Gbp5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gbp5
Entrez Gene ID	229898
Full Name	guanylate binding protein 5
Synonyms	5330409J06Rik,Gbp5a
General protein information	Preferred Names guanylate binding protein 5 Names guanylate-binding protein 5 GBP-5 GTP-binding protein 5 guanine nucleotide-binding protein 5 guanylate nucleotide binding protein 5 muGBP-5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 H1

mRNA and Protein(s)

mRNA	Protein	Name
NM_153564.2	NP_705792.2	guanylate-binding protein 5

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gbp5	NP_705792.2
Rattus norvegicus (Norway rat)	Gbp5	NP_001102039.2
Canis lupus familiaris (dog)	GBP5	XP_547291.3
Bos taurus (cattle)	GBP5	NP_001069214.1
Homo sapiens (human)	GBP5	NP_001127958.1
Pan troglodytes (chimpanzee)	GBP5	XP_003308254.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of potential biomarkers for post-traumatic complications released after trauma-hemorrhage from murine Kupffer cells and its investigation in lung and liver.
Schultze C, Hildebrand F, Noack S, Krettek C, Zeckey C, Neunaber C
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals21(7)645-52(2016 Nov)

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.
Meunier E, Wallet P, Dreier RF, Costanzo S, Anton L, R?hl S, Dussurgey S, Dick MS, Kistner A, Rigard M, Degrandi D, Pfeffer K, Yamamoto M, Henry T, Broz P
Nature immunology16(5)476-484(2015 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genome-wide expression of isolated Kupffer cells following pressure-controlled hemorrhage revealed a significant increase of gene expression of Cxcl10, Il4ra, Csf2rb2, Lcn2, and Gbp5, which might represent new biomarkers for early diagnosis of post-traumatic complications.
Title: Identification of potential biomarkers for post-traumatic complications released after trauma-hemorrhage from murine Kupffer cells and its investigation in lung and liver.

this study identified guanylate-binding proteins GBP2 and GBP5 as key activators of AIM2 during infection with F. novicida.
Title: Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.

guanylate binding protein 5 (GBP5) stimulates inflammasome assembly; GBP5 promoted selective NLRP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents; GBP5 serves as a unique rheostat for NLRP3 inflammasome activation
Title: GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals.

Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro.
Title: Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro.

The following Gbp5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gbp5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02872	NM_153564.2 Latest version!	Mus musculus guanylate binding protein 5 (Gbp5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$349.30 $499.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gbp5 ( NM_153564.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_705792.2 Mus musculus guanylate binding protein 5 (Gbp5), mRNA.

