Ywhag cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ywhag
Entrez Gene ID	22628
Full Name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Synonyms	14-3-3gamma,D7Bwg1348e
General protein information	Preferred Names tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Names 14-3-3 protein gamma 14-3-3 gamma 14-3-3 protein gamma subtype 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide 3-monooxgenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 G2

mRNA and Protein(s)

mRNA	Protein	Name
NM_018871.3	NP_061359.2	14-3-3 protein gamma

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	YWHAG	XP_519163.3
	YWHAG	XP_001109164.1
Bos taurus (cattle)	YWHAG	NP_777218.2
Gallus gallus (chicken)	YWHAG	NP_001026648.1
Homo sapiens (human)	YWHAG	NP_036611.2
Canis lupus familiaris (dog)	YWHAG	XP_005621043.1
Mus musculus (house mouse)	Ywhag	NP_061359.2
Rattus norvegicus (Norway rat)	Ywhag	NP_062249.1
Xenopus tropicalis (tropical clawed frog)	ywhag	NP_001072309.1

Gene Ontology
Bibliography

Related articles in PubMed

Direct interaction with 14-3-3? promotes surface expression of Best1 channel in astrocyte.
Oh SJ, Woo J, Lee YS, Cho M, Kim E, Cho NC, Park JY, Pae AN, Justin Lee C, Hwang EM
Molecular brain10(1)51(2017 Nov)

Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.
Kurogi S, Sekimoto T, Funamoto T, Ota T, Nakamura S, Nagai T, Nakahara M, Yoshinobu K, Araki K, Araki M, Chosa E
Scientific reports740692(2017 Jan)

Ablation of the 14-3-3gamma Protein Results in Neuronal Migration Delay and Morphological Defects in the Developing Cerebral Cortex.
Wachi T, Cornell B, Marshall C, Zhukarev V, Baas PW, Toyo-oka K
Developmental neurobiology76(6)600-14(2016 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study found that in utero 14-3-3gamma-deficiency resulted in delays in neuronal migration as well as morphological defects.
Title: Ablation of the 14-3-3gamma Protein Results in Neuronal Migration Delay and Morphological Defects in the Developing Cerebral Cortex.

Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3gamma, and Dok-7 proteins and phosphorylates the latter two.
Title: Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3?, and Dok-7 proteins and phosphorylates the latter two.

Ser(58) phosphorylation and Lys(49) acetylation of 14-3-3gamm occur in a coordinated time-dependent manner to regulate 14-3-3gamma homodimerization.
Title: Protein modifications regulate the role of 14-3-3? adaptor protein in cAMP-induced steroidogenesis in MA-10 Leydig cells.

These results showed that the cell surface expression of TRPM4 channels is mediated by 14-3-3gamma binding.
Title: Depletion of 14-3-3? reduces the surface expression of Transient Receptor Potential Melastatin 4b (TRPM4b) channels and attenuates TRPM4b-mediated glutamate-induced neuronal cell death.

hypoxia can activate p53 through inactivation of MDMX by the ATR-Chk1-MDMX-14-3-3gamma pathway.
Title: Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3? inactivation of MDMX protein.

The following Ywhag gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ywhag cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18111	NM_018871.3 Latest version!	Mus musculus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide (Ywhag), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ywhag ( NM_018871.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_061359.2 Mus musculus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide (Ywhag), mRNA.

