Hlf cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hlf
Entrez Gene ID	217082
Full Name	hepatic leukemia factor
Synonyms	E230015K02Rik
General protein information	Preferred Names hepatic leukemia factor Names hepatic leukemia factor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 C\|11 55.03 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006533005.3	XP_006533068.1	hepatic leukemia factor isoform X2
XM_030245856.1	XP_030101716.1	hepatic leukemia factor isoform X3
XM_006533007.2	XP_006533070.1	hepatic leukemia factor isoform X3
NM_172563.3	NP_766151.1	hepatic leukemia factor
XM_006533004.1	XP_006533067.1	hepatic leukemia factor isoform X1
XM_006533006.1	XP_006533069.1	hepatic leukemia factor isoform X2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HLF	XP_511894.2
Danio rerio (zebrafish)	hlfa	NP_001070802.1
Homo sapiens (human)	HLF	NP_002117.1
Canis lupus familiaris (dog)	HLF	XP_866525.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006376	XP_316411.4
Bos taurus (cattle)	HLF	NP_001179366.1
Mus musculus (house mouse)	Hlf	NP_766151.1
Drosophila melanogaster (fruit fly)	Pdp1	NP_001261545.1
Xenopus tropicalis (tropical clawed frog)	hlf	XP_004918616.1
	HLF	XP_001103594.1
Gallus gallus (chicken)	HLF	XP_415649.3
Rattus norvegicus (Norway rat)	LOC690286	XP_006247198.1

Gene Ontology
Bibliography

Related articles in PubMed

Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration.
Komorowska K, Doyle A, Wahlestedt M, Subramaniam A, Debnath S, Chen J, Soneji S, Van Handel B, Mikkola HKA, Miharada K, Bryder D, Larsson J, Magnusson M
Cell reports21(12)3514-3523(2017 Dec)

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstr?m E, Pachnis V, Marklund U
Gastroenterology(2017 Oct)

Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying Focal Epilepsy.
Li P, Fu X, Smith NA, Ziobro J, Curiel J, Tenga MJ, Martin B, Freedman S, Cea-Del Rio CA, Oboti L, Tsuchida TN, Oluigbo C, Yaun A, Magge SN, O'Neill B, Kao A, Zelleke TG, Depositario-Cabacar DT, Ghimbovschi S, Knoblach S, Ho CY, Corbin JG, Goodkin HP, Vicini S, Huntsman MM, Gaillard WD, Valdez G, Liu JS
Neuron96(2)387-401.e6(2017 Oct)

Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns.
Hanley O, Zewdu R, Cohen LJ, Jung H, Lacombe J, Philippidou P, Lee DH, Selleri L, Dasen JS
Neuron91(5)1005-1020(2016 Sep)

Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations.
Hawkins NA, Kearney JA
Epilepsy research11920-3(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results demonstrate that Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations and that modulation of the pyridoxine pathway can also influence phenotype severity
Title: Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations.

Data indicate that Meis homeobox 1 (MEIS1) is required for the maintenance of myeloid-lymphoid leukemia protein MLL-fusion gene leukemia, and hepatic leukemia factor (HLF)is a key downstream mediator of Meis1.
Title: MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia.

Conditional expression of E2A-HLF induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.
Title: Conditional Expression of E2A-HLF Induces B-Cell Precursor Death and Myeloproliferative-Like Disease in Knock-In Mice.

we demonstrate that D site albumin promoter binding protein/thyrotroph embryonic factor/hepatic leukemia factor triple knockout mice develop cardiac hypertrophy and left ventricular dysfunction associated with a low blood pressure
Title: Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circadian PAR bZip transcription factors DBP, HLF, and TEF.

Data show that the clock knockout mice or mice devoid of dbp/hlf/tef (triple knockout) exhibit significant changes in renal expression of several key regulators of water or sodium balance.
Title: Molecular clock is involved in predictive circadian adjustment of renal function.

