Stoml3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Stoml3
Entrez Gene ID	229277
Full Name	stomatin (Epb7.2)-like 3
Synonyms	Epb7.2l,SLP3,sro
General protein information	Preferred Names stomatin (Epb7.2)-like 3 Names stomatin-like protein 3 SLP-3 stomatin related olfactory protein SRO stomatin-related olfactory protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 C

mRNA and Protein(s)

mRNA	Protein	Name
NM_153156.1	NP_694796.1	stomatin-like protein 3
NM_153156.2	NP_694796.1	stomatin-like protein 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	STOML3	NP_660329.1
	STOML3	XP_001086610.1
Xenopus tropicalis (tropical clawed frog)	stoml3	NP_989344.1
Canis lupus familiaris (dog)	STOML3	XP_543126.4
Gallus gallus (chicken)	STOML3	XP_425632.3
Neurospora crassa	NCU03388	XP_956835.2
Danio rerio (zebrafish)	stoml3a	NP_001092220.1
Pan troglodytes (chimpanzee)	STOML3	XP_522665.1
Bos taurus (cattle)	STOML3	NP_001074378.1
Mus musculus (house mouse)	Stoml3	NP_694796.1
Magnaporthe oryzae (rice blast fungus)	MGG_02410	XP_003709195.1

Gene Ontology
Bibliography

Related articles in PubMed

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel C, Pifferi S, Picci C, G?k C, Hoffmann D, Bali KK, Lampe A, Lapatsina L, Fleischer R, Smith ES, B?gay V, Moroni M, Estebanez L, K?hnemund J, Walcher J, Specker E, Neuenschwander M, von Kries JP, Haucke V, Kuner R, Poulet JF, Schmoranzer J, Poole K, Lewin GR
Nature neuroscience20(2)209-218(2017 Feb)

Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex.
Munoz I, Danelli L, Claver J, Goudin N, Kurowska M, Madera-Salcedo IK, Huang JD, Fischer A, Gonz?lez-Espinosa C, de Saint Basile G, Blank U, M?nasch? G
The Journal of cell biology215(2)203-216(2016 Oct)

Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons.
Qi Y, Andolfi L, Frattini F, Mayer F, Lazzarino M, Hu J
Nature communications68512(2015 Oct)

Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch.
Poole K, Herget R, Lapatsina L, Ngo HD, Lewin GR
Nature communications53520(2014 Mar)

Stomatin-domain protein interactions with acid-sensing ion channels modulate nociceptor mechanosensitivity.
Moshourab RA, Wetzel C, Martinez-Salgado C, Lewin GR
The Journal of physiology591(22)5555-74(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

STOML3 inhibitors in the skin also reversibly attenuate fine touch perception in normal mice.
Title: Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.

PI3K-dependent formation of a kinesin-1/Slp3/Rab27b complex is critical for the microtubule-dependent movement of secretory granules required for mast cell degranulation.
Title: Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex.

In C57BL/6N, but not STOML3(-/-) mice, tactile allodynia is attenuated by cholesterol depletion, suggesting that membrane stiffening by STOML3 is essential for mechanical sensitivity.
Title: Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons.

STOML3 is the first potent modulator of Piezo channels that tunes the sensitivity of mechanically gated channels to detect molecular-scale stimuli relevant for fine touch.
Title: Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch.

Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons.
Title: Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons.

The following Stoml3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Stoml3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu02537	NM_153156.2 Latest version!	Mus musculus stomatin (Epb7.2)-like 3 (Stoml3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OMu02537	NM_153156.1	Mus musculus stomatin (Epb7.2)-like 3 (Stoml3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Stoml3 ( NM_153156.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_694796.1 Mus musculus stomatin (Epb7.2)-like 3 (Stoml3), mRNA.

