Slc30a10 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc30a10
Entrez Gene ID	226781
Full Name	solute carrier family 30, member 10
Synonyms	E130106K10Rik,Gm212
General protein information	Preferred Names solute carrier family 30, member 10 Names zinc transporter 10 znT-10
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 H5

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033286.2	NP_001028458.1	zinc transporter 10

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC30A10	NP_061183.2
Bos taurus (cattle)	SLC30A10	NP_001179109.1
Danio rerio (zebrafish)	slc30a10	NP_001121706.1
	SLC30A10	XP_001103570.1
Rattus norvegicus (Norway rat)	Slc30a10	NP_001099455.1
Gallus gallus (chicken)	SLC30A10	XP_419410.3
Xenopus tropicalis (tropical clawed frog)	slc30a10	XP_002936066.2
Pan troglodytes (chimpanzee)	SLC30A10	XP_525065.1
Mus musculus (house mouse)	Slc30a10	NP_001028458.1

Gene Ontology
Bibliography

Related articles in PubMed

Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production.
Liu C, Hutchens S, Jursa T, Shawlot W, Polishchuk EV, Polishchuk RS, Dray BK, Gore AC, Aschner M, Smith DR, Mukhopadhyay S
The Journal of biological chemistry292(40)16605-16615(2017 10)

Protective function of SLC30A10 induced via PERK-ATF4 pathway against 1-methyl-4-phenylpyridinium.
Go S, Kurita H, Yokoo K, Inden M, Kambe T, Hozumi I
Biochemical and biophysical research communications490(4)1307-1313(2017 09)

Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice.
Hutchens S, Liu C, Jursa T, Shawlot W, Chaffee BK, Yin W, Gore AC, Aschner M, Smith DR, Mukhopadhyay S
The Journal of biological chemistry292(23)9760-9773(2017 06)

Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity.
Zhao Y, Feresin RG, Falcon-Perez JM, Salazar G
Traffic (Copenhagen, Denmark)17(3)267-88(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the hypothyroidism phenotype of Slc30a10 single knockouts is induced by elevated thyroid manganese, which blocks thyroxine production. These findings provide new insights into the mechanisms of manganese detoxification and manganese-induced thyroid dysfunction.
Title: Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production.

SLC30A10 has a protective role in 1-methyl-4-phenylpyridinium-induced toxicity via PERK-ATF4 pathway.
Title: Protective function of SLC30A10 induced via PERK-ATF4 pathway against 1-methyl-4-phenylpyridinium.

discovery highlights the importance of determining the role of thyroid dysfunction in the onset and progression of manganese-induced disease and identifies Slc30a10 knock-out mice as a new model for studying thyroid biology.
Title: Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice.

The following Slc30a10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc30a10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12564	NM_001033286.2 Latest version!	Mus musculus solute carrier family 30, member 10 (Slc30a10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc30a10 ( NM_001033286.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001028458.1 Mus musculus solute carrier family 30, member 10 (Slc30a10), mRNA.

Price & Availability↑

CloneID	OMu12564
Clone ID Related Accession (Same CDS sequence)	NM_001033286.2
Accession Version	NM_001033286.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1413bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-20
Organism	Mus musculus(house mouse)
Product	zinc transporter 10
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB665136.1, AK136932.1 and AC131980.9. On Jan 14, 2006 this sequence version replaced NM_001033286.1. ##Evidence-Data-START## Transcript exon combination :: AK136932.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END##

