Becn2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Becn2
Entrez Gene ID	226720
Full Name	beclin 2
Synonyms	Beclin-2,Gm104
General protein information	Preferred Names beclin 2 Names beclin-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 H4

mRNA and Protein(s)

mRNA	Protein	Name
NM_001290692.1	NP_001277621.1	beclin-2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids.
Kuramoto K, Wang N, Fan Y, Zhang W, Schoenen FJ, Frankowski KJ, Marugan J, Zhou Y, Huang S, He C
Autophagy12(9)1460-71(2016 Sep)

Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.
Dong X, Cheng A, Zou Z, Yang YS, Sumpter RM Jr, Huang CL, Bhagat G, Virgin HW, Lira SA, Levine B
Proceedings of the National Academy of Sciences of the United States of America113(11)2994-9(2016 Mar)

Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.
He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B
Cell154(5)1085-99(2013 Aug)

Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP,
PLoS biology7(5)e1000112(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a protein involved in macroautophagy/autophagy (a conserved lysosomal degradation pathway), BECN2 (beclin 2), mediates cannabinoid tolerance by preventing CNR1 recycling and resensitization after prolonged agonist exposure, and deletion of Becn2 rescues CNR1 activity in mouse brain and conveys resistance to analgesic tolerance to chronic cannabinoids
Title: Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids.

Monoallelic loss of Becn2 accelerates progression of vGPCR-induced lesions resembling human Kaposi's sarcoma. Beclin 2 is protects against the pathogenic effects of KSHV GPCR by facilitating its endolysosomal degradation.
Title: Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.

Study identified a previously uncharacterized mammalian-specific protein, Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components.[Beclin 2]
Title: Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.

The following Becn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Becn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15488	NM_001290692.1 Latest version!	Mus musculus beclin 2 (Becn2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Becn2 ( NM_001290692.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001277621.1 Mus musculus beclin 2 (Becn2), mRNA.

Price & Availability↑

CloneID	OMu15488
Clone ID Related Accession (Same CDS sequence)	NM_001290692.1
Accession Version	NM_001290692.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	beclin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB838749.1, KF511582.1 and CJ207428.1. ##Evidence-Data-START## Transcript exon combination :: CJ207428.1, SRR1660817.298932.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164132 [ECO:0000348] ##Evidence-Data-END##

ATGTCTCCTG CCCTCTTCCT GTGCCAGCGC TGCAAAGAAC CCCTGAAACT CTTACAGCAG 
CAGGGGGGGC CCTTGGAAGT CCAGCACCAC GCCAATACCC CCACAGAAAT TCCAGTTTCT 
GCAGAGTCCC AAGTCAGGAC CTCCGGCAGA CCCCACTCTG ACGGTGGCAG GGTGTCCCAG 
GGAAGTGCCC TCTGCACTTT TACTCTGCTT ACCTCTGGCG GACCGGACTC TGAAGGTGGC 
ACGACGTCCC AGGGAAATGC CTGCTGTACC TTTACTCTGC TTGGTGAATC TGCCTCCATG 
AGAACTATGA ACACTATCCA AAATACTGTC TTAGAGACCT TCGAAATCCT CTCCGACCAA 
AAGGTGGTGG ACCACCCGCT GTGTGTGGAC TGTACCGACC ATCTTCTGAT GCAACTAGAC 
GACCAGCTCG CTCTCCTGGC ATCTGACAAC CAGAAGTACA AAAGTTTCCA GGACAGAGAG 
TTGCTGGTGA GTGAGGAAGA GAGGGAGGCG CTACACGCGG AGCTTTGTGC CGAACTGTCC 
AGTCTGGAGC AGGAGGAAGC AAGGCTGACC CAGGAGCTAG AGGATTTAGA CGGCCATCAT 
GCAAGGGTAG CCGCTGAACT CAGAGCAGCC CAGGCCGAGA GCAAGGAGCT GTATAAACAG 
CATGAGCAGC ACAGGGTCGA GTACTCTGTT TTCAAGATGG AACAGCTGGA GCTGATGGAC 
CAGCTGAGCA GTGTGGAGAA CCAGCTGACG TATGCCCTGA GTCAGCAGTA CCGCTTAAGA 
CAGACCAATA TCTTCAACGC CACATTTACC ATTTCAGATG AGGGTCCCTT GGGCGTTATC 
AACAATTTTA GGCTGGGCTG TCTCCCCGGG GTCCGGGTGG GCTGGACTGA GATCAGTTCT 
GCCTGGGGAC AGACAGTCTT ACTGCTCTTC AGCTTGTCCA AGATAGCTGG ACTGCAATTC 
CAGAGATATC AACTGGTTCC CTTTGGGGAC CATTCCTATC TCAAGTCCTT GACTGGTGAT 
GGCGTGCTGC CCTTATTCTC TGATGGGAGC CACAGCGTCT TCTTGAATAA CAAGTTTGAC 
TGTGGGATGA AGGCCTTCCT GGACTGTCTT CAGCAGTTTG TGGAGGAGAT TGAGAGGGAT 
GAGAGATGCC CCTGCCTGCC CTACAGGATC CATGTGAAGG AAGGGCTGAT GGAGGATGTC 
TGGGACAGTG GGGAGTGCTG CTCCATCAGG ACCCATCTGA ACACGGAGGA GGAGTGGTCC 
AGGGCTCTGA AATTCATGCT TTCGGACTTG AAGTTGATCC TTGCTTGGGC TTCCTTAAGG 
TTTTCCAGAG TCCAGAGGCC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277621.1
CDS	42..1385
Translation	MSPALFLCQRCKEPLKLLQQQGGPLEVQHHANTPTEIPVSAESQVRTSGRPHSDGGRVSQGSALCTFTLLTSGGPDSEGGTTSQGNACCTFTLLGESASMRTMNTIQNTVLETFEILSDQKVVDHPLCVDCTDHLLMQLDDQLALLASDNQKYKSFQDRELLVSEEEREALHAELCAELSSLEQEEARLTQELEDLDGHHARVAAELRAAQAESKELYKQHEQHRVEYSVFKMEQLELMDQLSSVENQLTYALSQQYRLRQTNIFNATFTISDEGPLGVINNFRLGCLPGVRVGWTEISSAWGQTVLLLFSLSKIAGLQFQRYQLVPFGDHSYLKSLTGDGVLPLFSDGSHSVFLNNKFDCGMKAFLDCLQQFVEEIERDERCPCLPYRIHVKEGLMEDVWDSGECCSIRTHLNTEEEWSRALKFMLSDLKLILAWASLRFSRVQRP

