Tdgf1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tdgf1
Entrez Gene ID	21667
Full Name	teratocarcinoma-derived growth factor 1
Synonyms	CR1,cripto
General protein information	Preferred Names teratocarcinoma-derived growth factor 1 Names teratocarcinoma-derived growth factor TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR) cripto growth factor epidermal growth factor-like Cripto protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9 F2\|9 60.79 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011562.2	NP_035692.2	teratocarcinoma-derived growth factor precursor
XM_017313275.2	XP_017168764.1	teratocarcinoma-derived growth factor isoform X1
XM_017313275.1	XP_017168764.1	teratocarcinoma-derived growth factor isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TDGF1	NP_003203.1
	LOC712918	XP_001114010.1
Mus musculus (house mouse)	Tdgf1	NP_035692.2
Rattus norvegicus (Norway rat)	Tdgf1	XP_001056317.2
Bos taurus (cattle)	TDGF1	NP_001073827.1
Bos taurus (cattle)	LOC101906048	XP_005220011.1
Pan troglodytes (chimpanzee)	TDGF1	XP_001151101.1
Canis lupus familiaris (dog)	TDGF1	XP_005633250.1
Xenopus tropicalis (tropical clawed frog)	tdgf1.1	NP_001078829.1

Gene Ontology
Bibliography

Related articles in PubMed

Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling.
Huang X, Balmer S, Yang F, Fidalgo M, Li D, Guallar D, Hadjantonakis AK, Wang J
eLife6(2017 Nov)

The epigenetic modifier Fam208a is required to maintain epiblast cell fitness.
Bhargava S, Cox B, Polydorou C, Gresakova V, Korinek V, Strnad H, Sedlacek R, Epp TA, Chawengsaksophak K
Scientific reports7(1)9322(2017 Aug)

SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice.
Zhao L, Arsenault M, Ng ET, Longmuss E, Chau TC, Hartwig S, Koopman P
Developmental biology423(1)46-56(2017 03)

A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO.
Lee GH, Fujita M, Takaoka K, Murakami Y, Fujihara Y, Kanzawa N, Murakami KI, Kajikawa E, Takada Y, Saito K, Ikawa M, Hamada H, Maeda Y, Kinoshita T
The Journal of cell biology215(5)705-718(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings suggest that CRIPTO expression may be a useful serological marker for diagnostic and/or prognostic purposes during germ cell cancer management.
Title: Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors.

MEF2C has a role in regulating outflow tract alignment and transcriptional control of Tdgf1
Title: MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1.

Dissection of the mechanism by which this occurs indicates that mCripto-1 activates receptor activator NF-kappaB/receptor activator NF-kappaB ligand, and NF-kappaB signaling pathways.
Title: Cripto-1 ablation disrupts alveolar development in the mouse mammary gland through a progesterone receptor-mediated pathway.

CR1 protein fragments bind tightly to PfRh4 and also function as soluble inhibitors to block PfRh4 binding to red blood cells and to inhibit the PfRh4-CR1 invasion pathway
Title: Characterization of Inhibitors and Monoclonal Antibodies That Modulate the Interaction between Plasmodium falciparum Adhesin PfRh4 with Its Erythrocyte Receptor Complement Receptor 1.

our findings strongly suggest that Cripto-1 is a potential driver of mammary tumorigenesis
Title: Cripto-1 as a novel therapeutic target for triple negative breast cancer.

The following Tdgf1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tdgf1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu08386	NM_011562.2 Latest version!	Mus musculus teratocarcinoma-derived growth factor 1 (Tdgf1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu82774	XM_017313275.2 Latest version!	Mus musculus teratocarcinoma-derived growth factor 1 (Tdgf1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu82774	XM_017313275.1	Mus musculus teratocarcinoma-derived growth factor 1 (Tdgf1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tdgf1 ( NM_011562.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035692.2 Mus musculus teratocarcinoma-derived growth factor 1 (Tdgf1), mRNA.

