Dpysl3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dpysl3
Entrez Gene ID	22240
Full Name	dihydropyrimidinase-like 3
Synonyms	CRMP-4,DRP-3,TUC4,ULIP-1,Ulip,Ulip1
General protein information	Preferred Names dihydropyrimidinase-like 3 Names dihydropyrimidinase-related protein 3 collapsin response mediator protein 4 unc-33-like phosphoprotein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18\|18 B3
Summary	This gene encodes a protein that belongs to the TUC (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are phosphoproteins that function in axonal guidance and neuronal differentiation during development and regeneration of the nervous system. A mutation in the human gene is associated with amyotrophic lateral sclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001136086.2	NP_001129558.1	dihydropyrimidinase-related protein 3 isoform 1
NM_001291455.1	NP_001278384.1	dihydropyrimidinase-related protein 3 CRMP4b
NM_009468.5	NP_033494.1	dihydropyrimidinase-related protein 3 CRMP4a

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	DPYSL3	NP_989824.1
Danio rerio (zebrafish)	dpysl3	NP_001018348.1
Mus musculus (house mouse)	Dpysl3	NP_033494.1
Xenopus tropicalis (tropical clawed frog)	dpysl3	NP_001005637.1
Homo sapiens (human)	DPYSL3	NP_001184223.1
Pan troglodytes (chimpanzee)	DPYSL3	XP_003310939.1
	DPYSL3	XP_001102251.1
Bos taurus (cattle)	DPYSL3	NP_001094538.1
Rattus norvegicus (Norway rat)	Dpysl3	NP_037066.1
Canis lupus familiaris (dog)	DPYSL3	XP_544332.3

Gene Ontology
Bibliography

Related articles in PubMed

Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism.
Tsutiya A, Nakano Y, Hansen-Kiss E, Kelly B, Nishihara M, Goshima Y, Corsmeier D, White P, Herman GE, Ohtani-Kaneko R
Scientific reports7(1)16812(2017 Dec)

CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling.
Abdallah BM, Figeac F, Larsen KH, Ditzel N, Keshari P, Isa A, Jafari A, Andersen TL, Delaisse JM, Goshima Y, Ohshima T, Kassem M
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research32(5)913-926(2017 May)

CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain.
Takaya R, Nagai J, Piao W, Niisato E, Nakabayashi T, Yamazaki Y, Nakamura F, Yamashita N, Kolattukudy P, Goshima Y, Ohshima T
Brain research1655161-167(2017 01)

A rare motor neuron deleterious missense mutation in the DPYSL3 (CRMP4) gene is associated with ALS.
Blasco H, Bernard-Marissal N, Vourc'h P, Guettard YO, Sunyach C, Augereau O, Khederchah J, Mouzat K, Antar C, Gordon PH, Veyrat-Durebex C, Besson G, Andersen PM, Salachas F, Meininger V, Camu W, Pettmann B, Andres CR, Corcia P,
Human mutation34(7)953-60(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results indicate that CRMP1 and CRMP4 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex during development.
Title: CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain.

Crmp4 deletion promotes axonal growth and nociceptive recovery after spinal cord injury.
Title: Deletion of Crmp4 attenuates CSPG-induced inhibition of axonal growth and induces nociceptive recovery after spinal cord injury.

CRMP4-deficient mice show reduced inflammation and suppressed dopaminergic neuronal death in a model of Parkinson's disease.
Title: Loss of collapsin response mediator protein 4 suppresses dopaminergic neuron death in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.

our data suggest that disruption of CRMP4 produces a temporary alteration in the thickness of the external of the olfactory bulb, which is constituted mainly of mitral cell apical dendrites, through the enhanced growth of these dendrites
Title: Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb.

These results suggest that deletion of CRMP4 is a unique therapeutic strategy that overcomes two obstacles to CNS repair after SCI.
Title: Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation.

