The following Themis2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Themis2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu17965 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001033308.2 | |
| Accession Version | NM_001033308.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1992bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-16 | |
| Organism | Mus musculus(house mouse) | |
| Product | protein THEMIS2 | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK150471.1. On Apr 6, 2007 this sequence version replaced NM_001033308.1. ##Evidence-Data-START## Transcript exon combination :: AK150471.1, AK153536.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## | |
1 | ATGGAGCCGG TGCCGCTGCA GGACTTTGTG AGCGGCCTGG ACCCCACCTC CCTTCCGCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001028480.1 |
| CDS | 12..2003 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001033308.2 |
1 | ATGGAGCCGG TGCCGCTGCA GGACTTTGTG AGCGGCCTGG ACCCCACCTC CCTTCCGCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu73533 | |
| Clone ID Related Accession (Same CDS sequence) | XM_011250230.3 , XM_011250230.2 | |
| Accession Version | XM_011250230.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1695bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-06-21 | |
| Organism | Mus musculus(house mouse) | |
| Product | protein THEMIS2 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011250230.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCCCCAGA ACTCCACCCG GTGGCCCATT TACTTCAAGT CAACTCAGAG AATTGTCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011248532.1 |
| CDS | 1091..2785 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011250230.2 |
1 | ATGCCCCAGA ACTCCACCCG GTGGCCCATT TACTTCAAGT CAACTCAGAG AATTGTCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu73533 | |
| Clone ID Related Accession (Same CDS sequence) | XM_011250230.3 , XM_011250230.2 | |
| Accession Version | XM_011250230.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1695bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-07 | |
| Organism | Mus musculus(house mouse) | |
| Product | protein THEMIS2 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011250230.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCCCCAGA ACTCCACCCG GTGGCCCATT TACTTCAAGT CAACTCAGAG AATTGTCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011248532.1 |
| CDS | 1078..2772 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011250230.3 |
1 | ATGCCCCAGA ACTCCACCCG GTGGCCCATT TACTTCAAGT CAACTCAGAG AATTGTCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Themis2 lowers the threshold for B cell activation during positive selection. |
Themis2 is not required for B cell development, activation, and antibody responses. |
Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function. |
Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production. |
