Nox3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nox3
Entrez Gene ID	224480
Full Name	NADPH oxidase 3
Synonyms	GP91-3,het,nmf250
General protein information	Preferred Names NADPH oxidase 3 Names NADPH oxidase 3 head-tilt
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 A1\|17 2.05 cM
Summary	This gene encodes a member of the NOX family of NADPH oxidases. These enzymes catalyze the transfer of electrons from NADPH to molecular oxygen to produce superoxide and other reactive oxygen species (ROS). The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia, which are crystalline structures of the inner ear involved in the perception of gravity and linear acceleration. In mouse mutations of this gene lead to the absence of otoconia and vestibular dysfunction. [provided by RefSeq, Jun 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_198958.2	NP_945196.2	NADPH oxidase 3

Pathways from BioSystems

Homologies

	NOX3	XP_001093827.1
Bos taurus (cattle)	NOX3	NP_001178262.1
Homo sapiens (human)	NOX3	NP_056533.1
Pan troglodytes (chimpanzee)	NOX3	XP_527546.2
Gallus gallus (chicken)	NOX3	XP_004935703.1
Canis lupus familiaris (dog)	NOX3	NP_001095303.1
Mus musculus (house mouse)	Nox3	NP_945196.2
Rattus norvegicus (Norway rat)	Nox3	NP_001004216.1

Gene Ontology
Bibliography

Related articles in PubMed

NADPH oxidase-2 mediates zinc deficiency-induced oxidative stress and kidney damage.
Li MS, Adesina SE, Ellis CL, Gooch JL, Hoover RS, Williams CR
American journal of physiology. Cell physiology312(1)C47-C55(2017 Jan)

Spatiotemporal differences in otoconial gene expression.
Xu Y, Zhang Y, Lundberg YW
Genesis (New York, N.Y. : 2000)54(12)613-625(2016 Dec)

An Endothelial Hsp70-TLR4 Axis Limits Nox3 Expression and Protects Against Oxidant Injury in Lungs.
Zhang Y, Shan P, Srivastava A, Jiang G, Zhang X, Lee PJ
Antioxidants & redox signaling24(17)991-1012(2016 Jun)

NOX3, a superoxide-generating NADPH oxidase of the inner ear.
B?nfi B, Malgrange B, Knisz J, Steger K, Dubois-Dauphin M, Krause KH
The Journal of biological chemistry279(44)46065-72(2004 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Together, these findings reveal that Nox2 is a Zn(2+)-regulated enzyme that mediates ZnD-induced oxidative stress and kidney hypertrophy. Understanding the specific mechanisms by which ZnD contributes to kidney damage may have an important impact on the treatment of chronic kidney disease.
Title: NADPH oxidase-2 mediates zinc deficiency-induced oxidative stress and kidney damage.

Hsp70 activates Stat3 and suppresses Nox3 via TLR4
Title: An Endothelial Hsp70-TLR4 Axis Limits Nox3 Expression and Protects Against Oxidant Injury in Lungs.

Although Nox3 overexpression revealed no apparent effect, depletion of Nox3 decreased the number of spermatogonial stem cells in both cultured spermatogonia and freshly isolated testis cells.
Title: ROS-Generating Oxidase Nox3 Regulates the Self-Renewal of Mouse Spermatogonial Stem Cells.

Nox3 mutants and heterozygotes demonstrated a greater susceptibility to noise-induced hearing loss.
Title: Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss.

Mutations of Nox3 include retrovirus insertion, missense mutations, splice donor mutation, a splice acceptor mutation and premature translational termination.
Title: Molecular characterization of an allelic series of mutations in the mouse Nox3 gene.

The following Nox3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nox3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17172	NM_198958.2 Latest version!	Mus musculus NADPH oxidase 3 (Nox3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nox3 ( NM_198958.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_945196.2 Mus musculus NADPH oxidase 3 (Nox3), mRNA.

Price & Availability↑

CloneID	OMu17172
Clone ID Related Accession (Same CDS sequence)	NM_198958.2
Accession Version	NM_198958.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	NADPH oxidase 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC098838.3 and AY573240.1. On Nov 17, 2006 this sequence version replaced NM_198958.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC106862.2, AY182377.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849384, SAMN00849385 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END##

