Unc45b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Unc45b
Entrez Gene ID	217012
Full Name	unc-45 myosin chaperone B
Synonyms	AA445617,Cmya4,D230041A13Rik,Unc45
General protein information	Preferred Names unc-45 myosin chaperone B Names protein unc-45 homolog B UNC-45B cardiomyopathy associated 4 striated muscle UNC45 unc-45 homolog B
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 C

mRNA and Protein(s)

mRNA	Protein	Name
NM_178680.4	NP_848795.3	protein unc-45 homolog B

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Unc45b	NP_001100498.1
Danio rerio (zebrafish)	unc45b	NP_705959.1
Drosophila melanogaster (fruit fly)	unc-45	NP_524796.1
Pan troglodytes (chimpanzee)	UNC45B	XP_001174363.2
Mus musculus (house mouse)	Unc45b	NP_848795.3
Gallus gallus (chicken)	UNC45B	XP_004946569.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003727	XP_310258.5
Canis lupus familiaris (dog)	UNC45B	XP_005624856.1
Bos taurus (cattle)	UNC45B	XP_002695676.1
Xenopus tropicalis (tropical clawed frog)	unc45b	NP_001172057.1
Homo sapiens (human)	UNC45B	NP_775259.1
	UNC45B	XP_001113905.2
Caenorhabditis elegans (roundworm)	unc-45	NP_497205.1

Gene Ontology
Bibliography

Related articles in PubMed

Arid3b is essential for second heart field cell deployment and heart patterning.
Uribe V, Bad?a-Careaga C, Casanova JC, Dom?nguez JN, de la Pompa JL, Sanz-Ezquerro JJ
Development (Cambridge, England)141(21)4168-81(2014 Nov)

Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke.
Nicholls P, Bujalowski PJ, Epstein HF, Boehning DF, Barral JM, Oberhauser AF
FEBS letters588(21)3977-81(2014 Nov)

Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking.
Bird JE, Takagi Y, Billington N, Strub MP, Sellers JR, Friedman TB
Proceedings of the National Academy of Sciences of the United States of America111(34)12390-5(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

UNC-45B and Hsp90 involved in sarcomere function
Title: Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke.

vertebrate Unc45 isoforms clearly demonstrates a direct role for Unc45 in Hsp90-mediated myosin motor domain folding and highlights major differences between the isoforms in substrate specificity and mechanism
Title: Unc45 activates Hsp90-dependent folding of the myosin motor domain.

mammalian Unc45b is a cytosolic protein that forms a stable complex with Hsp90, selectively binds the unfolded conformation of the myosin motor domain, and promotes motor domain folding
Title: Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain.

The following Unc45b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Unc45b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07548	NM_178680.4 Latest version!	Mus musculus unc-45 myosin chaperone B (Unc45b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$545.30 $779.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Unc45b ( NM_178680.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_848795.3 Mus musculus unc-45 myosin chaperone B (Unc45b), mRNA.

