Zpr1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Zpr1
Entrez Gene ID	22687
Full Name	ZPR1 zinc finger
Synonyms	AI303781,Zfp259,Znf259
General protein information	Preferred Names ZPR1 zinc finger Names zinc finger protein ZPR1 zinc finger protein 259
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A5.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_011752.2	NP_035882.1	zinc finger protein ZPR1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ZNF259	XP_001152978.1
Bos taurus (cattle)	ZNF259	NP_001033593.1
Homo sapiens (human)	ZPR1	NP_003895.1
Saccharomyces cerevisiae (baker's yeast)	ZPR1	NP_011727.3
Schizosaccharomyces pombe (fission yeast)	zpr1	NP_594291.1
Magnaporthe oryzae (rice blast fungus)	MGG_03238	XP_003716738.1
Oryza sativa (rice)	Os08g0471900	NP_001062017.1
Mus musculus (house mouse)	Zfp259	NP_035882.1
Rattus norvegicus (Norway rat)	Zfp259	NP_001131118.1
Drosophila melanogaster (fruit fly)	Zpr1	NP_572532.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004417	XP_562161.4
Caenorhabditis elegans (roundworm)	CELE_W03F9.1	NP_503138.1
Gallus gallus (chicken)	ZNF259	XP_003642643.1
Danio rerio (zebrafish)	zpr1	NP_998273.1
Eremothecium gossypii	AGOS_ACL137C	NP_983267.1
Neurospora crassa	NCU08507	XP_963436.1
Arabidopsis thaliana (thale cress)	AT5G37340	NP_974856.1
Arabidopsis thaliana (thale cress)	AT5G22480	NP_197640.1
Canis lupus familiaris (dog)	ZNF259	XP_850312.1
Kluyveromyces lactis	KLLA0E16215g	XP_454680.1
Xenopus tropicalis (tropical clawed frog)	znf259	NP_001017134.1

Gene Ontology
Bibliography

Related articles in PubMed

Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy.
Genabai NK, Kannan A, Ahmad S, Jiang X, Bhatia K, Gangwani L
Scientific reports7(1)8295(2017 Aug)

The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy.
Ahmad S, Wang Y, Shaik GM, Burghes AH, Gangwani L
Human molecular genetics21(12)2745-58(2012 Jun)

Generation of a zinc finger protein ZPR1 mutant that constitutively interacted with translation elongation factor 1alpha.
Yanaka N, Kaseda Y, Tanaka A, Nogusa Y, Sumiyoshi N, Kato N
Bioscience, biotechnology, and biochemistry73(12)2809-11(2009 Dec)

Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes.
Mishra AK, Gangwani L, Davis RJ, Lambright DG
Proceedings of the National Academy of Sciences of the United States of America104(35)13930-5(2007 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that the severity of disease correlates negatively with ZPR1 levels and ZPR1 may be a protective modifier of spinal muscular atrophy (SMA).
Title: The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy.

the interaction of ZPR1 and eEF1alpha
Title: Generation of a zinc finger protein ZPR1 mutant that constitutively interacted with translation elongation factor 1alpha.

ZPR1-deficient mice exhibit axonal pathology and neurodegeneration
Title: Deficiency of the zinc finger protein ZPR1 causes neurodegeneration.

ZPR1 contributes to the regulation of survival motor neurons complexes and that it is essential for cell survival
Title: ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies.

The following Zpr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Zpr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17878	NM_011752.2 Latest version!	Mus musculus ZPR1 zinc finger (Zpr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$272.30 $389.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Zpr1 ( NM_011752.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035882.1 Mus musculus ZPR1 zinc finger (Zpr1), mRNA.

