Tm4sf4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tm4sf4
Entrez Gene ID	229302
Full Name	transmembrane 4 superfamily member 4
Synonyms	Iltmp
General protein information	Preferred Names transmembrane 4 superfamily member 4 Names transmembrane 4 L6 family member 4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_145539.2	NP_663514.2	transmembrane 4 L6 family member 4

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	tm4sf4	NP_001003489.1
Mus musculus (house mouse)	Tm4sf4	NP_663514.2
Rattus norvegicus (Norway rat)	Tm4sf4	NP_446237.1
Xenopus tropicalis (tropical clawed frog)	tm4sf4	NP_988958.1
Homo sapiens (human)	TM4SF4	NP_004608.1
	TM4SF4	XP_001108653.1
Canis lupus familiaris (dog)	TM4SF4	XP_854442.1
Gallus gallus (chicken)	TM4SF4	XP_001234023.1
Pan troglodytes (chimpanzee)	TM4SF4	XP_001170324.1
Bos taurus (cattle)	TM4SF4	NP_001029478.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H, Stuart JM, Gu W
BMC immunology17(1)25(2016 08)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Wnt signaling specifies and patterns intestinal endoderm.
Sherwood RI, Maehr R, Mazzoni EO, Melton DA
Mechanisms of development128(7-10)387-400(2011 Sep-Dec)

The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration.
Anderson KR, Singer RA, Balderes DA, Hernandez-Lagunas L, Johnson CW, Artinger KB, Sussel L
Development (Cambridge, England)138(15)3213-24(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that Tm4sf4 is localized to the ductal epithelium and Ngn3(+) islet progenitor cells, and that pancreatic tm4sf4 expression and regulation by Nkx2.2 is conserved during development.
Title: The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration.

The following Tm4sf4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tm4sf4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11749	NM_145539.2 Latest version!	Mus musculus transmembrane 4 superfamily member 4 (Tm4sf4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tm4sf4 ( NM_145539.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_663514.2 Mus musculus transmembrane 4 superfamily member 4 (Tm4sf4), mRNA.

Price & Availability↑

CloneID	OMu11749
Clone ID Related Accession (Same CDS sequence)	NM_145539.2
Accession Version	NM_145539.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 609bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	transmembrane 4 L6 family member 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB840196.1, AK165731.1 and BP772386.1. On Sep 30, 2009 this sequence version replaced NM_145539.1. ##Evidence-Data-START## Transcript exon combination :: AK148484.1, BC010814.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTACTG GGGGCTGTGC CAGGTGCCTG GGGGGCACCC TCATTCCCCT GGCTGTGTTT 
GGCCTCCTGG CAAATATCCT GTTGTTCTTT CCTGGAGGAA AAGTGGTGAA CGACAAAAGC 
CACCTTTCGG ATGAGGTCTG GTACTTCGGA GGAATATTGG GAAGTGGAGT CTTGATGATC 
TTCCCTGCGC TTGTGTTCTT GGGCCTGCAG AACAACGACT GCTGCGGATG CTGTGGCAAT 
GAGGGCTGTG GGAAGCGATT TGCGATGTTC ACCTCCACGT TGTTTGCTGT GATTGGATTC 
TTAGGTGCTG GCTACTCATT TATCGTCTCA GCTGTTTCTA TCAACAAGGG TCCTAAATGC 
TTCATGGCCA ATGGTACATG GGGATACCCC TTCCACGATG GTGATTATCT AAAAGACCAA 
GCCTTGTGGA GCGAGTGCAA AGAGCCCCGT GATGTGGTCC CCTGGAACCT CACCCTCTTC 
TCCATTCTGC TGGTCATCGG AGGGATCCAG ATGGTTCTCT GTGCCATCCA GGTGATCAAT 
GGCCTCCTGG GAACTCTCTG TGGAGACTGC CAGTGCTGTG GCTGCTGTGG GGGTGATGGA 
CCAGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663514.2
CDS	206..814
Translation	MCTGGCARCLGGTLIPLAVFGLLANILLFFPGGKVVNDKSHLSDEVWYFGGILGSGVLMIFPALVFLGLQNNDCCGCCGNEGCGKRFAMFTSTLFAVIGFLGAGYSFIVSAVSINKGPKCFMANGTWGYPFHDGDYLKDQALWSECKEPRDVVPWNLTLFSILLVIGGIQMVLCAIQVINGLLGTLCGDCQCCGCCGGDGPV

Target ORF information:

RefSeq Version	NM_145539.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus transmembrane 4 superfamily member 4 (Tm4sf4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145539.2

ORF Insert Sequence:

ATGTGTACTG GGGGCTGTGC CAGGTGCCTG GGGGGCACCC TCATTCCCCT GGCTGTGTTT 
GGCCTCCTGG CAAATATCCT GTTGTTCTTT CCTGGAGGAA AAGTGGTGAA CGACAAAAGC 
CACCTTTCGG ATGAGGTCTG GTACTTCGGA GGAATATTGG GAAGTGGAGT CTTGATGATC 
TTCCCTGCGC TTGTGTTCTT GGGCCTGCAG AACAACGACT GCTGCGGATG CTGTGGCAAT 
GAGGGCTGTG GGAAGCGATT TGCGATGTTC ACCTCCACGT TGTTTGCTGT GATTGGATTC 
TTAGGTGCTG GCTACTCATT TATCGTCTCA GCTGTTTCTA TCAACAAGGG TCCTAAATGC 
TTCATGGCCA ATGGTACATG GGGATACCCC TTCCACGATG GTGATTATCT AAAAGACCAA 
GCCTTGTGGA GCGAGTGCAA AGAGCCCCGT GATGTGGTCC CCTGGAACCT CACCCTCTTC 
TCCATTCTGC TGGTCATCGG AGGGATCCAG ATGGTTCTCT GTGCCATCCA GGTGATCAAT 
GGCCTCCTGG GAACTCTCTG TGGAGACTGC CAGTGCTGTG GCTGCTGTGG GGGTGATGGA 
CCAGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
BMC immunology17(1)25(2016 08)
Liu X,Jiao Y,Cao Y,Deng N,Ma Y,Hasty KA,Kang A,Chen H,Stuart JM,Gu W

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Wnt signaling specifies and patterns intestinal endoderm.
Mechanisms of development128(7-10)387-400(2011 Sep-Dec)
Sherwood RI,Maehr R,Mazzoni EO,Melton DA

The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration.
Development (Cambridge, England)138(15)3213-24(2011 Aug)
Anderson KR,Singer RA,Balderes DA,Hernandez-Lagunas L,Johnson CW,Artinger KB,Sussel L

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Tm4sf4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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