice are more susceptible to Salmonella infection, supporting a role for CLEC12A in antibacterial defense pathways in vivo.
Title: Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.

Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.
Title: Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.

Anti-Clec12A mAb alone produced only moderate responses, but these were amplified by coinjecting only small amounts of LPS as a dendritic cell activation agent
Title: The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses.

mMICL recognises an endogenous ligand in a variety of murine tissues, suggesting that the receptor plays a role in homeostasis
Title: Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand.

The following Clec12a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clec12a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu23035	NM_177686.4 Latest version!	Mus musculus C-type lectin domain family 12, member a (Clec12a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu23035	XM_011241323.3 Latest version!	Mus musculus C-type lectin domain family 12, member a (Clec12a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu23035	XM_011241323.1	Mus musculus C-type lectin domain family 12, member a (Clec12a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu23035	XM_011241323.2	Mus musculus C-type lectin domain family 12, member a (Clec12a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Clec12a ( NM_177686.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_808354.1 Mus musculus C-type lectin domain family 12, member a (Clec12a), mRNA.

Price & Availability↑

CloneID	OMu23035
Clone ID Related Accession (Same CDS sequence)	XM_011241323.1 , NM_177686.4 , XM_011241323.3 , XM_011241323.2
Accession Version	NM_177686.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	C-type lectin domain family 12 member A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB850261.1, AK084335.1 and AC138620.4. On Feb 18, 2011 this sequence version replaced NM_177686.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK084335.1, BC094904.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTGAAG AAATTGTTTA TGCAAATCTC AAAATCCAGG ACCCTGATAA AAAAGAAGAA 
ACCCAGAAGT CTGACAAATG TGGGGGAAAA GTATCCGCCG ATGCTTCCCA TTCACAGCAA 
AAAACAGTCT TGATTCTGAT TCTTCTATGC CTTCTGCTGT TCATTGGAAT GGGGGTCTTA 
GGAGGCATCT TTTATACAAC TTTGGCAACA GAAATGATAA AATCGAATCA ATTGCAAAGG 
GCCAAGGAAG AACTTCAGGA AAATGTTTCC CTACAGCTGA AGCACAATCT CAACAGCTCC 
AAGAAAATCA AGAACCTTTC TGCCATGCTG CAAAGCACAG CCACCCAGCT GTGCCGAGAG 
CTGTATAGCA AAGAACCAGA GCACAAATGT AAACCATGTC CAAAGGGTTC AGAATGGTAC 
AAGGACAGCT GTTATTCTCA ACTCAATCAG TATGGAACAT GGCAAGAGAG TGTCATGGCC 
TGCTCTGCTC GGAATGCCAG CCTCCTGAAG GTTAAGAACA AGGATGTGCT GGAATTTATA 
AAGTACAAGA AGCTACGCTA TTTTTGGCTT GCATTGTTGC CCAGAAAAGA TCGCACACAA 
TATCCACTAA GTGAGAAGAT GTTCCTCTCT GAAGAGTCTG AAAGAAGCAC AGATGACATA 
GATAAGAAGT ACTGCGGATA TATAGACAGG GTCAATGTTT ATTATACATA CTGCACTGAT 
GAGAACAATA TCATATGTGA AGAGACAGCC AGCAAGGTGC AGTTGGAAAG TGTGTTGAAT 
GGCCTCCCAG AGGATAGCAG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808354.1
CDS	178..981
Translation	MSEEIVYANLKIQDPDKKEETQKSDKCGGKVSADASHSQQKTVLILILLCLLLFIGMGVLGGIFYTTLATEMIKSNQLQRAKEELQENVSLQLKHNLNSSKKIKNLSAMLQSTATQLCRELYSKEPEHKCKPCPKGSEWYKDSCYSQLNQYGTWQESVMACSARNASLLKVKNKDVLEFIKYKKLRYFWLALLPRKDRTQYPLSEKMFLSEESERSTDDIDKKYCGYIDRVNVYYTYCTDENNIICEETASKVQLESVLNGLPEDSR

Target ORF information:

RefSeq Version	NM_177686.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus C-type lectin domain family 12, member a (Clec12a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177686.4

ORF Insert Sequence:

ATGTCTGAAG AAATTGTTTA TGCAAATCTC AAAATCCAGG ACCCTGATAA AAAAGAAGAA 
ACCCAGAAGT CTGACAAATG TGGGGGAAAA GTATCCGCCG ATGCTTCCCA TTCACAGCAA 
AAAACAGTCT TGATTCTGAT TCTTCTATGC CTTCTGCTGT TCATTGGAAT GGGGGTCTTA 
GGAGGCATCT TTTATACAAC TTTGGCAACA GAAATGATAA AATCGAATCA ATTGCAAAGG 
GCCAAGGAAG AACTTCAGGA AAATGTTTCC CTACAGCTGA AGCACAATCT CAACAGCTCC 
AAGAAAATCA AGAACCTTTC TGCCATGCTG CAAAGCACAG CCACCCAGCT GTGCCGAGAG 
CTGTATAGCA AAGAACCAGA GCACAAATGT AAACCATGTC CAAAGGGTTC AGAATGGTAC 
AAGGACAGCT GTTATTCTCA ACTCAATCAG TATGGAACAT GGCAAGAGAG TGTCATGGCC 
TGCTCTGCTC GGAATGCCAG CCTCCTGAAG GTTAAGAACA AGGATGTGCT GGAATTTATA 
AAGTACAAGA AGCTACGCTA TTTTTGGCTT GCATTGTTGC CCAGAAAAGA TCGCACACAA 
TATCCACTAA GTGAGAAGAT GTTCCTCTCT GAAGAGTCTG AAAGAAGCAC AGATGACATA 
GATAAGAAGT ACTGCGGATA TATAGACAGG GTCAATGTTT ATTATACATA CTGCACTGAT 
GAGAACAATA TCATATGTGA AGAGACAGCC AGCAAGGTGC AGTTGGAAAG TGTGTTGAAT 
GGCCTCCCAG AGGATAGCAG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Clec12a ( XM_011241323.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011239625.1 Mus musculus C-type lectin domain family 12, member a (Clec12a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu23035
Clone ID Related Accession (Same CDS sequence)	XM_011241323.1 , NM_177686.4 , XM_011241323.3 , XM_011241323.2
Accession Version	XM_011241323.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	C-type lectin domain family 12 member A isoform X1
Comment

ATGTCTGAAG AAATTGTTTA TGCAAATCTC AAAATCCAGG ACCCTGATAA AAAAGAAGAA 
ACCCAGAAGT CTGACAAATG TGGGGGAAAA GTATCCGCCG ATGCTTCCCA TTCACAGCAA 
AAAACAGTCT TGATTCTGAT TCTTCTATGC CTTCTGCTGT TCATTGGAAT GGGGGTCTTA 
GGAGGCATCT TTTATACAAC TTTGGCAACA GAAATGATAA AATCGAATCA ATTGCAAAGG 
GCCAAGGAAG AACTTCAGGA AAATGTTTCC CTACAGCTGA AGCACAATCT CAACAGCTCC 
AAGAAAATCA AGAACCTTTC TGCCATGCTG CAAAGCACAG CCACCCAGCT GTGCCGAGAG 
CTGTATAGCA AAGAACCAGA GCACAAATGT AAACCATGTC CAAAGGGTTC AGAATGGTAC 
AAGGACAGCT GTTATTCTCA ACTCAATCAG TATGGAACAT GGCAAGAGAG TGTCATGGCC 
TGCTCTGCTC GGAATGCCAG CCTCCTGAAG GTTAAGAACA AGGATGTGCT GGAATTTATA 
AAGTACAAGA AGCTACGCTA TTTTTGGCTT GCATTGTTGC CCAGAAAAGA TCGCACACAA 
TATCCACTAA GTGAGAAGAT GTTCCTCTCT GAAGAGTCTG AAAGAAGCAC AGATGACATA 
GATAAGAAGT ACTGCGGATA TATAGACAGG GTCAATGTTT ATTATACATA CTGCACTGAT 
GAGAACAATA TCATATGTGA AGAGACAGCC AGCAAGGTGC AGTTGGAAAG TGTGTTGAAT 
GGCCTCCCAG AGGATAGCAG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011239625.1
Translation	MSEEIVYANLKIQDPDKKEETQKSDKCGGKVSADASHSQQKTVLILILLCLLLFIGMGVLGGIFYTTLATEMIKSNQLQRAKEELQENVSLQLKHNLNSSKKIKNLSAMLQSTATQLCRELYSKEPEHKCKPCPKGSEWYKDSCYSQLNQYGTWQESVMACSARNASLLKVKNKDVLEFIKYKKLRYFWLALLPRKDRTQYPLSEKMFLSEESERSTDDIDKKYCGYIDRVNVYYTYCTDENNIICEETASKVQLESVLNGLPEDSR