Price & Availability↑

CloneID	OMu02537
Clone ID Related Accession (Same CDS sequence)	NM_153156.1 , NM_153156.2
Accession Version	NM_153156.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 864bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Mus musculus(house mouse)
Product	stomatin-like protein 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB085692.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB085692.1, BC058224.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGGATTCAC CGGAGAAACT GGAGAAGAAC AATTTAGTGG GCACCAACAA AAGCCGGCTT 
GGTGTGTGCG GCTGGATCCT GTTTTTCCTT TCCTTCCTGC TGATGCTCGT TACCTTCCCA 
ATCTCAGTAT GGATGTGCTT GAAGATCATT AAGGAGTATG AGCGCGCTGT TGTCTTCAGA 
CTGGGACGCA TCCAAGCTGA TAAAGCCAAG GGACCAGGTT TGATCCTGGT CCTGCCTTGC 
ATTGACGTGT TTGTCAAAGT AGATCTTCGA ACGGTTACTT GTAACATTCC TCCACAAGAG 
ATCCTCACGA GAGACTCTGT GACCACCCAA GTGGATGGAG TCGTCTATTA CAGAATCTAC 
AGCGCCGTCT CAGCCGTGGC CAATGTGAAC GATGTTCACC AGGCCACGTT CCTGCTGGCT 
CAGACCACTC TGAGAAATGT CTTAGGGACA CAGACCTTGT CCCAGATCTT GTCTGGGCGA 
GAAGAGATCG CACATAGCAT CCAGACCTTG CTTGATGATG CCACCGAGCT CTGGGGAATC 
CGAGTGGCCC GGGTGGAAAT CAAAGATGTC CGGATTCCTG TGCAGCTGCA GAGGTCCATG 
GCGGCTGAGG CTGAGGCTAC CCGGGAAGCC AGAGCCAAGG TCCTTGCAGC AGAGGGAGAA 
ATGAATGCTT CAAAGTCTCT GAAGTCAGCT TCCATGGTGC TGGCAGAGTC CCCCGTCGCC 
CTCCAACTTC GGTACCTGCA GACCTTGACC ACAGTGGCCA CGGAGAAAAA TTCCACCATT 
GTGTTTCCCT TGCCGATGAA CATACTTGAG GGCATTGGTG GCATCAGCTA TGGCAACAAT 
AAGAAGGTCA CTGCTAAAGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694796.1
CDS	1..864
Translation	MDSPEKLEKNNLVGTNKSRLGVCGWILFFLSFLLMLVTFPISVWMCLKIIKEYERAVVFRLGRIQADKAKGPGLILVLPCIDVFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQATFLLAQTTLRNVLGTQTLSQILSGREEIAHSIQTLLDDATELWGIRVARVEIKDVRIPVQLQRSMAAEAEATREARAKVLAAEGEMNASKSLKSASMVLAESPVALQLRYLQTLTTVATEKNSTIVFPLPMNILEGIGGISYGNNKKVTAKA

Target ORF information:

RefSeq Version	NM_153156.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus stomatin (Epb7.2)-like 3 (Stoml3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153156.1

ORF Insert Sequence:

ATGGATTCAC CGGAGAAACT GGAGAAGAAC AATTTAGTGG GCACCAACAA AAGCCGGCTT 
GGTGTGTGCG GCTGGATCCT GTTTTTCCTT TCCTTCCTGC TGATGCTCGT TACCTTCCCA 
ATCTCAGTAT GGATGTGCTT GAAGATCATT AAGGAGTATG AGCGCGCTGT TGTCTTCAGA 
CTGGGACGCA TCCAAGCTGA TAAAGCCAAG GGACCAGGTT TGATCCTGGT CCTGCCTTGC 
ATTGACGTGT TTGTCAAAGT AGATCTTCGA ACGGTTACTT GTAACATTCC TCCACAAGAG 
ATCCTCACGA GAGACTCTGT GACCACCCAA GTGGATGGAG TCGTCTATTA CAGAATCTAC 
AGCGCCGTCT CAGCCGTGGC CAATGTGAAC GATGTTCACC AGGCCACGTT CCTGCTGGCT 
CAGACCACTC TGAGAAATGT CTTAGGGACA CAGACCTTGT CCCAGATCTT GTCTGGGCGA 
GAAGAGATCG CACATAGCAT CCAGACCTTG CTTGATGATG CCACCGAGCT CTGGGGAATC 
CGAGTGGCCC GGGTGGAAAT CAAAGATGTC CGGATTCCTG TGCAGCTGCA GAGGTCCATG 
GCGGCTGAGG CTGAGGCTAC CCGGGAAGCC AGAGCCAAGG TCCTTGCAGC AGAGGGAGAA 
ATGAATGCTT CAAAGTCTCT GAAGTCAGCT TCCATGGTGC TGGCAGAGTC CCCCGTCGCC 
CTCCAACTTC GGTACCTGCA GACCTTGACC ACAGTGGCCA CGGAGAAAAA TTCCACCATT 
GTGTTTCCCT TGCCGATGAA CATACTTGAG GGCATTGGTG GCATCAGCTA TGGCAACAAT 
AAGAAGGTCA CTGCTAAAGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Stoml3 ( NM_153156.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_694796.1 Mus musculus stomatin (Epb7.2)-like 3 (Stoml3), mRNA.

Price & Availability↑

CloneID	OMu02537
Clone ID Related Accession (Same CDS sequence)	NM_153156.1 , NM_153156.2
Accession Version	NM_153156.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 864bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-26
Organism	Mus musculus(house mouse)
Product	stomatin-like protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC158162.13. On Jun 19, 2019 this sequence version replaced NM_153156.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058224.1, SRR5189670.130329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGATTCAC CGGAGAAACT GGAGAAGAAC AATTTAGTGG GCACCAACAA AAGCCGGCTT 
GGTGTGTGCG GCTGGATCCT GTTTTTCCTT TCCTTCCTGC TGATGCTCGT TACCTTCCCA 
ATCTCAGTAT GGATGTGCTT GAAGATCATT AAGGAGTATG AGCGCGCTGT TGTCTTCAGA 
CTGGGACGCA TCCAAGCTGA TAAAGCCAAG GGACCAGGTT TGATCCTGGT CCTGCCTTGC 
ATTGACGTGT TTGTCAAAGT AGATCTTCGA ACGGTTACTT GTAACATTCC TCCACAAGAG 
ATCCTCACGA GAGACTCTGT GACCACCCAA GTGGATGGAG TCGTCTATTA CAGAATCTAC 
AGCGCCGTCT CAGCCGTGGC CAATGTGAAC GATGTTCACC AGGCCACGTT CCTGCTGGCT 
CAGACCACTC TGAGAAATGT CTTAGGGACA CAGACCTTGT CCCAGATCTT GTCTGGGCGA 
GAAGAGATCG CACATAGCAT CCAGACCTTG CTTGATGATG CCACCGAGCT CTGGGGAATC 
CGAGTGGCCC GGGTGGAAAT CAAAGATGTC CGGATTCCTG TGCAGCTGCA GAGGTCCATG 
GCGGCTGAGG CTGAGGCTAC CCGGGAAGCC AGAGCCAAGG TCCTTGCAGC AGAGGGAGAA 
ATGAATGCTT CAAAGTCTCT GAAGTCAGCT TCCATGGTGC TGGCAGAGTC CCCCGTCGCC 
CTCCAACTTC GGTACCTGCA GACCTTGACC ACAGTGGCCA CGGAGAAAAA TTCCACCATT 
GTGTTTCCCT TGCCGATGAA CATACTTGAG GGCATTGGTG GCATCAGCTA TGGCAACAAT 
AAGAAGGTCA CTGCTAAAGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694796.1
CDS	87..950
Translation	MDSPEKLEKNNLVGTNKSRLGVCGWILFFLSFLLMLVTFPISVWMCLKIIKEYERAVVFRLGRIQADKAKGPGLILVLPCIDVFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQATFLLAQTTLRNVLGTQTLSQILSGREEIAHSIQTLLDDATELWGIRVARVEIKDVRIPVQLQRSMAAEAEATREARAKVLAAEGEMNASKSLKSASMVLAESPVALQLRYLQTLTTVATEKNSTIVFPLPMNILEGIGGISYGNNKKVTAKA

