Tub cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tub
Entrez Gene ID	22141
Full Name	tubby bipartite transcription factor
Synonyms	rd5,tub
General protein information	Preferred Names tubby bipartite transcription factor Names tubby protein retinal degeneration 5 tubby candidate
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 E3\|7 57.21 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_021885.4	NP_068685.1	tubby protein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TUB	XP_005633682.1
Mus musculus (house mouse)	Tub	NP_068685.1
Gallus gallus (chicken)	TUB	XP_420992.3
Oryza sativa (rice)	Os03g0351400	NP_001050117.1
Xenopus tropicalis (tropical clawed frog)	tub	NP_001007493.1
	TUB	XP_002799697.1
Rattus norvegicus (Norway rat)	Tub	NP_037209.1
Caenorhabditis elegans (roundworm)	tub-1	NP_495710.1
Homo sapiens (human)	TUB	NP_003311.2
Pan troglodytes (chimpanzee)	TUB	XP_003312952.1
Bos taurus (cattle)	TUB	NP_001179089.1
Danio rerio (zebrafish)	tub	XP_005172409.1

Gene Ontology
Bibliography

Related articles in PubMed

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
Badgandi HB, Hwang SH, Shimada IS, Loriot E, Mukhopadhyay S
The Journal of cell biology216(3)743-760(2017 Mar)

C-terminally mutated tubby protein accumulates in aggresomes.
Kim S, Sung HJ, Lee JW, Kim YH, Oh YS, Yoon KA, Heo K, Suh PG
BMB reports50(1)37-42(2017 Jan)

Correlation of ER stress and retinal degeneration in tubby mice.
Cai X, Chen L, McGinnis JF
Experimental eye research140130-138(2015 Nov)

Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia.
Loktev AV, Jackson PK
Cell reports5(5)1316-29(2013 Dec)

Characterization of a novel genetically obese mouse model demonstrating early onset hyperphagia and hyperleptinemia.
Nakahara K, Bannai M, Maruyama K, Suzuki Y, Okame R, Murakami N
American journal of physiology. Endocrinology and metabolism305(3)E451-63(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We found that the mutant Tub proteins were mostly localized to puncta found in the perinuclear region and that the C-terminus was important for its solubility. our results suggest that the malfunctions of the Tub mutant are caused by its misfolding and subsequent localization to aggresomes.
Title: C-terminally mutated tubby protein accumulates in aggresomes.

These results suggest that tubby is a ligand to facilitate microglial phagocytosis through MerTK for the maintenance of CNS homeostasis.
Title: Tubby regulates microglial phagocytosis through MerTK.

Mtap1a, which modifies hearing loss in Tub(tub/tub) mice, also modifies retinal degeneration in Tub and Tulp1 mice; functionally nonredundant members of the TULP family (TUB and TULP1) share a common functional interaction with MTAP1A
Title: An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice.

Tubby and Tulp1 function as phagocytosis sigmals (eat-me) for retinal pigment epithelium cells and other phagocytes.
Title: Identification of tubby and tubby-like protein 1 as eat-me signals by phage display.

TUB plays a role in insulin signalling and fuel homeostasis in adipocytes.
Title: Expression and modulation of TUB by insulin and thyroid hormone in primary rat and murine 3T3-L1 adipocytes.

The following Tub gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tub cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22226	NM_021885.4 Latest version!	Mus musculus tubby bipartite transcription factor (Tub), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$300.30 $429.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tub ( NM_021885.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_068685.1 Mus musculus tubby bipartite transcription factor (Tub), mRNA.

Price & Availability↑

CloneID	OMu22226
Clone ID Related Accession (Same CDS sequence)	NM_021885.4
Accession Version	NM_021885.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1518bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-07
Organism	Mus musculus(house mouse)
Product	tubby protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK147700.1 and BC096554.1. On Dec 23, 2005 this sequence version replaced NM_021885.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147700.1, BC096554.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849379 [ECO:0000348] ##Evidence-Data-END##

