Tsn cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tsn
Entrez Gene ID	22099
Full Name	translin
Synonyms	2610034C24Rik,AU040286,C3PO,TB-RBP
General protein information	Preferred Names translin Names translin component 3 of promoter of RISC testis/brain-RNA-binding protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 E2.3

mRNA and Protein(s)

mRNA	Protein	Name
XM_030252998.1	XP_030108858.1	translin isoform X1
NM_011650.4	NP_035780.1	translin
NM_011650.3	NP_035780.1	translin

Pathways from BioSystems

Homologies

Homo sapiens (human)	TSN	NP_004613.1
	TSN	XP_001085908.1
Bos taurus (cattle)	TSN	NP_001068890.1
Gallus gallus (chicken)	TSN	NP_990404.1
Neurospora crassa	NCU06664	XP_960911.1
Pan troglodytes (chimpanzee)	TSN	XP_515770.1
Mus musculus (house mouse)	Tsn	NP_035780.1
Arabidopsis thaliana (thale cress)	AT2G37020	NP_565857.2
Danio rerio (zebrafish)	tsn	NP_001020623.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005538	XP_315537.4
Magnaporthe oryzae (rice blast fungus)	MGG_05995	XP_003711841.1
Xenopus tropicalis (tropical clawed frog)	mllt4	NP_001007517.1
Canis lupus familiaris (dog)	TSN	XP_003639748.1
Rattus norvegicus (Norway rat)	Tsn	NP_068530.1
Schizosaccharomyces pombe (fission yeast)	tsn1	NP_594557.2
Oryza sativa (rice)	Os10g0443200	NP_001064703.1
Drosophila melanogaster (fruit fly)	trsn	NP_610591.1

Gene Ontology
Bibliography

Related articles in PubMed

Learning induces the translin/trax RNase complex to express activin receptors for persistent memory.
Park AJ, Havekes R, Fu X, Hansen R, Tudor JC, Peixoto L, Li Z, Wu YC, Poplawski SG, Baraban JM, Abel T
eLife6(2017 Sep)

Rescuing dicer defects via inhibition of an anti-dicing nuclease.
Asada K, Canestrari E, Fu X, Li Z, Makowski E, Wu YC, Mito JK, Kirsch DG, Baraban J, Paroo Z
Cell reports9(4)1471-81(2014 Nov)

Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms.
Wu YC, Williamson R, Li Z, Vicario A, Xu J, Kasai M, Chern Y, Tongiorgi E, Baraban JM
Journal of neurochemistry116(6)1112-21(2011 Mar)

Analysis of nucleic acid binding by a recombinant translin-trax complex.
Lluis M, Hoe W, Schleit J, Robertus J
Biochemical and biophysical research communications396(3)709-13(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings indicate that miRNA depletion in dicer deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.
Title: Rescuing dicer defects via inhibition of an anti-dicing nuclease.

These in vivo and in vitro findings of this study indicated that dendritic trafficking of BDNF mRNA can be mediated by both translin-dependent and -independent mechanisms.
Title: Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms.

trax acts to regulate translin's RNA and DNA binding affinities as part of a cellular RNA trafficking mechanism.
Title: Analysis of nucleic acid binding by a recombinant translin-trax complex.

Findings implicate abnormal dendritic trafficking of BDNF mRNA in the pathophysiology of neuropsychiatric disorders linked to the translin G196A mutation.
Title: Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation.

The binding of TSN to miR-122a increases its in vivo stability, suggesting an additional posttranscriptional function for TSN
Title: The DNA/RNA-binding protein, translin, binds microRNA122a and increases its in vivo stability.