Target ORF information:

RefSeq Version	XM_011241323.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus C-type lectin domain family 12, member a (Clec12a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011241323.1

ORF Insert Sequence:

ATGTCTGAAG AAATTGTTTA TGCAAATCTC AAAATCCAGG ACCCTGATAA AAAAGAAGAA 
ACCCAGAAGT CTGACAAATG TGGGGGAAAA GTATCCGCCG ATGCTTCCCA TTCACAGCAA 
AAAACAGTCT TGATTCTGAT TCTTCTATGC CTTCTGCTGT TCATTGGAAT GGGGGTCTTA 
GGAGGCATCT TTTATACAAC TTTGGCAACA GAAATGATAA AATCGAATCA ATTGCAAAGG 
GCCAAGGAAG AACTTCAGGA AAATGTTTCC CTACAGCTGA AGCACAATCT CAACAGCTCC 
AAGAAAATCA AGAACCTTTC TGCCATGCTG CAAAGCACAG CCACCCAGCT GTGCCGAGAG 
CTGTATAGCA AAGAACCAGA GCACAAATGT AAACCATGTC CAAAGGGTTC AGAATGGTAC 
AAGGACAGCT GTTATTCTCA ACTCAATCAG TATGGAACAT GGCAAGAGAG TGTCATGGCC 
TGCTCTGCTC GGAATGCCAG CCTCCTGAAG GTTAAGAACA AGGATGTGCT GGAATTTATA 
AAGTACAAGA AGCTACGCTA TTTTTGGCTT GCATTGTTGC CCAGAAAAGA TCGCACACAA 
TATCCACTAA GTGAGAAGAT GTTCCTCTCT GAAGAGTCTG AAAGAAGCAC AGATGACATA 
GATAAGAAGT ACTGCGGATA TATAGACAGG GTCAATGTTT ATTATACATA CTGCACTGAT 
GAGAACAATA TCATATGTGA AGAGACAGCC AGCAAGGTGC AGTTGGAAAG TGTGTTGAAT 
GGCCTCCCAG AGGATAGCAG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Clec12a ( XM_011241323.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011239625.1 Mus musculus C-type lectin domain family 12, member a (Clec12a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu23035
Clone ID Related Accession (Same CDS sequence)	XM_011241323.1 , NM_177686.4 , XM_011241323.3 , XM_011241323.2
Accession Version	XM_011241323.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	C-type lectin domain family 12 member A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011241323.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTGAAG AAATTGTTTA TGCAAATCTC AAAATCCAGG ACCCTGATAA AAAAGAAGAA 
ACCCAGAAGT CTGACAAATG TGGGGGAAAA GTATCCGCCG ATGCTTCCCA TTCACAGCAA 
AAAACAGTCT TGATTCTGAT TCTTCTATGC CTTCTGCTGT TCATTGGAAT GGGGGTCTTA 
GGAGGCATCT TTTATACAAC TTTGGCAACA GAAATGATAA AATCGAATCA ATTGCAAAGG 
GCCAAGGAAG AACTTCAGGA AAATGTTTCC CTACAGCTGA AGCACAATCT CAACAGCTCC 
AAGAAAATCA AGAACCTTTC TGCCATGCTG CAAAGCACAG CCACCCAGCT GTGCCGAGAG 
CTGTATAGCA AAGAACCAGA GCACAAATGT AAACCATGTC CAAAGGGTTC AGAATGGTAC 
AAGGACAGCT GTTATTCTCA ACTCAATCAG TATGGAACAT GGCAAGAGAG TGTCATGGCC 
TGCTCTGCTC GGAATGCCAG CCTCCTGAAG GTTAAGAACA AGGATGTGCT GGAATTTATA 
AAGTACAAGA AGCTACGCTA TTTTTGGCTT GCATTGTTGC CCAGAAAAGA TCGCACACAA 
TATCCACTAA GTGAGAAGAT GTTCCTCTCT GAAGAGTCTG AAAGAAGCAC AGATGACATA 
GATAAGAAGT ACTGCGGATA TATAGACAGG GTCAATGTTT ATTATACATA CTGCACTGAT 
GAGAACAATA TCATATGTGA AGAGACAGCC AGCAAGGTGC AGTTGGAAAG TGTGTTGAAT 
GGCCTCCCAG AGGATAGCAG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011239625.1
CDS	111..914
Translation	MSEEIVYANLKIQDPDKKEETQKSDKCGGKVSADASHSQQKTVLILILLCLLLFIGMGVLGGIFYTTLATEMIKSNQLQRAKEELQENVSLQLKHNLNSSKKIKNLSAMLQSTATQLCRELYSKEPEHKCKPCPKGSEWYKDSCYSQLNQYGTWQESVMACSARNASLLKVKNKDVLEFIKYKKLRYFWLALLPRKDRTQYPLSEKMFLSEESERSTDDIDKKYCGYIDRVNVYYTYCTDENNIICEETASKVQLESVLNGLPEDSR