The following Dpysl3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dpysl3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu20315	NM_001136086.2 Latest version!	Mus musculus dihydropyrimidinase-like 3 (Dpysl3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu20627	NM_001291455.1 Latest version!	Mus musculus dihydropyrimidinase-like 3 (Dpysl3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OMu20461	NM_009468.5 Latest version!	Mus musculus dihydropyrimidinase-like 3 (Dpysl3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dpysl3 ( NM_001136086.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001129558.1 Mus musculus dihydropyrimidinase-like 3 (Dpysl3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu20315
Clone ID Related Accession (Same CDS sequence)	NM_001136086.2
Accession Version	NM_001136086.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	dihydropyrimidinase-related protein 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK133040.1, AC101718.6 and BQ175584.1. On Apr 17, 2014 this sequence version replaced NM_001136086.1. Transcript Variant: This variant (1) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from an alternate start codon compared to variant 3. The encoded isoform (1) has a distinct N-terminus and is shorter than CRMP4b. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK133040.1, AK077000.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTATTCAC CATCAAGAAA CAAAATCCGG CAGAGTGACC GTCTTCTAAT CAAGGGAGGG 
AGAATCGTCA ATGATGATCA GTCCTTTTAT GCTGATATTT ACATGGAGGA TGGCTTAATA 
AAGCAAATTG GAGACAATCT GATTGTCCCC GGAGGTGTGA AGACCATCGA GGCCAACGGG 
AAGATGGTGA TCCCTGGAGG CATTGACGTC CATACCCACT TCCAGATGCC TTACAAGGGA 
ATGACCACAG TGGACGATTT CTTCCAAGGG ACAAAGGCTG CCTTAGCGGG AGGCACCACC 
ATGATCATTG ACCACGTGGT ACCTGAACCT GAGTCTAGCC TGACAGAGGC CTATGAAAAG 
TGGCGTGAGT GGGCCGATGG GAAGAGCTGC TGTGACTATG CTTTGCATGT GGACATCACC 
CACTGGAATG ACAGCGTCAA GCAGGAGGTA CAGAGCCTCA GCAAGGAAAA AGGCGTTAAC 
TCCTTCATGG TTTACATGGC CTACAAGGAT TTATATCAAG TGTCCAACAC AGAGCTCTAT 
GAGATCTTCA CCTGCCTGGG AGAGCTGGGG GCCATTGCTC AAGTTCATGC CGAGAATGGA 
GATATCATTG CCCAGGAGCA GGCACGGATG CTGGAAATGG GGATAACCGG CCCAGAAGGC 
CACGTTCTGA GCAGACCGGA AGAGCTGGAA GCTGAGGCTG TGTTCCGTGC CATCACCGTC 
GCCAGCCAGA CCAACTGCCC CCTCTATGTC ACCAAGGTCA TGAGCAAGAG CGCGGCTGAT 
CTCATCTCAC AAGCCAGGAA GAAAGGAAAT GTGGTCTTTG GCGAGCCCAT CACTGCCAGC 
CTGGGAATAG ATGGAACTCA TTACTGGAGT AAGAACTGGG CCAAAGCAGC TGCGTTTGTG 
ACATCCCCAC CTCTGAGCCC TGACCCTACC ACACCTGACT ACATCAACTC CTTGCTGGCC 
AGCGGGGATC TGCAGCTCTC TGGAAGTGCC CACTGTACCT TTAGCACTGC CCAGAAAGCC 
ATTGGGAAGG ACAACTTCAC AGCCATCCCT GAAGGCACCA ATGGCGTGGA GGAGCGTATG 
TCTGTCATCT GGGACAAGGC TGTGGCCACG GGGAAGATGG ATGAAAACCA GTTTGTGGCC 
GTGACAAGCA CCAATGCTGC CAAGATATTC AACCTGTACC CTCGAAAGGG GAGAATAGCT 
GTGGGCTCTG ACAGCGACCT TGTCATCTGG GATCCAGATG CCTTGAAGAT TGTCTCTGCC 
AAGAACCACC AGTCGGTTGC CGAATACAAC ATCTTTGAAG GGATGGAGCT GCGTGGTGCA 
CCTCTGGTGG TTATCTGCCA GGGCAAGATC ATGCTGGAAG ATGGCAACCT GCACGTGACC 
CAGGGGGCTG GCCGCTTCAT TCCCTGCAGC CCATTCTCTG ACTATGTCTA TAAGCGCATT 
AAAGCAAGGA GGAAGATGGC AGACCTGCAT GCAGTCCCAA GAGGCATGTA TGATGGACCA 
GTGTTTGACT TGACCACCAC CCCCAAGGGG GGCACCCCAG CTGGCTCTAC TCGGGGCTCT 
CCCACTCGGC CAAACCCGCC AGTGAGGAAC CTCCATCAGT CAGGATTTAG CCTGTCAGGC 
ACCCAAGTGG ATGAGGGTGT CCGCTCAGCT AGCAAACGCA TTGTGGCACC CCCTGGAGGC 
CGTTCTAACA TCACATCCCT GAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129558.1
CDS	175..1881
Translation	MYSPSRNKIRQSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQSLSKEKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQVHAENGDIIAQEQARMLEMGITGPEGHVLSRPEELEAEAVFRAITVASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDSDLVIWDPDALKIVSAKNHQSVAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSTRGSPTRPNPPVRNLHQSGFSLSGTQVDEGVRSASKRIVAPPGGRSNITSLS

