Astl cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Astl
Entrez Gene ID	215095
Full Name	astacin-like metalloendopeptidase (M12 family)
Synonyms	7420700F21,C87576,Sas1b
General protein information	Preferred Names astacin-like metalloendopeptidase (M12 family) Names astacin-like metalloendopeptidase astl oocyte astacin ovastacin sperm acrosomal SLLP1 sperm acrosomal SLLP1-binding protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 F1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001291003.1	NP_001277932.1	astacin-like metalloendopeptidase isoform a precursor
NM_172539.3	NP_766127.1	astacin-like metalloendopeptidase isoform b

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Astl	NP_001099974.1
	LOC100430790	XP_002799475.1
Drosophila melanogaster (fruit fly)	CG5715	NP_651242.1
Pan troglodytes (chimpanzee)	ASTL	XP_003309175.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006144	XP_316205.3
Canis lupus familiaris (dog)	ASTL	XP_005630449.1
Bos taurus (cattle)	ASTL	XP_002691176.1
Mus musculus (house mouse)	Astl	NP_766127.1
Homo sapiens (human)	ASTL	NP_001002036.3

Gene Ontology
Bibliography

Related articles in PubMed

Intracellular activation of ovastacin mediates pre-fertilization hardening of the zona pellucida.
K?rschgen H, Kuske M, Karmilin K, Yiallouros I, Balbach M, Floehr J, Wachten D, Jahnen-Dechent W, St?cker W
Molecular human reproduction23(9)607-616(2017 Sep)

A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice.
Xiong B, Zhao Y, Beall S, Sadusky AB, Dean J
PLoS genetics13(1)e1006580(2017 Jan)

Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy.
Burkart AD, Xiong B, Baibakov B, Jim?nez-Movilla M, Dean J
The Journal of cell biology197(1)37-44(2012 Apr)

Astacin-like metallo-endopeptidase is dynamically expressed in embryonic stem cells and embryonic epithelium during morphogenesis.
Acloque H, Lavial F, Pain B
Developmental dynamics : an official publication of the American Association of Anatomists241(3)574-82(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Seven amino acid motif near Astl N-terminus is necessary and sufficient for cortical granule localization.
Title: A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice.

Ovastacin is a pioneer component of mouse cortical granules and plays a definitive role in the postfertilization block to sperm binding that ensures monospermic fertilization and successful development
Title: Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy.

Data show that SAS1B/SAS1R (Sperm Acrosomal SLLP1 Binding/Sperm Acrosomal SLLP1 receptor) bound to sperm acrosomal protein SlLP1 with high affinity.
Title: Oocyte specific oolemmal SAS1B involved in sperm binding through intra-acrosomal SLLP1 during fertilization.

ASTL is dynamically expressed in the embryonic epithelium and in embryonic stem cells, suggesting an important function for the control of epithelial cell behavior during early development.
Title: Astacin-like metallo-endopeptidase is dynamically expressed in embryonic stem cells and embryonic epithelium during morphogenesis.

cloning and characterization of ovastacin; could play in mammals a physiological function similar to that performed by hatching proteases in evolutionary distant species from arthropods to fish [ovastacin]
Title: Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish.