The following Tsn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tsn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu08525	NM_011650.4 Latest version!	Mus musculus translin (Tsn), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu85111	XM_030252998.1 Latest version!	Mus musculus translin (Tsn), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu08525	NM_011650.3	Mus musculus translin (Tsn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tsn ( NM_011650.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035780.1 Mus musculus translin (Tsn), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu08525
Clone ID Related Accession (Same CDS sequence)	NM_011650.4 , NM_011650.3
Accession Version	NM_011650.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Mus musculus(house mouse)
Product	translin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC121531.10 and CX243508.1. On Feb 16, 2018 this sequence version replaced NM_011650.3. Transcript Variant: This variant (1) represents the longer, protein-coding variant. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK165598.1, AF234179.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164133, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTGTGA GCGAGATCTT CGTGGAGCTG CAGGGCTTTT TGGCTGCCGA GCAGGACATC 
CGAGAGGAAA TACGAAAAGT TGTACAGAGT TTAGAACAAA CTGCTCGAGA GATTTTGACC 
CTACTTCAAG GGGTCCACCA GGGTACTGGA TTTCAGGACA TTCCAAAGAG GTGCTTGAAA 
GCGAGAGAAC ATTTCAGTAC AGTAAAAACA CATCTCACGT CCCTGAAGAC CAAGTTCCCC 
GCTGAGCAGT ATTACAGGTT TCATGAGCAT TGGCGGTTCG TGCTTCAGCG CCTGGTCTTC 
CTGGCAGCAT TTGTGGTATA TTTGGAAACA GAGACCCTGG TGACCCGAGA GGCTGTTACA 
GAGATTCTTG GCATTGAACC AGATCGGGAA AAAGGGTTTC ATCTGGATGT GGAAGATTAT 
CTCTCAGGAG TTTTAATTCT TGCCAGTGAA CTGTCGAGGC TGTCTGTCAA CAGTGTCACT 
GCTGGAGACT ACTCTCGGCC CCTTCACATT TCTACTTTCA TCAATGAGCT GGATTCTGGT 
TTTCGTCTTC TCAATCTGAA AAATGACTCC CTGAGGAAGC GCTACGACGG CTTGAAGTAC 
GATGTGAAGA AAGTAGAGGA GGTGGTCTAT GACCTTTCCA TCCGAGGCTT CAATAAGGAG 
ACAGCAGCGG CTTGTGGTGA AAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035780.1
CDS	281..967
Translation	MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQDIPKRCLKAREHFSTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFNKETAAACGEK

Target ORF information:

RefSeq Version	NM_011650.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus translin (Tsn), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011650.4

ORF Insert Sequence:

ATGTCTGTGA GCGAGATCTT CGTGGAGCTG CAGGGCTTTT TGGCTGCCGA GCAGGACATC 
CGAGAGGAAA TACGAAAAGT TGTACAGAGT TTAGAACAAA CTGCTCGAGA GATTTTGACC 
CTACTTCAAG GGGTCCACCA GGGTACTGGA TTTCAGGACA TTCCAAAGAG GTGCTTGAAA 
GCGAGAGAAC ATTTCAGTAC AGTAAAAACA CATCTCACGT CCCTGAAGAC CAAGTTCCCC 
GCTGAGCAGT ATTACAGGTT TCATGAGCAT TGGCGGTTCG TGCTTCAGCG CCTGGTCTTC 
CTGGCAGCAT TTGTGGTATA TTTGGAAACA GAGACCCTGG TGACCCGAGA GGCTGTTACA 
GAGATTCTTG GCATTGAACC AGATCGGGAA AAAGGGTTTC ATCTGGATGT GGAAGATTAT 
CTCTCAGGAG TTTTAATTCT TGCCAGTGAA CTGTCGAGGC TGTCTGTCAA CAGTGTCACT 
GCTGGAGACT ACTCTCGGCC CCTTCACATT TCTACTTTCA TCAATGAGCT GGATTCTGGT 
TTTCGTCTTC TCAATCTGAA AAATGACTCC CTGAGGAAGC GCTACGACGG CTTGAAGTAC 
GATGTGAAGA AAGTAGAGGA GGTGGTCTAT GACCTTTCCA TCCGAGGCTT CAATAAGGAG 
ACAGCAGCGG CTTGTGGTGA AAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tsn ( NM_011650.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035780.1 Mus musculus translin (Tsn), mRNA.