Target ORF information:

RefSeq Version	NM_001136086.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus dihydropyrimidinase-like 3 (Dpysl3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136086.2

ORF Insert Sequence:

ATGTATTCAC CATCAAGAAA CAAAATCCGG CAGAGTGACC GTCTTCTAAT CAAGGGAGGG 
AGAATCGTCA ATGATGATCA GTCCTTTTAT GCTGATATTT ACATGGAGGA TGGCTTAATA 
AAGCAAATTG GAGACAATCT GATTGTCCCC GGAGGTGTGA AGACCATCGA GGCCAACGGG 
AAGATGGTGA TCCCTGGAGG CATTGACGTC CATACCCACT TCCAGATGCC TTACAAGGGA 
ATGACCACAG TGGACGATTT CTTCCAAGGG ACAAAGGCTG CCTTAGCGGG AGGCACCACC 
ATGATCATTG ACCACGTGGT ACCTGAACCT GAGTCTAGCC TGACAGAGGC CTATGAAAAG 
TGGCGTGAGT GGGCCGATGG GAAGAGCTGC TGTGACTATG CTTTGCATGT GGACATCACC 
CACTGGAATG ACAGCGTCAA GCAGGAGGTA CAGAGCCTCA GCAAGGAAAA AGGCGTTAAC 
TCCTTCATGG TTTACATGGC CTACAAGGAT TTATATCAAG TGTCCAACAC AGAGCTCTAT 
GAGATCTTCA CCTGCCTGGG AGAGCTGGGG GCCATTGCTC AAGTTCATGC CGAGAATGGA 
GATATCATTG CCCAGGAGCA GGCACGGATG CTGGAAATGG GGATAACCGG CCCAGAAGGC 
CACGTTCTGA GCAGACCGGA AGAGCTGGAA GCTGAGGCTG TGTTCCGTGC CATCACCGTC 
GCCAGCCAGA CCAACTGCCC CCTCTATGTC ACCAAGGTCA TGAGCAAGAG CGCGGCTGAT 
CTCATCTCAC AAGCCAGGAA GAAAGGAAAT GTGGTCTTTG GCGAGCCCAT CACTGCCAGC 
CTGGGAATAG ATGGAACTCA TTACTGGAGT AAGAACTGGG CCAAAGCAGC TGCGTTTGTG 
ACATCCCCAC CTCTGAGCCC TGACCCTACC ACACCTGACT ACATCAACTC CTTGCTGGCC 
AGCGGGGATC TGCAGCTCTC TGGAAGTGCC CACTGTACCT TTAGCACTGC CCAGAAAGCC 
ATTGGGAAGG ACAACTTCAC AGCCATCCCT GAAGGCACCA ATGGCGTGGA GGAGCGTATG 
TCTGTCATCT GGGACAAGGC TGTGGCCACG GGGAAGATGG ATGAAAACCA GTTTGTGGCC 
GTGACAAGCA CCAATGCTGC CAAGATATTC AACCTGTACC CTCGAAAGGG GAGAATAGCT 
GTGGGCTCTG ACAGCGACCT TGTCATCTGG GATCCAGATG CCTTGAAGAT TGTCTCTGCC 
AAGAACCACC AGTCGGTTGC CGAATACAAC ATCTTTGAAG GGATGGAGCT GCGTGGTGCA 
CCTCTGGTGG TTATCTGCCA GGGCAAGATC ATGCTGGAAG ATGGCAACCT GCACGTGACC 
CAGGGGGCTG GCCGCTTCAT TCCCTGCAGC CCATTCTCTG ACTATGTCTA TAAGCGCATT 
AAAGCAAGGA GGAAGATGGC AGACCTGCAT GCAGTCCCAA GAGGCATGTA TGATGGACCA 
GTGTTTGACT TGACCACCAC CCCCAAGGGG GGCACCCCAG CTGGCTCTAC TCGGGGCTCT 