Price & Availability↑

CloneID	OMu08386
Clone ID Related Accession (Same CDS sequence)	NM_011562.2
Accession Version	NM_011562.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	teratocarcinoma-derived growth factor precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ074826.1, AK133730.1 and BC052646.1. On Mar 24, 2007 this sequence version replaced NM_011562.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052646.1, AK133730.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGTACT TCTCATCCAG TGTGGTTTTG CTTGTGGCCA TTTCCAGTGC GTTTGAATTT 
GGACCCGTTG CTGGGAGAGA CCTTGCCATC AGAGATAACA GCATTTGGGA CCAGAAAGAA 
CCTGCCGTAC GCGATCGGTC TTTCCAGTTT GTGCCTTCCG TGGGGATACA GAACAGTAAG 
TCGCTTAATA AAACTTGCTG TCTGAATGGA GGGACTTGCA TCCTGGGGTC CTTCTGTGCC 
TGCCCTCCTT CCTTCTATGG ACGCAACTGT GAACATGATG TTCGCAAAGA GCACTGTGGG 
TCTATCCTCC ATGGCACCTG GCTGCCCAAG AAGTGTTCCC TGTGCAGATG CTGGCACGGC 
CAGCTCCACT GTCTTCCTCA GACCTTTCTA CCTGGCTGTG ATGGTCACGT GATGGACCAG 
GACCTCAAAG CATCCGGGAC TCCGTGTCAA ACGCCGTCTG TGACGACCAC TTTTATGCTA 
GCTGGCGCCT GCCTTTTTCT AGATATGAAA GTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035692.2
CDS	316..831
Translation	MGYFSSSVVLLVAISSAFEFGPVAGRDLAIRDNSIWDQKEPAVRDRSFQFVPSVGIQNSKSLNKTCCLNGGTCILGSFCACPPSFYGRNCEHDVRKEHCGSILHGTWLPKKCSLCRCWHGQLHCLPQTFLPGCDGHVMDQDLKASGTPCQTPSVTTTFMLAGACLFLDMKV

Target ORF information:

RefSeq Version	NM_011562.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus teratocarcinoma-derived growth factor 1 (Tdgf1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011562.2

ORF Insert Sequence:

ATGGGGTACT TCTCATCCAG TGTGGTTTTG CTTGTGGCCA TTTCCAGTGC GTTTGAATTT 
GGACCCGTTG CTGGGAGAGA CCTTGCCATC AGAGATAACA GCATTTGGGA CCAGAAAGAA 
CCTGCCGTAC GCGATCGGTC TTTCCAGTTT GTGCCTTCCG TGGGGATACA GAACAGTAAG 
TCGCTTAATA AAACTTGCTG TCTGAATGGA GGGACTTGCA TCCTGGGGTC CTTCTGTGCC 
TGCCCTCCTT CCTTCTATGG ACGCAACTGT GAACATGATG TTCGCAAAGA GCACTGTGGG 
TCTATCCTCC ATGGCACCTG GCTGCCCAAG AAGTGTTCCC TGTGCAGATG CTGGCACGGC 
CAGCTCCACT GTCTTCCTCA GACCTTTCTA CCTGGCTGTG ATGGTCACGT GATGGACCAG 
GACCTCAAAG CATCCGGGAC TCCGTGTCAA ACGCCGTCTG TGACGACCAC TTTTATGCTA 
GCTGGCGCCT GCCTTTTTCT AGATATGAAA GTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tdgf1 ( XM_017313275.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017168764.1 Mus musculus teratocarcinoma-derived growth factor 1 (Tdgf1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu82774
Clone ID Related Accession (Same CDS sequence)	XM_017313275.2 , XM_017313275.1
Accession Version	XM_017313275.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	teratocarcinoma-derived growth factor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017313275.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCACTTC ATGCTGGGAC CAGCTATCAG ACCATCAGAC TAGGTGACCA ATCTGGTCCA 
ACCATGAAAG TTATTTCCCT GAAAGGTAAG TCGCTTAATA AAACTTGCTG TCTGAATGGA 
GGGACTTGCA TCCTGGGGTC CTTCTGTGCC TGCCCTCCTT CCTTCTATGG ACGCAACTGT 
GAACATGATG TTCGCAAAGA GCACTGTGGG TCTATCCTCC ATGGCACCTG GCTGCCCAAG 
AAGTGTTCCC TGTGCAGATG CTGGCACGGC CAGCTCCACT GTCTTCCTCA GACCTTTCTA 
CCTGGCTGTG ATGGTCACGT GATGGACCAG GACCTCAAAG CATCCGGGAC TCCGTGTCAA 
ACGCCGTCTG TGACGACCAC TTTTATGCTA GCTGGCGCCT GCCTTTTTCT AGATATGAAA 
GTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017168764.1
CDS	74..499
Translation	MPLHAGTSYQTIRLGDQSGPTMKVISLKGKSLNKTCCLNGGTCILGSFCACPPSFYGRNCEHDVRKEHCGSILHGTWLPKKCSLCRCWHGQLHCLPQTFLPGCDGHVMDQDLKASGTPCQTPSVTTTFMLAGACLFLDMKV

Target ORF information:

RefSeq Version	XM_017313275.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus teratocarcinoma-derived growth factor 1 (Tdgf1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017313275.2

ORF Insert Sequence:

ATGCCACTTC ATGCTGGGAC CAGCTATCAG ACCATCAGAC TAGGTGACCA ATCTGGTCCA 
ACCATGAAAG TTATTTCCCT GAAAGGTAAG TCGCTTAATA AAACTTGCTG TCTGAATGGA 
GGGACTTGCA TCCTGGGGTC CTTCTGTGCC TGCCCTCCTT CCTTCTATGG ACGCAACTGT 
GAACATGATG TTCGCAAAGA GCACTGTGGG TCTATCCTCC ATGGCACCTG GCTGCCCAAG 
AAGTGTTCCC TGTGCAGATG CTGGCACGGC CAGCTCCACT GTCTTCCTCA GACCTTTCTA 
CCTGGCTGTG ATGGTCACGT GATGGACCAG GACCTCAAAG CATCCGGGAC TCCGTGTCAA 
ACGCCGTCTG TGACGACCAC TTTTATGCTA GCTGGCGCCT GCCTTTTTCT AGATATGAAA 
GTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tdgf1 ( XM_017313275.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017168764.1 Mus musculus teratocarcinoma-derived growth factor 1 (Tdgf1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu82774
Clone ID Related Accession (Same CDS sequence)	XM_017313275.2 , XM_017313275.1
Accession Version	XM_017313275.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	teratocarcinoma-derived growth factor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCACTTC ATGCTGGGAC CAGCTATCAG ACCATCAGAC TAGGTGACCA ATCTGGTCCA 
ACCATGAAAG TTATTTCCCT GAAAGGTAAG TCGCTTAATA AAACTTGCTG TCTGAATGGA 
GGGACTTGCA TCCTGGGGTC CTTCTGTGCC TGCCCTCCTT CCTTCTATGG ACGCAACTGT 
GAACATGATG TTCGCAAAGA GCACTGTGGG TCTATCCTCC ATGGCACCTG GCTGCCCAAG 
AAGTGTTCCC TGTGCAGATG CTGGCACGGC CAGCTCCACT GTCTTCCTCA GACCTTTCTA 
CCTGGCTGTG ATGGTCACGT GATGGACCAG GACCTCAAAG CATCCGGGAC TCCGTGTCAA 
ACGCCGTCTG TGACGACCAC TTTTATGCTA GCTGGCGCCT GCCTTTTTCT AGATATGAAA 
GTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017168764.1
CDS	76..501
Translation	MPLHAGTSYQTIRLGDQSGPTMKVISLKGKSLNKTCCLNGGTCILGSFCACPPSFYGRNCEHDVRKEHCGSILHGTWLPKKCSLCRCWHGQLHCLPQTFLPGCDGHVMDQDLKASGTPCQTPSVTTTFMLAGACLFLDMKV

Target ORF information:

RefSeq Version	XM_017313275.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus teratocarcinoma-derived growth factor 1 (Tdgf1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017313275.1

ORF Insert Sequence:

ATGCCACTTC ATGCTGGGAC CAGCTATCAG ACCATCAGAC TAGGTGACCA ATCTGGTCCA 
ACCATGAAAG TTATTTCCCT GAAAGGTAAG TCGCTTAATA AAACTTGCTG TCTGAATGGA 
GGGACTTGCA TCCTGGGGTC CTTCTGTGCC TGCCCTCCTT CCTTCTATGG ACGCAACTGT 
GAACATGATG TTCGCAAAGA GCACTGTGGG TCTATCCTCC ATGGCACCTG GCTGCCCAAG 
AAGTGTTCCC TGTGCAGATG CTGGCACGGC CAGCTCCACT GTCTTCCTCA GACCTTTCTA 
CCTGGCTGTG ATGGTCACGT GATGGACCAG GACCTCAAAG CATCCGGGAC TCCGTGTCAA 
ACGCCGTCTG TGACGACCAC TTTTATGCTA GCTGGCGCCT GCCTTTTTCT AGATATGAAA 
GTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling.
eLife6(2017 Nov)
Huang X,Balmer S,Yang F,Fidalgo M,Li D,Guallar D,Hadjantonakis AK,Wang J

The epigenetic modifier Fam208a is required to maintain epiblast cell fitness.
Scientific reports7(1)9322(2017 Aug)
Bhargava S,Cox B,Polydorou C,Gresakova V,Korinek V,Strnad H,Sedlacek R,Epp TA,Chawengsaksophak K

SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice.
Developmental biology423(1)46-56(2017 03)
Zhao L,Arsenault M,Ng ET,Longmuss E,Chau TC,Hartwig S,Koopman P

A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO.
The Journal of cell biology215(5)705-718(2016 Dec)
Lee GH,Fujita M,Takaoka K,Murakami Y,Fujihara Y,Kanzawa N,Murakami KI,Kajikawa E,Takada Y,Saito K,Ikawa M,Hamada H,Maeda Y,Kinoshita T

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Tdgf1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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