Price & Availability↑

CloneID	OMu07548
Clone ID Related Accession (Same CDS sequence)	NM_178680.4
Accession Version	NM_178680.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2790bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	protein unc-45 homolog B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY133112.1, AK084418.1 and BC084585.1. On Nov 10, 2009 this sequence version replaced NM_178680.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC084585.1, AK052294.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGAGG CTGAAGCGGC ACAGCTGAAG GAGGAGGGGA ACCGGCATTT TCAGCTCCAG 
GATTACAAGG CGGCCACCAA GAGCTACAGC CAGGCCCTGA AGCTGACCAA GGACAAGGCT 
CTGCTAGCTA CACTCTACCG GAATCGGGCA GCCTGCGGCC TGAAAATGGA GAGCTACGCC 
CAGGCAGCCT CGGATGCTTC CAGAGCCATT GACATCAACT CTGCTGACAT CAAAGCATTG 
TATCGGCGAT GCCAGGCACT GGAGCATCTT GGCAAGTTGG ACCAGGCATT CAAGGATGTG 
CAGCGCTGTG CTACCCTGGA GCCAAGGAAC CAGAACTTCC AGGAGACACT GCGGAGGCTC 
AACACCAGCA TCCAAGAGCA GCTCCGTGTG CAGTTTTCTA CAGACTCCAG GGTACAGACG 
ATGTTTGAAA TTCTTCTGAA CGAAAACAGC GAGGCTGATA AGCGAGAGAA GGCTGCCAAC 
AACCTCATTG TCCTGGGCCG TGAAGAAGCG GGTGCTGAGA GGATCTTCCA GAGCAATGGA 
GTGGCTCTGC TGCTGCAGCT TATGAACACC CAGCGGCCTG AGCTGCTGCT AGCGGCTGTG 
CGGACGCTGT CTGGCATGTG CAGTGGCCAC AGAGCTAGGG CCACCGCCAT CCTGCACGCA 
GTCCGCATAG ACAGAATCTG CAGCCTCATG GCCCTGGAGA ATGAAGAGAT GTCCCTGGCT 
GTCTGCAACC TGCTCCAGGC CATCATTGAC TCCCTGTCTG GAGAGGACAA GAGAGAGCAT 
CGTGGGAAGG AGGAGGCCTT GGTTCTAGAT ACCAAGAAGG ACCTGAAGCA GATCACCAGC 
CACCTGCTGG ACATGCTGGT CAGTAAGAAA GTGTCTGGGC AGGGCAGAGA CCAGGCACTG 
AACCTGCTTA ATAAGAATGT CCCCAGGAAG GACCTGTCCA TTCATGACAA CTCACGCACC 
ATCTATGTTG TAGATAACGG TCTGAGGAAG ATCCTGAAGG TGGTGGGGCA GGTTCCAGAC 
CTGCCCTCCT GCCTACCCCT GACGGACAAC ACCCGCATGC TGGCCTCCAT CCTCATCAAC 
AAGCTCTATG ATGACCTGCG CTGTGACCCA GAGCGCGACC ACTTCCGCAA GATCTGTGAG 
GAGTATATCA CGAGCAAATT TGACCCCCAG GACATGGACA AGAATGTAAA TGCCATCCAG 
ACGGTGTCCG GCATCTTGCA GGGGCCCTTT GACCTGGGCA ATCAGCTGCT GGGCATGAAA 
GGTGTGATGG AGATGATGGT GGCTCTGTGT GGCTCGGAGC GCGAGGCAGA CCAGCTGGTG 
GCTGTGGAGG CTCTCATCCA CGCCTCCACG AAGCTCAGCC GGGCCACCTT CATCATCACC 
AACGGAGTGA CACTTCTTAA GCAGATCTAC AAGACCACAA AGAATGAGAA GATCAAGATC 
CGCACGCTGG TGGGGCTCTG TAAACTTGGC TCAGCTGGAG GCTCCGACTA TGGTCTCAGA 
CAGTTTGCTG AAGGGTCAAC AGAGAAGCTA GCCAAGCAGT GTCGAAAGTG GCTGTGTAAC 
ACCGCCATAG ACACCCGGAC GCGGCGCTGG GCAGTGGAGG GCCTGGCCTA CCTCACGCTG 