CCCACTCGGC CAAACCCGCC AGTGAGGAAC CTCCATCAGT CAGGATTTAG CCTGTCAGGC 
ACCCAAGTGG ATGAGGGTGT CCGCTCAGCT AGCAAACGCA TTGTGGCACC CCCTGGAGGC 
CGTTCTAACA TCACATCCCT GAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dpysl3 ( NM_001291455.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001278384.1 Mus musculus dihydropyrimidinase-like 3 (Dpysl3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu20627
Clone ID Related Accession (Same CDS sequence)	NM_001291455.1
Accession Version	NM_001291455.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2052bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	dihydropyrimidinase-related protein 3 CRMP4b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC101718.6, AK149024.1 and BQ175584.1. On Apr 17, 2014 this sequence version replaced XM_006525780.1. Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (CRMP4b, also known as isoform 3). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149024.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCGG GCCGAAGGGG TTGGGACAGC TCCCACGAGG ACGACCTGCC TGTGTACTTG 
GCCCGTCCGG GCACCACAGA TCAGGTCCCA CGGCAGAAGT ACGGTGGCAT GTTCTGCAAC 
GTGGAGGGTG CCTTCGAGAG CAAGACGTTG GATTTTGATG CCCTGAGTGT GGGACAGCGC 
GGCGCCAAGA CTCCCCGGAG CAGCCAGGGC AGCGGCCGTG GCGCAGGGAA CCGGCCCGGG 
ATGGAAGTGG ACGCGCGCAG GGGCCCGGGC CGGGAGGAGA GCAGGGAACC CGCGCCGGAG 
TCCCCCAAGC CCGCTGGGGT GGAGATCCGG AGCGCCACCG GCAAGGAGGT CTTGCAGAAC 
CTTGGTCCCA AGGACAAGAG TGACCGTCTT CTAATCAAGG GAGGGAGAAT CGTCAATGAT 
GATCAGTCCT TTTATGCTGA TATTTACATG GAGGATGGCT TAATAAAGCA AATTGGAGAC 
AATCTGATTG TCCCCGGAGG TGTGAAGACC ATCGAGGCCA ACGGGAAGAT GGTGATCCCT 
GGAGGCATTG ACGTCCATAC CCACTTCCAG ATGCCTTACA AGGGAATGAC CACAGTGGAC 
GATTTCTTCC AAGGGACAAA GGCTGCCTTA GCGGGAGGCA CCACCATGAT CATTGACCAC 
GTGGTACCTG AACCTGAGTC TAGCCTGACA GAGGCCTATG AAAAGTGGCG TGAGTGGGCC 
GATGGGAAGA GCTGCTGTGA CTATGCTTTG CATGTGGACA TCACCCACTG GAATGACAGC 
GTCAAGCAGG AGGTACAGAG CCTCAGCAAG GAAAAAGGCG TTAACTCCTT CATGGTTTAC 
