Fitm2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fitm2
Entrez Gene ID	228859
Full Name	fat storage-inducing transmembrane protein 2
Synonyms	AI414861,D930001I22Rik,Fit2
General protein information	Preferred Names fat storage-inducing transmembrane protein 2 Names fat storage-inducing transmembrane protein 2 fat-inducing protein 2 fat-inducing transcript 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 H3

mRNA and Protein(s)

mRNA	Protein	Name
NM_173397.4	NP_775573.1	fat storage-inducing transmembrane protein 2

Pathways from BioSystems

Homologies

	FITM2	XP_001082092.1
Canis lupus familiaris (dog)	FITM2	XP_543006.3
Gallus gallus (chicken)	FITM2	XP_417378.2
Pan troglodytes (chimpanzee)	FITM2	XP_514663.2
Bos taurus (cattle)	FITM2	NP_001096565.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006131	XP_316194.4
Caenorhabditis elegans (roundworm)	ZK265.9	NP_001021865.1
Rattus norvegicus (Norway rat)	Fitm2	NP_001101269.1
Homo sapiens (human)	FITM2	NP_001073941.1
Mus musculus (house mouse)	Fitm2	NP_775573.1
Danio rerio (zebrafish)	fitm2	NP_001018334.1
Drosophila melanogaster (fruit fly)	CG10671	NP_729053.2
Xenopus tropicalis (tropical clawed frog)	fitm2	NP_001090654.1

Gene Ontology
Bibliography

Related articles in PubMed

Postnatal Deletion of Fat Storage-inducing Transmembrane Protein 2 (FIT2/FITM2) Causes Lethal Enteropathy.
Goh VJ, Tan JS, Tan BC, Seow C, Ong WY, Lim YC, Sun L, Ghosh S, Silver DL
The Journal of biological chemistry290(42)25686-99(2015 Oct)

Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissue.
Miranda DA, Kim JH, Nguyen LN, Cheng W, Tan BC, Goh VJ, Tan JS, Yaligar J, Kn BP, Velan SS, Wang H, Silver DL
The Journal of biological chemistry289(14)9560-72(2014 Apr)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation.
Gross DA, Zhan C, Silver DL
Proceedings of the National Academy of Sciences of the United States of America108(49)19581-6(2011 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data support the conclusion that FIT2 plays an essential role in regulating intestinal health and survival postnatally
Title: Postnatal Deletion of Fat Storage-inducing Transmembrane Protein 2 (FIT2/FITM2) Causes Lethal Enteropathy.

These data support the conclusion that FIT2 plays an essential, physiological role in fat storage in vivo.
Title: Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissue.

Findings indicate that lipid droplet (LD)produced by storage-inducing transmembrane proteins 2 (FIT2) were approximately 80% larger than storage-inducing transmembrane proteins 1 (FIT1).
Title: Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation.

FIT2 expression in skeletal muscle plays an unexpected function in regulating muscle energy metabolism and indicates an important role for lipid droplet formation in this process
Title: Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2.

FIT2 is a 6 transmembrane domain-containing protein whose conformation likely regulates its activity in mediating lipid droplet formation.
Title: Structural insights into triglyceride storage mediated by fat storage-inducing transmembrane (FIT) protein 2.

The following Fitm2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fitm2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04563	NM_173397.4 Latest version!	Mus musculus fat storage-inducing transmembrane protein 2 (Fitm2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fitm2 ( NM_173397.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_775573.1 Mus musculus fat storage-inducing transmembrane protein 2 (Fitm2), mRNA.