GACGCTGACG TGAAGGACGA CTTTGTCCAG GACATCCCTG CTCTGCAGGC CATGTTTGAG 
TTGGCCAAGA CCAGTGACAA GACCATCCTC TACTCAGTGG CCAACACCCT GGTAAACTGC 
ACCAACAGCT ATGATGTCAA GGAGGTCGTC CCTGAGCTGG TGCAGCTGGC CAAGTTCTCC 
AAGCAACATG TGCCAGAGGA GCACCCCAAG GACAAGAAGG ACTTCGTTGA CTTGCGGGTG 
AAACGTCTTC TGAAGGCAGG TGTCATATCT GCACTGGCCT GCATGGTGAA GGCAGACAGT 
GCCATCCTCA CAGACCAGAC CAAGGAGCTG CTGGCCAGGG TATTCCTGGC ACTCTGTGAC 
AATCCAAAGG ACCGGGGCAC CATTGTAGCT CAAGGTGGTG GCAAGGCCCT GATCCCCCTG 
GCTTTGGAGG GCACAGATGT GGGCAAGGTG AAGGCAGCCC ATGGGCTAGC CAAGATTGCT 
GCTGTCTCCA ACCCGGACAT TGCCTTCCCT GGGGAGAGGG TATATGAGGT GGTGCGGCCC 
CTCGTGAGTC TCCTGGACAC ACAGAGGGAT GGGCTTCAGA ACTATGAGGC TCTGCTGGGA 
CTGACTAACC TGTCTGGGCG CAGTGACAAA CTCAGGCAGA AGATCTTCAA GGAGAAGGCC 
TTGCCAGACA TTGAAAACTA CATGTTTGAG AACCATGACC AGCTACGGCA GGCAGCCACC 
GAATGCATGT GTAACATGGT GCTCAATAAG GAGGTTCAGG AGAGGTTCCT GGCCGATGGG 
AATGATCGTC TGAAGCTGGT GGTGCTGCTC TGTGGGGAGG ATGACCACAA ACTGCAGAAC 
GCAGCAGCTG GAGCTCTAGC CATGCTGACC GCGGCACATA AGAAACTGTG CCTCAAGATG 
ACGGAGGTGA CAACCCAGTG GCTGGAGATC CTACAGCGGC TTTGCCTGCA TGACCAGTTG 
TCCGTGCAGC ACCGGGGCCT GGTCATTGCC CACAACCTGC TATCAGCGGA TGCTGAGCTG 
GCGAGGAAGC TGGTGGAGAG CGAGCTGCTG GAGATCCTGA CTGTGGTGGG AAAGCAGGAG 
CCAGATGAGA AGAGAGCGGC TGTGGTCCAG ACAGCCCGGG AGTGTCTTAT CAAGTGCATG 
GATTATGGCT TCATCAAGCC GGTGTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848795.3
CDS	108..2897
Translation	MAEAEAAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDKALLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQETLRRLNTSIQEQLRVQFSTDSRVQTMFEILLNENSEADKREKAANNLIVLGREEAGAERIFQSNGVALLLQLMNTQRPELLLAAVRTLSGMCSGHRARATAILHAVRIDRICSLMALENEEMSLAVCNLLQAIIDSLSGEDKREHRGKEEALVLDTKKDLKQITSHLLDMLVSKKVSGQGRDQALNLLNKNVPRKDLSIHDNSRTIYVVDNGLRKILKVVGQVPDLPSCLPLTDNTRMLASILINKLYDDLRCDPERDHFRKICEEYITSKFDPQDMDKNVNAIQTVSGILQGPFDLGNQLLGMKGVMEMMVALCGSEREADQLVAVEALIHASTKLSRATFIITNGVTLLKQIYKTTKNEKIKIRTLVGLCKLGSAGGSDYGLRQFAEGSTEKLAKQCRKWLCNTAIDTRTRRWAVEGLAYLTLDADVKDDFVQDIPALQAMFELAKTSDKTILYSVANTLVNCTNSYDVKEVVPELVQLAKFSKQHVPEEHPKDKKDFVDLRVKRLLKAGVISALACMVKADSAILTDQTKELLARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHGLAKIAAVSNPDIAFPGERVYEVVRPLVSLLDTQRDGLQNYEALLGLTNLSGRSDKLRQKIFKEKALPDIENYMFENHDQLRQAATECMCNMVLNKEVQERFLADGNDRLKLVVLLCGEDDHKLQNAAAGALAMLTAAHKKLCLKMTEVTTQWLEILQRLCLHDQLSVQHRGLVIAHNLLSADAELARKLVESELLEILTVVGKQEPDEKRAAVVQTARECLIKCMDYGFIKPVS