Price & Availability↑

CloneID	OMu08525
Clone ID Related Accession (Same CDS sequence)	NM_011650.4 , NM_011650.3
Accession Version	NM_011650.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-16
Organism	Mus musculus(house mouse)
Product	translin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC121531.10. On Nov 17, 2006 this sequence version replaced NM_011650.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF234179.1, AK165598.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164133, SAMN01164135 [ECO:0000348] ##Evidence-Data-END##

ATGTCTGTGA GCGAGATCTT CGTGGAGCTG CAGGGCTTTT TGGCTGCCGA GCAGGACATC 
CGAGAGGAAA TACGAAAAGT TGTACAGAGT TTAGAACAAA CTGCTCGAGA GATTTTGACC 
CTACTTCAAG GGGTCCACCA GGGTACTGGA TTTCAGGACA TTCCAAAGAG GTGCTTGAAA 
GCGAGAGAAC ATTTCAGTAC AGTAAAAACA CATCTCACGT CCCTGAAGAC CAAGTTCCCC 
GCTGAGCAGT ATTACAGGTT TCATGAGCAT TGGCGGTTCG TGCTTCAGCG CCTGGTCTTC 
CTGGCAGCAT TTGTGGTATA TTTGGAAACA GAGACCCTGG TGACCCGAGA GGCTGTTACA 
GAGATTCTTG GCATTGAACC AGATCGGGAA AAAGGGTTTC ATCTGGATGT GGAAGATTAT 
CTCTCAGGAG TTTTAATTCT TGCCAGTGAA CTGTCGAGGC TGTCTGTCAA CAGTGTCACT 
GCTGGAGACT ACTCTCGGCC CCTTCACATT TCTACTTTCA TCAATGAGCT GGATTCTGGT 
TTTCGTCTTC TCAATCTGAA AAATGACTCC CTGAGGAAGC GCTACGACGG CTTGAAGTAC 
GATGTGAAGA AAGTAGAGGA GGTGGTCTAT GACCTTTCCA TCCGAGGCTT CAATAAGGAG 
ACAGCAGCGG CTTGTGGTGA AAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035780.1
CDS	67..753
Translation	MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQDIPKRCLKAREHFSTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFNKETAAACGEK

Target ORF information:

RefSeq Version	NM_011650.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus translin (Tsn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011650.3

ORF Insert Sequence:

ATGTCTGTGA GCGAGATCTT CGTGGAGCTG CAGGGCTTTT TGGCTGCCGA GCAGGACATC 
CGAGAGGAAA TACGAAAAGT TGTACAGAGT TTAGAACAAA CTGCTCGAGA GATTTTGACC 
CTACTTCAAG GGGTCCACCA GGGTACTGGA TTTCAGGACA TTCCAAAGAG GTGCTTGAAA 
GCGAGAGAAC ATTTCAGTAC AGTAAAAACA CATCTCACGT CCCTGAAGAC CAAGTTCCCC 
GCTGAGCAGT ATTACAGGTT TCATGAGCAT TGGCGGTTCG TGCTTCAGCG CCTGGTCTTC 
CTGGCAGCAT TTGTGGTATA TTTGGAAACA GAGACCCTGG TGACCCGAGA GGCTGTTACA 
GAGATTCTTG GCATTGAACC AGATCGGGAA AAAGGGTTTC ATCTGGATGT GGAAGATTAT 
CTCTCAGGAG TTTTAATTCT TGCCAGTGAA CTGTCGAGGC TGTCTGTCAA CAGTGTCACT 
GCTGGAGACT ACTCTCGGCC CCTTCACATT TCTACTTTCA TCAATGAGCT GGATTCTGGT 
TTTCGTCTTC TCAATCTGAA AAATGACTCC CTGAGGAAGC GCTACGACGG CTTGAAGTAC 
GATGTGAAGA AAGTAGAGGA GGTGGTCTAT GACCTTTCCA TCCGAGGCTT CAATAAGGAG 
ACAGCAGCGG CTTGTGGTGA AAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tsn ( XM_030252998.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030108858.1 Mus musculus translin (Tsn), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu85111
Clone ID Related Accession (Same CDS sequence)	XM_030252998.1
Accession Version	XM_030252998.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	translin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTGTGA GCGAGATCTT CGTGGAGCTG CAGGGCTTTT TGGCTGCCGA GCAGGACATC 
CGAGAGGAAA TACGAAAAGT TGTACAGAGT TTAGAACAAA CTGCTCGAGA GATTTTGACC 
CTACTTCAAG GGGTCCACCA GGGTACTGGA TTTCAGGACA TTCCAAAGAG GTGCTTGAAA 
GCGAGAGAAC ATTTCAGTAC AGTAAAAACA CATCTCACGT CCCTGAAGAC CAAGTTCCCC 
GCTGAGCAGT ATTACAGGTT TCATGAGCAT TGGCGGTTCG TGCTTCAGCG CCTGGTCTTC 
CTGGCAGCAT TTGTGGTATA TTTGGAAACA GAGACCCTGG TGACCCGAGA GGCTGTTACA 
GAGATTCTTG GCATCGAGGC TGTCTGTCAA CAGTGTCACT GCTGGAGACT ACTCTCGGCC 
CCTTCACATT TCTACTTTCA TCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030108858.1
CDS	396..842
Translation	MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQDIPKRCLKAREHFSTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEAVCQQCHCWRLLSAPSHFYFHQ

Target ORF information:

RefSeq Version	XM_030252998.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus translin (Tsn), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030252998.1

ORF Insert Sequence:

ATGTCTGTGA GCGAGATCTT CGTGGAGCTG CAGGGCTTTT TGGCTGCCGA GCAGGACATC 
CGAGAGGAAA TACGAAAAGT TGTACAGAGT TTAGAACAAA CTGCTCGAGA GATTTTGACC 
CTACTTCAAG GGGTCCACCA GGGTACTGGA TTTCAGGACA TTCCAAAGAG GTGCTTGAAA 
GCGAGAGAAC ATTTCAGTAC AGTAAAAACA CATCTCACGT CCCTGAAGAC CAAGTTCCCC 
GCTGAGCAGT ATTACAGGTT TCATGAGCAT TGGCGGTTCG TGCTTCAGCG CCTGGTCTTC 
CTGGCAGCAT TTGTGGTATA TTTGGAAACA GAGACCCTGG TGACCCGAGA GGCTGTTACA 
GAGATTCTTG GCATCGAGGC TGTCTGTCAA CAGTGTCACT GCTGGAGACT ACTCTCGGCC 
CCTTCACATT TCTACTTTCA TCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Learning induces the translin/trax RNase complex to express activin receptors for persistent memory.
eLife6(2017 Sep)
Park AJ,Havekes R,Fu X,Hansen R,Tudor JC,Peixoto L,Li Z,Wu YC,Poplawski SG,Baraban JM,Abel T

Rescuing dicer defects via inhibition of an anti-dicing nuclease.
Cell reports9(4)1471-81(2014 Nov)
Asada K,Canestrari E,Fu X,Li Z,Makowski E,Wu YC,Mito JK,Kirsch DG,Baraban J,Paroo Z

Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms.
Journal of neurochemistry116(6)1112-21(2011 Mar)
Wu YC,Williamson R,Li Z,Vicario A,Xu J,Kasai M,Chern Y,Tongiorgi E,Baraban JM

Analysis of nucleic acid binding by a recombinant translin-trax complex.
Biochemical and biophysical research communications396(3)709-13(2010 Jun)
Lluis M,Hoe W,Schleit J,Robertus J

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Tsn cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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