Price & Availability↑

CloneID	OMu17878
Clone ID Related Accession (Same CDS sequence)	NM_011752.2
Accession Version	NM_011752.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1380bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	zinc finger protein ZPR1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC164105.4. On Mar 20, 2007 this sequence version replaced NM_011752.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.42068.1, AK168061.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTGCCA GCGGGGCTGT GCAGCCGGGA CACCCGGGGG CCGCCGTCGG GCCCTCGCCC 
GCTGCGGCTG CGTCACCAGC CACCGGGCCT TTGTTCCGGC CCCTCAGCGC CGAGGATGAG 
GAGCAACAGC CCACCGAGAT CGAGTCACTG TGCATGAACT GTTACCGGAA CGGCACGACG 
CGACTTCTGC TCACCAAGAT CCCCTTCTTT AGAGAAATCA TCGTGAGCTC CTTTTCCTGC 
GAACACTGTG GCTGGAACAA CACGGAGATC CAGTCTGCAG GCAGGATCCA GGACCAGGGA 
GTGCGCTACA CCTTGACCGT GAGAAGCCAA GAGGACATGA ACAGAGAAGT GGTAAAGACA 
GACTCTGCCA CCACAAGGAT CCCCGAGCTG GATTTTGAGA TTCCAGCCTT CAGCCAGAAG 
GGAGCTCTGA CCACTGTTGA AGGACTCATC AGCCGTGCGA TCTCTGGCCT GGAACAGGAT 
CAGCCCACAC GACGGGCAGT GGAAGGTGCC ATCGCAGAGA GAATTGATGA GTTCATTGGC 
AAACTGAAGG ACCTAAAGCA AATGGCTTCC CCTTTCACAC TGGTCATTGA TGATCCCTCG 
GGAAACAGCT TTGTAGAAAA CCCACATGCT CCCCAGAAAG ATAATGCCTT GGTGATCACA 
TACTATGACC GAACCCCACA GCAAGCTGAG ATGCTGGGGC TCCAAGCAGA AGCACCAGAG 
GAGAAGGCGG AAGAGGAAGA CCTTAGAAAC GAAGTGCTCC AGTTCAACAC TAACTGCCCA 
GAGTGCAACG CTCCGGCTCA GACCAACATG AAGCTTGTCC AAATCCCCCA CTTTAAAGAG 
GTTATCATCA TGGCCACCAA CTGTGAGAAT TGTGGGCATC GGACTAATGA GGTGAAGTCC 
GGAGGAGCTG TAGAACCTTT GGGTACCAGG ATCACCCTCC ACATCACAGA TCCCTCAGAC 
ATGACCAGAG ACCTCCTCAA GTCTGAGACC TGTAGTGTGG AAATCCCAGA GCTTGAGTTT 
GAACTGGGAA TGGCTGTACT TGGGGGCAAG TTCACCACTC TAGAAGGACT GCTGAAAGAC 
ATCCGAGAAC TGGTAACCAA GAACCCATTC ACACTGGGCG ACAGCTCTAA TCCTGACCAG 
TCAGAGAAAC TGCAGGAGTT TAGCCAGAAG TTGGGCCAGA TCATCGAGGG CAAGATGAAG 
GCCCACTTTA TCATGAATGA TCCAGCAGGA AACAGTTATC TGCAGAATGT GTATGCACCT 
GAAGACGATC CAGAGATGAA GGTCGAGCGG TACAAACGCA CCTTTGACCA AAATGAGGAG 
CTCGGGCTCA ATGACATGAA GACAGAGGGC TATGAGGCGG GCCTGGCCCC ACAGCGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035882.1
CDS	134..1513
Translation	MSASGAVQPGHPGAAVGPSPAAAASPATGPLFRPLSAEDEEQQPTEIESLCMNCYRNGTTRLLLTKIPFFREIIVSSFSCEHCGWNNTEIQSAGRIQDQGVRYTLTVRSQEDMNREVVKTDSATTRIPELDFEIPAFSQKGALTTVEGLISRAISGLEQDQPTRRAVEGAIAERIDEFIGKLKDLKQMASPFTLVIDDPSGNSFVENPHAPQKDNALVITYYDRTPQQAEMLGLQAEAPEEKAEEEDLRNEVLQFNTNCPECNAPAQTNMKLVQIPHFKEVIIMATNCENCGHRTNEVKSGGAVEPLGTRITLHITDPSDMTRDLLKSETCSVEIPELEFELGMAVLGGKFTTLEGLLKDIRELVTKNPFTLGDSSNPDQSEKLQEFSQKLGQIIEGKMKAHFIMNDPAGNSYLQNVYAPEDDPEMKVERYKRTFDQNEELGLNDMKTEGYEAGLAPQR

Target ORF information:

RefSeq Version	NM_011752.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ZPR1 zinc finger (Zpr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011752.2

ORF Insert Sequence:

ATGTCTGCCA GCGGGGCTGT GCAGCCGGGA CACCCGGGGG CCGCCGTCGG GCCCTCGCCC 
GCTGCGGCTG CGTCACCAGC CACCGGGCCT TTGTTCCGGC CCCTCAGCGC CGAGGATGAG 
GAGCAACAGC CCACCGAGAT CGAGTCACTG TGCATGAACT GTTACCGGAA CGGCACGACG 
CGACTTCTGC TCACCAAGAT CCCCTTCTTT AGAGAAATCA TCGTGAGCTC CTTTTCCTGC 
GAACACTGTG GCTGGAACAA CACGGAGATC CAGTCTGCAG GCAGGATCCA GGACCAGGGA 
GTGCGCTACA CCTTGACCGT GAGAAGCCAA GAGGACATGA ACAGAGAAGT GGTAAAGACA 
GACTCTGCCA CCACAAGGAT CCCCGAGCTG GATTTTGAGA TTCCAGCCTT CAGCCAGAAG 
GGAGCTCTGA CCACTGTTGA AGGACTCATC AGCCGTGCGA TCTCTGGCCT GGAACAGGAT 
CAGCCCACAC GACGGGCAGT GGAAGGTGCC ATCGCAGAGA GAATTGATGA GTTCATTGGC 
AAACTGAAGG ACCTAAAGCA AATGGCTTCC CCTTTCACAC TGGTCATTGA TGATCCCTCG 
GGAAACAGCT TTGTAGAAAA CCCACATGCT CCCCAGAAAG ATAATGCCTT GGTGATCACA 
TACTATGACC GAACCCCACA GCAAGCTGAG ATGCTGGGGC TCCAAGCAGA AGCACCAGAG 
GAGAAGGCGG AAGAGGAAGA CCTTAGAAAC GAAGTGCTCC AGTTCAACAC TAACTGCCCA 
GAGTGCAACG CTCCGGCTCA GACCAACATG AAGCTTGTCC AAATCCCCCA CTTTAAAGAG 
GTTATCATCA TGGCCACCAA CTGTGAGAAT TGTGGGCATC GGACTAATGA GGTGAAGTCC 
GGAGGAGCTG TAGAACCTTT GGGTACCAGG ATCACCCTCC ACATCACAGA TCCCTCAGAC 
ATGACCAGAG ACCTCCTCAA GTCTGAGACC TGTAGTGTGG AAATCCCAGA GCTTGAGTTT 
GAACTGGGAA TGGCTGTACT TGGGGGCAAG TTCACCACTC TAGAAGGACT GCTGAAAGAC 
ATCCGAGAAC TGGTAACCAA GAACCCATTC ACACTGGGCG ACAGCTCTAA TCCTGACCAG 
TCAGAGAAAC TGCAGGAGTT TAGCCAGAAG TTGGGCCAGA TCATCGAGGG CAAGATGAAG 
GCCCACTTTA TCATGAATGA TCCAGCAGGA AACAGTTATC TGCAGAATGT GTATGCACCT 
GAAGACGATC CAGAGATGAA GGTCGAGCGG TACAAACGCA CCTTTGACCA AAATGAGGAG 
CTCGGGCTCA ATGACATGAA GACAGAGGGC TATGAGGCGG GCCTGGCCCC ACAGCGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy.
Scientific reports7(1)8295(2017 Aug)
Genabai NK,Kannan A,Ahmad S,Jiang X,Bhatia K,Gangwani L

The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy.
Human molecular genetics21(12)2745-58(2012 Jun)
Ahmad S,Wang Y,Shaik GM,Burghes AH,Gangwani L

Generation of a zinc finger protein ZPR1 mutant that constitutively interacted with translation elongation factor 1alpha.
Bioscience, biotechnology, and biochemistry73(12)2809-11(2009 Dec)
Yanaka N,Kaseda Y,Tanaka A,Nogusa Y,Sumiyoshi N,Kato N

Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes.
Proceedings of the National Academy of Sciences of the United States of America104(35)13930-5(2007 Aug)
Mishra AK,Gangwani L,Davis RJ,Lambright DG

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Zpr1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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