Target ORF information:

RefSeq Version	NM_178680.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus unc-45 myosin chaperone B (Unc45b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178680.4

ORF Insert Sequence:

ATGGCAGAGG CTGAAGCGGC ACAGCTGAAG GAGGAGGGGA ACCGGCATTT TCAGCTCCAG 
GATTACAAGG CGGCCACCAA GAGCTACAGC CAGGCCCTGA AGCTGACCAA GGACAAGGCT 
CTGCTAGCTA CACTCTACCG GAATCGGGCA GCCTGCGGCC TGAAAATGGA GAGCTACGCC 
CAGGCAGCCT CGGATGCTTC CAGAGCCATT GACATCAACT CTGCTGACAT CAAAGCATTG 
TATCGGCGAT GCCAGGCACT GGAGCATCTT GGCAAGTTGG ACCAGGCATT CAAGGATGTG 
CAGCGCTGTG CTACCCTGGA GCCAAGGAAC CAGAACTTCC AGGAGACACT GCGGAGGCTC 
AACACCAGCA TCCAAGAGCA GCTCCGTGTG CAGTTTTCTA CAGACTCCAG GGTACAGACG 
ATGTTTGAAA TTCTTCTGAA CGAAAACAGC GAGGCTGATA AGCGAGAGAA GGCTGCCAAC 
AACCTCATTG TCCTGGGCCG TGAAGAAGCG GGTGCTGAGA GGATCTTCCA GAGCAATGGA 
GTGGCTCTGC TGCTGCAGCT TATGAACACC CAGCGGCCTG AGCTGCTGCT AGCGGCTGTG 
CGGACGCTGT CTGGCATGTG CAGTGGCCAC AGAGCTAGGG CCACCGCCAT CCTGCACGCA 
GTCCGCATAG ACAGAATCTG CAGCCTCATG GCCCTGGAGA ATGAAGAGAT GTCCCTGGCT 
GTCTGCAACC TGCTCCAGGC CATCATTGAC TCCCTGTCTG GAGAGGACAA GAGAGAGCAT 
CGTGGGAAGG AGGAGGCCTT GGTTCTAGAT ACCAAGAAGG ACCTGAAGCA GATCACCAGC 
CACCTGCTGG ACATGCTGGT CAGTAAGAAA GTGTCTGGGC AGGGCAGAGA CCAGGCACTG 
AACCTGCTTA ATAAGAATGT CCCCAGGAAG GACCTGTCCA TTCATGACAA CTCACGCACC 
ATCTATGTTG TAGATAACGG TCTGAGGAAG ATCCTGAAGG TGGTGGGGCA GGTTCCAGAC 
CTGCCCTCCT GCCTACCCCT GACGGACAAC ACCCGCATGC TGGCCTCCAT CCTCATCAAC 
AAGCTCTATG ATGACCTGCG CTGTGACCCA GAGCGCGACC ACTTCCGCAA GATCTGTGAG 
GAGTATATCA CGAGCAAATT TGACCCCCAG GACATGGACA AGAATGTAAA TGCCATCCAG 
ACGGTGTCCG GCATCTTGCA GGGGCCCTTT GACCTGGGCA ATCAGCTGCT GGGCATGAAA 
GGTGTGATGG AGATGATGGT GGCTCTGTGT GGCTCGGAGC GCGAGGCAGA CCAGCTGGTG 
GCTGTGGAGG CTCTCATCCA CGCCTCCACG AAGCTCAGCC GGGCCACCTT CATCATCACC 
AACGGAGTGA CACTTCTTAA GCAGATCTAC AAGACCACAA AGAATGAGAA GATCAAGATC 
CGCACGCTGG TGGGGCTCTG TAAACTTGGC TCAGCTGGAG GCTCCGACTA TGGTCTCAGA 
CAGTTTGCTG AAGGGTCAAC AGAGAAGCTA GCCAAGCAGT GTCGAAAGTG GCTGTGTAAC 
ACCGCCATAG ACACCCGGAC GCGGCGCTGG GCAGTGGAGG GCCTGGCCTA CCTCACGCTG 
GACGCTGACG TGAAGGACGA CTTTGTCCAG GACATCCCTG CTCTGCAGGC CATGTTTGAG 