The following Hlf gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hlf cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu46103	XM_006533006.1 Latest version!	Mus musculus hepatic leukemia factor (Hlf), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu46103	XM_006533005.3 Latest version!	Mus musculus hepatic leukemia factor (Hlf), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu46104	XM_006533007.2 Latest version!	Mus musculus hepatic leukemia factor (Hlf), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu46102	XM_006533004.1 Latest version!	Mus musculus hepatic leukemia factor (Hlf), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu03686	NM_172563.3 Latest version!	Mus musculus hepatic leukemia factor (Hlf), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu46104	XM_030245856.1 Latest version!	Mus musculus hepatic leukemia factor (Hlf), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hlf ( XM_006533005.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006533068.1 Mus musculus hepatic leukemia factor (Hlf), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu46103
Clone ID Related Accession (Same CDS sequence)	XM_006533005.3 , XM_006533006.1
Accession Version	XM_006533005.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	hepatic leukemia factor isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006533005.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACTTGG AGGAATTCCT GTCAGAGAAT GGCATCCCCC CGAGTCCGTC GCAGCACGAC 
CACAGCCCTC ACCCCCCTGG CTTGCAACCA GCTTCCTCCA CGGCGCCCTC GGTCATGGAT 
CTCAGCAGCC GGGCCACAGC GCCCCTCCAC CCGGGCATCC CGTCTCCGAA CTGTATGCAG 
AGCCCCATCA GACCAGGCCA GCTGTTGCCA GCAAACCGCA ATACACCGAG TCCCATTGAC 
CCTGACACCA TCCAGGTACC AGTCGGGTAT GAACCAGACC CGGCAGACCT TGCCCTCTCC 
AGCATCCCGG GGCAGGAAAT GTTTGACCCT CGCAAACGGA AGTTCTCTGA GGAAGAACTG 
AAGCCACAGC CCATGATTAA GAAAGCTCGC AAAGTCTTCA TTCCCGATGA TTTGAAGCAG 
GATGACAAGT ACTGGGCGAG GCGCAGAAAG AACAACATGG CGGCCAAGCG CTCCCGTGAT 
GCCCGGCGGC TGAAGGAGAA CCAGATCGCA ATCCGGGCCT CATTCCTGGA GAAGGAGAAC 
TCGGCCCTCC GCCAGGAGGT GGCTGATTTA AGGAAGGAGC TGGGCAAATG CAAGAACATA 
CTTGCCAAGT ACGAGGCCAG GCACGGGCCC CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006533068.1
CDS	243..878
Translation	MDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSTAPSVMDLSSRATAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKQDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL

Target ORF information:

RefSeq Version	XM_006533005.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus hepatic leukemia factor (Hlf), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006533005.3

ORF Insert Sequence:

ATGGACTTGG AGGAATTCCT GTCAGAGAAT GGCATCCCCC CGAGTCCGTC GCAGCACGAC 
CACAGCCCTC ACCCCCCTGG CTTGCAACCA GCTTCCTCCA CGGCGCCCTC GGTCATGGAT 
CTCAGCAGCC GGGCCACAGC GCCCCTCCAC CCGGGCATCC CGTCTCCGAA CTGTATGCAG 
AGCCCCATCA GACCAGGCCA GCTGTTGCCA GCAAACCGCA ATACACCGAG TCCCATTGAC 
CCTGACACCA TCCAGGTACC AGTCGGGTAT GAACCAGACC CGGCAGACCT TGCCCTCTCC 
AGCATCCCGG GGCAGGAAAT GTTTGACCCT CGCAAACGGA AGTTCTCTGA GGAAGAACTG 
AAGCCACAGC CCATGATTAA GAAAGCTCGC AAAGTCTTCA TTCCCGATGA TTTGAAGCAG 
GATGACAAGT ACTGGGCGAG GCGCAGAAAG AACAACATGG CGGCCAAGCG CTCCCGTGAT 
GCCCGGCGGC TGAAGGAGAA CCAGATCGCA ATCCGGGCCT CATTCCTGGA GAAGGAGAAC 
TCGGCCCTCC GCCAGGAGGT GGCTGATTTA AGGAAGGAGC TGGGCAAATG CAAGAACATA 
CTTGCCAAGT ACGAGGCCAG GCACGGGCCC CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hlf ( XM_006533006.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006533069.1 Mus musculus hepatic leukemia factor (Hlf), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OMu46103
Clone ID Related Accession (Same CDS sequence)	XM_006533005.3 , XM_006533006.1
Accession Version	XM_006533006.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	hepatic leukemia factor isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACTTGG AGGAATTCCT GTCAGAGAAT GGCATCCCCC CGAGTCCGTC GCAGCACGAC 
CACAGCCCTC ACCCCCCTGG CTTGCAACCA GCTTCCTCCA CGGCGCCCTC GGTCATGGAT 
CTCAGCAGCC GGGCCACAGC GCCCCTCCAC CCGGGCATCC CGTCTCCGAA CTGTATGCAG 
AGCCCCATCA GACCAGGCCA GCTGTTGCCA GCAAACCGCA ATACACCGAG TCCCATTGAC 
CCTGACACCA TCCAGGTACC AGTCGGGTAT GAACCAGACC CGGCAGACCT TGCCCTCTCC 
AGCATCCCGG GGCAGGAAAT GTTTGACCCT CGCAAACGGA AGTTCTCTGA GGAAGAACTG 
AAGCCACAGC CCATGATTAA GAAAGCTCGC AAAGTCTTCA TTCCCGATGA TTTGAAGCAG 
GATGACAAGT ACTGGGCGAG GCGCAGAAAG AACAACATGG CGGCCAAGCG CTCCCGTGAT 
GCCCGGCGGC TGAAGGAGAA CCAGATCGCA ATCCGGGCCT CATTCCTGGA GAAGGAGAAC 
TCGGCCCTCC GCCAGGAGGT GGCTGATTTA AGGAAGGAGC TGGGCAAATG CAAGAACATA 
CTTGCCAAGT ACGAGGCCAG GCACGGGCCC CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006533069.1
CDS	180..815
Translation	MDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSTAPSVMDLSSRATAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKQDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL

Target ORF information:

RefSeq Version	XM_006533006.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus hepatic leukemia factor (Hlf), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006533006.1

ORF Insert Sequence:

ATGGACTTGG AGGAATTCCT GTCAGAGAAT GGCATCCCCC CGAGTCCGTC GCAGCACGAC 
CACAGCCCTC ACCCCCCTGG CTTGCAACCA GCTTCCTCCA CGGCGCCCTC GGTCATGGAT 
CTCAGCAGCC GGGCCACAGC GCCCCTCCAC CCGGGCATCC CGTCTCCGAA CTGTATGCAG 
AGCCCCATCA GACCAGGCCA GCTGTTGCCA GCAAACCGCA ATACACCGAG TCCCATTGAC 
CCTGACACCA TCCAGGTACC AGTCGGGTAT GAACCAGACC CGGCAGACCT TGCCCTCTCC 
AGCATCCCGG GGCAGGAAAT GTTTGACCCT CGCAAACGGA AGTTCTCTGA GGAAGAACTG 
AAGCCACAGC CCATGATTAA GAAAGCTCGC AAAGTCTTCA TTCCCGATGA TTTGAAGCAG 
GATGACAAGT ACTGGGCGAG GCGCAGAAAG AACAACATGG CGGCCAAGCG CTCCCGTGAT 
GCCCGGCGGC TGAAGGAGAA CCAGATCGCA ATCCGGGCCT CATTCCTGGA GAAGGAGAAC 
TCGGCCCTCC GCCAGGAGGT GGCTGATTTA AGGAAGGAGC TGGGCAAATG CAAGAACATA 
CTTGCCAAGT ACGAGGCCAG GCACGGGCCC CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hlf ( XM_006533007.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006533070.1 Mus musculus hepatic leukemia factor (Hlf), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OMu46104
Clone ID Related Accession (Same CDS sequence)	XM_030245856.1 , XM_006533007.2
Accession Version	XM_006533007.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	hepatic leukemia factor isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006533007.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACTTGG AGGAATTCCT GTCAGAGAAT GGCATCCCCC CGAGTCCGTC GCAGCACGAC 
CACAGCCCTC ACCCCCCTGG CTTGCAACCA GCTTCCTCCA CGGCGCCCTC GGTCATGGAT 
CTCAGCAGCC GGGCCACAGC GCCCCTCCAC CCGGGCATCC CGTCTCCGAA CTGTATGCAG 
AGCCCCATCA GACCAGGCCA GCTGTTGCCA GCAAACCGCA ATACACCGAG TCCCATTGAC 
CCTGACACCA TCCAGGTACC AGTCGGGTAT GAACCAGACC CGGCAGACCT TGCCCTCTCC 
AGCATCCCGG GGCAGGAAAT GTTTGACCCT CGCAAACGGA AGTTCTCTGA GGAAGAACTG 
AAGCCACAGC CCATGATTAA GAAAGCTCGC AAAGTCTTCA TTCCCGATGA TTTGAAGGAT 
GACAAGTACT GGGCGAGGCG CAGAAAGAAC AACATGGCGG CCAAGCGCTC CCGTGATGCC 
CGGCGGCTGA AGGAGAACCA GATCGCAATC CGGGCCTCAT TCCTGGAGAA GGAGAACTCG 
GCCCTCCGCC AGGAGGTGGC TGATTTAAGG AAGGAGCTGG GCAAATGCAA GAACATACTT 
GCCAAGTACG AGGCCAGGCA CGGGCCCCTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006533070.1
CDS	241..873
Translation	MDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSTAPSVMDLSSRATAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL

Target ORF information:

RefSeq Version	XM_006533007.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus hepatic leukemia factor (Hlf), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006533007.2

ORF Insert Sequence:

ATGGACTTGG AGGAATTCCT GTCAGAGAAT GGCATCCCCC CGAGTCCGTC GCAGCACGAC 
CACAGCCCTC ACCCCCCTGG CTTGCAACCA GCTTCCTCCA CGGCGCCCTC GGTCATGGAT 
CTCAGCAGCC GGGCCACAGC GCCCCTCCAC CCGGGCATCC CGTCTCCGAA CTGTATGCAG 
AGCCCCATCA GACCAGGCCA GCTGTTGCCA GCAAACCGCA ATACACCGAG TCCCATTGAC 
CCTGACACCA TCCAGGTACC AGTCGGGTAT GAACCAGACC CGGCAGACCT TGCCCTCTCC 
AGCATCCCGG GGCAGGAAAT GTTTGACCCT CGCAAACGGA AGTTCTCTGA GGAAGAACTG 
AAGCCACAGC CCATGATTAA GAAAGCTCGC AAAGTCTTCA TTCCCGATGA TTTGAAGGAT 
GACAAGTACT GGGCGAGGCG CAGAAAGAAC AACATGGCGG CCAAGCGCTC CCGTGATGCC 
CGGCGGCTGA AGGAGAACCA GATCGCAATC CGGGCCTCAT TCCTGGAGAA GGAGAACTCG 
GCCCTCCGCC AGGAGGTGGC TGATTTAAGG AAGGAGCTGG GCAAATGCAA GAACATACTT 
GCCAAGTACG AGGCCAGGCA CGGGCCCCTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hlf ( XM_006533004.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006533067.1 Mus musculus hepatic leukemia factor (Hlf), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu46102
Clone ID Related Accession (Same CDS sequence)	XM_006533004.1
Accession Version	XM_006533004.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 891bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	hepatic leukemia factor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAAAA TGTCCCGACA GCTCCCCTTG AACCCCACCT TTATCCCGCC TCCCTACGGC 
GTGCTCAGGT CCCTGCTGGA GAACCCGCTG AAGCTCCCCC TTCATCCTGA AGACGCATTT 
AGTAAAGAAA AAGACAAAGG AAAGAAGCTG GACGATGAGA GCAGCAGCCC GACCGTCCCC 
CAGTCCGCCT TCTTGGGACC CACCTTATGG GACAAAACCC TTCCCTATGA CGGAGATACT 
TTCCAGCTGG AATACATGGA CTTGGAGGAA TTCCTGTCAG AGAATGGCAT CCCCCCGAGT 
CCGTCGCAGC ACGACCACAG CCCTCACCCC CCTGGCTTGC AACCAGCTTC CTCCACGGCG 
CCCTCGGTCA TGGATCTCAG CAGCCGGGCC ACAGCGCCCC TCCACCCGGG CATCCCGTCT 
CCGAACTGTA TGCAGAGCCC CATCAGACCA GGCCAGCTGT TGCCAGCAAA CCGCAATACA 
CCGAGTCCCA TTGACCCTGA CACCATCCAG GTACCAGTCG GGTATGAACC AGACCCGGCA 
GACCTTGCCC TCTCCAGCAT CCCGGGGCAG GAAATGTTTG ACCCTCGCAA ACGGAAGTTC 
TCTGAGGAAG AACTGAAGCC ACAGCCCATG ATTAAGAAAG CTCGCAAAGT CTTCATTCCC 
GATGATTTGA AGCAGGATGA CAAGTACTGG GCGAGGCGCA GAAAGAACAA CATGGCGGCC 
AAGCGCTCCC GTGATGCCCG GCGGCTGAAG GAGAACCAGA TCGCAATCCG GGCCTCATTC 
CTGGAGAAGG AGAACTCGGC CCTCCGCCAG GAGGTGGCTG ATTTAAGGAA GGAGCTGGGC 
AAATGCAAGA ACATACTTGC CAAGTACGAG GCCAGGCACG GGCCCCTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006533067.1
CDS	553..1443
Translation	MEKMSRQLPLNPTFIPPPYGVLRSLLENPLKLPLHPEDAFSKEKDKGKKLDDESSSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSTAPSVMDLSSRATAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKQDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL

Target ORF information:

RefSeq Version	XM_006533004.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus hepatic leukemia factor (Hlf), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006533004.1

ORF Insert Sequence:

ATGGAGAAAA TGTCCCGACA GCTCCCCTTG AACCCCACCT TTATCCCGCC TCCCTACGGC 
GTGCTCAGGT CCCTGCTGGA GAACCCGCTG AAGCTCCCCC TTCATCCTGA AGACGCATTT 
AGTAAAGAAA AAGACAAAGG AAAGAAGCTG GACGATGAGA GCAGCAGCCC GACCGTCCCC 
CAGTCCGCCT TCTTGGGACC CACCTTATGG GACAAAACCC TTCCCTATGA CGGAGATACT 
TTCCAGCTGG AATACATGGA CTTGGAGGAA TTCCTGTCAG AGAATGGCAT CCCCCCGAGT 
CCGTCGCAGC ACGACCACAG CCCTCACCCC CCTGGCTTGC AACCAGCTTC CTCCACGGCG 
CCCTCGGTCA TGGATCTCAG CAGCCGGGCC ACAGCGCCCC TCCACCCGGG CATCCCGTCT 
CCGAACTGTA TGCAGAGCCC CATCAGACCA GGCCAGCTGT TGCCAGCAAA CCGCAATACA 
CCGAGTCCCA TTGACCCTGA CACCATCCAG GTACCAGTCG GGTATGAACC AGACCCGGCA 
GACCTTGCCC TCTCCAGCAT CCCGGGGCAG GAAATGTTTG ACCCTCGCAA ACGGAAGTTC 
TCTGAGGAAG AACTGAAGCC ACAGCCCATG ATTAAGAAAG CTCGCAAAGT CTTCATTCCC 
GATGATTTGA AGCAGGATGA CAAGTACTGG GCGAGGCGCA GAAAGAACAA CATGGCGGCC 
AAGCGCTCCC GTGATGCCCG GCGGCTGAAG GAGAACCAGA TCGCAATCCG GGCCTCATTC 
CTGGAGAAGG AGAACTCGGC CCTCCGCCAG GAGGTGGCTG ATTTAAGGAA GGAGCTGGGC 
AAATGCAAGA ACATACTTGC CAAGTACGAG GCCAGGCACG GGCCCCTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hlf ( NM_172563.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766151.1 Mus musculus hepatic leukemia factor (Hlf), mRNA.