ATGCCGGTGT GCTGGATTCT GAACGAGAGT GGGTCCTTCG TGGTTGCTCT CTTATGGCTG 
GCAGTAAACG CCTATCTGTT TATTGACACA TTCTTCTGGT ATACTGAAGA GGAGGCTTTC 
TTTTATACAC GAGTTATTCT GGGTTCCGCA TTGGCATGGG CCCGGGCATC TGCCGTGTGC 
CTGAATTTTA ACTGCATGCT AATTCTGTTA CCTGTCAGTC GGAACTTCAT TTCACTGGTG 
AGAGGAACAA GTGTGTGCTG TAGAGGACCA TGGAGAAGAC AACTAGACAA AAACCTCAAC 
TTCCACAAAC TCGTTGCCTA CGGGATAGCT GTCAATTCAG TTATCCACAT TGTGGCACAC 
TTGTTCAACC TGGAGCGTTA TCACCTGGGT CAGGCCAAGG ATGCTGAAGG GCTGCTGGCT 
GCACTTTCCA AACTTGGCGA TGCCCCAAAT GAGAGCTACC TCAATCCAGT CCGCACCTTT 
GATATGGGCA CAACCACTGA GCTATTGATG ACAGTGTCAG GAATTACTGG CCTGGGTATC 
TCTCTGGCTC TGGTCTTCAT CATGACCTCT TCAACCGAAT TCATCAGAAG GTCCTCTTAT 
GAGCTCTTCT GGTACACACA CCATATCTTT GTCTTCTTCT TCATCAGTCT GGCCATCCAC 
GGAGGAGGTC GCATCATTCG AGGCCAAACT CCAGAGAGTC TCCGGCTGCA CAATGTCACG 
TACTGCAGAG ACCACTATGC TGAATGGCAG GCAGCTGCCT TATGCCCTGT ACCTCAATTT 
TCTGGCAAGG AACCTTCGGC CTGGAAATGG GCTTTGGGTC CTGTGGTCTT GTATGCGTGT 
GAAAGAATAA TTAGGTTCTG GAGATCTCAC CAAGAAGTTG TCATTACCAA GGTGGTGAGT 
CACCCATCTG CAGTCCTGGA ACTTCACATG AAGAAGCGAG ACTTCAAGAT GGCACCTGGA 
CAGTACATCT TCATCCAGTG CCCATCTGTC TCCCCCCTGG AGTGGCACCC CTTCACTCTC 
ACCTCCGCTC CCCAGGAGGA CTTCTTCAGT GTACACATCA GAGCCTCAGG AGACTGGACA 
GAGGCGTTAT TGAAGGCCTT TAGAGTAGAG GGACAGGCTC CCAGTGAGCT CTGTAGCATG 
CCGAGGCTAG CAGTGGATGG GCCCTTTGGA GGCTCTCTGG CAGATGTATT TCACTACCCC 
GTGAGCGTGT GCATTGCAAC GGGAATTGGA GTCACTCCCT TCGCCTCTCT TCTGAAGTCT 
GTGTGGTATA AGTGTTGTGA ATCACAGAGC CTGCCTGAGC TGAGCAAGGT GTACTTCTAT 
TGGATCTGCC GGGATGCCGG AGCATTTGAG TGGTTTGCTG ATCTGTTACT GTCACTGGAA 
ACACGGATGA GTGAACAAGG GAAGGCTCAT TTACTGAGCT ACCATATATA TCTCACTGGC 
TGGGATGAAA ACCAGGCAAT TCACATAGCT TTACACTGGG ATGAAAGTCT GGATGTGATA 
ACAGGCTTAA AGCAGAAGGC TTTCTATGGG CGACCCAACT GGAACGACGA ATTCAAGCAG 
ATTGCCTACA ATCACCCCAG CAGCAGCATT GGCGTGTTCT TCTGTGGATC CAAAGCCATG 
TCAAAGACTC TTCAAAAGAT GTGTCGTTTG TACTCATCTG TGGATCCGAG GGGCGTTCAT 
TTCTATTACA ACAAGGAAAA CTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_945196.2
CDS	61..1767
Translation	MPVCWILNESGSFVVALLWLAVNAYLFIDTFFWYTEEEAFFYTRVILGSALAWARASAVCLNFNCMLILLPVSRNFISLVRGTSVCCRGPWRRQLDKNLNFHKLVAYGIAVNSVIHIVAHLFNLERYHLGQAKDAEGLLAALSKLGDAPNESYLNPVRTFDMGTTTELLMTVSGITGLGISLALVFIMTSSTEFIRRSSYELFWYTHHIFVFFFISLAIHGGGRIIRGQTPESLRLHNVTYCRDHYAEWQAAALCPVPQFSGKEPSAWKWALGPVVLYACERIIRFWRSHQEVVITKVVSHPSAVLELHMKKRDFKMAPGQYIFIQCPSVSPLEWHPFTLTSAPQEDFFSVHIRASGDWTEALLKAFRVEGQAPSELCSMPRLAVDGPFGGSLADVFHYPVSVCIATGIGVTPFASLLKSVWYKCCESQSLPELSKVYFYWICRDAGAFEWFADLLLSLETRMSEQGKAHLLSYHIYLTGWDENQAIHIALHWDESLDVITGLKQKAFYGRPNWNDEFKQIAYNHPSSSIGVFFCGSKAMSKTLQKMCRLYSSVDPRGVHFYYNKENF

Target ORF information:

RefSeq Version	NM_198958.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus NADPH oxidase 3 (Nox3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198958.2

ORF Insert Sequence:

ATGCCGGTGT GCTGGATTCT GAACGAGAGT GGGTCCTTCG TGGTTGCTCT CTTATGGCTG 
GCAGTAAACG CCTATCTGTT TATTGACACA TTCTTCTGGT ATACTGAAGA GGAGGCTTTC 
TTTTATACAC GAGTTATTCT GGGTTCCGCA TTGGCATGGG CCCGGGCATC TGCCGTGTGC 
CTGAATTTTA ACTGCATGCT AATTCTGTTA CCTGTCAGTC GGAACTTCAT TTCACTGGTG 
AGAGGAACAA GTGTGTGCTG TAGAGGACCA TGGAGAAGAC AACTAGACAA AAACCTCAAC 
TTCCACAAAC TCGTTGCCTA CGGGATAGCT GTCAATTCAG TTATCCACAT TGTGGCACAC 
TTGTTCAACC TGGAGCGTTA TCACCTGGGT CAGGCCAAGG ATGCTGAAGG GCTGCTGGCT 
GCACTTTCCA AACTTGGCGA TGCCCCAAAT GAGAGCTACC TCAATCCAGT CCGCACCTTT 
GATATGGGCA CAACCACTGA GCTATTGATG ACAGTGTCAG GAATTACTGG CCTGGGTATC 
TCTCTGGCTC TGGTCTTCAT CATGACCTCT TCAACCGAAT TCATCAGAAG GTCCTCTTAT 
GAGCTCTTCT GGTACACACA CCATATCTTT GTCTTCTTCT TCATCAGTCT GGCCATCCAC 
GGAGGAGGTC GCATCATTCG AGGCCAAACT CCAGAGAGTC TCCGGCTGCA CAATGTCACG 
TACTGCAGAG ACCACTATGC TGAATGGCAG GCAGCTGCCT TATGCCCTGT ACCTCAATTT 
TCTGGCAAGG AACCTTCGGC CTGGAAATGG GCTTTGGGTC CTGTGGTCTT GTATGCGTGT 
GAAAGAATAA TTAGGTTCTG GAGATCTCAC CAAGAAGTTG TCATTACCAA GGTGGTGAGT 
CACCCATCTG CAGTCCTGGA ACTTCACATG AAGAAGCGAG ACTTCAAGAT GGCACCTGGA 
CAGTACATCT TCATCCAGTG CCCATCTGTC TCCCCCCTGG AGTGGCACCC CTTCACTCTC 
ACCTCCGCTC CCCAGGAGGA CTTCTTCAGT GTACACATCA GAGCCTCAGG AGACTGGACA 
GAGGCGTTAT TGAAGGCCTT TAGAGTAGAG GGACAGGCTC CCAGTGAGCT CTGTAGCATG 
CCGAGGCTAG CAGTGGATGG GCCCTTTGGA GGCTCTCTGG CAGATGTATT TCACTACCCC 
GTGAGCGTGT GCATTGCAAC GGGAATTGGA GTCACTCCCT TCGCCTCTCT TCTGAAGTCT 
GTGTGGTATA AGTGTTGTGA ATCACAGAGC CTGCCTGAGC TGAGCAAGGT GTACTTCTAT 
TGGATCTGCC GGGATGCCGG AGCATTTGAG TGGTTTGCTG ATCTGTTACT GTCACTGGAA 
ACACGGATGA GTGAACAAGG GAAGGCTCAT TTACTGAGCT ACCATATATA TCTCACTGGC 
TGGGATGAAA ACCAGGCAAT TCACATAGCT TTACACTGGG ATGAAAGTCT GGATGTGATA 
ACAGGCTTAA AGCAGAAGGC TTTCTATGGG CGACCCAACT GGAACGACGA ATTCAAGCAG 
ATTGCCTACA ATCACCCCAG CAGCAGCATT GGCGTGTTCT TCTGTGGATC CAAAGCCATG 
TCAAAGACTC TTCAAAAGAT GTGTCGTTTG TACTCATCTG TGGATCCGAG GGGCGTTCAT 
TTCTATTACA ACAAGGAAAA CTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NADPH oxidase-2 mediates zinc deficiency-induced oxidative stress and kidney damage.
American journal of physiology. Cell physiology312(1)C47-C55(2017 Jan)
Li MS,Adesina SE,Ellis CL,Gooch JL,Hoover RS,Williams CR

Spatiotemporal differences in otoconial gene expression.
Genesis (New York, N.Y. : 2000)54(12)613-625(2016 Dec)
Xu Y,Zhang Y,Lundberg YW

An Endothelial Hsp70-TLR4 Axis Limits Nox3 Expression and Protects Against Oxidant Injury in Lungs.
Antioxidants & redox signaling24(17)991-1012(2016 Jun)
Zhang Y,Shan P,Srivastava A,Jiang G,Zhang X,Lee PJ

NOX3, a superoxide-generating NADPH oxidase of the inner ear.
The Journal of biological chemistry279(44)46065-72(2004 Oct)
B?nfi B,Malgrange B,Knisz J,Steger K,Dubois-Dauphin M,Krause KH

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Nox3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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