Price & Availability↑

CloneID	OMu18111
Clone ID Related Accession (Same CDS sequence)	NM_018871.3
Accession Version	NM_018871.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	14-3-3 protein gamma
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY244024.1, AK164356.1, AK153307.1 and BB419675.1. On May 7, 2009 this sequence version replaced NM_018871.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.95574.1, SRR1660815.52593.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGACC GCGAGCAACT GGTGCAGAAA GCCCGGCTGG CCGAGCAGGC GGAGCGCTAC 
GACGATATGG CCGCGGCCAT GAAGAACGTG ACCGAGCTGA ACGAACCACT GTCCAATGAG 
GAACGGAACC TCCTGTCGGT GGCCTACAAG AACGTGGTGG GGGCTCGCCG CTCCTCCTGG 
AGGGTCATCA GCAGCATCGA GCAGAAGACG TCTGCGGACG GCAACGAGAA GAAGATCGAG 
ATGGTCCGAG CCTACCGGGA GAAGATCGAG AAGGAGCTGG AGGCCGTGTG CCAGGACGTG 
CTGAGCCTGC TGGACAACTA CCTGATCAAG AACTGCAGCG AGACCCAGTA CGAGAGCAAG 
GTGTTCTACC TGAAGATGAA AGGGGACTAT TACCGTTACC TGGCAGAAGT GGCCACCGGG 
GAGAAGAGGG CGACCGTGGT GGAGTCGTCT GAGAAGGCCT ACAGCGAAGC CCACGAGATC 
AGCAAGGAGC ACATGCAGCC CACCCACCCC ATCCGGCTGG GCCTGGCGCT CAACTACTCG 
GTTTTCTACT ATGAGATCCA GAACGCCCCG GAGCAAGCGT GCCACCTGGC CAAGACCGCC 
TTCGACGACG CCATCGCCGA GCTCGACACT CTGAACGAGG ACTCCTACAA GGACTCCACT 
CTGATCATGC AGCTGCTCCG AGACAACCTC ACGCTCTGGA CGAGCGACCA GCAAGACGAC 
GACGGCGGTG AAGGCAACAA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061359.2
CDS	233..976
Translation	MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN

Target ORF information:

RefSeq Version	NM_018871.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide (Ywhag), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018871.3

ORF Insert Sequence:

ATGGTGGACC GCGAGCAACT GGTGCAGAAA GCCCGGCTGG CCGAGCAGGC GGAGCGCTAC 
GACGATATGG CCGCGGCCAT GAAGAACGTG ACCGAGCTGA ACGAACCACT GTCCAATGAG 
GAACGGAACC TCCTGTCGGT GGCCTACAAG AACGTGGTGG GGGCTCGCCG CTCCTCCTGG 
AGGGTCATCA GCAGCATCGA GCAGAAGACG TCTGCGGACG GCAACGAGAA GAAGATCGAG 
ATGGTCCGAG CCTACCGGGA GAAGATCGAG AAGGAGCTGG AGGCCGTGTG CCAGGACGTG 
CTGAGCCTGC TGGACAACTA CCTGATCAAG AACTGCAGCG AGACCCAGTA CGAGAGCAAG 
GTGTTCTACC TGAAGATGAA AGGGGACTAT TACCGTTACC TGGCAGAAGT GGCCACCGGG 
GAGAAGAGGG CGACCGTGGT GGAGTCGTCT GAGAAGGCCT ACAGCGAAGC CCACGAGATC 
AGCAAGGAGC ACATGCAGCC CACCCACCCC ATCCGGCTGG GCCTGGCGCT CAACTACTCG 
GTTTTCTACT ATGAGATCCA GAACGCCCCG GAGCAAGCGT GCCACCTGGC CAAGACCGCC 
TTCGACGACG CCATCGCCGA GCTCGACACT CTGAACGAGG ACTCCTACAA GGACTCCACT 
CTGATCATGC AGCTGCTCCG AGACAACCTC ACGCTCTGGA CGAGCGACCA GCAAGACGAC 
GACGGCGGTG AAGGCAACAA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Direct interaction with 14-3-3? promotes surface expression of Best1 channel in astrocyte.
Molecular brain10(1)51(2017 Nov)
Oh SJ,Woo J,Lee YS,Cho M,Kim E,Cho NC,Park JY,Pae AN,Justin Lee C,Hwang EM

Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.
Scientific reports740692(2017 Jan)
Kurogi S,Sekimoto T,Funamoto T,Ota T,Nakamura S,Nagai T,Nakahara M,Yoshinobu K,Araki K,Araki M,Chosa E

Ablation of the 14-3-3gamma Protein Results in Neuronal Migration Delay and Morphological Defects in the Developing Cerebral Cortex.
Developmental neurobiology76(6)600-14(2016 Jun)
Wachi T,Cornell B,Marshall C,Zhukarev V,Baas PW,Toyo-oka K

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Ywhag cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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