Phlda1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Phlda1
Entrez Gene ID	21664
Full Name	pleckstrin homology like domain, family A, member 1
Synonyms	DT1P1B11,TDAG51,Tdag
General protein information	Preferred Names pleckstrin homology like domain, family A, member 1 Names pleckstrin homology-like domain family A member 1 PQ-rich protein PQR protein T-cell death associated T-cell death-associated gene 51 protein proline- and glutamine-rich protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_009344.3	NP_033370.2	pleckstrin homology-like domain family A member 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PHLDA1	XP_005629218.1
Mus musculus (house mouse)	Phlda1	NP_033370.2
Danio rerio (zebrafish)	phlda1	NP_001006011.1
Homo sapiens (human)	PHLDA1	NP_031376.3
Pan troglodytes (chimpanzee)	PHLDA1	XP_001161528.1
	LOC719036	XP_001117606.2
Rattus norvegicus (Norway rat)	Phlda1	NP_058876.2
Xenopus tropicalis (tropical clawed frog)	phlda1	NP_001015853.1

Gene Ontology
Bibliography

Related articles in PubMed

The Pleckstrin homology like domain family member, TDAG51, is temporally regulated during skeletal muscle regeneration.
Coleman SK, Cao AW, Rebalka IA, Gyulay G, Chambers PJ, Tupling AR, Austin RC, Hawke TJ
Biochemical and biophysical research communications495(1)499-505(2018 01)

Regulation of PHLDA1 Expression by JAK2-ERK1/2-STAT3 Signaling Pathway.
Lyu JH, Huang B, Park DW, Baek SH
Journal of cellular biochemistry117(2)483-90(2016 Feb)

PHLDA1 Promotes Lung Contusion by Regulating the Toll-Like Receptor 2 Signaling Pathway.
Wang S, Zhang H, Wang A, Huang D, Fan J, Lu L, Chen X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology40(5)1198-1206(2016)

Up-regulation of TDAG51 is a dependent factor of LPS-induced RAW264.7 macrophages proliferation and cell cycle progression.
Jiao HW, Jia XX, Zhao TJ, Rong H, Zhang JN, Cheng Y, Zhu HP, Xu KL, Guo SY, Shi QY, Zhang H, Wang FY, Chen CF, Du L
Immunopharmacology and immunotoxicology38(2)124-30(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The data presented herein demonstrate TDAG51 expression to be upregulated in damaged skeletal muscle and its absence attenuates the early phases of muscle regeneration.
Title: The Pleckstrin homology like domain family member, TDAG51, is temporally regulated during skeletal muscle regeneration.

The JAK2-ERK1/2-STAT3 pathway is an important signaling pathway for regulation of PHLDA1 expression.
Title: Regulation of PHLDA1 Expression by JAK2-ERK1/2-STAT3 Signaling Pathway.

PHLDA1 plays a critical role in the development of progressive lung contusion and subsequent inflammation.
Title: PHLDA1 Promotes Lung Contusion by Regulating the Toll-Like Receptor 2 Signaling Pathway.

These findings suggested that TDAG51 up-regulation is a dependent event during LPS-mediated proliferation and cell cycle progression, and which increase our understanding of the interaction mechanism between LPS and macrophages.
Title: Up-regulation of TDAG51 is a dependent factor of LPS-induced RAW264.7 macrophages proliferation and cell cycle progression.

TDAG51 has a protective role in oxidative stress-induced cell death in mouse embryonic fibroblasts.
Title: TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts.

The following Phlda1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Phlda1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03975	NM_009344.3 Latest version!	Mus musculus pleckstrin homology like domain, family A, member 1 (Phlda1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Phlda1 ( NM_009344.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033370.2 Mus musculus pleckstrin homology like domain, family A, member 1 (Phlda1), mRNA.