ATGGGCCGTT ACTCAGGCAA GACGTGCCGG CTGCTGTTCA TGCTGGTGCT CACCGCGGCC 
TTCTTCGTGG CCGAGCTGGT GTCGGGTTAC CTGGGCAACT CCATCGCGCT GCTCTCGGAC 
TCGTTCAACA TGCTGTCAGA CCTGATCTCG CTGTGCGTGG GCCTGGGCTC CGGCTACATC 
GCGCGGCGCG GTCCCCGCGG CTCCAGTGCC ACCTACGGCT ACGTGCGGGC CGAGGTGGTG 
GGCGCGCTCA GCAACGCAGT CTTCCTCACT GCGCTCTGCT TCACCATCTT CGTGGAGGCC 
GTGTTGCGCC TTGCGCGGCC CGAGCGCATC GACGACCCGG AGCTGGTGCT TATCGTGGGA 
GCCCTGGGGC TGGCGGTCAA CGTGGTGGGG CTGCTCATCT TCCAGGACTG CGGCGCCTGC 
TTCTCCCGCT GCACGCGGGG TCGCCGGACC CGCCCTTCGC AGCAGCCAAG CCAGGGGGAT 
CCTCGTGGCG CTTTGGGGTG TCCCCAAGAG GCTGCGACAG CCACAGCTCC TGGCTCGGGC 
ACAGCAGTGA CTCTCCGGGG GTCCTCGGCC GGAAGAAAGC AGCAGGAGGG CGCGACCGTG 
TTCTCTAATG TAGCAGGTGA TTCCCTGAAC ACCGAGAATG AACCAGAAGA GACGACGAAA 
AAAGAGAAGA AGTCTGAAGC ACTCAATATC AGAGGTGTTC TTTTGCACGT GATGGGAGAT 
GCCTTGGGGT CCGTGGTTGT GGTCATCACG GCTATCATAT TCTATGTTCA GCCCCTGAGA 
CGTGAAGACC CGTGTAACTG GCAGTGCTAC ATTGACCCCA GTTTGACTGT TGTCATGGTC 
ATCATTATCT TATCGTCAGC TTTCCCACTG ATCAAAGAGA CTGCTGTCAT CTTGCTGCAG 
ATGGTCCCCA AGGGGGTCAA CATGGAAGAG CTGATGAGCC AGCTGTCTAC CGTGCCTGGG 
ATTAGCAGTG TGCATGAAGT GCACATCTGG GAACTTATAA GTGGGAAGAT CATTGCCACC 
TTGCACATCA AACACCAGAA GGGCACGGAA TACCAGGATG CCAGCAGAAA AATCCGAGAG 
ATCTTCCACC ATGCTGGAAT CCACAACGTG ACTATCCAGT TCGAAACCCT GGACTTGAAG 
GAAGCCCTGG AGCAGAAGGA CTTCTTGCTG ACCTGCAGTG CTCCCTGCAT CACCCAGAGC 
TGCGCTAAGA AGCTGTGCTG TCCCCCGGGG ACACTGCCTC TGGCTCTCGT CAACGGTTGT 
GCAGAGCACA ATGGCAGGTC CTCTCGAGAG TCTTACCGAA GCATAGAAGC TCCAGAAGTG 
GCCATCGATG TGGATGGCTG TCCAAGGGAG CAGGGACAGA CTCTCAGCAA GACTCAGGAG 
AGACAACATT ATGAAAACAG TACTCATTTT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028458.1
CDS	217..1629
Translation	MGRYSGKTCRLLFMLVLTAAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLGSGYIARRGPRGSSATYGYVRAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGALGLAVNVVGLLIFQDCGACFSRCTRGRRTRPSQQPSQGDPRGALGCPQEAATATAPGSGTAVTLRGSSAGRKQQEGATVFSNVAGDSLNTENEPEETTKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVQPLRREDPCNWQCYIDPSLTVVMVIIILSSAFPLIKETAVILLQMVPKGVNMEELMSQLSTVPGISSVHEVHIWELISGKIIATLHIKHQKGTEYQDASRKIREIFHHAGIHNVTIQFETLDLKEALEQKDFLLTCSAPCITQSCAKKLCCPPGTLPLALVNGCAEHNGRSSRESYRSIEAPEVAIDVDGCPREQGQTLSKTQERQHYENSTHF

Target ORF information:

RefSeq Version	NM_001033286.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 30, member 10 (Slc30a10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033286.2

ORF Insert Sequence:

ATGGGCCGTT ACTCAGGCAA GACGTGCCGG CTGCTGTTCA TGCTGGTGCT CACCGCGGCC 
TTCTTCGTGG CCGAGCTGGT GTCGGGTTAC CTGGGCAACT CCATCGCGCT GCTCTCGGAC 
TCGTTCAACA TGCTGTCAGA CCTGATCTCG CTGTGCGTGG GCCTGGGCTC CGGCTACATC 
GCGCGGCGCG GTCCCCGCGG CTCCAGTGCC ACCTACGGCT ACGTGCGGGC CGAGGTGGTG 
GGCGCGCTCA GCAACGCAGT CTTCCTCACT GCGCTCTGCT TCACCATCTT CGTGGAGGCC 
GTGTTGCGCC TTGCGCGGCC CGAGCGCATC GACGACCCGG AGCTGGTGCT TATCGTGGGA 
GCCCTGGGGC TGGCGGTCAA CGTGGTGGGG CTGCTCATCT TCCAGGACTG CGGCGCCTGC 
TTCTCCCGCT GCACGCGGGG TCGCCGGACC CGCCCTTCGC AGCAGCCAAG CCAGGGGGAT 
CCTCGTGGCG CTTTGGGGTG TCCCCAAGAG GCTGCGACAG CCACAGCTCC TGGCTCGGGC 
ACAGCAGTGA CTCTCCGGGG GTCCTCGGCC GGAAGAAAGC AGCAGGAGGG CGCGACCGTG 
TTCTCTAATG TAGCAGGTGA TTCCCTGAAC ACCGAGAATG AACCAGAAGA GACGACGAAA 
AAAGAGAAGA AGTCTGAAGC ACTCAATATC AGAGGTGTTC TTTTGCACGT GATGGGAGAT 
GCCTTGGGGT CCGTGGTTGT GGTCATCACG GCTATCATAT TCTATGTTCA GCCCCTGAGA 
CGTGAAGACC CGTGTAACTG GCAGTGCTAC ATTGACCCCA GTTTGACTGT TGTCATGGTC 
ATCATTATCT TATCGTCAGC TTTCCCACTG ATCAAAGAGA CTGCTGTCAT CTTGCTGCAG 
ATGGTCCCCA AGGGGGTCAA CATGGAAGAG CTGATGAGCC AGCTGTCTAC CGTGCCTGGG 
ATTAGCAGTG TGCATGAAGT GCACATCTGG GAACTTATAA GTGGGAAGAT CATTGCCACC 
TTGCACATCA AACACCAGAA GGGCACGGAA TACCAGGATG CCAGCAGAAA AATCCGAGAG 
ATCTTCCACC ATGCTGGAAT CCACAACGTG ACTATCCAGT TCGAAACCCT GGACTTGAAG 
GAAGCCCTGG AGCAGAAGGA CTTCTTGCTG ACCTGCAGTG CTCCCTGCAT CACCCAGAGC 
TGCGCTAAGA AGCTGTGCTG TCCCCCGGGG ACACTGCCTC TGGCTCTCGT CAACGGTTGT 
GCAGAGCACA ATGGCAGGTC CTCTCGAGAG TCTTACCGAA GCATAGAAGC TCCAGAAGTG 
GCCATCGATG TGGATGGCTG TCCAAGGGAG CAGGGACAGA CTCTCAGCAA GACTCAGGAG 
AGACAACATT ATGAAAACAG TACTCATTTT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production.
The Journal of biological chemistry292(40)16605-16615(2017 10)
Liu C,Hutchens S,Jursa T,Shawlot W,Polishchuk EV,Polishchuk RS,Dray BK,Gore AC,Aschner M,Smith DR,Mukhopadhyay S

Protective function of SLC30A10 induced via PERK-ATF4 pathway against 1-methyl-4-phenylpyridinium.
Biochemical and biophysical research communications490(4)1307-1313(2017 09)
Go S,Kurita H,Yokoo K,Inden M,Kambe T,Hozumi I

Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice.
The Journal of biological chemistry292(23)9760-9773(2017 06)
Hutchens S,Liu C,Jursa T,Shawlot W,Chaffee BK,Yin W,Gore AC,Aschner M,Smith DR,Mukhopadhyay S

Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity.
Traffic (Copenhagen, Denmark)17(3)267-88(2016 Mar)
Zhao Y,Feresin RG,Falcon-Perez JM,Salazar G

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Slc30a10 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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