Slc10a4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc10a4
Entrez Gene ID	231290
Full Name	solute carrier family 10 (sodium/bile acid cotransporter family), member 4
Synonyms	E130304D01
General protein information	Preferred Names solute carrier family 10 (sodium/bile acid cotransporter family), member 4 Names sodium/bile acid cotransporter 4 Na(+)/bile acid cotransporter 4 solute carrier family 10 member 4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 C3.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_173403.2	NP_775579.2	sodium/bile acid cotransporter 4

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC10A4	NP_689892.1
Canis lupus familiaris (dog)	SLC10A4	XP_005628227.1
Mus musculus (house mouse)	Slc10a4	NP_775579.2
	SLC10A4	XP_001103529.1
Bos taurus (cattle)	SLC10A4	NP_001071493.1
Rattus norvegicus (Norway rat)	Slc10a4	NP_001008555.1
Gallus gallus (chicken)	SLC10A4	XP_001233594.2
Xenopus tropicalis (tropical clawed frog)	slc10a4	XP_002933503.1

Gene Ontology
Bibliography

Related articles in PubMed

SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo.
Pettersson H, Zarnegar B, Westin A, Persson V, Peuckert C, Jonsson J, Hallgren J, Kullander K
Scientific reports7(1)1085(2017 Apr)

Characterization of cognitive impairments and neurotransmitter changes in a novel transgenic mouse lacking Slc10a4.
Melief EJ, Gibbs JT, Li X, Morgan RG, Keene CD, Montine TJ, Palmiter RD, Darvas M
Neuroscience324399-406(2016 Jun)

Expression, sorting and transport studies for the orphan carrier SLC10A4 in neuronal and non-neuronal cell lines and in Xenopus laevis oocytes.
Schmidt S, Moncada M, Burger S, Geyer J
BMC neuroscience1635(2015 Jun)

A role for solute carrier family 10 member 4, or vesicular aminergic-associated transporter, in structural remodelling and transmitter release at the mouse neuromuscular junction.
Patra K, Lyons DJ, Bauer P, Hilscher MM, Sharma S, Le?o RN, Kullander K
The European journal of neuroscience41(3)316-27(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study indicates that loss of SLC10A4 protein results in neurotransmitter imbalance and cognitive impairment in null mice
Title: Characterization of cognitive impairments and neurotransmitter changes in a novel transgenic mouse lacking Slc10a4.

SLC10A4 failed to show transport activity for a series of neurotransmitters and neuromodulators, indicating that SLC10A4 does not seem to represent a typical neurotransmitter transporter such as DAT, SERT, CHT1 or VMAT2
Title: Expression, sorting and transport studies for the orphan carrier SLC10A4 in neuronal and non-neuronal cell lines and in Xenopus laevis oocytes.

Results demonstrate that SLC10A4 is a vesicular monoaminergic and cholinergic associated transporter that is important for dopamine homeostasis and neuromodulation in vivo
Title: SLC10A4 is a vesicular amine-associated transporter modulating dopamine homeostasis.

Results suggest that VAAT modulates neuromuscular junction transmission efficiency and, as such, may represent a novel target for treatment of disorders affecting motor neurons
Title: A role for solute carrier family 10 member 4, or vesicular aminergic-associated transporter, in structural remodelling and transmitter release at the mouse neuromuscular junction.

absence of the recently discovered synaptic vesicle protein Slc10a4 results in increased sensitivity to cholinergic stimulation
Title: The synaptic protein encoded by the gene Slc10A4 suppresses epileptiform activity and regulates sensitivity to cholinergic chemoconvulsants.

The following Slc10a4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc10a4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04572	NM_173403.2 Latest version!	Mus musculus solute carrier family 10 (sodium/bile acid cotransporter family), member 4 (Slc10a4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc10a4 ( NM_173403.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_775579.2 Mus musculus solute carrier family 10 (sodium/bile acid cotransporter family), member 4 (Slc10a4), mRNA.

