Ctdsp1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ctdsp1
Entrez Gene ID	227292
Full Name	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
Synonyms	GIP,NLIIF,Nif3,SCP1
General protein information	Preferred Names CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Names carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 NLI-interacting factor 3 golli-interacting protein nuclear LIM interactor-interacting factor 3 small C-terminal domain phosphatase 1 small CTD phosphatase 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 C3

mRNA and Protein(s)

mRNA	Protein	Name
NM_153088.2	NP_694728.1	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CTDSP1	NP_067021.1
Bos taurus (cattle)	CTDSP1	NP_001179369.1
Gallus gallus (chicken)	CTDSP1	XP_003641697.2
Rattus norvegicus (Norway rat)	Ctdsp1	NP_001121551.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011422	XP_317884.3
Neurospora crassa	NCU08380	XP_965283.1
Pan troglodytes (chimpanzee)	CTDSP1	XP_001156881.1
	CTDSP1	XP_001090300.1
Canis lupus familiaris (dog)	CTDSP1	XP_005640700.1
Mus musculus (house mouse)	Ctdsp1	NP_694728.1
Drosophila melanogaster (fruit fly)	CG5830	NP_648825.1
Caenorhabditis elegans (roundworm)	scpl-1	NP_740911.2
Magnaporthe oryzae (rice blast fungus)	MGG_03646	XP_003716243.1
Xenopus tropicalis (tropical clawed frog)	ctdsp1	XP_002933982.1

Gene Ontology
Bibliography

Related articles in PubMed

Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis.
Liao P, Wang W, Li Y, Wang R, Jin J, Pang W, Chen Y, Shen M, Wang X, Jiang D, Pang J, Liu M, Lin X, Feng XH, Wang P, Ge X
eLife6(2017 Mar)

Regulatory effect of the glial Golli-BG21 protein on the full-length murine small C-terminal domain phosphatase (SCP1, or Golli-interacting protein).
Jaramillo-Tatis S, Vassall KA, Bamm VV, Harauz G
Biochemical and biophysical research communications447(4)633-7(2014 May)

MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein.
Zhu Y, Lu Y, Zhang Q, Liu JJ, Li TJ, Yang JR, Zeng C, Zhuang SM
Nucleic acids research40(10)4615-25(2012 May)

Suppression of BMP-Smad signaling axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase.
Kokabu S, Ohte S, Sasanuma H, Shin M, Yoneyama K, Murata E, Kanomata K, Nojima J, Ono Y, Yoda T, Fukuda T, Katagiri T
Molecular endocrinology (Baltimore, Md.)25(3)474-81(2011 Mar)

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Developmental cell18(4)675-85(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Consistently, the authors observed increased AKT phosphorylation and angiogenesis followed by enhanced tumorigenesis in Ctdsp1 (which encodes SCP1) gene - knockout mice. Importantly, they discovered that the membrane localization of SCP1 is crucial for impeding angiogenesis and tumor growth, and this localization depends on palmitoylation of a conserved cysteine motif within its NH2 terminus.
Title: Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis.

Golli-BG21 enhanced SCP1/GIP phosphatase activity, whereas PKCalpha-phosphorylated BG21 inhibited its activity, suggesting a potential role of BG21 as a molecular switch ("quick-brake mechanism") on SCP1/GIP.
Title: Regulatory effect of the glial Golli-BG21 protein on the full-length murine small C-terminal domain phosphatase (SCP1, or Golli-interacting protein).

Findings suggest that SCP1 may inhibit the osteoblastic differentiation induced by the BMP-Smad axis via Runx2 by suppressing downstream effector(s).
Title: Suppression of BMP-Smad signaling axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase.

Expression and purification of the active variant of recombinant murine Golli-interacting protein (GIP) and its characterization
Title: Expression and purification of the active variant of recombinant murine Golli-interacting protein (GIP)--characterization of its phosphatase activity and interaction with Golli-BG21.

The following Ctdsp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ctdsp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02251	NM_153088.2 Latest version!	Mus musculus CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 (Ctdsp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ctdsp1 ( NM_153088.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_694728.1 Mus musculus CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 (Ctdsp1), mRNA.

