Soat2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Soat2
Entrez Gene ID	223920
Full Name	sterol O-acyltransferase 2
Synonyms	ACAT2,D15Wsu97e
General protein information	Preferred Names sterol O-acyltransferase 2 Names sterol O-acyltransferase 2 ACAT-2 acyl-CoA:cholesterol acyltransferase acyl-coenzyme A:cholesterol acyltransferase 2 cholesterol acyltransferase 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 F2\|15 57.33 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006520887.3	XP_006520950.1	sterol O-acyltransferase 2 isoform X1
NM_146064.1	NP_666176.1	sterol O-acyltransferase 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SOAT2	XP_005637467.1
Bos taurus (cattle)	SOAT2	NP_001095446.1
Rattus norvegicus (Norway rat)	Soat2	NP_714950.2
Homo sapiens (human)	SOAT2	NP_003569.1
Pan troglodytes (chimpanzee)	SOAT2	XP_001141788.1
Mus musculus (house mouse)	Soat2	NP_666176.1
	SOAT2	XP_001102393.1
Xenopus tropicalis (tropical clawed frog)	LOC101730739	XP_004912012.1
Xenopus tropicalis (tropical clawed frog)	soat2	NP_001135718.1

Gene Ontology
Bibliography

Related articles in PubMed

Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.
Wang YJ, Bian Y, Luo J, Lu M, Xiong Y, Guo SY, Yin HY, Lin X, Li Q, Chang CCY, Chang TY, Li BL, Song BL
Nature cell biology19(7)808-819(2017 Jul)

Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism.
Yang W, Bai Y, Xiong Y, Zhang J, Chen S, Zheng X, Meng X, Li L, Wang J, Xu C, Yan C, Wang L, Chang CC, Chang TY, Zhang T, Zhou P, Song BL, Liu W, Sun SC, Liu X, Li BL, Xu C
Nature531(7596)651-5(2016 Mar)

Sterol O-Acyltransferase 2-Driven Cholesterol Esterification Opposes Liver X Receptor-Stimulated Fecal Neutral Sterol Loss.
Warrier M, Zhang J, Bura K, Kelley K, Wilson MD, Rudel LL, Brown JM
Lipids51(2)151-7(2016 Feb)

Targeted Knockdown of Hepatic SOAT2 With Antisense Oligonucleotides Stabilizes Atherosclerotic Plaque in ApoB100-only LDLr-/- Mice.
Melchior JT, Olson JD, Kelley KL, Wilson MD, Sawyer JK, Link KM, Rudel LL
Arteriosclerosis, thrombosis, and vascular biology35(9)1920-7(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These studies demonstrate that SOAT2 is a negative regulator of LXR-stimulated fecal neutral sterol loss in mice.
Title: Sterol O-Acyltransferase 2-Driven Cholesterol Esterification Opposes Liver X Receptor-Stimulated Fecal Neutral Sterol Loss.

Hepatic knockdown of SOAT2 in apoB100-only, LDLr(-/-) mice resulted in remodeling of aortic atherosclerotic lesions into a stable phenotype, suggesting SOAT2 is a viable target for the treatment of atherosclerosis.
Title: Targeted Knockdown of Hepatic SOAT2 With Antisense Oligonucleotides Stabilizes Atherosclerotic Plaque in ApoB100-only LDLr-/- Mice.

effect the loss of SOAT2 function has on tissue esterified cholesterol sequestration in lysosomal acid lipase-deficient mice in a model of cholesteryl ester storage disease
Title: Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver.

Aortic atherosclerosis development was significantly lower in SOAT2 knock-out mice.
Title: Cholesterol esters (CE) derived from hepatic sterol O-acyltransferase 2 (SOAT2) are associated with more atherosclerosis than CE from intestinal SOAT2.

SOAT2 causes hepatic cholesterol to be swiftly mobilized and packaged onto nascent lipoproteins that feed cholesterol into the TICE pathway for fecal excretion.
Title: Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion.