The following Astl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Astl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14391	NM_172539.3 Latest version!	Mus musculus astacin-like metalloendopeptidase (M12 family) (Astl), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu16784	NM_001291003.1 Latest version!	Mus musculus astacin-like metalloendopeptidase (M12 family) (Astl), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Astl ( NM_172539.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766127.1 Mus musculus astacin-like metalloendopeptidase (M12 family) (Astl), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu14391
Clone ID Related Accession (Same CDS sequence)	NM_172539.3
Accession Version	NM_172539.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1245bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-15
Organism	Mus musculus(house mouse)
Product	astacin-like metalloendopeptidase isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL845368.6, AK033037.1 and DV662582.1. On Mar 21, 2014 this sequence version replaced NM_172539.2. Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: AK033037.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGCAC CCTCAGCATC CAGATGTTCT GGAGTCTGCA GTACCAGTGT TCCAGAAGGC 
TTCACTCCTG AGGGAAGCCC GGTATTTCAG GACAAGGACA TCCCCGCAAT TAACCAAGGG 
CTCATCTCAG AGGAGACCCC AGAAAGCAGC TTCCTGGTAG AAGGGGACAT TATCCGGCCA 
AGCCCTTTCC GATTGTTGTC AGTGACCAAT AATAAATGGC CCAAGGGCGT TGGTGGCTTT 
GTGGAGATCC CCTTCCTGCT TTCCAGAAAG TATGATGAAC TCAGCCGCCG GGTCATTATG 
GATGCCTTTG CTGAGTTTGA ACGTTTCACA TGCATCCGGT TTGTTGCCTA CCATGGTCAG 
AGAGACTTTG TTTCCATTCT TCCTATGGCG GGGTGTTTCT CTGGTGTGGG ACGCAGTGGA 
GGGATGCAGG TGGTGTCCTT GGCACCCACT TGTCTCCGGA AGGGCCGAGG CATTGTCCTA 
CATGAGCTCA TGCACGTACT TGGCTTCTGG CATGAGCATT CACGGGCAGA TCGGGACCGC 
TACATCCAAG TCAACTGGAA CGAGATCCTC CCGGGCTTTG AAATCAACTT CATCAAGTCA 
CGGAGTACCA ATATGTTAGT TCCCTATGAC TACTCATCTG TGATGCATTA TGGGAGATTT 
GCCTTCAGCT GGCGTGGGCA GCCCACCATC ATACCACTCT GGACCTCCAG TGTTCACATT 
GGCCAGCGAT GGAACCTGAG TACCTCAGAT ATCACCCGGG TCTGCAGGCT GTATAACTGC 
AGCCGGAGTG TCCCTGACTC CCACGGGAGA GGGTTTGAGG CCCAGAGTGA TGGAAGCAGC 
CTCACCCCTG CCTCTATATC ACGTCTACAA AGACTTCTCG AGGCACTGTC AGAGGAATCT 
GGAAGCTCTG CCCCTAGTGG CTCCAGGACT GGAGGCCAGA GTATTGCCGG GCTTGGTAAC 
AGCCAGCAAG GATGGGAGCA TCCTCCTCAG AGCACATTCA GTGTGGGAGC CTTGGCAAGA 
CCACCTCAGA TGCTAGCCGA TGCTTCAAAA TCGGGGCCTG GAGCAGGTGC AGACAGCTTG 
TCTCTAGAGC AGTTCCAGCT AGCCCAGGCC CCCACTGTAC CTCTTGCTCT ATTTCCAGAA 
GCCAGAGACA AGCCAGCACC TATCCAAGAT GCCTTTGAGA GGCTAGCTCC ACTTCCAGGA 
GGCTGTGCAC CTGGAAGTCA CATTAGAGAG GTGCCCAGAG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766127.1
CDS	256..1500
Translation	MGAPSASRCSGVCSTSVPEGFTPEGSPVFQDKDIPAINQGLISEETPESSFLVEGDIIRPSPFRLLSVTNNKWPKGVGGFVEIPFLLSRKYDELSRRVIMDAFAEFERFTCIRFVAYHGQRDFVSILPMAGCFSGVGRSGGMQVVSLAPTCLRKGRGIVLHELMHVLGFWHEHSRADRDRYIQVNWNEILPGFEINFIKSRSTNMLVPYDYSSVMHYGRFAFSWRGQPTIIPLWTSSVHIGQRWNLSTSDITRVCRLYNCSRSVPDSHGRGFEAQSDGSSLTPASISRLQRLLEALSEESGSSAPSGSRTGGQSIAGLGNSQQGWEHPPQSTFSVGALARPPQMLADASKSGPGAGADSLSLEQFQLAQAPTVPLALFPEARDKPAPIQDAFERLAPLPGGCAPGSHIREVPRD

Target ORF information:

RefSeq Version	NM_172539.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus astacin-like metalloendopeptidase (M12 family) (Astl), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172539.3

ORF Insert Sequence:

ATGGGAGCAC CCTCAGCATC CAGATGTTCT GGAGTCTGCA GTACCAGTGT TCCAGAAGGC 
TTCACTCCTG AGGGAAGCCC GGTATTTCAG GACAAGGACA TCCCCGCAAT TAACCAAGGG 
CTCATCTCAG AGGAGACCCC AGAAAGCAGC TTCCTGGTAG AAGGGGACAT TATCCGGCCA 
AGCCCTTTCC GATTGTTGTC AGTGACCAAT AATAAATGGC CCAAGGGCGT TGGTGGCTTT 
GTGGAGATCC CCTTCCTGCT TTCCAGAAAG TATGATGAAC TCAGCCGCCG GGTCATTATG 
GATGCCTTTG CTGAGTTTGA ACGTTTCACA TGCATCCGGT TTGTTGCCTA CCATGGTCAG 
AGAGACTTTG TTTCCATTCT TCCTATGGCG GGGTGTTTCT CTGGTGTGGG ACGCAGTGGA 
GGGATGCAGG TGGTGTCCTT GGCACCCACT TGTCTCCGGA AGGGCCGAGG CATTGTCCTA 
CATGAGCTCA TGCACGTACT TGGCTTCTGG CATGAGCATT CACGGGCAGA TCGGGACCGC 
TACATCCAAG TCAACTGGAA CGAGATCCTC CCGGGCTTTG AAATCAACTT CATCAAGTCA 
CGGAGTACCA ATATGTTAGT TCCCTATGAC TACTCATCTG TGATGCATTA TGGGAGATTT 
GCCTTCAGCT GGCGTGGGCA GCCCACCATC ATACCACTCT GGACCTCCAG TGTTCACATT 
GGCCAGCGAT GGAACCTGAG TACCTCAGAT ATCACCCGGG TCTGCAGGCT GTATAACTGC 
AGCCGGAGTG TCCCTGACTC CCACGGGAGA GGGTTTGAGG CCCAGAGTGA TGGAAGCAGC 
CTCACCCCTG CCTCTATATC ACGTCTACAA AGACTTCTCG AGGCACTGTC AGAGGAATCT 
GGAAGCTCTG CCCCTAGTGG CTCCAGGACT GGAGGCCAGA GTATTGCCGG GCTTGGTAAC 
AGCCAGCAAG GATGGGAGCA TCCTCCTCAG AGCACATTCA GTGTGGGAGC CTTGGCAAGA 
CCACCTCAGA TGCTAGCCGA TGCTTCAAAA TCGGGGCCTG GAGCAGGTGC AGACAGCTTG 
TCTCTAGAGC AGTTCCAGCT AGCCCAGGCC CCCACTGTAC CTCTTGCTCT ATTTCCAGAA 
GCCAGAGACA AGCCAGCACC TATCCAAGAT GCCTTTGAGA GGCTAGCTCC ACTTCCAGGA 
GGCTGTGCAC CTGGAAGTCA CATTAGAGAG GTGCCCAGAG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Astl ( NM_001291003.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001277932.1 Mus musculus astacin-like metalloendopeptidase (M12 family) (Astl), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu16784
Clone ID Related Accession (Same CDS sequence)	NM_001291003.1
Accession Version	NM_001291003.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1308bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	astacin-like metalloendopeptidase isoform a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV649054.1, BC064729.1 and DV662582.1. On Mar 21, 2014 this sequence version replaced XM_006499122.1. Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: BC064729.1, AJ537599.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTATCA TGGGAAGCCT GTGGCCTTGG ATATTAACTA TGCTCTCCTT GCTAGGTTTG 
AGCATGGGAG CACCCTCAGC ATCCAGATGT TCTGGAGTCT GCAGTACCAG TGTTCCAGAA 
GGCTTCACTC CTGAGGGAAG CCCGGTATTT CAGGACAAGG ACATCCCCGC AATTAACCAA 
GGGCTCATCT CAGAGGAGAC CCCAGAAAGC AGCTTCCTGG TAGAAGGGGA CATTATCCGG 
CCAAGCCCTT TCCGATTGTT GTCAGTGACC AATAATAAAT GGCCCAAGGG CGTTGGTGGC 
TTTGTGGAGA TCCCCTTCCT GCTTTCCAGA AAGTATGATG AACTCAGCCG CCGGGTCATT 
ATGGATGCCT TTGCTGAGTT TGAACGTTTC ACATGCATCC GGTTTGTTGC CTACCATGGT 
CAGAGAGACT TTGTTTCCAT TCTTCCTATG GCGGGGTGTT TCTCTGGTGT GGGACGCAGT 
GGAGGGATGC AGGTGGTGTC CTTGGCACCC ACTTGTCTCC GGAAGGGCCG AGGCATTGTC 
CTACATGAGC TCATGCACGT ACTTGGCTTC TGGCATGAGC ATTCACGGGC AGATCGGGAC 
CGCTACATCC AAGTCAACTG GAACGAGATC CTCCCGGGCT TTGAAATCAA CTTCATCAAG 
TCACGGAGTA CCAATATGTT AGTTCCCTAT GACTACTCAT CTGTGATGCA TTATGGGAGA 
TTTGCCTTCA GCTGGCGTGG GCAGCCCACC ATCATACCAC TCTGGACCTC CAGTGTTCAC 
ATTGGCCAGC GATGGAACCT GAGTACCTCA GATATCACCC GGGTCTGCAG GCTGTATAAC 
TGCAGCCGGA GTGTCCCTGA CTCCCACGGG AGAGGGTTTG AGGCCCAGAG TGATGGAAGC 
AGCCTCACCC CTGCCTCTAT ATCACGTCTA CAAAGACTTC TCGAGGCACT GTCAGAGGAA 
TCTGGAAGCT CTGCCCCTAG TGGCTCCAGG ACTGGAGGCC AGAGTATTGC CGGGCTTGGT 
AACAGCCAGC AAGGATGGGA GCATCCTCCT CAGAGCACAT TCAGTGTGGG AGCCTTGGCA 
AGACCACCTC AGATGCTAGC CGATGCTTCA AAATCGGGGC CTGGAGCAGG TGCAGACAGC 
TTGTCTCTAG AGCAGTTCCA GCTAGCCCAG GCCCCCACTG TACCTCTTGC TCTATTTCCA 
GAAGCCAGAG ACAAGCCAGC ACCTATCCAA GATGCCTTTG AGAGGCTAGC TCCACTTCCA 
GGAGGCTGTG CACCTGGAAG TCACATTAGA GAGGTGCCCA GAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277932.1
CDS	62..1369
Translation	MGIMGSLWPWILTMLSLLGLSMGAPSASRCSGVCSTSVPEGFTPEGSPVFQDKDIPAINQGLISEETPESSFLVEGDIIRPSPFRLLSVTNNKWPKGVGGFVEIPFLLSRKYDELSRRVIMDAFAEFERFTCIRFVAYHGQRDFVSILPMAGCFSGVGRSGGMQVVSLAPTCLRKGRGIVLHELMHVLGFWHEHSRADRDRYIQVNWNEILPGFEINFIKSRSTNMLVPYDYSSVMHYGRFAFSWRGQPTIIPLWTSSVHIGQRWNLSTSDITRVCRLYNCSRSVPDSHGRGFEAQSDGSSLTPASISRLQRLLEALSEESGSSAPSGSRTGGQSIAGLGNSQQGWEHPPQSTFSVGALARPPQMLADASKSGPGAGADSLSLEQFQLAQAPTVPLALFPEARDKPAPIQDAFERLAPLPGGCAPGSHIREVPRD