Price & Availability↑

CloneID	OMu02251
Clone ID Related Accession (Same CDS sequence)	NM_153088.2
Accession Version	NM_153088.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP765657.1, AK167390.1 and BE948438.1. On May 16, 2009 this sequence version replaced NM_153088.1. ##Evidence-Data-START## Transcript exon combination :: AY028804.1, BC065158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAGCT CGGCCGTCAT TACTCAGATC AGCAAGGAGG AGGCGCGGGG CCCGCTGCGG 
GGCAAAGGTG ACCAGAAGTC AGCAGTTTCC CAGAAGCCCC GGAGTCGGGG CATCCTCCAC 
TCCCTCTTCT GCTGTGTCTG CCGGGATGAT GGGGAGCCCC TACCTGCCCA CAGTGGGGCT 
CCCCTGCTGG TGGAGGAAAA TGGCGCCATC CCTAAGCACA CCCCAGTCCA GTACCTGCTT 
CCCGAGGCCA AGGCCCAGGA CTCAGACAAG ATCTGCGTCG TCATCGACCT GGACGAGACC 
CTGGTGCACA GCTCCTTCAA GCCAGTGAAC AATGCGGACT TCATCATCCC GGTGGAGATA 
GATGGAGTGG TCCACCAGGT CTATGTGCTG AAGCGGCCCC ACGTAGATGA GTTCCTACAG 
CGAATGGGCG AGCTCTTTGA ATGTGTGCTG TTCACTGCCA GCCTTGCCAA GTACGCAGAC 
CCTGTAGCTG ATCTGCTGGA CAAGTGGGGA GCCTTCCGTG CCAGGCTGTT TCGAGAGTCG 
TGTGTCTTCC ACCGGGGGAA CTACGTAAAG GACCTGAGCA GGCTGGGCCG AGACCTGCGG 
CGAGTGCTCA TTCTAGACAA CTCACCCGCC TCCTATGTCT TCCATCCAGA CAATGCCGTA 
CCAGTGGCCT CGTGGTTTGA CAACATGAGT GACACTGAGC TACACGATCT CTTACCCTTC 
TTTGAGCAAC TCAGCCGCGT GGACGACGTA TACTCAGTGC TCAGACAGCC TAGGCCCGGG 
AGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694728.1
CDS	290..1075
Translation	MDSSAVITQISKEEARGPLRGKGDQKSAVSQKPRSRGILHSLFCCVCRDDGEPLPAHSGAPLLVEENGAIPKHTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS

Target ORF information:

RefSeq Version	NM_153088.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 (Ctdsp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153088.2

ORF Insert Sequence:

ATGGACAGCT CGGCCGTCAT TACTCAGATC AGCAAGGAGG AGGCGCGGGG CCCGCTGCGG 
GGCAAAGGTG ACCAGAAGTC AGCAGTTTCC CAGAAGCCCC GGAGTCGGGG CATCCTCCAC 
TCCCTCTTCT GCTGTGTCTG CCGGGATGAT GGGGAGCCCC TACCTGCCCA CAGTGGGGCT 
CCCCTGCTGG TGGAGGAAAA TGGCGCCATC CCTAAGCACA CCCCAGTCCA GTACCTGCTT 
CCCGAGGCCA AGGCCCAGGA CTCAGACAAG ATCTGCGTCG TCATCGACCT GGACGAGACC 
CTGGTGCACA GCTCCTTCAA GCCAGTGAAC AATGCGGACT TCATCATCCC GGTGGAGATA 
GATGGAGTGG TCCACCAGGT CTATGTGCTG AAGCGGCCCC ACGTAGATGA GTTCCTACAG 
CGAATGGGCG AGCTCTTTGA ATGTGTGCTG TTCACTGCCA GCCTTGCCAA GTACGCAGAC 
CCTGTAGCTG ATCTGCTGGA CAAGTGGGGA GCCTTCCGTG CCAGGCTGTT TCGAGAGTCG 
TGTGTCTTCC ACCGGGGGAA CTACGTAAAG GACCTGAGCA GGCTGGGCCG AGACCTGCGG 
CGAGTGCTCA TTCTAGACAA CTCACCCGCC TCCTATGTCT TCCATCCAGA CAATGCCGTA 
CCAGTGGCCT CGTGGTTTGA CAACATGAGT GACACTGAGC TACACGATCT CTTACCCTTC 
TTTGAGCAAC TCAGCCGCGT GGACGACGTA TACTCAGTGC TCAGACAGCC TAGGCCCGGG 
AGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis.
eLife6(2017 Mar)
Liao P,Wang W,Li Y,Wang R,Jin J,Pang W,Chen Y,Shen M,Wang X,Jiang D,Pang J,Liu M,Lin X,Feng XH,Wang P,Ge X

Regulatory effect of the glial Golli-BG21 protein on the full-length murine small C-terminal domain phosphatase (SCP1, or Golli-interacting protein).
Biochemical and biophysical research communications447(4)633-7(2014 May)
Jaramillo-Tatis S,Vassall KA,Bamm VV,Harauz G

MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein.
Nucleic acids research40(10)4615-25(2012 May)
Zhu Y,Lu Y,Zhang Q,Liu JJ,Li TJ,Yang JR,Zeng C,Zhuang SM

Suppression of BMP-Smad signaling axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase.
Molecular endocrinology (Baltimore, Md.)25(3)474-81(2011 Mar)
Kokabu S,Ohte S,Sasanuma H,Shin M,Yoneyama K,Murata E,Kanomata K,Nojima J,Ono Y,Yoda T,Fukuda T,Katagiri T

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Developmental cell18(4)675-85(2010 Apr)
Guo G,Huss M,Tong GQ,Wang C,Li Sun L,Clarke ND,Robson P

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Ctdsp1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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