Price & Availability↑

CloneID	OMu04563
Clone ID Related Accession (Same CDS sequence)	NM_173397.4
Accession Version	NM_173397.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	fat storage-inducing transmembrane protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK043244.1. On Jun 3, 2007 this sequence version replaced NM_173397.3. ##Evidence-Data-START## Transcript exon combination :: AK043244.1, AK054016.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCACC TGGAGCGCTG CGCGTGGTTT CTCCGCGGGA CGCTGGTGAG GGCGACGGTG 
CGGCGCCACC TGCCCTGGGC GCTGGTGGCC GCCATGCTGG CGGGCTCGGT CGTCAAGGAG 
CTGTCCCCGC TGCCCGAGAG CTACCTCAGC AACAAGCGCA ACGTCCTCAA CGTGTATTTT 
GTTAAATTGG CCTGGGCCTG GACAGTCTGT CTCCTCCTGC CTTTCATTGC CCTTACCAAC 
TACCACCTGA CGGGCAAGAC CAGCCTGGTC CTGCGGCGGT TGAGCACCCT CCTCGTGGGC 
ACAGCCATCT GGTATATCTG CACAGCCCTC TTCTCCAACA TTGAGCACTA TACAGGCAGC 
TGCTACCAGT CCCCGGCCCT GGAGGGCATC AGACAGGAGC ATCGCAGCAA GCAGCAGTGC 
CACCGGGAAG GGGGCTTCTG GCATGGCTTT GACATCTCGG GCCACTCCTT CCTCTTGACC 
TTCTGTGCGC TCATGATTGT GGAAGAGATG GCCGTGCTGC ATGAGGTGAA GACGGACCGC 
GGCCACCACC TCCATGCCGC CATCACCACC CTGGTTGTCG CCCTGGGTTT CCTGACCTTC 
ATCTGGGTGT GGATGTTTCT GTGCACAGCC GTTTATTTCC ACGACTTGAC CCAGAAAGTG 
TTCGGCACCA TGTTTGGTTT GTTGGGCTGG TACGGAACAT ATGGGTATTG GTATCTGAAG 
TCTTTCTCTC CAGGACTTCC TCCCCAGAGT TGTAGTTTGA CTTTGAAGCG AGATACTTAC 
AAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775573.1
CDS	55..843
Translation	MEHLERCAWFLRGTLVRATVRRHLPWALVAAMLAGSVVKELSPLPESYLSNKRNVLNVYFVKLAWAWTVCLLLPFIALTNYHLTGKTSLVLRRLSTLLVGTAIWYICTALFSNIEHYTGSCYQSPALEGIRQEHRSKQQCHREGGFWHGFDISGHSFLLTFCALMIVEEMAVLHEVKTDRGHHLHAAITTLVVALGFLTFIWVWMFLCTAVYFHDLTQKVFGTMFGLLGWYGTYGYWYLKSFSPGLPPQSCSLTLKRDTYKK

Target ORF information:

RefSeq Version	NM_173397.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus fat storage-inducing transmembrane protein 2 (Fitm2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173397.4

ORF Insert Sequence:

ATGGAGCACC TGGAGCGCTG CGCGTGGTTT CTCCGCGGGA CGCTGGTGAG GGCGACGGTG 
CGGCGCCACC TGCCCTGGGC GCTGGTGGCC GCCATGCTGG CGGGCTCGGT CGTCAAGGAG 
CTGTCCCCGC TGCCCGAGAG CTACCTCAGC AACAAGCGCA ACGTCCTCAA CGTGTATTTT 
GTTAAATTGG CCTGGGCCTG GACAGTCTGT CTCCTCCTGC CTTTCATTGC CCTTACCAAC 
TACCACCTGA CGGGCAAGAC CAGCCTGGTC CTGCGGCGGT TGAGCACCCT CCTCGTGGGC 
ACAGCCATCT GGTATATCTG CACAGCCCTC TTCTCCAACA TTGAGCACTA TACAGGCAGC 
TGCTACCAGT CCCCGGCCCT GGAGGGCATC AGACAGGAGC ATCGCAGCAA GCAGCAGTGC 
CACCGGGAAG GGGGCTTCTG GCATGGCTTT GACATCTCGG GCCACTCCTT CCTCTTGACC 
TTCTGTGCGC TCATGATTGT GGAAGAGATG GCCGTGCTGC ATGAGGTGAA GACGGACCGC 
GGCCACCACC TCCATGCCGC CATCACCACC CTGGTTGTCG CCCTGGGTTT CCTGACCTTC 
ATCTGGGTGT GGATGTTTCT GTGCACAGCC GTTTATTTCC ACGACTTGAC CCAGAAAGTG 
TTCGGCACCA TGTTTGGTTT GTTGGGCTGG TACGGAACAT ATGGGTATTG GTATCTGAAG 
TCTTTCTCTC CAGGACTTCC TCCCCAGAGT TGTAGTTTGA CTTTGAAGCG AGATACTTAC 
AAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Postnatal Deletion of Fat Storage-inducing Transmembrane Protein 2 (FIT2/FITM2) Causes Lethal Enteropathy.
The Journal of biological chemistry290(42)25686-99(2015 Oct)
Goh VJ,Tan JS,Tan BC,Seow C,Ong WY,Lim YC,Sun L,Ghosh S,Silver DL

Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissue.
The Journal of biological chemistry289(14)9560-72(2014 Apr)
Miranda DA,Kim JH,Nguyen LN,Cheng W,Tan BC,Goh VJ,Tan JS,Yaligar J,Kn BP,Velan SS,Wang H,Silver DL

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation.
Proceedings of the National Academy of Sciences of the United States of America108(49)19581-6(2011 Dec)
Gross DA,Zhan C,Silver DL

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Fitm2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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