Price & Availability↑

CloneID	OMu03975
Clone ID Related Accession (Same CDS sequence)	NM_009344.3
Accession Version	NM_009344.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Mus musculus(house mouse)
Product	pleckstrin homology-like domain family A member 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U44088.1 and BY378082.1. On Apr 9, 2009 this sequence version replaced NM_009344.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U44088.1, AK158890.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAGGCGTA CGCCGGCTGC CGAGCGCCTC TCGGAGCTGG GTTTTCCCCC GCGGCGCGGG 
CGCCAGGAGC CGCCTTTTCC GCTGGGTGTC ACTCGGGGGT GGGGAGGGTG GCCCATTGAA 
AAGCGCCGCG AGGGGCCCCG GCCAGTGCCC TTCAGTGAGC GCTCGCCGGA GGACGGCAGA 
GAGCAGCCCG CTCACGGCTC CGGGATCTTG TGGCGAGTCA GGACGCGCCT GTCCCTCTGC 
CGGGACCCCG AGCCACCGCC GCCGCCGCCA CCGCTCTGTC TCCTGCGAGT CAGCCTTCTC 
TGCGCGCTCC GGGCGGGCGG CCGCGGAAGC CGCTGGGGCG AGGACGGCGC AGGGCTGCTA 
CTGCTACCCC CAGCCGGAGC GTCTGGAAGC CTGAAGGCCG AGCGGAGCAG CAGCACCCCT 
TATGCCGGAA GGATGCTGGA GAACAGCGGC TGCAAGGCGC TGAAGGAAGG AGTGCTGGAA 
AAGCGAAGCG ACGGGCTGCT GCAGCTCTGG AAGAAAAAGT GCTGCATCCT CACCGAGGAA 
GGGCTACTGC TCATACCGCC CAAGCAGCTA CAACAGCAGC AGCAGCAGCA ACAGCCCGGG 
CAGGGGACGG CCGAACCGTC CCAACCTAGT GGCCCCACCG TCGCCAGCCT TGAGCCACCA 
GTCAAGCTGA AGGAATTGCA CTTTTCCAAT ATGAAGACTG TAGACTGCGT GGAGCGCAAG 
GGCAAGTACA TGTACTTCAC TGTGGTGATG ACGGAGGGCA AAGAGATCGA CTTTCGGTGC 
CCCCAGGACC AGGGCTGGAA CGCCGAGATC ACGTTGCAGA TGGTGCAGTA CAAAAATCGC 
CAGGCCATAC TGGCGGTCAA GTCTACCAGG CAGAAGCAGC AGCACCTGGT CCAGCAGCAG 
CCTCCGCAGA CGCAGCAGAT CCAACCCCAG CCCCAGCCGC AGATCCAACC CCAGCCCCAG 
CCGCAGATCC AGCCTCAACC CCAACCCCAG CCCCAACCTC AGCCCCAACC TCAGCCCCAA 
CCCCAACCCC AACAGCTCCA CTCCTACCCG CATCCGCATC CTCATCCTTA CTCTCACCCG 
CACCAGCACC CACACCCGCA CCCGCACCCG CACCCTCACC CTCACCCTCA CCCGTACCAA 
CTCCAGCACG CGCACCAGCC TCTTCACTCG CAGCCGCAGG GTCACCGGCT TCTCCGCAGC 
ACCTCCAACT CTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033370.2
CDS	120..1337
Translation	MRRTPAAERLSELGFPPRRGRQEPPFPLGVTRGWGGWPIEKRREGPRPVPFSERSPEDGREQPAHGSGILWRVRTRLSLCRDPEPPPPPPPLCLLRVSLLCALRAGGRGSRWGEDGAGLLLLPPAGASGSLKAERSSSTPYAGRMLENSGCKALKEGVLEKRSDGLLQLWKKKCCILTEEGLLLIPPKQLQQQQQQQQPGQGTAEPSQPSGPTVASLEPPVKLKELHFSNMKTVDCVERKGKYMYFTVVMTEGKEIDFRCPQDQGWNAEITLQMVQYKNRQAILAVKSTRQKQQHLVQQQPPQTQQIQPQPQPQIQPQPQPQIQPQPQPQPQPQPQPQPQPQPQQLHSYPHPHPHPYSHPHQHPHPHPHPHPHPHPHPYQLQHAHQPLHSQPQGHRLLRSTSNSA

Target ORF information:

RefSeq Version	NM_009344.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus pleckstrin homology like domain, family A, member 1 (Phlda1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009344.3

ORF Insert Sequence:

ATGAGGCGTA CGCCGGCTGC CGAGCGCCTC TCGGAGCTGG GTTTTCCCCC GCGGCGCGGG 
CGCCAGGAGC CGCCTTTTCC GCTGGGTGTC ACTCGGGGGT GGGGAGGGTG GCCCATTGAA 
AAGCGCCGCG AGGGGCCCCG GCCAGTGCCC TTCAGTGAGC GCTCGCCGGA GGACGGCAGA 
GAGCAGCCCG CTCACGGCTC CGGGATCTTG TGGCGAGTCA GGACGCGCCT GTCCCTCTGC 
CGGGACCCCG AGCCACCGCC GCCGCCGCCA CCGCTCTGTC TCCTGCGAGT CAGCCTTCTC 
TGCGCGCTCC GGGCGGGCGG CCGCGGAAGC CGCTGGGGCG AGGACGGCGC AGGGCTGCTA 
CTGCTACCCC CAGCCGGAGC GTCTGGAAGC CTGAAGGCCG AGCGGAGCAG CAGCACCCCT 
TATGCCGGAA GGATGCTGGA GAACAGCGGC TGCAAGGCGC TGAAGGAAGG AGTGCTGGAA 
AAGCGAAGCG ACGGGCTGCT GCAGCTCTGG AAGAAAAAGT GCTGCATCCT CACCGAGGAA 
GGGCTACTGC TCATACCGCC CAAGCAGCTA CAACAGCAGC AGCAGCAGCA ACAGCCCGGG 
CAGGGGACGG CCGAACCGTC CCAACCTAGT GGCCCCACCG TCGCCAGCCT TGAGCCACCA 
GTCAAGCTGA AGGAATTGCA CTTTTCCAAT ATGAAGACTG TAGACTGCGT GGAGCGCAAG 
GGCAAGTACA TGTACTTCAC TGTGGTGATG ACGGAGGGCA AAGAGATCGA CTTTCGGTGC 
CCCCAGGACC AGGGCTGGAA CGCCGAGATC ACGTTGCAGA TGGTGCAGTA CAAAAATCGC 
CAGGCCATAC TGGCGGTCAA GTCTACCAGG CAGAAGCAGC AGCACCTGGT CCAGCAGCAG 
CCTCCGCAGA CGCAGCAGAT CCAACCCCAG CCCCAGCCGC AGATCCAACC CCAGCCCCAG 
CCGCAGATCC AGCCTCAACC CCAACCCCAG CCCCAACCTC AGCCCCAACC TCAGCCCCAA 
CCCCAACCCC AACAGCTCCA CTCCTACCCG CATCCGCATC CTCATCCTTA CTCTCACCCG 
CACCAGCACC CACACCCGCA CCCGCACCCG CACCCTCACC CTCACCCTCA CCCGTACCAA 
CTCCAGCACG CGCACCAGCC TCTTCACTCG CAGCCGCAGG GTCACCGGCT TCTCCGCAGC 
ACCTCCAACT CTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Pleckstrin homology like domain family member, TDAG51, is temporally regulated during skeletal muscle regeneration.
Biochemical and biophysical research communications495(1)499-505(2018 01)
Coleman SK,Cao AW,Rebalka IA,Gyulay G,Chambers PJ,Tupling AR,Austin RC,Hawke TJ

Regulation of PHLDA1 Expression by JAK2-ERK1/2-STAT3 Signaling Pathway.
Journal of cellular biochemistry117(2)483-90(2016 Feb)
Lyu JH,Huang B,Park DW,Baek SH

PHLDA1 Promotes Lung Contusion by Regulating the Toll-Like Receptor 2 Signaling Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology40(5)1198-1206(2016)
Wang S,Zhang H,Wang A,Huang D,Fan J,Lu L,Chen X

Up-regulation of TDAG51 is a dependent factor of LPS-induced RAW264.7 macrophages proliferation and cell cycle progression.
Immunopharmacology and immunotoxicology38(2)124-30(2016)
Jiao HW,Jia XX,Zhao TJ,Rong H,Zhang JN,Cheng Y,Zhu HP,Xu KL,Guo SY,Shi QY,Zhang H,Wang FY,Chen CF,Du L

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Phlda1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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