THRSP cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	THRSP
Entrez Gene ID	21835
Full Name	thyroid hormone responsive
Synonyms	S14,SPOT14
General protein information	Preferred Names thyroid hormone responsive Names thyroid hormone-inducible hepatic protein spot 14 protein thyroid hormone responsive SPOT14 homolog
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 7 Map Location: 7\|7 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_009381.3	NP_033407.1	thyroid hormone-inducible hepatic protein
NM_009381.2	NP_033407.1	thyroid hormone-inducible hepatic protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	THRSP	XP_522120.1
Rattus norvegicus (Norway rat)	Thrsp	NP_036835.2
	THRSP	XP_001092657.1
Mus musculus (house mouse)	Thrsp	NP_033407.1
Homo sapiens (human)	THRSP	NP_003242.1
Canis lupus familiaris (dog)	THRSP	XP_005633501.1
Bos taurus (cattle)	THRSP	NP_001035623.1

Gene Ontology
Bibliography

Related articles in PubMed

SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer.
Suresh S, Durakoglugil D, Zhou X, Zhu B, Comerford SA, Xing C, Xie XJ, York B, O'Donnell KA
PLoS genetics13(3)e1006650(2017 Mar)

Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
Fonseca TL, Fernandes GW, McAninch EA, Bocco BM, Abdalla SM, Ribeiro MO, Moh?csik P, Fekete C, Li D, Xing X, Wang T, Gereben B, Bianco AC
Proceedings of the National Academy of Sciences of the United States of America112(45)14018-23(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

S14 has a potential role in regulating mammary tumor growth and fatty acid synthesis in vivo. Modulating the amount of medium chain fatty acids, by changing the levels of S14, has the potential to impact malignant mammary tumor phenotypes.
Title: Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis.

Data indicate SPOT14 as a potent marker for adult NSPCs that react dynamically to positive and negative neurogenic regulators.
Title: SPOT14-positive neural stem/progenitor cells in the hippocampus respond dynamically to neurogenic regulators.

These findings implicate Spot14 as a direct protein enhancer of FASN catalysis in the mammary gland during lactation when maximal MCFA production is needed.
Title: Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium.

Thyroid hormone-responsive SPOT 14 homolog promotes hepatic lipogenesis, and its expression is regulated by liver X receptor alpha through a sterol regulatory element-binding protein 1c-dependent mechanism in mice.
Title: Thyroid hormone-responsive SPOT 14 homolog promotes hepatic lipogenesis, and its expression is regulated by liver X receptor ? through a sterol regulatory element-binding protein 1c-dependent mechanism in mice.

The structure of S14 suggests a mechanism whereby heterodimer formation with MIG12 attenuates the ability of MIG12 to activate ACC.
Title: Crystal structure of Spot 14, a modulator of fatty acid synthesis.

The following THRSP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the THRSP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04048	NM_009381.2 Latest version!	Mus musculus thyroid hormone responsive (Thrsp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu76899	NM_009381.3 Latest version!	Mus musculus thyroid hormone responsive (Thrsp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

THRSP ( NM_009381.2 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_033407.1 Mus musculus thyroid hormone responsive (Thrsp), mRNA.

Price & Availability↑

CloneID	OMu04048
Clone ID Related Accession (Same CDS sequence)	NM_009381.2
Accession Version	NM_009381.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	thyroid hormone-inducible hepatic protein
Comment

ATGCAAGTGC TAACGAAACG CTATCCCAAG AACTGCCTGC TGACAGTCAT GGATCGGTAC 
TCCGCGGTGG TGCGGAACAT GGAGCAGGTG GTGATGATCC CCAGCCTTCT GAGGGATGTG 
CAGCTGAGTG GGCCTGGGGG CTCGGTCCAG GACGGAGCCC CTGATCTCTA TACCTACTTC 
ACCATGCTCA AGAGCATCTG TGTAGAAGTG GACCACGGGC TGCTGCCAAG GGAGGAATGG 
CAGGCCAAGG TGGCTGGCAA CGAAACCAGC GAGGCTGAGA ACGACGCTGC TGAAACGGAG 
GAGGCCGAAG AAGACAGGAT CTCGGAGGAG CTGGACCTAG AAGCCCAGTT CCACCTGCAC 
TTCTGCAGCC TCCATCACAT CCTTACCCAC CTGACCCGGA AAGCACAGGA GGTGACGCGG 
AAATACCAGG AAATGACAGG GCAGGTCCTG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033407.1
Translation	MQVLTKRYPKNCLLTVMDRYSAVVRNMEQVVMIPSLLRDVQLSGPGGSVQDGAPDLYTYFTMLKSICVEVDHGLLPREEWQAKVAGNETSEAENDAAETEEAEEDRISEELDLEAQFHLHFCSLHHILTHLTRKAQEVTRKYQEMTGQVL

Target ORF information:

RefSeq Version	NM_009381.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus thyroid hormone responsive (Thrsp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009381.2