Target ORF information:

RefSeq Version	XM_011241323.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus C-type lectin domain family 12, member a (Clec12a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011241323.3

ORF Insert Sequence:

ATGTCTGAAG AAATTGTTTA TGCAAATCTC AAAATCCAGG ACCCTGATAA AAAAGAAGAA 
ACCCAGAAGT CTGACAAATG TGGGGGAAAA GTATCCGCCG ATGCTTCCCA TTCACAGCAA 
AAAACAGTCT TGATTCTGAT TCTTCTATGC CTTCTGCTGT TCATTGGAAT GGGGGTCTTA 
GGAGGCATCT TTTATACAAC TTTGGCAACA GAAATGATAA AATCGAATCA ATTGCAAAGG 
GCCAAGGAAG AACTTCAGGA AAATGTTTCC CTACAGCTGA AGCACAATCT CAACAGCTCC 
AAGAAAATCA AGAACCTTTC TGCCATGCTG CAAAGCACAG CCACCCAGCT GTGCCGAGAG 
CTGTATAGCA AAGAACCAGA GCACAAATGT AAACCATGTC CAAAGGGTTC AGAATGGTAC 
AAGGACAGCT GTTATTCTCA ACTCAATCAG TATGGAACAT GGCAAGAGAG TGTCATGGCC 
TGCTCTGCTC GGAATGCCAG CCTCCTGAAG GTTAAGAACA AGGATGTGCT GGAATTTATA 
AAGTACAAGA AGCTACGCTA TTTTTGGCTT GCATTGTTGC CCAGAAAAGA TCGCACACAA 
TATCCACTAA GTGAGAAGAT GTTCCTCTCT GAAGAGTCTG AAAGAAGCAC AGATGACATA 
GATAAGAAGT ACTGCGGATA TATAGACAGG GTCAATGTTT ATTATACATA CTGCACTGAT 
GAGAACAATA TCATATGTGA AGAGACAGCC AGCAAGGTGC AGTTGGAAAG TGTGTTGAAT 
GGCCTCCCAG AGGATAGCAG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Clec12a ( XM_011241323.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011239625.1 Mus musculus C-type lectin domain family 12, member a (Clec12a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu23035
Clone ID Related Accession (Same CDS sequence)	XM_011241323.1 , NM_177686.4 , XM_011241323.3 , XM_011241323.2
Accession Version	XM_011241323.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	C-type lectin domain family 12 member A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011241323.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTGAAG AAATTGTTTA TGCAAATCTC AAAATCCAGG ACCCTGATAA AAAAGAAGAA 
ACCCAGAAGT CTGACAAATG TGGGGGAAAA GTATCCGCCG ATGCTTCCCA TTCACAGCAA 
AAAACAGTCT TGATTCTGAT TCTTCTATGC CTTCTGCTGT TCATTGGAAT GGGGGTCTTA 
GGAGGCATCT TTTATACAAC TTTGGCAACA GAAATGATAA AATCGAATCA ATTGCAAAGG 
GCCAAGGAAG AACTTCAGGA AAATGTTTCC CTACAGCTGA AGCACAATCT CAACAGCTCC 
AAGAAAATCA AGAACCTTTC TGCCATGCTG CAAAGCACAG CCACCCAGCT GTGCCGAGAG 
CTGTATAGCA AAGAACCAGA GCACAAATGT AAACCATGTC CAAAGGGTTC AGAATGGTAC 
AAGGACAGCT GTTATTCTCA ACTCAATCAG TATGGAACAT GGCAAGAGAG TGTCATGGCC 
TGCTCTGCTC GGAATGCCAG CCTCCTGAAG GTTAAGAACA AGGATGTGCT GGAATTTATA 
AAGTACAAGA AGCTACGCTA TTTTTGGCTT GCATTGTTGC CCAGAAAAGA TCGCACACAA 
TATCCACTAA GTGAGAAGAT GTTCCTCTCT GAAGAGTCTG AAAGAAGCAC AGATGACATA 
GATAAGAAGT ACTGCGGATA TATAGACAGG GTCAATGTTT ATTATACATA CTGCACTGAT 
GAGAACAATA TCATATGTGA AGAGACAGCC AGCAAGGTGC AGTTGGAAAG TGTGTTGAAT 
GGCCTCCCAG AGGATAGCAG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011239625.1
CDS	109..912
Translation	MSEEIVYANLKIQDPDKKEETQKSDKCGGKVSADASHSQQKTVLILILLCLLLFIGMGVLGGIFYTTLATEMIKSNQLQRAKEELQENVSLQLKHNLNSSKKIKNLSAMLQSTATQLCRELYSKEPEHKCKPCPKGSEWYKDSCYSQLNQYGTWQESVMACSARNASLLKVKNKDVLEFIKYKKLRYFWLALLPRKDRTQYPLSEKMFLSEESERSTDDIDKKYCGYIDRVNVYYTYCTDENNIICEETASKVQLESVLNGLPEDSR