TTGGCCAAGA CCAGTGACAA GACCATCCTC TACTCAGTGG CCAACACCCT GGTAAACTGC 
ACCAACAGCT ATGATGTCAA GGAGGTCGTC CCTGAGCTGG TGCAGCTGGC CAAGTTCTCC 
AAGCAACATG TGCCAGAGGA GCACCCCAAG GACAAGAAGG ACTTCGTTGA CTTGCGGGTG 
AAACGTCTTC TGAAGGCAGG TGTCATATCT GCACTGGCCT GCATGGTGAA GGCAGACAGT 
GCCATCCTCA CAGACCAGAC CAAGGAGCTG CTGGCCAGGG TATTCCTGGC ACTCTGTGAC 
AATCCAAAGG ACCGGGGCAC CATTGTAGCT CAAGGTGGTG GCAAGGCCCT GATCCCCCTG 
GCTTTGGAGG GCACAGATGT GGGCAAGGTG AAGGCAGCCC ATGGGCTAGC CAAGATTGCT 
GCTGTCTCCA ACCCGGACAT TGCCTTCCCT GGGGAGAGGG TATATGAGGT GGTGCGGCCC 
CTCGTGAGTC TCCTGGACAC ACAGAGGGAT GGGCTTCAGA ACTATGAGGC TCTGCTGGGA 
CTGACTAACC TGTCTGGGCG CAGTGACAAA CTCAGGCAGA AGATCTTCAA GGAGAAGGCC 
TTGCCAGACA TTGAAAACTA CATGTTTGAG AACCATGACC AGCTACGGCA GGCAGCCACC 
GAATGCATGT GTAACATGGT GCTCAATAAG GAGGTTCAGG AGAGGTTCCT GGCCGATGGG 
AATGATCGTC TGAAGCTGGT GGTGCTGCTC TGTGGGGAGG ATGACCACAA ACTGCAGAAC 
GCAGCAGCTG GAGCTCTAGC CATGCTGACC GCGGCACATA AGAAACTGTG CCTCAAGATG 
ACGGAGGTGA CAACCCAGTG GCTGGAGATC CTACAGCGGC TTTGCCTGCA TGACCAGTTG 
TCCGTGCAGC ACCGGGGCCT GGTCATTGCC CACAACCTGC TATCAGCGGA TGCTGAGCTG 
GCGAGGAAGC TGGTGGAGAG CGAGCTGCTG GAGATCCTGA CTGTGGTGGG AAAGCAGGAG 
CCAGATGAGA AGAGAGCGGC TGTGGTCCAG ACAGCCCGGG AGTGTCTTAT CAAGTGCATG 
GATTATGGCT TCATCAAGCC GGTGTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Arid3b is essential for second heart field cell deployment and heart patterning.
Development (Cambridge, England)141(21)4168-81(2014 Nov)
Uribe V,Bad?a-Careaga C,Casanova JC,Dom?nguez JN,de la Pompa JL,Sanz-Ezquerro JJ

Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke.
FEBS letters588(21)3977-81(2014 Nov)
Nicholls P,Bujalowski PJ,Epstein HF,Boehning DF,Barral JM,Oberhauser AF

Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking.
Proceedings of the National Academy of Sciences of the United States of America111(34)12390-5(2014 Aug)
Bird JE,Takagi Y,Billington N,Strub MP,Sellers JR,Friedman TB

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Unc45b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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