The following Soat2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Soat2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu51260	XM_006520887.3 Latest version!	Mus musculus sterol O-acyltransferase 2 (Soat2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu12181	NM_146064.1 Latest version!	Mus musculus sterol O-acyltransferase 2 (Soat2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Soat2 ( XM_006520887.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006520950.1 Mus musculus sterol O-acyltransferase 2 (Soat2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu51260
Clone ID Related Accession (Same CDS sequence)	XM_006520887.3
Accession Version	XM_006520887.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	sterol O-acyltransferase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000081.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006520887.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGCCAA AGGTGCCCCA GCTTCGGAGG AGAGAAGGGC TGGGAGAGGA GCAGGAGAAG 
GGAGCCCGTG GAGGAGAAGG GAACGCAAGG ACACACGGAA CCCCAGACTT GGTGCAATGG 
ACTCGACATA TGGAGGCTGT GAAGACACAG TTTCTGGAGC AAGCACAGAG AGAGTTGGCA 
GAGCTGTTGG ATCGGGCCCT ATGGGAGGCT ATGCAAGCTT ACCCCAAACA AGACAGACCT 
CTTCCCTCCG CTGCCCCAGA TTCTACAAGC AAGACCCAAG AGTTACACCC TGGAAAACGG 
AAAGTTTTCA TCACCCGCAA GTCACTGATC GATGAGCTAA TGGAGGTGCA ACATTTCCGA 
ACCATCTACC ACATGTTCAT AGCGGGCCTA TGCGTCCTGA TCATCAGCAC CCTGGCCATC 
GACTTCATTG ATGAGGGCAG GTTGATGCTG GAGTTTGACT TACTCCTCTT CAGCTTCGGA 
CAGCTGCCCT TGGCGCTGAT GACCTGGGTT CCCATGTTCC TGTCTACGCT CCTAGTGCCC 
TACCAGACCC TGTGGCTGTG GGCCAGGCCG CGCGCTGGGG GTGCCTGGAT GCTGGGGGCC 
AGCCTGGGCT GCGTTCTGCT GGCTGCCCAC GCTGTGGTGC TCTGCGTCCT GCCGGTGCAC 
GTGTCAGTGA GGCATGAGCT TCCGCCCGCC TCGCGCTGCG TGCTGGTCTT TGAGCAGGTC 
AGATTGCTGA TGAAAAGCTA CTCCTTCCTG AGAGAGACTG TGCCTGGGAT CTTTTGTGTC 
AGAGGAGGAA AGGGCATCAG CCCCCCAAGT TTCTCCAGCT ACCTCTACTT CCTCTTCTGC 
CCTACACTTA TCTACAGAGA GACATACCCC AGGACACCCA GCATCAGGTG GAACTATGTG 
GCCAAGAACT TTGCCCAGGT CCTGGGCTGT TTGCTCTATG CCTGCTTCAT CCTGGGCCGC 
CTCTGTGTCC CTGTCTTTGC CAACATGAGC CGGGAACCCT TCAGCACCCG GGCTCTGCTG 
CTCTCCATCT TGCATGCCAC GGGGCCAGGA CTGGTGGAAC TCGACTTCCT TCTCCAACTA 
CTACCGCACC TGGAACGTCG TGGTCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006520950.1
CDS	220..1329
Translation	MQPKVPQLRRREGLGEEQEKGARGGEGNARTHGTPDLVQWTRHMEAVKTQFLEQAQRELAELLDRALWEAMQAYPKQDRPLPSAAPDSTSKTQELHPGKRKVFITRKSLIDELMEVQHFRTIYHMFIAGLCVLIISTLAIDFIDEGRLMLEFDLLLFSFGQLPLALMTWVPMFLSTLLVPYQTLWLWARPRAGGAWMLGASLGCVLLAAHAVVLCVLPVHVSVRHELPPASRCVLVFEQVRLLMKSYSFLRETVPGIFCVRGGKGISPPSFSSYLYFLFCPTLIYRETYPRTPSIRWNYVAKNFAQVLGCLLYACFILGRLCVPVFANMSREPFSTRALLLSILHATGPGLVELDFLLQLLPHLERRGP

Target ORF information:

RefSeq Version	XM_006520887.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus sterol O-acyltransferase 2 (Soat2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006520887.3

ORF Insert Sequence:

ATGCAGCCAA AGGTGCCCCA GCTTCGGAGG AGAGAAGGGC TGGGAGAGGA GCAGGAGAAG 
GGAGCCCGTG GAGGAGAAGG GAACGCAAGG ACACACGGAA CCCCAGACTT GGTGCAATGG 
ACTCGACATA TGGAGGCTGT GAAGACACAG TTTCTGGAGC AAGCACAGAG AGAGTTGGCA 
GAGCTGTTGG ATCGGGCCCT ATGGGAGGCT ATGCAAGCTT ACCCCAAACA AGACAGACCT 
CTTCCCTCCG CTGCCCCAGA TTCTACAAGC AAGACCCAAG AGTTACACCC TGGAAAACGG 
AAAGTTTTCA TCACCCGCAA GTCACTGATC GATGAGCTAA TGGAGGTGCA ACATTTCCGA 
ACCATCTACC ACATGTTCAT AGCGGGCCTA TGCGTCCTGA TCATCAGCAC CCTGGCCATC 
GACTTCATTG ATGAGGGCAG GTTGATGCTG GAGTTTGACT TACTCCTCTT CAGCTTCGGA 
CAGCTGCCCT TGGCGCTGAT GACCTGGGTT CCCATGTTCC TGTCTACGCT CCTAGTGCCC 
TACCAGACCC TGTGGCTGTG GGCCAGGCCG CGCGCTGGGG GTGCCTGGAT GCTGGGGGCC 
AGCCTGGGCT GCGTTCTGCT GGCTGCCCAC GCTGTGGTGC TCTGCGTCCT GCCGGTGCAC 
GTGTCAGTGA GGCATGAGCT TCCGCCCGCC TCGCGCTGCG TGCTGGTCTT TGAGCAGGTC 
AGATTGCTGA TGAAAAGCTA CTCCTTCCTG AGAGAGACTG TGCCTGGGAT CTTTTGTGTC 
AGAGGAGGAA AGGGCATCAG CCCCCCAAGT TTCTCCAGCT ACCTCTACTT CCTCTTCTGC 
CCTACACTTA TCTACAGAGA GACATACCCC AGGACACCCA GCATCAGGTG GAACTATGTG 
GCCAAGAACT TTGCCCAGGT CCTGGGCTGT TTGCTCTATG CCTGCTTCAT CCTGGGCCGC 
CTCTGTGTCC CTGTCTTTGC CAACATGAGC CGGGAACCCT TCAGCACCCG GGCTCTGCTG 
CTCTCCATCT TGCATGCCAC GGGGCCAGGA CTGGTGGAAC TCGACTTCCT TCTCCAACTA 
CTACCGCACC TGGAACGTCG TGGTCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Soat2 ( NM_146064.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_666176.1 Mus musculus sterol O-acyltransferase 2 (Soat2), mRNA.