ATGGCCTACA AGGATTTATA TCAAGTGTCC AACACAGAGC TCTATGAGAT CTTCACCTGC 
CTGGGAGAGC TGGGGGCCAT TGCTCAAGTT CATGCCGAGA ATGGAGATAT CATTGCCCAG 
GAGCAGGCAC GGATGCTGGA AATGGGGATA ACCGGCCCAG AAGGCCACGT TCTGAGCAGA 
CCGGAAGAGC TGGAAGCTGA GGCTGTGTTC CGTGCCATCA CCGTCGCCAG CCAGACCAAC 
TGCCCCCTCT ATGTCACCAA GGTCATGAGC AAGAGCGCGG CTGATCTCAT CTCACAAGCC 
AGGAAGAAAG GAAATGTGGT CTTTGGCGAG CCCATCACTG CCAGCCTGGG AATAGATGGA 
ACTCATTACT GGAGTAAGAA CTGGGCCAAA GCAGCTGCGT TTGTGACATC CCCACCTCTG 
AGCCCTGACC CTACCACACC TGACTACATC AACTCCTTGC TGGCCAGCGG GGATCTGCAG 
CTCTCTGGAA GTGCCCACTG TACCTTTAGC ACTGCCCAGA AAGCCATTGG GAAGGACAAC 
TTCACAGCCA TCCCTGAAGG CACCAATGGC GTGGAGGAGC GTATGTCTGT CATCTGGGAC 
AAGGCTGTGG CCACGGGGAA GATGGATGAA AACCAGTTTG TGGCCGTGAC AAGCACCAAT 
GCTGCCAAGA TATTCAACCT GTACCCTCGA AAGGGGAGAA TAGCTGTGGG CTCTGACAGC 
GACCTTGTCA TCTGGGATCC AGATGCCTTG AAGATTGTCT CTGCCAAGAA CCACCAGTCG 
GTTGCCGAAT ACAACATCTT TGAAGGGATG GAGCTGCGTG GTGCACCTCT GGTGGTTATC 
TGCCAGGGCA AGATCATGCT GGAAGATGGC AACCTGCACG TGACCCAGGG GGCTGGCCGC 
TTCATTCCCT GCAGCCCATT CTCTGACTAT GTCTATAAGC GCATTAAAGC AAGGAGGAAG 
ATGGCAGACC TGCATGCAGT CCCAAGAGGC ATGTATGATG GACCAGTGTT TGACTTGACC 
ACCACCCCCA AGGGGGGCAC CCCAGCTGGC TCTACTCGGG GCTCTCCCAC TCGGCCAAAC 
CCGCCAGTGA GGAACCTCCA TCAGTCAGGA TTTAGCCTGT CAGGCACCCA AGTGGATGAG 
GGTGTCCGCT CAGCTAGCAA ACGCATTGTG GCACCCCCTG GAGGCCGTTC TAACATCACA 
TCCCTGAGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278384.1
CDS	80..2131
Translation	MASGRRGWDSSHEDDLPVYLARPGTTDQVPRQKYGGMFCNVEGAFESKTLDFDALSVGQRGAKTPRSSQGSGRGAGNRPGMEVDARRGPGREESREPAPESPKPAGVEIRSATGKEVLQNLGPKDKSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQSLSKEKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQVHAENGDIIAQEQARMLEMGITGPEGHVLSRPEELEAEAVFRAITVASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDSDLVIWDPDALKIVSAKNHQSVAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSTRGSPTRPNPPVRNLHQSGFSLSGTQVDEGVRSASKRIVAPPGGRSNITSLS