Price & Availability↑

CloneID	OMu04572
Clone ID Related Accession (Same CDS sequence)	NM_173403.2
Accession Version	NM_173403.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1314bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Mus musculus(house mouse)
Product	sodium/bile acid cotransporter 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK087479.1 and AK149202.1. On Feb 8, 2006 this sequence version replaced NM_173403.1. ##Evidence-Data-START## Transcript exon combination :: AK149202.1, AK087479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAGCC TGGACAACAC CACCCTGCTC CTTGCCCCGT CCTCGCTGCT GCCTGACAAC 
CTCACCCTGT CTCCCAACGC CGGCAGCCCG AGCGCCAGCA CCCTTTCGCC TCTCGCTGTC 
ACCTCTAGTC CCGGTCCGGG GCTCAGCCTC GCTCCAAGTC CAAGCATCGG CTTTAGCCCC 
GAGGCAACCC CGACTCCAGA GCCCACGAGC AGCAGCCTCA CGGTCGGCGT GGCTGGCCAG 
GGCTCCTCCG CTTTCCCCCG GCCCTGGATC CCCCACGAGC CCCCATTCTG GGACACGCCG 
CTCAACCACG GGCTGAATGT GTTTGTGGGC GCCGCCTTGT GCATCACCAT GCTGGGTCTA 
GGCTGTACCG TGGACGTGAA CCACTTCGGG GCGCACGTCC GGCGGCCCGT GGGCGCTCTG 
CTGGCTGCGC TCTGCCAGTT CGGCTTCTTG CCGCTGCTAG CCTTCTTGCT GGCCCTCATC 
TTCAAGCTGG ATGAGGTGGC CGCGGTGGCT GTACTCCTAT GTGGCTGCTG TCCTGGTGGA 
AATCTCTCCA ATCTCATGTC CCTGCTGGTA GACGGCGACA TGAACCTCAG CATCATCATG 
ACCATTTCCT CCACACTCCT GGCCCTGGTG TTGATGCCCC TCTGCCTCTG GATCTACAGC 
CGTGCCTGGA TCAATACCCC TCTGGTGCAA TTGCTCCCCC TAGGGGCAGT CACCCTGACT 
CTCTGCAGCA CTCTCATTCC TATTGGGCTA GGCGTCTTCA TTCGCTACAA ATACAACCGC 
GTGGCTGACT ACATCGTGAA GGTTTCCCTG TGGTCTCTGC TTGTGACCCT GGTGGTTCTT 
TTCATAATGA CTGGCACCAT GCTGGGACCT GAACTGCTGG CAAGCATTCC CGCAACTGTT 
TACGTGGTCG CCATTTTTAT GCCTCTGGCG GGCTACGCCT CGGGTTATGG CTTAGCTACC 
CTCTTCCACC TCCCGCCCAA CTGCAAGCGG ACTGTGTGTC TGGAAACAGG AAGTCAGAAC 
GTGCAGCTCT GCACTGCGAT TCTCAAACTG GCCTTCCCGC CTCGCTTTAT AGGTAGCATG 
TACATGTTCC CTCTGCTCTA CGCCCTCTTC CAGTCTGCCG AGGCAGGGGT CTTCGTGTTG 
ATCTACAAAA TGTACGGAAG TGAGATACTG CACAAGCGAG AGGCCCTAGA CGAAGACGAA 
GACACCGATA TTTCTTATAA GAAACTGAAA GAAGAGGAAA TGGCAGACAC CTCCTATGGC 
ACCGTGGGGA CGGATGACTT AGTGATGATG GAGACCACCC AGACCGCCCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775579.2
CDS	164..1477
Translation	MDSLDNTTLLLAPSSLLPDNLTLSPNAGSPSASTLSPLAVTSSPGPGLSLAPSPSIGFSPEATPTPEPTSSSLTVGVAGQGSSAFPRPWIPHEPPFWDTPLNHGLNVFVGAALCITMLGLGCTVDVNHFGAHVRRPVGALLAALCQFGFLPLLAFLLALIFKLDEVAAVAVLLCGCCPGGNLSNLMSLLVDGDMNLSIIMTISSTLLALVLMPLCLWIYSRAWINTPLVQLLPLGAVTLTLCSTLIPIGLGVFIRYKYNRVADYIVKVSLWSLLVTLVVLFIMTGTMLGPELLASIPATVYVVAIFMPLAGYASGYGLATLFHLPPNCKRTVCLETGSQNVQLCTAILKLAFPPRFIGSMYMFPLLYALFQSAEAGVFVLIYKMYGSEILHKREALDEDEDTDISYKKLKEEEMADTSYGTVGTDDLVMMETTQTAL

Target ORF information:

RefSeq Version	NM_173403.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 10 (sodium/bile acid cotransporter family), member 4 (Slc10a4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173403.2