Target ORF information:

RefSeq Version	NM_001290692.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus beclin 2 (Becn2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001290692.1

ORF Insert Sequence:

ATGTCTCCTG CCCTCTTCCT GTGCCAGCGC TGCAAAGAAC CCCTGAAACT CTTACAGCAG 
CAGGGGGGGC CCTTGGAAGT CCAGCACCAC GCCAATACCC CCACAGAAAT TCCAGTTTCT 
GCAGAGTCCC AAGTCAGGAC CTCCGGCAGA CCCCACTCTG ACGGTGGCAG GGTGTCCCAG 
GGAAGTGCCC TCTGCACTTT TACTCTGCTT ACCTCTGGCG GACCGGACTC TGAAGGTGGC 
ACGACGTCCC AGGGAAATGC CTGCTGTACC TTTACTCTGC TTGGTGAATC TGCCTCCATG 
AGAACTATGA ACACTATCCA AAATACTGTC TTAGAGACCT TCGAAATCCT CTCCGACCAA 
AAGGTGGTGG ACCACCCGCT GTGTGTGGAC TGTACCGACC ATCTTCTGAT GCAACTAGAC 
GACCAGCTCG CTCTCCTGGC ATCTGACAAC CAGAAGTACA AAAGTTTCCA GGACAGAGAG 
TTGCTGGTGA GTGAGGAAGA GAGGGAGGCG CTACACGCGG AGCTTTGTGC CGAACTGTCC 
AGTCTGGAGC AGGAGGAAGC AAGGCTGACC CAGGAGCTAG AGGATTTAGA CGGCCATCAT 
GCAAGGGTAG CCGCTGAACT CAGAGCAGCC CAGGCCGAGA GCAAGGAGCT GTATAAACAG 
CATGAGCAGC ACAGGGTCGA GTACTCTGTT TTCAAGATGG AACAGCTGGA GCTGATGGAC 
CAGCTGAGCA GTGTGGAGAA CCAGCTGACG TATGCCCTGA GTCAGCAGTA CCGCTTAAGA 
CAGACCAATA TCTTCAACGC CACATTTACC ATTTCAGATG AGGGTCCCTT GGGCGTTATC 
AACAATTTTA GGCTGGGCTG TCTCCCCGGG GTCCGGGTGG GCTGGACTGA GATCAGTTCT 
GCCTGGGGAC AGACAGTCTT ACTGCTCTTC AGCTTGTCCA AGATAGCTGG ACTGCAATTC 
CAGAGATATC AACTGGTTCC CTTTGGGGAC CATTCCTATC TCAAGTCCTT GACTGGTGAT 
GGCGTGCTGC CCTTATTCTC TGATGGGAGC CACAGCGTCT TCTTGAATAA CAAGTTTGAC 
TGTGGGATGA AGGCCTTCCT GGACTGTCTT CAGCAGTTTG TGGAGGAGAT TGAGAGGGAT 
GAGAGATGCC CCTGCCTGCC CTACAGGATC CATGTGAAGG AAGGGCTGAT GGAGGATGTC 
TGGGACAGTG GGGAGTGCTG CTCCATCAGG ACCCATCTGA ACACGGAGGA GGAGTGGTCC 
AGGGCTCTGA AATTCATGCT TTCGGACTTG AAGTTGATCC TTGCTTGGGC TTCCTTAAGG 
TTTTCCAGAG TCCAGAGGCC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids.
Autophagy12(9)1460-71(2016 Sep)
Kuramoto K,Wang N,Fan Y,Zhang W,Schoenen FJ,Frankowski KJ,Marugan J,Zhou Y,Huang S,He C

Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.
Proceedings of the National Academy of Sciences of the United States of America113(11)2994-9(2016 Mar)
Dong X,Cheng A,Zou Z,Yang YS,Sumpter RM Jr,Huang CL,Bhagat G,Virgin HW,Lira SA,Levine B

Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.
Cell154(5)1085-99(2013 Aug)
He C,Wei Y,Sun K,Li B,Dong X,Zou Z,Liu Y,Kinch LN,Khan S,Sinha S,Xavier RJ,Grishin NV,Xiao G,Eskelinen EL,Scherer PE,Whistler JL,Levine B

Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS biology7(5)e1000112(2009 May)
Church DM,Goodstadt L,Hillier LW,Zody MC,Goldstein S,She X,Bult CJ,Agarwala R,Cherry JL,DiCuccio M,Hlavina W,Kapustin Y,Meric P,Maglott D,Birtle Z,Marques AC,Graves T,Zhou S,Teague B,Potamousis K,Churas C,Place M,Herschleb J,Runnheim R,Forrest D,Amos-Landgraf J,Schwartz DC,Cheng Z,Lindblad-Toh K,Eichler EE,Ponting CP,

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Becn2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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