ORF Insert Sequence:

ATGCAAGTGC TAACGAAACG CTATCCCAAG AACTGCCTGC TGACAGTCAT GGATCGGTAC 
TCCGCGGTGG TGCGGAACAT GGAGCAGGTG GTGATGATCC CCAGCCTTCT GAGGGATGTG 
CAGCTGAGTG GGCCTGGGGG CTCGGTCCAG GACGGAGCCC CTGATCTCTA TACCTACTTC 
ACCATGCTCA AGAGCATCTG TGTAGAAGTG GACCACGGGC TGCTGCCAAG GGAGGAATGG 
CAGGCCAAGG TGGCTGGCAA CGAAACCAGC GAGGCTGAGA ACGACGCTGC TGAAACGGAG 
GAGGCCGAAG AAGACAGGAT CTCGGAGGAG CTGGACCTAG AAGCCCAGTT CCACCTGCAC 
TTCTGCAGCC TCCATCACAT CCTTACCCAC CTGACCCGGA AAGCACAGGA GGTGACGCGG 
AAATACCAGG AAATGACAGG GCAGGTCCTG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THRSP ( NM_009381.3 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_033407.1 Mus musculus thyroid hormone responsive (Thrsp), mRNA.

Price & Availability↑

CloneID	OMu76899
Clone ID Related Accession (Same CDS sequence)	NM_009381.3
Accession Version	NM_009381.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-22
Organism	Mus musculus(house mouse)
Product	thyroid hormone-inducible hepatic protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC172193.2, BY238050.1, AK077300.1 and AI117155.1. On Nov 25, 2015 this sequence version replaced NM_009381.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ266831.1, BC009165.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAAGTGC TAACGAAACG CTATCCCAAG AACTGCCTGC TGACAGTCAT GGATCGGTAC 
TCCGCGGTGG TGCGGAACAT GGAGCAGGTG GTGATGATCC CCAGCCTTCT GAGGGATGTG 
CAGCTGAGTG GGCCTGGGGG CTCGGTCCAG GACGGAGCCC CTGATCTCTA TACCTACTTC 
ACCATGCTCA AGAGCATCTG TGTAGAAGTG GACCACGGGC TGCTGCCAAG GGAGGAATGG 
CAGGCCAAGG TGGCTGGCAA CGAAACCAGC GAGGCTGAGA ACGACGCTGC TGAAACGGAG 
GAGGCCGAAG AAGACAGGAT CTCGGAGGAG CTGGACCTAG AAGCCCAGTT CCACCTGCAC 
TTCTGCAGCC TCCATCACAT CCTTACCCAC CTGACCCGGA AAGCACAGGA GGTGACGCGG 
AAATACCAGG AAATGACAGG GCAGGTTCTG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033407.1
CDS	48..500
Translation	MQVLTKRYPKNCLLTVMDRYSAVVRNMEQVVMIPSLLRDVQLSGPGGSVQDGAPDLYTYFTMLKSICVEVDHGLLPREEWQAKVAGNETSEAENDAAETEEAEEDRISEELDLEAQFHLHFCSLHHILTHLTRKAQEVTRKYQEMTGQVL

Target ORF information:

RefSeq Version	NM_009381.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus thyroid hormone responsive (Thrsp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009381.3

ORF Insert Sequence:

ATGCAAGTGC TAACGAAACG CTATCCCAAG AACTGCCTGC TGACAGTCAT GGATCGGTAC 
TCCGCGGTGG TGCGGAACAT GGAGCAGGTG GTGATGATCC CCAGCCTTCT GAGGGATGTG 
CAGCTGAGTG GGCCTGGGGG CTCGGTCCAG GACGGAGCCC CTGATCTCTA TACCTACTTC 
ACCATGCTCA AGAGCATCTG TGTAGAAGTG GACCACGGGC TGCTGCCAAG GGAGGAATGG 
CAGGCCAAGG TGGCTGGCAA CGAAACCAGC GAGGCTGAGA ACGACGCTGC TGAAACGGAG 
GAGGCCGAAG AAGACAGGAT CTCGGAGGAG CTGGACCTAG AAGCCCAGTT CCACCTGCAC 
TTCTGCAGCC TCCATCACAT CCTTACCCAC CTGACCCGGA AAGCACAGGA GGTGACGCGG 
AAATACCAGG AAATGACAGG GCAGGTTCTG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer.
PLoS genetics13(3)e1006650(2017 Mar)
Suresh S,Durakoglugil D,Zhou X,Zhu B,Comerford SA,Xing C,Xie XJ,York B,O'Donnell KA

Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
Proceedings of the National Academy of Sciences of the United States of America112(45)14018-23(2015 Nov)
Fonseca TL,Fernandes GW,McAninch EA,Bocco BM,Abdalla SM,Ribeiro MO,Moh?csik P,Fekete C,Li D,Xing X,Wang T,Gereben B,Bianco AC

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THRSP cDNA ORF clone, Mus musculus(House mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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