Price & Availability↑

CloneID	OMu03686
Clone ID Related Accession (Same CDS sequence)	NM_172563.3
Accession Version	NM_172563.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	hepatic leukemia factor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ164739.1, BC058705.1 and AL626785.26. On Feb 6, 2007 this sequence version replaced NM_172563.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.111899.1, SRR1660815.21302.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849387, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAAA TGTCCCGACA GCTCCCCTTG AACCCCACCT TTATCCCGCC TCCCTACGGC 
GTGCTCAGGT CCCTGCTGGA GAACCCGCTG AAGCTCCCCC TTCATCCTGA AGACGCATTT 
AGTAAAGAAA AAGACAAAGG AAAGAAGCTG GACGATGAGA GCAGCAGCCC GACCGTCCCC 
CAGTCCGCCT TCTTGGGACC CACCTTATGG GACAAAACCC TTCCCTATGA CGGAGATACT 
TTCCAGCTGG AATACATGGA CTTGGAGGAA TTCCTGTCAG AGAATGGCAT CCCCCCGAGT 
CCGTCGCAGC ACGACCACAG CCCTCACCCC CCTGGCTTGC AACCAGCTTC CTCCACGGCG 
CCCTCGGTCA TGGATCTCAG CAGCCGGGCC ACAGCGCCCC TCCACCCGGG CATCCCGTCT 
CCGAACTGTA TGCAGAGCCC CATCAGACCA GGCCAGCTGT TGCCAGCAAA CCGCAATACA 
CCGAGTCCCA TTGACCCTGA CACCATCCAG GTACCAGTCG GGTATGAACC AGACCCGGCA 
GACCTTGCCC TCTCCAGCAT CCCGGGGCAG GAAATGTTTG ACCCTCGCAA ACGGAAGTTC 
TCTGAGGAAG AACTGAAGCC ACAGCCCATG ATTAAGAAAG CTCGCAAAGT CTTCATTCCC 
GATGATTTGA AGGATGACAA GTACTGGGCG AGGCGCAGAA AGAACAACAT GGCGGCCAAG 
CGCTCCCGTG ATGCCCGGCG GCTGAAGGAG AACCAGATCG CAATCCGGGC CTCATTCCTG 
GAGAAGGAGA ACTCGGCCCT CCGCCAGGAG GTGGCTGATT TAAGGAAGGA GCTGGGCAAA 
TGCAAGAACA TACTTGCCAA GTACGAGGCC AGGCACGGGC CCCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766151.1
CDS	554..1441
Translation	MEKMSRQLPLNPTFIPPPYGVLRSLLENPLKLPLHPEDAFSKEKDKGKKLDDESSSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSTAPSVMDLSSRATAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL

Target ORF information:

RefSeq Version	NM_172563.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus hepatic leukemia factor (Hlf), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172563.3

ORF Insert Sequence:

ATGGAGAAAA TGTCCCGACA GCTCCCCTTG AACCCCACCT TTATCCCGCC TCCCTACGGC 
GTGCTCAGGT CCCTGCTGGA GAACCCGCTG AAGCTCCCCC TTCATCCTGA AGACGCATTT 
AGTAAAGAAA AAGACAAAGG AAAGAAGCTG GACGATGAGA GCAGCAGCCC GACCGTCCCC 
CAGTCCGCCT TCTTGGGACC CACCTTATGG GACAAAACCC TTCCCTATGA CGGAGATACT 
TTCCAGCTGG AATACATGGA CTTGGAGGAA TTCCTGTCAG AGAATGGCAT CCCCCCGAGT 
CCGTCGCAGC ACGACCACAG CCCTCACCCC CCTGGCTTGC AACCAGCTTC CTCCACGGCG 
CCCTCGGTCA TGGATCTCAG CAGCCGGGCC ACAGCGCCCC TCCACCCGGG CATCCCGTCT 
CCGAACTGTA TGCAGAGCCC CATCAGACCA GGCCAGCTGT TGCCAGCAAA CCGCAATACA 
CCGAGTCCCA TTGACCCTGA CACCATCCAG GTACCAGTCG GGTATGAACC AGACCCGGCA 
GACCTTGCCC TCTCCAGCAT CCCGGGGCAG GAAATGTTTG ACCCTCGCAA ACGGAAGTTC 
TCTGAGGAAG AACTGAAGCC ACAGCCCATG ATTAAGAAAG CTCGCAAAGT CTTCATTCCC 
GATGATTTGA AGGATGACAA GTACTGGGCG AGGCGCAGAA AGAACAACAT GGCGGCCAAG 
CGCTCCCGTG ATGCCCGGCG GCTGAAGGAG AACCAGATCG CAATCCGGGC CTCATTCCTG 
GAGAAGGAGA ACTCGGCCCT CCGCCAGGAG GTGGCTGATT TAAGGAAGGA GCTGGGCAAA 
TGCAAGAACA TACTTGCCAA GTACGAGGCC AGGCACGGGC CCCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hlf ( XM_030245856.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030101716.1 Mus musculus hepatic leukemia factor (Hlf), transcript variant X5, mRNA.