ORF Insert Sequence:

ATGGACAGCC TGGACAACAC CACCCTGCTC CTTGCCCCGT CCTCGCTGCT GCCTGACAAC 
CTCACCCTGT CTCCCAACGC CGGCAGCCCG AGCGCCAGCA CCCTTTCGCC TCTCGCTGTC 
ACCTCTAGTC CCGGTCCGGG GCTCAGCCTC GCTCCAAGTC CAAGCATCGG CTTTAGCCCC 
GAGGCAACCC CGACTCCAGA GCCCACGAGC AGCAGCCTCA CGGTCGGCGT GGCTGGCCAG 
GGCTCCTCCG CTTTCCCCCG GCCCTGGATC CCCCACGAGC CCCCATTCTG GGACACGCCG 
CTCAACCACG GGCTGAATGT GTTTGTGGGC GCCGCCTTGT GCATCACCAT GCTGGGTCTA 
GGCTGTACCG TGGACGTGAA CCACTTCGGG GCGCACGTCC GGCGGCCCGT GGGCGCTCTG 
CTGGCTGCGC TCTGCCAGTT CGGCTTCTTG CCGCTGCTAG CCTTCTTGCT GGCCCTCATC 
TTCAAGCTGG ATGAGGTGGC CGCGGTGGCT GTACTCCTAT GTGGCTGCTG TCCTGGTGGA 
AATCTCTCCA ATCTCATGTC CCTGCTGGTA GACGGCGACA TGAACCTCAG CATCATCATG 
ACCATTTCCT CCACACTCCT GGCCCTGGTG TTGATGCCCC TCTGCCTCTG GATCTACAGC 
CGTGCCTGGA TCAATACCCC TCTGGTGCAA TTGCTCCCCC TAGGGGCAGT CACCCTGACT 
CTCTGCAGCA CTCTCATTCC TATTGGGCTA GGCGTCTTCA TTCGCTACAA ATACAACCGC 
GTGGCTGACT ACATCGTGAA GGTTTCCCTG TGGTCTCTGC TTGTGACCCT GGTGGTTCTT 
TTCATAATGA CTGGCACCAT GCTGGGACCT GAACTGCTGG CAAGCATTCC CGCAACTGTT 
TACGTGGTCG CCATTTTTAT GCCTCTGGCG GGCTACGCCT CGGGTTATGG CTTAGCTACC 
CTCTTCCACC TCCCGCCCAA CTGCAAGCGG ACTGTGTGTC TGGAAACAGG AAGTCAGAAC 
GTGCAGCTCT GCACTGCGAT TCTCAAACTG GCCTTCCCGC CTCGCTTTAT AGGTAGCATG 
TACATGTTCC CTCTGCTCTA CGCCCTCTTC CAGTCTGCCG AGGCAGGGGT CTTCGTGTTG 
ATCTACAAAA TGTACGGAAG TGAGATACTG CACAAGCGAG AGGCCCTAGA CGAAGACGAA 
GACACCGATA TTTCTTATAA GAAACTGAAA GAAGAGGAAA TGGCAGACAC CTCCTATGGC 
ACCGTGGGGA CGGATGACTT AGTGATGATG GAGACCACCC AGACCGCCCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo.
Scientific reports7(1)1085(2017 Apr)
Pettersson H,Zarnegar B,Westin A,Persson V,Peuckert C,Jonsson J,Hallgren J,Kullander K

Characterization of cognitive impairments and neurotransmitter changes in a novel transgenic mouse lacking Slc10a4.
Neuroscience324399-406(2016 Jun)
Melief EJ,Gibbs JT,Li X,Morgan RG,Keene CD,Montine TJ,Palmiter RD,Darvas M

Expression, sorting and transport studies for the orphan carrier SLC10A4 in neuronal and non-neuronal cell lines and in Xenopus laevis oocytes.
BMC neuroscience1635(2015 Jun)
Schmidt S,Moncada M,Burger S,Geyer J

A role for solute carrier family 10 member 4, or vesicular aminergic-associated transporter, in structural remodelling and transmitter release at the mouse neuromuscular junction.
The European journal of neuroscience41(3)316-27(2015 Feb)
Patra K,Lyons DJ,Bauer P,Hilscher MM,Sharma S,Le?o RN,Kullander K

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Slc10a4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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