Price & Availability↑

CloneID	OMu02872
Clone ID Related Accession (Same CDS sequence)	NM_153564.2
Accession Version	NM_153564.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1773bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Mus musculus(house mouse)
Product	guanylate-binding protein 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK030414.1 and AC102108.12. On or before May 4, 2006 this sequence version replaced XM_001052121.1, XM_001052120.1, XM_001052122.1, NM_153564.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058555.1, AF422243.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCAG AGATTCACAT GCCAGAACCC TTGTGCCTCA TTGGGAGCAC CGAGGGACAC 
CTAGTAACTA ACCAGGAAGC CCTGAAGATT CTGTCTGCCA TCACACAGCC AGTGGTGGTG 
GTAGCCATTG TGGGTCTTTA TCGCACAGGC AAATCCTACC TGATGAACAA GCTGGCTGGG 
AAGGAGAAGG GCTTTTCTGT TGGATCCACT GTACAGTCTC ACACCAAGGG GATCTGGATG 
TGGTGTGTGC CTCACCCCCA AAAGCCAGAC CACACTTTGG TTCTGCTTGA CACTGAAGGC 
CTGGGAGATG TGGAGAAGGA TGATAAAAAG AATGATACTC AGATCTTTGC ACTAGCAATC 
CTCCTCAGTA GCACCTTTGT ATACAACACT ATGAACAAAA TTGACCAGGG GGCTATCGAC 
CTATTGCACA ATGTGACAGA ACTGACAGAC TTGCTCCGGA CAAGAAACTC CTCTGATTCT 
AATCAAACTG AGGGTGAGGG ACCTGCTGAC ATGAGCTTCT TCCCAGACTT GGTGTGGACT 
CTGAGAGATT TCTTCCTGGA CCTGCAAGCC AATGGGCATG CCATCACATC AGATGAATAT 
CTGGAGAATT CACTGAAGCT GAAGCAAGGT AGCGATGAAA GAACTCAAAC ATTCAATCTA 
CCGCGGCTGT GCATACAGAA GTTCTTCCCA GTAAAGAAAT GCTTTGTTTT TGACGCTCCT 
GCGCTTGGAA GTAAGCTTTC CCAGCTTCCA ACACTCAGCA ACGAGGAGCT GAACTCAGAT 
TTTGTGCAGG ACCTTTCAGA ATTCTGTTCA CACATCTTCA CCCAATCTAA GACCAAGACT 
CTTCCAGGAG GCATCCAGGT CAACGGACCT CGTCTAGAAA GCCTGGTGCT GACTTATGTC 
GATGCCATCA ACAGCGGGGC TCTGCCTTCC ATAGAGAACA CAGTAGTAAC CTTGGCCCGG 
AGGGAGAACT CTGCAGCAGT TCAAAAGGCC ATTGGTCACT ACGATCAGCT GATGAGCGAG 
AAGGTGCAGC TGCCCACAGA GACCCTCCAG GAGCTGCTGG ACCTGCACCG GACCTGTGAG 
CGAGAGGCCA TAGAAATCTT CAGGAAGCAT TCGTTCAAGG ATGAGGGTGA ATTTTTCCAG 
AAAGAATTGG AGAGCCTACT AAGTGCAAAG CAGGATGAGA TTTGTAAGAA GAACGCGGAT 
GCTTCTGCAG CCCTCTGCTC AACCCTACTT GGGAGTATTT TTAAGCCTCT GGAACAAGAA 
GTGGCGCAGG AGTTCTATCA TAAACCAGGA GGCCACAAGC TCTTCCTTCA GAGGATGGAA 
CAGCTGAAGG CAAATTACCG TCAGCAGCCA GGGAAGGGAA CACAGGCTGA GGAAGTGCTG 
CAGACCTATT TGAACGCCAA AGAAACAGTG AGCCGTACAA TTCTACAAAC AGACCAGGTT 
CTCACAGACA AGGAGATCCA GAGTAAAGCG GAACAAGAAA GAGCAGAGGC TGCCCGGCTC 
GAAGCACAGA GGTTGGAGGC TATTCGCATC CAGGAAGAGC AAAGGAAAGC AGAGATGGAG 
AGACAGCATC AAGAGCAATT GAGGCAAATA GCATTGGAGA AGGCAAGAGT TGCACAAGAG 
CAACAGTGGA TCCTGAAGCA GAGAGCCCAG GAAGAGGCTG ATAGAATCAA GGCAGAGCAG 
GAAGCTCAAC TCAGAGCACT TCAACAGCAG CTCCAACACA TGAGGGAAAT GAACCACCAC 
CGTAGACATC ATCATGACTG TGTTATAAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_705792.2
CDS	67..1839
Translation	MAPEIHMPEPLCLIGSTEGHLVTNQEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKEKGFSVGSTVQSHTKGIWMWCVPHPQKPDHTLVLLDTEGLGDVEKDDKKNDTQIFALAILLSSTFVYNTMNKIDQGAIDLLHNVTELTDLLRTRNSSDSNQTEGEGPADMSFFPDLVWTLRDFFLDLQANGHAITSDEYLENSLKLKQGSDERTQTFNLPRLCIQKFFPVKKCFVFDAPALGSKLSQLPTLSNEELNSDFVQDLSEFCSHIFTQSKTKTLPGGIQVNGPRLESLVLTYVDAINSGALPSIENTVVTLARRENSAAVQKAIGHYDQLMSEKVQLPTETLQELLDLHRTCEREAIEIFRKHSFKDEGEFFQKELESLLSAKQDEICKKNADASAALCSTLLGSIFKPLEQEVAQEFYHKPGGHKLFLQRMEQLKANYRQQPGKGTQAEEVLQTYLNAKETVSRTILQTDQVLTDKEIQSKAEQERAEAARLEAQRLEAIRIQEEQRKAEMERQHQEQLRQIALEKARVAQEQQWILKQRAQEEADRIKAEQEAQLRALQQQLQHMREMNHHRRHHHDCVIS

Target ORF information:

RefSeq Version	NM_153564.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus guanylate binding protein 5 (Gbp5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153564.2

ORF Insert Sequence:

ATGGCCCCAG AGATTCACAT GCCAGAACCC TTGTGCCTCA TTGGGAGCAC CGAGGGACAC 
CTAGTAACTA ACCAGGAAGC CCTGAAGATT CTGTCTGCCA TCACACAGCC AGTGGTGGTG 
GTAGCCATTG TGGGTCTTTA TCGCACAGGC AAATCCTACC TGATGAACAA GCTGGCTGGG 
AAGGAGAAGG GCTTTTCTGT TGGATCCACT GTACAGTCTC ACACCAAGGG GATCTGGATG 
TGGTGTGTGC CTCACCCCCA AAAGCCAGAC CACACTTTGG TTCTGCTTGA CACTGAAGGC 
CTGGGAGATG TGGAGAAGGA TGATAAAAAG AATGATACTC AGATCTTTGC ACTAGCAATC 
CTCCTCAGTA GCACCTTTGT ATACAACACT ATGAACAAAA TTGACCAGGG GGCTATCGAC 
CTATTGCACA ATGTGACAGA ACTGACAGAC TTGCTCCGGA CAAGAAACTC CTCTGATTCT 
AATCAAACTG AGGGTGAGGG ACCTGCTGAC ATGAGCTTCT TCCCAGACTT GGTGTGGACT 
CTGAGAGATT TCTTCCTGGA CCTGCAAGCC AATGGGCATG CCATCACATC AGATGAATAT 
CTGGAGAATT CACTGAAGCT GAAGCAAGGT AGCGATGAAA GAACTCAAAC ATTCAATCTA 
CCGCGGCTGT GCATACAGAA GTTCTTCCCA GTAAAGAAAT GCTTTGTTTT TGACGCTCCT 
GCGCTTGGAA GTAAGCTTTC CCAGCTTCCA ACACTCAGCA ACGAGGAGCT GAACTCAGAT 
TTTGTGCAGG ACCTTTCAGA ATTCTGTTCA CACATCTTCA CCCAATCTAA GACCAAGACT 
CTTCCAGGAG GCATCCAGGT CAACGGACCT CGTCTAGAAA GCCTGGTGCT GACTTATGTC 
GATGCCATCA ACAGCGGGGC TCTGCCTTCC ATAGAGAACA CAGTAGTAAC CTTGGCCCGG 
AGGGAGAACT CTGCAGCAGT TCAAAAGGCC ATTGGTCACT ACGATCAGCT GATGAGCGAG 
AAGGTGCAGC TGCCCACAGA GACCCTCCAG GAGCTGCTGG ACCTGCACCG GACCTGTGAG 
CGAGAGGCCA TAGAAATCTT CAGGAAGCAT TCGTTCAAGG ATGAGGGTGA ATTTTTCCAG 
AAAGAATTGG AGAGCCTACT AAGTGCAAAG CAGGATGAGA TTTGTAAGAA GAACGCGGAT 
GCTTCTGCAG CCCTCTGCTC AACCCTACTT GGGAGTATTT TTAAGCCTCT GGAACAAGAA 
GTGGCGCAGG AGTTCTATCA TAAACCAGGA GGCCACAAGC TCTTCCTTCA GAGGATGGAA 
CAGCTGAAGG CAAATTACCG TCAGCAGCCA GGGAAGGGAA CACAGGCTGA GGAAGTGCTG 
CAGACCTATT TGAACGCCAA AGAAACAGTG AGCCGTACAA TTCTACAAAC AGACCAGGTT 
CTCACAGACA AGGAGATCCA GAGTAAAGCG GAACAAGAAA GAGCAGAGGC TGCCCGGCTC 
GAAGCACAGA GGTTGGAGGC TATTCGCATC CAGGAAGAGC AAAGGAAAGC AGAGATGGAG 
AGACAGCATC AAGAGCAATT GAGGCAAATA GCATTGGAGA AGGCAAGAGT TGCACAAGAG 
CAACAGTGGA TCCTGAAGCA GAGAGCCCAG GAAGAGGCTG ATAGAATCAA GGCAGAGCAG 
GAAGCTCAAC TCAGAGCACT TCAACAGCAG CTCCAACACA TGAGGGAAAT GAACCACCAC 
CGTAGACATC ATCATGACTG TGTTATAAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of potential biomarkers for post-traumatic complications released after trauma-hemorrhage from murine Kupffer cells and its investigation in lung and liver.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals21(7)645-52(2016 Nov)
Schultze C,Hildebrand F,Noack S,Krettek C,Zeckey C,Neunaber C

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.
Nature immunology16(5)476-484(2015 May)
Meunier E,Wallet P,Dreier RF,Costanzo S,Anton L,R?hl S,Dussurgey S,Dick MS,Kistner A,Rigard M,Degrandi D,Pfeffer K,Yamamoto M,Henry T,Broz P

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Gbp5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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