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CloneID	OMu46104
Clone ID Related Accession (Same CDS sequence)	XM_030245856.1 , XM_006533007.2
Accession Version	XM_030245856.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	hepatic leukemia factor isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACTTGG AGGAATTCCT GTCAGAGAAT GGCATCCCCC CGAGTCCGTC GCAGCACGAC 
CACAGCCCTC ACCCCCCTGG CTTGCAACCA GCTTCCTCCA CGGCGCCCTC GGTCATGGAT 
CTCAGCAGCC GGGCCACAGC GCCCCTCCAC CCGGGCATCC CGTCTCCGAA CTGTATGCAG 
AGCCCCATCA GACCAGGCCA GCTGTTGCCA GCAAACCGCA ATACACCGAG TCCCATTGAC 
CCTGACACCA TCCAGGTACC AGTCGGGTAT GAACCAGACC CGGCAGACCT TGCCCTCTCC 
AGCATCCCGG GGCAGGAAAT GTTTGACCCT CGCAAACGGA AGTTCTCTGA GGAAGAACTG 
AAGCCACAGC CCATGATTAA GAAAGCTCGC AAAGTCTTCA TTCCCGATGA TTTGAAGGAT 
GACAAGTACT GGGCGAGGCG CAGAAAGAAC AACATGGCGG CCAAGCGCTC CCGTGATGCC 
CGGCGGCTGA AGGAGAACCA GATCGCAATC CGGGCCTCAT TCCTGGAGAA GGAGAACTCG 
GCCCTCCGCC AGGAGGTGGC TGATTTAAGG AAGGAGCTGG GCAAATGCAA GAACATACTT 
GCCAAGTACG AGGCCAGGCA CGGGCCCCTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030101716.1
CDS	180..812
Translation	MDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSTAPSVMDLSSRATAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL

Target ORF information:

RefSeq Version	XM_030245856.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus hepatic leukemia factor (Hlf), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030245856.1

ORF Insert Sequence:

ATGGACTTGG AGGAATTCCT GTCAGAGAAT GGCATCCCCC CGAGTCCGTC GCAGCACGAC 
CACAGCCCTC ACCCCCCTGG CTTGCAACCA GCTTCCTCCA CGGCGCCCTC GGTCATGGAT 
CTCAGCAGCC GGGCCACAGC GCCCCTCCAC CCGGGCATCC CGTCTCCGAA CTGTATGCAG 
AGCCCCATCA GACCAGGCCA GCTGTTGCCA GCAAACCGCA ATACACCGAG TCCCATTGAC 
CCTGACACCA TCCAGGTACC AGTCGGGTAT GAACCAGACC CGGCAGACCT TGCCCTCTCC 
AGCATCCCGG GGCAGGAAAT GTTTGACCCT CGCAAACGGA AGTTCTCTGA GGAAGAACTG 
AAGCCACAGC CCATGATTAA GAAAGCTCGC AAAGTCTTCA TTCCCGATGA TTTGAAGGAT 
GACAAGTACT GGGCGAGGCG CAGAAAGAAC AACATGGCGG CCAAGCGCTC CCGTGATGCC 
CGGCGGCTGA AGGAGAACCA GATCGCAATC CGGGCCTCAT TCCTGGAGAA GGAGAACTCG 
GCCCTCCGCC AGGAGGTGGC TGATTTAAGG AAGGAGCTGG GCAAATGCAA GAACATACTT 
GCCAAGTACG AGGCCAGGCA CGGGCCCCTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration.
Cell reports21(12)3514-3523(2017 Dec)
Komorowska K,Doyle A,Wahlestedt M,Subramaniam A,Debnath S,Chen J,Soneji S,Van Handel B,Mikkola HKA,Miharada K,Bryder D,Larsson J,Magnusson M

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Gastroenterology(2017 Oct)
Memic F,Knoflach V,Morarach K,Sadler R,Laranjeira C,Hjerling-Leffler J,Sundstr?m E,Pachnis V,Marklund U

Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying Focal Epilepsy.
Neuron96(2)387-401.e6(2017 Oct)
Li P,Fu X,Smith NA,Ziobro J,Curiel J,Tenga MJ,Martin B,Freedman S,Cea-Del Rio CA,Oboti L,Tsuchida TN,Oluigbo C,Yaun A,Magge SN,O'Neill B,Kao A,Zelleke TG,Depositario-Cabacar DT,Ghimbovschi S,Knoblach S,Ho CY,Corbin JG,Goodkin HP,Vicini S,Huntsman MM,Gaillard WD,Valdez G,Liu JS

Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns.
Neuron91(5)1005-1020(2016 Sep)
Hanley O,Zewdu R,Cohen LJ,Jung H,Lacombe J,Philippidou P,Lee DH,Selleri L,Dasen JS

Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations.
Epilepsy research11920-3(2016 Jan)
Hawkins NA,Kearney JA

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Hlf cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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