Price & Availability↑

CloneID	OMu12181
Clone ID Related Accession (Same CDS sequence)	NM_146064.1
Accession Version	NM_146064.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1578bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Mus musculus(house mouse)
Product	sterol O-acyltransferase 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC025931.1. On Mar 16, 2004 this sequence version replaced NM_011433.1. Sequence Note: This sequence has been modified as follows: removed 44 bp suspected to be vector contamination from the 3' end. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025931.1, AF078751.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCCAA AGGTGCCCCA GCTTCGGAGG AGAGAAGGGC TGGGAGAGGA GCAGGAGAAG 
GGAGCCCGTG GAGGAGAAGG GAACGCAAGG ACACACGGAA CCCCAGACTT GGTGCAATGG 
ACTCGACATA TGGAGGCTGT GAAGACACAG TTTCTGGAGC AAGCACAGAG AGAGTTGGCA 
GAGCTGTTGG ATCGGGCCCT ATGGGAGGCT ATGCAAGCTT ACCCCAAACA AGACAGACCT 
CTTCCCTCCG CTGCCCCAGA TTCTACAAGC AAGACCCAAG AGTTACACCC TGGAAAACGG 
AAAGTTTTCA TCACCCGCAA GTCACTGATC GATGAGCTAA TGGAGGTGCA ACATTTCCGA 
ACCATCTACC ACATGTTCAT AGCGGGCCTA TGCGTCCTGA TCATCAGCAC CCTGGCCATC 
GACTTCATTG ATGAGGGCAG GTTGATGCTG GAGTTTGACT TACTCCTCTT CAGCTTCGGA 
CAGCTGCCCT TGGCGCTGAT GACCTGGGTT CCCATGTTCC TGTCTACGCT CCTAGTGCCC 
TACCAGACCC TGTGGCTGTG GGCCAGGCCG CGCGCTGGGG GTGCCTGGAT GCTGGGGGCC 
AGCCTGGGCT GCGTTCTGCT GGCTGCCCAC GCTGTGGTGC TCTGCGTCCT GCCGGTGCAC 
GTGTCAGTGA GGCATGAGCT TCCGCCCGCC TCGCGCTGCG TGCTGGTCTT TGAGCAGGTC 
AGATTGCTGA TGAAAAGCTA CTCCTTCCTG AGAGAGACTG TGCCTGGGAT CTTTTGTGTC 
AGAGGAGGAA AGGGCATCAG CCCCCCAAGT TTCTCCAGCT ACCTCTACTT CCTCTTCTGC 
CCTACACTTA TCTACAGAGA GACATACCCC AGGACACCCA GCATCAGGTG GAACTATGTG 
GCCAAGAACT TTGCCCAGGT CCTGGGCTGT TTGCTCTATG CCTGCTTCAT CCTGGGCCGC 
CTCTGTGTCC CTGTCTTTGC CAACATGAGC CGGGAACCCT TCAGCACCCG GGCTCTGCTG 
CTCTCCATCT TGCATGCCAC GGGGCCAGGC ATCTTCATGC TGCTCCTCAT CTTCTTCGCC 
TTCCTGCACT GCTGGCTCAA CGCCTTCGCC GAGATGCTGC GGTTTGGAGA CAGGATGTTC 
TACCGGGACT GGTGGAACTC GACTTCCTTC TCCAACTACT ACCGCACCTG GAACGTCGTG 
GTCCATGACT GGCTGTACAG CTATGTGTAT CAAGATGGGC TGTGGCTCTT AGGCAGGCGG 
GCTCGCGGGG TGGCCATGCT GGGAGTGTTC CTGGTGTCTG CGGTGGTTCA TGAGTATATC 
TTCTGCTTCG TCCTGGGGTT CTTCTACCCG GTCATGCTGA TGCTATTCCT TGTTTTCGGG 
GGGCTGCTGA ATTTCACCAT GAACGACAGG CACACAGGTC CAGCCTGGAA CATCCTGATG 
TGGACCTTTC TCTTCATGGG CCAGGGCATC CAGGTCAGCC TATACTGCCA GGAGTGGTAT 
GCTCGTCGAC ACTGTCCCCT GCCCCAGACA ACATTCTGGG GGATGGTGAC ACCCCGCTCT 
TGGTCCTGCC ATCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_666176.1
CDS	60..1637
Translation	MQPKVPQLRRREGLGEEQEKGARGGEGNARTHGTPDLVQWTRHMEAVKTQFLEQAQRELAELLDRALWEAMQAYPKQDRPLPSAAPDSTSKTQELHPGKRKVFITRKSLIDELMEVQHFRTIYHMFIAGLCVLIISTLAIDFIDEGRLMLEFDLLLFSFGQLPLALMTWVPMFLSTLLVPYQTLWLWARPRAGGAWMLGASLGCVLLAAHAVVLCVLPVHVSVRHELPPASRCVLVFEQVRLLMKSYSFLRETVPGIFCVRGGKGISPPSFSSYLYFLFCPTLIYRETYPRTPSIRWNYVAKNFAQVLGCLLYACFILGRLCVPVFANMSREPFSTRALLLSILHATGPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLWLLGRRARGVAMLGVFLVSAVVHEYIFCFVLGFFYPVMLMLFLVFGGLLNFTMNDRHTGPAWNILMWTFLFMGQGIQVSLYCQEWYARRHCPLPQTTFWGMVTPRSWSCHP

Target ORF information:

RefSeq Version	NM_146064.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus sterol O-acyltransferase 2 (Soat2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_146064.1

ORF Insert Sequence:

ATGCAGCCAA AGGTGCCCCA GCTTCGGAGG AGAGAAGGGC TGGGAGAGGA GCAGGAGAAG 
GGAGCCCGTG GAGGAGAAGG GAACGCAAGG ACACACGGAA CCCCAGACTT GGTGCAATGG 
ACTCGACATA TGGAGGCTGT GAAGACACAG TTTCTGGAGC AAGCACAGAG AGAGTTGGCA 
GAGCTGTTGG ATCGGGCCCT ATGGGAGGCT ATGCAAGCTT ACCCCAAACA AGACAGACCT 
CTTCCCTCCG CTGCCCCAGA TTCTACAAGC AAGACCCAAG AGTTACACCC TGGAAAACGG 
AAAGTTTTCA TCACCCGCAA GTCACTGATC GATGAGCTAA TGGAGGTGCA ACATTTCCGA 
ACCATCTACC ACATGTTCAT AGCGGGCCTA TGCGTCCTGA TCATCAGCAC CCTGGCCATC 
GACTTCATTG ATGAGGGCAG GTTGATGCTG GAGTTTGACT TACTCCTCTT CAGCTTCGGA 
CAGCTGCCCT TGGCGCTGAT GACCTGGGTT CCCATGTTCC TGTCTACGCT CCTAGTGCCC 
TACCAGACCC TGTGGCTGTG GGCCAGGCCG CGCGCTGGGG GTGCCTGGAT GCTGGGGGCC 
AGCCTGGGCT GCGTTCTGCT GGCTGCCCAC GCTGTGGTGC TCTGCGTCCT GCCGGTGCAC 
GTGTCAGTGA GGCATGAGCT TCCGCCCGCC TCGCGCTGCG TGCTGGTCTT TGAGCAGGTC 
AGATTGCTGA TGAAAAGCTA CTCCTTCCTG AGAGAGACTG TGCCTGGGAT CTTTTGTGTC 
AGAGGAGGAA AGGGCATCAG CCCCCCAAGT TTCTCCAGCT ACCTCTACTT CCTCTTCTGC 
CCTACACTTA TCTACAGAGA GACATACCCC AGGACACCCA GCATCAGGTG GAACTATGTG 
GCCAAGAACT TTGCCCAGGT CCTGGGCTGT TTGCTCTATG CCTGCTTCAT CCTGGGCCGC 
CTCTGTGTCC CTGTCTTTGC CAACATGAGC CGGGAACCCT TCAGCACCCG GGCTCTGCTG 
CTCTCCATCT TGCATGCCAC GGGGCCAGGC ATCTTCATGC TGCTCCTCAT CTTCTTCGCC 
TTCCTGCACT GCTGGCTCAA CGCCTTCGCC GAGATGCTGC GGTTTGGAGA CAGGATGTTC 
TACCGGGACT GGTGGAACTC GACTTCCTTC TCCAACTACT ACCGCACCTG GAACGTCGTG 
GTCCATGACT GGCTGTACAG CTATGTGTAT CAAGATGGGC TGTGGCTCTT AGGCAGGCGG 
GCTCGCGGGG TGGCCATGCT GGGAGTGTTC CTGGTGTCTG CGGTGGTTCA TGAGTATATC 
TTCTGCTTCG TCCTGGGGTT CTTCTACCCG GTCATGCTGA TGCTATTCCT TGTTTTCGGG 
GGGCTGCTGA ATTTCACCAT GAACGACAGG CACACAGGTC CAGCCTGGAA CATCCTGATG 
TGGACCTTTC TCTTCATGGG CCAGGGCATC CAGGTCAGCC TATACTGCCA GGAGTGGTAT 
GCTCGTCGAC ACTGTCCCCT GCCCCAGACA ACATTCTGGG GGATGGTGAC ACCCCGCTCT 
TGGTCCTGCC ATCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.
Nature cell biology19(7)808-819(2017 Jul)
Wang YJ,Bian Y,Luo J,Lu M,Xiong Y,Guo SY,Yin HY,Lin X,Li Q,Chang CCY,Chang TY,Li BL,Song BL

Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism.
Nature531(7596)651-5(2016 Mar)
Yang W,Bai Y,Xiong Y,Zhang J,Chen S,Zheng X,Meng X,Li L,Wang J,Xu C,Yan C,Wang L,Chang CC,Chang TY,Zhang T,Zhou P,Song BL,Liu W,Sun SC,Liu X,Li BL,Xu C

Sterol O-Acyltransferase 2-Driven Cholesterol Esterification Opposes Liver X Receptor-Stimulated Fecal Neutral Sterol Loss.
Lipids51(2)151-7(2016 Feb)
Warrier M,Zhang J,Bura K,Kelley K,Wilson MD,Rudel LL,Brown JM

Targeted Knockdown of Hepatic SOAT2 With Antisense Oligonucleotides Stabilizes Atherosclerotic Plaque in ApoB100-only LDLr-/- Mice.
Arteriosclerosis, thrombosis, and vascular biology35(9)1920-7(2015 Sep)
Melchior JT,Olson JD,Kelley KL,Wilson MD,Sawyer JK,Link KM,Rudel LL

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Soat2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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