Lrrtm3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lrrtm3
Entrez Gene ID	216028
Full Name	leucine rich repeat transmembrane neuronal 3
Synonyms	9630044H04Rik
General protein information	Preferred Names leucine rich repeat transmembrane neuronal 3 Names leucine-rich repeat transmembrane neuronal protein 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 B4

mRNA and Protein(s)

mRNA	Protein	Name
NM_178678.4	NP_848793.1	leucine-rich repeat transmembrane neuronal protein 3 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LRRTM3	XP_546127.2
Homo sapiens (human)	LRRTM3	NP_821079.3
Pan troglodytes (chimpanzee)	LRRTM3	XP_003312627.1
Mus musculus (house mouse)	Lrrtm3	NP_848793.1
Bos taurus (cattle)	LRRTM3	NP_001096753.1
Gallus gallus (chicken)	LRRTM3	NP_001186474.1
Rattus norvegicus (Norway rat)	Lrrtm3	NP_001099857.1
	LRRTM3	XP_002805754.1
Xenopus tropicalis (tropical clawed frog)	lrrtm3	XP_002936907.2

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding.
Um JW, Choi TY, Kang H, Cho YS, Choii G, Uvarov P, Park D, Jeong D, Jeon S, Lee D, Kim H, Lee SH, Bae YC, Choi SY, Airaksinen MS, Ko J
Cell reports14(4)808-822(2016 Feb)

Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons.
Lodato S, Molyneaux BJ, Zuccaro E, Goff LA, Chen HH, Yuan W, Meleski A, Takahashi E, Mahony S, Rinn JL, Gifford DK, Arlotta P
Nature neuroscience17(8)1046-54(2014 Aug)

Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.
Um JW, Pramanik G, Ko JS, Song MY, Lee D, Kim H, Park KS, S?dhof TC, Tabuchi K, Ko J
Cell reports6(6)1096-1109(2014 Mar)

LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).
Lincoln S, Allen M, Cox CL, Walker LP, Malphrus K, Qiu Y, Nguyen T, Rowley C, Kouri N, Crook J, Pankratz VS, Younkin S, Younkin L, Carrasquillo M, Zou F, Abdul-Hay SO, Springer W, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Lewis JM, Dickson D, Graff-Radford NR, Petersen RC, Eckman E, Younkin SG, Ertekin-Taner N
PloS one8(6)e64164(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LRRTM3 is required for dentate gyrus excitatory synapse development and regulates activity-dependent AMPAR surface expression.
Title: LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding.

protein interactions between LRRTM3, APP and BACE1, as well as complex associations between mRNA levels of LRRTM3, CTNNA3, APP and BACE1 in humans might influence APP metabolism and ultimately risk of AD
Title: LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).

The following Lrrtm3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lrrtm3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07545	NM_178678.4 Latest version!	Mus musculus leucine rich repeat transmembrane neuronal 3 (Lrrtm3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lrrtm3 ( NM_178678.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_848793.1 Mus musculus leucine rich repeat transmembrane neuronal 3 (Lrrtm3), mRNA.

Price & Availability↑

CloneID	OMu07545
Clone ID Related Accession (Same CDS sequence)	NM_178678.4
Accession Version	NM_178678.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1749bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	leucine-rich repeat transmembrane neuronal protein 3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC116138.21 and AC158604.5. On May 2, 2007 this sequence version replaced NM_178678.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK035882.1, SRR1660821.50092.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164139 [ECO:0000348] ##Evidence-Data-END##