ATGACTTCCA AGCCGCATTC CGACTGGATT CCTTACAGTG TCCTAGATGA TGAGGGCAGC 
AACCTGAGGC AGCAGAAGCT CGACCGGCAG CGGGCCCTGT TGGAACAGAA GCAGAAGAAG 
AAGCGCCAAG AGCCCTTGAT GGTACAGGCC AATGCAGATG GACGGCCCCG GAGTCGGCGA 
GCCCGGCAGT CAGAGGAGCA AGCCCCCCTG GTGGAGTCCT ACCTCAGCAG CAGTGGCAGC 
ACCAGCTACC AAGTTCAAGA GGCCGACTCG ATTGCCAGTG TACAGCTGGG AGCCACCCGC 
CCACCAGCAC CAGCCTCAGC CAAGAAATCC AAGGGAGCGG CTGCATCTGG GGGCCAGGGT 
GGAGCCCCTA GGAAGGAGAA GAAGGGAAAG CATAAAGGCA CCAGCGGGCC AGCAACTCTG 
GCAGAAGACA AGTCTGAGGC CCAAGGCCCA GTGCAGATCT TGACTGTGGG ACAGTCAGAC 
CACGACAAGG ATGCGGGAGA GACAGCAGCC GGCGGGGGCG CACAGCCCAG TGGGCAGGAC 
CTCCGTGCCA CGATGCAGAG GAAGGGCATC TCCAGCAGCA TGAGCTTTGA CGAGGACGAG 
GATGAGGATG AAAACAGCTC CAGCTCCTCC CAGCTAAACA GCAACACCCG CCCTAGTTCT 
GCCACTAGCA GAAAGTCCAT CCGGGAGGCA GCTTCAGCCC CCAGCCCAGC CGCCCCAGAG 
CCACCAGTGG ATATTGAGGT CCAGGATCTA GAGGAGTTTG CACTGAGGCC AGCCCCACAA 
GGGATCACCA TCAAATGCCG CATCACTCGG GACAAGAAGG GGATGGACCG CGGCATGTAC 
CCCACCTACT TTCTGCACCT AGACCGTGAG GATGGCAAGA AGGTGTTCCT CCTGGCGGGC 
AGGAAGAGAA AGAAGAGTAA AACTTCCAAT TACCTCATCT CTGTGGACCC AACAGACTTG 
TCTCGGGGAG GCGATAGCTA TATCGGGAAA TTGCGGTCCA ACCTGATGGG CACCAAGTTC 
ACCGTTTATG ACAATGGCGT CAACCCTCAG AAGGCATCCT CTTCCACGCT GGAAAGCGGA 
ACCTTGCGCC AGGAGCTGGC AGCGGTGTGC TATGAGACAA ATGTCCTAGG CTTCAAGGGA 
CCTCGGAAGA TGAGTGTGAT CGTCCCAGGC ATGAACATGG TTCATGAGAG AGTCTGTATC 
CGCCCCCGCA ATGAACATGA GACCCTGTTA GCACGCTGGC AGAACAAGAA CACGGAGAGC 
ATCATTGAGC TGCAGAACAA GACGCCAGTC TGGAATGATG ACACACAGTC CTATGTACTT 
AACTTCCACG GCCGTGTCAC ACAGGCTTCT GTGAAGAACT TCCAGATCAT CCACGGCAAT 
GACCCGGACT ACATCGTCAT GCAGTTTGGC CGGGTAGCAG AAGATGTGTT CACCATGGAT 
TACAACTACC CACTGTGTGC ACTGCAGGCC TTTGCCATTG CTCTGTCCAG CTTTGACAGC 
AAGCTGGCCT GCGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068685.1
CDS	222..1739
Translation	MTSKPHSDWIPYSVLDDEGSNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSIASVQLGATRPPAPASAKKSKGAAASGGQGGAPRKEKKGKHKGTSGPATLAEDKSEAQGPVQILTVGQSDHDKDAGETAAGGGAQPSGQDLRATMQRKGISSSMSFDEDEDEDENSSSSSQLNSNTRPSSATSRKSIREAASAPSPAAPEPPVDIEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVCIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE

Target ORF information:

RefSeq Version	NM_021885.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus tubby bipartite transcription factor (Tub), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021885.4

ORF Insert Sequence:

ATGACTTCCA AGCCGCATTC CGACTGGATT CCTTACAGTG TCCTAGATGA TGAGGGCAGC 
AACCTGAGGC AGCAGAAGCT CGACCGGCAG CGGGCCCTGT TGGAACAGAA GCAGAAGAAG 
AAGCGCCAAG AGCCCTTGAT GGTACAGGCC AATGCAGATG GACGGCCCCG GAGTCGGCGA 
GCCCGGCAGT CAGAGGAGCA AGCCCCCCTG GTGGAGTCCT ACCTCAGCAG CAGTGGCAGC 
ACCAGCTACC AAGTTCAAGA GGCCGACTCG ATTGCCAGTG TACAGCTGGG AGCCACCCGC 
CCACCAGCAC CAGCCTCAGC CAAGAAATCC AAGGGAGCGG CTGCATCTGG GGGCCAGGGT 
GGAGCCCCTA GGAAGGAGAA GAAGGGAAAG CATAAAGGCA CCAGCGGGCC AGCAACTCTG 
GCAGAAGACA AGTCTGAGGC CCAAGGCCCA GTGCAGATCT TGACTGTGGG ACAGTCAGAC 
CACGACAAGG ATGCGGGAGA GACAGCAGCC GGCGGGGGCG CACAGCCCAG TGGGCAGGAC 
CTCCGTGCCA CGATGCAGAG GAAGGGCATC TCCAGCAGCA TGAGCTTTGA CGAGGACGAG 
GATGAGGATG AAAACAGCTC CAGCTCCTCC CAGCTAAACA GCAACACCCG CCCTAGTTCT 
GCCACTAGCA GAAAGTCCAT CCGGGAGGCA GCTTCAGCCC CCAGCCCAGC CGCCCCAGAG 
CCACCAGTGG ATATTGAGGT CCAGGATCTA GAGGAGTTTG CACTGAGGCC AGCCCCACAA 
GGGATCACCA TCAAATGCCG CATCACTCGG GACAAGAAGG GGATGGACCG CGGCATGTAC 
CCCACCTACT TTCTGCACCT AGACCGTGAG GATGGCAAGA AGGTGTTCCT CCTGGCGGGC 
AGGAAGAGAA AGAAGAGTAA AACTTCCAAT TACCTCATCT CTGTGGACCC AACAGACTTG 
TCTCGGGGAG GCGATAGCTA TATCGGGAAA TTGCGGTCCA ACCTGATGGG CACCAAGTTC 
ACCGTTTATG ACAATGGCGT CAACCCTCAG AAGGCATCCT CTTCCACGCT GGAAAGCGGA 
ACCTTGCGCC AGGAGCTGGC AGCGGTGTGC TATGAGACAA ATGTCCTAGG CTTCAAGGGA 
CCTCGGAAGA TGAGTGTGAT CGTCCCAGGC ATGAACATGG TTCATGAGAG AGTCTGTATC 
CGCCCCCGCA ATGAACATGA GACCCTGTTA GCACGCTGGC AGAACAAGAA CACGGAGAGC 
ATCATTGAGC TGCAGAACAA GACGCCAGTC TGGAATGATG ACACACAGTC CTATGTACTT 
AACTTCCACG GCCGTGTCAC ACAGGCTTCT GTGAAGAACT TCCAGATCAT CCACGGCAAT 
GACCCGGACT ACATCGTCAT GCAGTTTGGC CGGGTAGCAG AAGATGTGTT CACCATGGAT 
TACAACTACC CACTGTGTGC ACTGCAGGCC TTTGCCATTG CTCTGTCCAG CTTTGACAGC 
AAGCTGGCCT GCGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
The Journal of cell biology216(3)743-760(2017 Mar)
Badgandi HB,Hwang SH,Shimada IS,Loriot E,Mukhopadhyay S

C-terminally mutated tubby protein accumulates in aggresomes.
BMB reports50(1)37-42(2017 Jan)
Kim S,Sung HJ,Lee JW,Kim YH,Oh YS,Yoon KA,Heo K,Suh PG

Correlation of ER stress and retinal degeneration in tubby mice.
Experimental eye research140130-138(2015 Nov)
Cai X,Chen L,McGinnis JF

Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia.
Cell reports5(5)1316-29(2013 Dec)
Loktev AV,Jackson PK

Characterization of a novel genetically obese mouse model demonstrating early onset hyperphagia and hyperleptinemia.
American journal of physiology. Endocrinology and metabolism305(3)E451-63(2013 Aug)
Nakahara K,Bannai M,Maruyama K,Suzuki Y,Okame R,Murakami N

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Tub cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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