Target ORF information:

RefSeq Version	NM_001291455.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dihydropyrimidinase-like 3 (Dpysl3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001291455.1

ORF Insert Sequence:

ATGGCTTCGG GCCGAAGGGG TTGGGACAGC TCCCACGAGG ACGACCTGCC TGTGTACTTG 
GCCCGTCCGG GCACCACAGA TCAGGTCCCA CGGCAGAAGT ACGGTGGCAT GTTCTGCAAC 
GTGGAGGGTG CCTTCGAGAG CAAGACGTTG GATTTTGATG CCCTGAGTGT GGGACAGCGC 
GGCGCCAAGA CTCCCCGGAG CAGCCAGGGC AGCGGCCGTG GCGCAGGGAA CCGGCCCGGG 
ATGGAAGTGG ACGCGCGCAG GGGCCCGGGC CGGGAGGAGA GCAGGGAACC CGCGCCGGAG 
TCCCCCAAGC CCGCTGGGGT GGAGATCCGG AGCGCCACCG GCAAGGAGGT CTTGCAGAAC 
CTTGGTCCCA AGGACAAGAG TGACCGTCTT CTAATCAAGG GAGGGAGAAT CGTCAATGAT 
GATCAGTCCT TTTATGCTGA TATTTACATG GAGGATGGCT TAATAAAGCA AATTGGAGAC 
AATCTGATTG TCCCCGGAGG TGTGAAGACC ATCGAGGCCA ACGGGAAGAT GGTGATCCCT 
GGAGGCATTG ACGTCCATAC CCACTTCCAG ATGCCTTACA AGGGAATGAC CACAGTGGAC 
GATTTCTTCC AAGGGACAAA GGCTGCCTTA GCGGGAGGCA CCACCATGAT CATTGACCAC 
GTGGTACCTG AACCTGAGTC TAGCCTGACA GAGGCCTATG AAAAGTGGCG TGAGTGGGCC 
GATGGGAAGA GCTGCTGTGA CTATGCTTTG CATGTGGACA TCACCCACTG GAATGACAGC 
GTCAAGCAGG AGGTACAGAG CCTCAGCAAG GAAAAAGGCG TTAACTCCTT CATGGTTTAC 
ATGGCCTACA AGGATTTATA TCAAGTGTCC AACACAGAGC TCTATGAGAT CTTCACCTGC 
CTGGGAGAGC TGGGGGCCAT TGCTCAAGTT CATGCCGAGA ATGGAGATAT CATTGCCCAG 
GAGCAGGCAC GGATGCTGGA AATGGGGATA ACCGGCCCAG AAGGCCACGT TCTGAGCAGA 
CCGGAAGAGC TGGAAGCTGA GGCTGTGTTC CGTGCCATCA CCGTCGCCAG CCAGACCAAC 
TGCCCCCTCT ATGTCACCAA GGTCATGAGC AAGAGCGCGG CTGATCTCAT CTCACAAGCC 
AGGAAGAAAG GAAATGTGGT CTTTGGCGAG CCCATCACTG CCAGCCTGGG AATAGATGGA 
ACTCATTACT GGAGTAAGAA CTGGGCCAAA GCAGCTGCGT TTGTGACATC CCCACCTCTG 
AGCCCTGACC CTACCACACC TGACTACATC AACTCCTTGC TGGCCAGCGG GGATCTGCAG 
CTCTCTGGAA GTGCCCACTG TACCTTTAGC ACTGCCCAGA AAGCCATTGG GAAGGACAAC 
TTCACAGCCA TCCCTGAAGG CACCAATGGC GTGGAGGAGC GTATGTCTGT CATCTGGGAC 
AAGGCTGTGG CCACGGGGAA GATGGATGAA AACCAGTTTG TGGCCGTGAC AAGCACCAAT 
GCTGCCAAGA TATTCAACCT GTACCCTCGA AAGGGGAGAA TAGCTGTGGG CTCTGACAGC 
GACCTTGTCA TCTGGGATCC AGATGCCTTG AAGATTGTCT CTGCCAAGAA CCACCAGTCG 
GTTGCCGAAT ACAACATCTT TGAAGGGATG GAGCTGCGTG GTGCACCTCT GGTGGTTATC 
TGCCAGGGCA AGATCATGCT GGAAGATGGC AACCTGCACG TGACCCAGGG GGCTGGCCGC 
TTCATTCCCT GCAGCCCATT CTCTGACTAT GTCTATAAGC GCATTAAAGC AAGGAGGAAG 
ATGGCAGACC TGCATGCAGT CCCAAGAGGC ATGTATGATG GACCAGTGTT TGACTTGACC 
ACCACCCCCA AGGGGGGCAC CCCAGCTGGC TCTACTCGGG GCTCTCCCAC TCGGCCAAAC 
CCGCCAGTGA GGAACCTCCA TCAGTCAGGA TTTAGCCTGT CAGGCACCCA AGTGGATGAG 
GGTGTCCGCT CAGCTAGCAA ACGCATTGTG GCACCCCCTG GAGGCCGTTC TAACATCACA 
TCCCTGAGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dpysl3 ( NM_009468.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033494.1 Mus musculus dihydropyrimidinase-like 3 (Dpysl3), transcript variant 2, mRNA.