ATGGGTTTCA ATGTAATTAG GCTACTGCGA GGATCAGCTG TAGCGGTGGT TCTAGCACCC 
ACTGTCTTAC TGACAATGCT TTCTTCTGCT GAACGAGGAT GCCCTAAGGG TTGTAGGTGT 
GAAGGCAAAA TGGTATACTG TGAGTCTCAG AAACTGCAGG AGATACCCTC GAGTATATCT 
GCCGGTTGCT TGGGTTTATC CCTTCGCTAC AACAGCCTCC AAAAACTTAA GTATAATCAA 
TTTAAAGGGC TCAATCAGCT CACCTGGCTC TACCTTGACC ACAACCACAT CAGCAATATC 
GACGAGAATG CTTTCAATGG GATACGCAGA CTCAAAGAGT TGATTCTGAG TTCCAACAGA 
ATCTCCTATT TCCTTAACAA CACCTTCAGA CCTGTGACCA ATTTACGGAA CTTGGATCTG 
TCCTACAATC AGCTCCATTC TCTGGGATCG GAACAGTTCC GGGGCTTGAG GAAGCTGCTT 
AGTTTACACC TCCGCTCCAA CTCACTGAGA ACCATCCCGG TGCGGATCTT CCAAGACTGT 
CGCAACCTGG AACTTCTGGA CCTGGGATAC AACCGGATCC GAAGTTTAGC CAGGAATGTC 
TTTGCTGGCA TGATCAGACT CAAAGAGCTT CACCTGGAGC ACAATCAATT TTCCAAGCTC 
AACCTGGCCC TGTTCCCAAG GCTGGTGAGC CTTCAGAACT TGTACATGCA GTGGAATAAA 
ATCAGTGTCA TAGGGCAAAC CATGTCCTGG ACCTGGAGTT CCTTACAGAG GCTCGACCTG 
TCTGGTAATG AGATCGAAGC CTTCAGCGGA CCCAGTGTCT TCCAGTGTGT TCCCAATCTG 
CAACGCCTCA ACCTGGATTC CAACAAGCTC ACATTTATTG GACAAGAGAT TCTGGATTCT 
TGGATCTCTC TCAATGACAT CAGTCTGGCT GGGAATATAT GGGAATGCAG CAGGAATATC 
TGTTCCCTGG TAAACTGGCT GAGAAGTTTT AAAGGTCTGA GAGAGAATAC AATCATCTGC 
GCCAGTCCCA AAGAGCTGCA GGGGGTTAAC GTGATCGATG CGGTGAAGAA CTACAGCATC 
TGTGGGAAGA GCACTACCAC AGAGAGGTTT GACCTGGCCA GGGCCCTCCC CAAGCCCACA 
TTTAAGCCCA AGCTCCCCAG GCCGAAGCAC GAGAGCAAGC CTCCTCTGCC CCCCACGGTG 
GGAGCTACCG AGCCCAGCCC AGAGACAGAT GTGGACACGG AGCACATCTC CTTCCATAAG 
ATCATCGCGG GCAGCGTGGC CCTTTTCCTG TCGGTGCTGG TCATCCTCCT GGTGATGTAC 
GTGTCCTGGA AGCGGTACCC CGCGAGCATG AAGCAGCTGC AGCAGCGCTC CCTCATGCGA 
AGGCACCGGA AGAAGAAACG GCAATCGCTC AAGCAGATGA CTCCAGGCAC CCAGGAATTT 
TATGTAGATT ATAAACCCAC CAACACGGAG ACCAGCGAGA TGCTGCTGAA CGGAACGGGA 
CCCTGCACCT ATAGCAAATC AGGCTCCAGG GAATGTGAGA TACCTTTATC AATGAATGTG 
TCAACCTTTC TGGCATATGA CCAGCCCACA ATAAGTTACT GTGGGGTCCA TCATGAACTC 
CTCTCCCATA AGTCCTTTGA AACGAATGCA CAGGAAGACA CGATGGAAAG CCACCTAGAG 
ACTGAGCTGG ACTTGAGCAC AATCACGTCA GCTGGCCGCA TCAGTGACCA TAAACCACAG 
CTGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848793.1
CDS	543..2291
Translation	MGFNVIRLLRGSAVAVVLAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYMQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLRSFKGLRENTIICASPKELQGVNVIDAVKNYSICGKSTTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGATEPSPETDVDTEHISFHKIIAGSVALFLSVLVILLVMYVSWKRYPASMKQLQQRSLMRRHRKKKRQSLKQMTPGTQEFYVDYKPTNTETSEMLLNGTGPCTYSKSGSRECEIPLSMNVSTFLAYDQPTISYCGVHHELLSHKSFETNAQEDTMESHLETELDLSTITSAGRISDHKPQLA

Target ORF information:

RefSeq Version	NM_178678.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus leucine rich repeat transmembrane neuronal 3 (Lrrtm3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178678.4

ORF Insert Sequence:

ATGGGTTTCA ATGTAATTAG GCTACTGCGA GGATCAGCTG TAGCGGTGGT TCTAGCACCC 
ACTGTCTTAC TGACAATGCT TTCTTCTGCT GAACGAGGAT GCCCTAAGGG TTGTAGGTGT 
GAAGGCAAAA TGGTATACTG TGAGTCTCAG AAACTGCAGG AGATACCCTC GAGTATATCT 
GCCGGTTGCT TGGGTTTATC CCTTCGCTAC AACAGCCTCC AAAAACTTAA GTATAATCAA 
TTTAAAGGGC TCAATCAGCT CACCTGGCTC TACCTTGACC ACAACCACAT CAGCAATATC 
GACGAGAATG CTTTCAATGG GATACGCAGA CTCAAAGAGT TGATTCTGAG TTCCAACAGA 
ATCTCCTATT TCCTTAACAA CACCTTCAGA CCTGTGACCA ATTTACGGAA CTTGGATCTG 
TCCTACAATC AGCTCCATTC TCTGGGATCG GAACAGTTCC GGGGCTTGAG GAAGCTGCTT 
AGTTTACACC TCCGCTCCAA CTCACTGAGA ACCATCCCGG TGCGGATCTT CCAAGACTGT 
CGCAACCTGG AACTTCTGGA CCTGGGATAC AACCGGATCC GAAGTTTAGC CAGGAATGTC 
TTTGCTGGCA TGATCAGACT CAAAGAGCTT CACCTGGAGC ACAATCAATT TTCCAAGCTC 
AACCTGGCCC TGTTCCCAAG GCTGGTGAGC CTTCAGAACT TGTACATGCA GTGGAATAAA 
ATCAGTGTCA TAGGGCAAAC CATGTCCTGG ACCTGGAGTT CCTTACAGAG GCTCGACCTG 
TCTGGTAATG AGATCGAAGC CTTCAGCGGA CCCAGTGTCT TCCAGTGTGT TCCCAATCTG 
CAACGCCTCA ACCTGGATTC CAACAAGCTC ACATTTATTG GACAAGAGAT TCTGGATTCT 
TGGATCTCTC TCAATGACAT CAGTCTGGCT GGGAATATAT GGGAATGCAG CAGGAATATC 
TGTTCCCTGG TAAACTGGCT GAGAAGTTTT AAAGGTCTGA GAGAGAATAC AATCATCTGC 
GCCAGTCCCA AAGAGCTGCA GGGGGTTAAC GTGATCGATG CGGTGAAGAA CTACAGCATC 
TGTGGGAAGA GCACTACCAC AGAGAGGTTT GACCTGGCCA GGGCCCTCCC CAAGCCCACA 
TTTAAGCCCA AGCTCCCCAG GCCGAAGCAC GAGAGCAAGC CTCCTCTGCC CCCCACGGTG 
GGAGCTACCG AGCCCAGCCC AGAGACAGAT GTGGACACGG AGCACATCTC CTTCCATAAG 
ATCATCGCGG GCAGCGTGGC CCTTTTCCTG TCGGTGCTGG TCATCCTCCT GGTGATGTAC 
GTGTCCTGGA AGCGGTACCC CGCGAGCATG AAGCAGCTGC AGCAGCGCTC CCTCATGCGA 
AGGCACCGGA AGAAGAAACG GCAATCGCTC AAGCAGATGA CTCCAGGCAC CCAGGAATTT 
TATGTAGATT ATAAACCCAC CAACACGGAG ACCAGCGAGA TGCTGCTGAA CGGAACGGGA 
CCCTGCACCT ATAGCAAATC AGGCTCCAGG GAATGTGAGA TACCTTTATC AATGAATGTG 
TCAACCTTTC TGGCATATGA CCAGCCCACA ATAAGTTACT GTGGGGTCCA TCATGAACTC 
CTCTCCCATA AGTCCTTTGA AACGAATGCA CAGGAAGACA CGATGGAAAG CCACCTAGAG 
ACTGAGCTGG ACTTGAGCAC AATCACGTCA GCTGGCCGCA TCAGTGACCA TAAACCACAG 
CTGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding.
Cell reports14(4)808-822(2016 Feb)
Um JW,Choi TY,Kang H,Cho YS,Choii G,Uvarov P,Park D,Jeong D,Jeon S,Lee D,Kim H,Lee SH,Bae YC,Choi SY,Airaksinen MS,Ko J

Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons.
Nature neuroscience17(8)1046-54(2014 Aug)
Lodato S,Molyneaux BJ,Zuccaro E,Goff LA,Chen HH,Yuan W,Meleski A,Takahashi E,Mahony S,Rinn JL,Gifford DK,Arlotta P

Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.
Cell reports6(6)1096-1109(2014 Mar)
Um JW,Pramanik G,Ko JS,Song MY,Lee D,Kim H,Park KS,S?dhof TC,Tabuchi K,Ko J

LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).
PloS one8(6)e64164(2013)
Lincoln S,Allen M,Cox CL,Walker LP,Malphrus K,Qiu Y,Nguyen T,Rowley C,Kouri N,Crook J,Pankratz VS,Younkin S,Younkin L,Carrasquillo M,Zou F,Abdul-Hay SO,Springer W,Sando SB,Aasly JO,Barcikowska M,Wszolek ZK,Lewis JM,Dickson D,Graff-Radford NR,Petersen RC,Eckman E,Younkin SG,Ertekin-Taner N

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Lrrtm3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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