Target ORF information:

RefSeq Version	XM_011241323.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus C-type lectin domain family 12, member a (Clec12a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011241323.2

ORF Insert Sequence:

ATGTCTGAAG AAATTGTTTA TGCAAATCTC AAAATCCAGG ACCCTGATAA AAAAGAAGAA 
ACCCAGAAGT CTGACAAATG TGGGGGAAAA GTATCCGCCG ATGCTTCCCA TTCACAGCAA 
AAAACAGTCT TGATTCTGAT TCTTCTATGC CTTCTGCTGT TCATTGGAAT GGGGGTCTTA 
GGAGGCATCT TTTATACAAC TTTGGCAACA GAAATGATAA AATCGAATCA ATTGCAAAGG 
GCCAAGGAAG AACTTCAGGA AAATGTTTCC CTACAGCTGA AGCACAATCT CAACAGCTCC 
AAGAAAATCA AGAACCTTTC TGCCATGCTG CAAAGCACAG CCACCCAGCT GTGCCGAGAG 
CTGTATAGCA AAGAACCAGA GCACAAATGT AAACCATGTC CAAAGGGTTC AGAATGGTAC 
AAGGACAGCT GTTATTCTCA ACTCAATCAG TATGGAACAT GGCAAGAGAG TGTCATGGCC 
TGCTCTGCTC GGAATGCCAG CCTCCTGAAG GTTAAGAACA AGGATGTGCT GGAATTTATA 
AAGTACAAGA AGCTACGCTA TTTTTGGCTT GCATTGTTGC CCAGAAAAGA TCGCACACAA 
TATCCACTAA GTGAGAAGAT GTTCCTCTCT GAAGAGTCTG AAAGAAGCAC AGATGACATA 
GATAAGAAGT ACTGCGGATA TATAGACAGG GTCAATGTTT ATTATACATA CTGCACTGAT 
GAGAACAATA TCATATGTGA AGAGACAGCC AGCAAGGTGC AGTTGGAAAG TGTGTTGAAT 
GGCCTCCCAG AGGATAGCAG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity.
Scientific reports7(1)2707(2017 Jun)
Sagar D,Singh NP,Ginwala R,Huang X,Philip R,Nagarkatti M,Nagarkatti P,Neumann K,Ruland J,Andrews AM,Ramirez SH,Khan ZK,Jain P

Antibody-mediated targeting of antigen to C-type lectin-like receptors Clec9A and Clec12A elicits different vaccination outcomes.
Molecular immunology81143-150(2017 Jan)
Macri C,Dumont C,Panozza S,Lahoud MH,Caminschi I,Villadangos JA,Johnston AP,Mintern JD

MICL controls inflammation in rheumatoid arthritis.
Annals of the rheumatic diseases75(7)1386-91(2016 Jul)
Redelinghuys P,Whitehead L,Augello A,Drummond RA,Levesque JM,Vautier S,Reid DM,Kerscher B,Taylor JA,Nigrovic PA,Wright J,Murray GI,Willment JA,Hocking LJ,Fernandes MJ,De Bari C,Mcinnes IB,Brown GD

Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.
Cell reports11(12)1905-18(2015 Jun)
Begun J,Lassen KG,Jijon HB,Baxt LA,Goel G,Heath RJ,Ng A,Tam JM,Kuo SY,Villablanca EJ,Fagbami L,Oosting M,Kumar V,Schenone M,Carr SA,Joosten LA,Vyas JM,Daly MJ,Netea MG,Brown GD,Wijmenga C,Xavier RJ

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Clec12a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報