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CloneID	OMu20461
Clone ID Related Accession (Same CDS sequence)	NM_009468.5
Accession Version	NM_009468.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1713bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	dihydropyrimidinase-related protein 3 CRMP4a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC101718.6 and BQ175584.1. On Apr 17, 2014 this sequence version replaced NM_009468.4. Transcript Variant: This variant (2) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from an alternate start codon compared to variant 3. The encoded isoform (CRMP4a, also known as isoform 2) has a distinct N-terminus and is shorter than CRMP4b. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X87817.1, SRR1660811.199417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCTACC AGGGCAAGAA GAACATTCCG CGGATCACGA GTGACCGTCT TCTAATCAAG 
GGAGGGAGAA TCGTCAATGA TGATCAGTCC TTTTATGCTG ATATTTACAT GGAGGATGGC 
TTAATAAAGC AAATTGGAGA CAATCTGATT GTCCCCGGAG GTGTGAAGAC CATCGAGGCC 
AACGGGAAGA TGGTGATCCC TGGAGGCATT GACGTCCATA CCCACTTCCA GATGCCTTAC 
AAGGGAATGA CCACAGTGGA CGATTTCTTC CAAGGGACAA AGGCTGCCTT AGCGGGAGGC 
ACCACCATGA TCATTGACCA CGTGGTACCT GAACCTGAGT CTAGCCTGAC AGAGGCCTAT 
GAAAAGTGGC GTGAGTGGGC CGATGGGAAG AGCTGCTGTG ACTATGCTTT GCATGTGGAC 
ATCACCCACT GGAATGACAG CGTCAAGCAG GAGGTACAGA GCCTCAGCAA GGAAAAAGGC 
GTTAACTCCT TCATGGTTTA CATGGCCTAC AAGGATTTAT ATCAAGTGTC CAACACAGAG 
CTCTATGAGA TCTTCACCTG CCTGGGAGAG CTGGGGGCCA TTGCTCAAGT TCATGCCGAG 
AATGGAGATA TCATTGCCCA GGAGCAGGCA CGGATGCTGG AAATGGGGAT AACCGGCCCA 
GAAGGCCACG TTCTGAGCAG ACCGGAAGAG CTGGAAGCTG AGGCTGTGTT CCGTGCCATC 
ACCGTCGCCA GCCAGACCAA CTGCCCCCTC TATGTCACCA AGGTCATGAG CAAGAGCGCG 
GCTGATCTCA TCTCACAAGC CAGGAAGAAA GGAAATGTGG TCTTTGGCGA GCCCATCACT 
GCCAGCCTGG GAATAGATGG AACTCATTAC TGGAGTAAGA ACTGGGCCAA AGCAGCTGCG 
TTTGTGACAT CCCCACCTCT GAGCCCTGAC CCTACCACAC CTGACTACAT CAACTCCTTG 
CTGGCCAGCG GGGATCTGCA GCTCTCTGGA AGTGCCCACT GTACCTTTAG CACTGCCCAG 
AAAGCCATTG GGAAGGACAA CTTCACAGCC ATCCCTGAAG GCACCAATGG CGTGGAGGAG 
CGTATGTCTG TCATCTGGGA CAAGGCTGTG GCCACGGGGA AGATGGATGA AAACCAGTTT 
GTGGCCGTGA CAAGCACCAA TGCTGCCAAG ATATTCAACC TGTACCCTCG AAAGGGGAGA 
ATAGCTGTGG GCTCTGACAG CGACCTTGTC ATCTGGGATC CAGATGCCTT GAAGATTGTC 
TCTGCCAAGA ACCACCAGTC GGTTGCCGAA TACAACATCT TTGAAGGGAT GGAGCTGCGT 
GGTGCACCTC TGGTGGTTAT CTGCCAGGGC AAGATCATGC TGGAAGATGG CAACCTGCAC 
GTGACCCAGG GGGCTGGCCG CTTCATTCCC TGCAGCCCAT TCTCTGACTA TGTCTATAAG 
CGCATTAAAG CAAGGAGGAA GATGGCAGAC CTGCATGCAG TCCCAAGAGG CATGTATGAT 
GGACCAGTGT TTGACTTGAC CACCACCCCC AAGGGGGGCA CCCCAGCTGG CTCTACTCGG 
GGCTCTCCCA CTCGGCCAAA CCCGCCAGTG AGGAACCTCC ATCAGTCAGG ATTTAGCCTG 
TCAGGCACCC AAGTGGATGA GGGTGTCCGC TCAGCTAGCA AACGCATTGT GGCACCCCCT 
GGAGGCCGTT CTAACATCAC ATCCCTGAGT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033494.1
CDS	350..2062
Translation	MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQSLSKEKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQVHAENGDIIAQEQARMLEMGITGPEGHVLSRPEELEAEAVFRAITVASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDSDLVIWDPDALKIVSAKNHQSVAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSTRGSPTRPNPPVRNLHQSGFSLSGTQVDEGVRSASKRIVAPPGGRSNITSLS

Target ORF information:

RefSeq Version	NM_009468.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus dihydropyrimidinase-like 3 (Dpysl3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009468.5

ORF Insert Sequence:

ATGTCCTACC AGGGCAAGAA GAACATTCCG CGGATCACGA GTGACCGTCT TCTAATCAAG 
GGAGGGAGAA TCGTCAATGA TGATCAGTCC TTTTATGCTG ATATTTACAT GGAGGATGGC 
TTAATAAAGC AAATTGGAGA CAATCTGATT GTCCCCGGAG GTGTGAAGAC CATCGAGGCC 
AACGGGAAGA TGGTGATCCC TGGAGGCATT GACGTCCATA CCCACTTCCA GATGCCTTAC 
AAGGGAATGA CCACAGTGGA CGATTTCTTC CAAGGGACAA AGGCTGCCTT AGCGGGAGGC 
ACCACCATGA TCATTGACCA CGTGGTACCT GAACCTGAGT CTAGCCTGAC AGAGGCCTAT 
GAAAAGTGGC GTGAGTGGGC CGATGGGAAG AGCTGCTGTG ACTATGCTTT GCATGTGGAC 
ATCACCCACT GGAATGACAG CGTCAAGCAG GAGGTACAGA GCCTCAGCAA GGAAAAAGGC 
GTTAACTCCT TCATGGTTTA CATGGCCTAC AAGGATTTAT ATCAAGTGTC CAACACAGAG 
CTCTATGAGA TCTTCACCTG CCTGGGAGAG CTGGGGGCCA TTGCTCAAGT TCATGCCGAG 
AATGGAGATA TCATTGCCCA GGAGCAGGCA CGGATGCTGG AAATGGGGAT AACCGGCCCA 
GAAGGCCACG TTCTGAGCAG ACCGGAAGAG CTGGAAGCTG AGGCTGTGTT CCGTGCCATC 
ACCGTCGCCA GCCAGACCAA CTGCCCCCTC TATGTCACCA AGGTCATGAG CAAGAGCGCG 
GCTGATCTCA TCTCACAAGC CAGGAAGAAA GGAAATGTGG TCTTTGGCGA GCCCATCACT 
GCCAGCCTGG GAATAGATGG AACTCATTAC TGGAGTAAGA ACTGGGCCAA AGCAGCTGCG 
TTTGTGACAT CCCCACCTCT GAGCCCTGAC CCTACCACAC CTGACTACAT CAACTCCTTG 
CTGGCCAGCG GGGATCTGCA GCTCTCTGGA AGTGCCCACT GTACCTTTAG CACTGCCCAG 
AAAGCCATTG GGAAGGACAA CTTCACAGCC ATCCCTGAAG GCACCAATGG CGTGGAGGAG 
CGTATGTCTG TCATCTGGGA CAAGGCTGTG GCCACGGGGA AGATGGATGA AAACCAGTTT 
GTGGCCGTGA CAAGCACCAA TGCTGCCAAG ATATTCAACC TGTACCCTCG AAAGGGGAGA 
ATAGCTGTGG GCTCTGACAG CGACCTTGTC ATCTGGGATC CAGATGCCTT GAAGATTGTC 
TCTGCCAAGA ACCACCAGTC GGTTGCCGAA TACAACATCT TTGAAGGGAT GGAGCTGCGT 
GGTGCACCTC TGGTGGTTAT CTGCCAGGGC AAGATCATGC TGGAAGATGG CAACCTGCAC 
GTGACCCAGG GGGCTGGCCG CTTCATTCCC TGCAGCCCAT TCTCTGACTA TGTCTATAAG 
CGCATTAAAG CAAGGAGGAA GATGGCAGAC CTGCATGCAG TCCCAAGAGG CATGTATGAT 
GGACCAGTGT TTGACTTGAC CACCACCCCC AAGGGGGGCA CCCCAGCTGG CTCTACTCGG 
GGCTCTCCCA CTCGGCCAAA CCCGCCAGTG AGGAACCTCC ATCAGTCAGG ATTTAGCCTG 
TCAGGCACCC AAGTGGATGA GGGTGTCCGC TCAGCTAGCA AACGCATTGT GGCACCCCCT 
GGAGGCCGTT CTAACATCAC ATCCCTGAGT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism.
Scientific reports7(1)16812(2017 Dec)
Tsutiya A,Nakano Y,Hansen-Kiss E,Kelly B,Nishihara M,Goshima Y,Corsmeier D,White P,Herman GE,Ohtani-Kaneko R

CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research32(5)913-926(2017 May)
Abdallah BM,Figeac F,Larsen KH,Ditzel N,Keshari P,Isa A,Jafari A,Andersen TL,Delaisse JM,Goshima Y,Ohshima T,Kassem M

CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain.
Brain research1655161-167(2017 01)
Takaya R,Nagai J,Piao W,Niisato E,Nakabayashi T,Yamazaki Y,Nakamura F,Yamashita N,Kolattukudy P,Goshima Y,Ohshima T

A rare motor neuron deleterious missense mutation in the DPYSL3 (CRMP4) gene is associated with ALS.
Human mutation34(7)953-60(2013 Jul)
Blasco H,Bernard-Marissal N,Vourc'h P,Guettard YO,Sunyach C,Augereau O,Khederchah J,Mouzat K,Antar C,Gordon PH,Veyrat-Durebex C,Besson G,Andersen PM,Salachas F,Meininger V,Camu W,Pettmann B,Andres CR,Corcia P,

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Dpysl3 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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