Target ORF information:

RefSeq Version	NM_153156.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus stomatin (Epb7.2)-like 3 (Stoml3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153156.2

ORF Insert Sequence:

ATGGATTCAC CGGAGAAACT GGAGAAGAAC AATTTAGTGG GCACCAACAA AAGCCGGCTT 
GGTGTGTGCG GCTGGATCCT GTTTTTCCTT TCCTTCCTGC TGATGCTCGT TACCTTCCCA 
ATCTCAGTAT GGATGTGCTT GAAGATCATT AAGGAGTATG AGCGCGCTGT TGTCTTCAGA 
CTGGGACGCA TCCAAGCTGA TAAAGCCAAG GGACCAGGTT TGATCCTGGT CCTGCCTTGC 
ATTGACGTGT TTGTCAAAGT AGATCTTCGA ACGGTTACTT GTAACATTCC TCCACAAGAG 
ATCCTCACGA GAGACTCTGT GACCACCCAA GTGGATGGAG TCGTCTATTA CAGAATCTAC 
AGCGCCGTCT CAGCCGTGGC CAATGTGAAC GATGTTCACC AGGCCACGTT CCTGCTGGCT 
CAGACCACTC TGAGAAATGT CTTAGGGACA CAGACCTTGT CCCAGATCTT GTCTGGGCGA 
GAAGAGATCG CACATAGCAT CCAGACCTTG CTTGATGATG CCACCGAGCT CTGGGGAATC 
CGAGTGGCCC GGGTGGAAAT CAAAGATGTC CGGATTCCTG TGCAGCTGCA GAGGTCCATG 
GCGGCTGAGG CTGAGGCTAC CCGGGAAGCC AGAGCCAAGG TCCTTGCAGC AGAGGGAGAA 
ATGAATGCTT CAAAGTCTCT GAAGTCAGCT TCCATGGTGC TGGCAGAGTC CCCCGTCGCC 
CTCCAACTTC GGTACCTGCA GACCTTGACC ACAGTGGCCA CGGAGAAAAA TTCCACCATT 
GTGTTTCCCT TGCCGATGAA CATACTTGAG GGCATTGGTG GCATCAGCTA TGGCAACAAT 
AAGAAGGTCA CTGCTAAAGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Nature neuroscience20(2)209-218(2017 Feb)
Wetzel C,Pifferi S,Picci C,G?k C,Hoffmann D,Bali KK,Lampe A,Lapatsina L,Fleischer R,Smith ES,B?gay V,Moroni M,Estebanez L,K?hnemund J,Walcher J,Specker E,Neuenschwander M,von Kries JP,Haucke V,Kuner R,Poulet JF,Schmoranzer J,Poole K,Lewin GR

Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex.
The Journal of cell biology215(2)203-216(2016 Oct)
Munoz I,Danelli L,Claver J,Goudin N,Kurowska M,Madera-Salcedo IK,Huang JD,Fischer A,Gonz?lez-Espinosa C,de Saint Basile G,Blank U,M?nasch? G

Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons.
Nature communications68512(2015 Oct)
Qi Y,Andolfi L,Frattini F,Mayer F,Lazzarino M,Hu J

Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch.
Nature communications53520(2014 Mar)
Poole K,Herget R,Lapatsina L,Ngo HD,Lewin GR

Stomatin-domain protein interactions with acid-sensing ion channels modulate nociceptor mechanosensitivity.
The Journal of physiology591(22)5555-74(2013 Nov)
Moshourab RA,Wetzel C,Martinez-Salgado C,Lewin GR

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Stoml3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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