Target ORF information:

RefSeq Version	NM_001291003.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus astacin-like metalloendopeptidase (M12 family) (Astl), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001291003.1

ORF Insert Sequence:

ATGGGTATCA TGGGAAGCCT GTGGCCTTGG ATATTAACTA TGCTCTCCTT GCTAGGTTTG 
AGCATGGGAG CACCCTCAGC ATCCAGATGT TCTGGAGTCT GCAGTACCAG TGTTCCAGAA 
GGCTTCACTC CTGAGGGAAG CCCGGTATTT CAGGACAAGG ACATCCCCGC AATTAACCAA 
GGGCTCATCT CAGAGGAGAC CCCAGAAAGC AGCTTCCTGG TAGAAGGGGA CATTATCCGG 
CCAAGCCCTT TCCGATTGTT GTCAGTGACC AATAATAAAT GGCCCAAGGG CGTTGGTGGC 
TTTGTGGAGA TCCCCTTCCT GCTTTCCAGA AAGTATGATG AACTCAGCCG CCGGGTCATT 
ATGGATGCCT TTGCTGAGTT TGAACGTTTC ACATGCATCC GGTTTGTTGC CTACCATGGT 
CAGAGAGACT TTGTTTCCAT TCTTCCTATG GCGGGGTGTT TCTCTGGTGT GGGACGCAGT 
GGAGGGATGC AGGTGGTGTC CTTGGCACCC ACTTGTCTCC GGAAGGGCCG AGGCATTGTC 
CTACATGAGC TCATGCACGT ACTTGGCTTC TGGCATGAGC ATTCACGGGC AGATCGGGAC 
CGCTACATCC AAGTCAACTG GAACGAGATC CTCCCGGGCT TTGAAATCAA CTTCATCAAG 
TCACGGAGTA CCAATATGTT AGTTCCCTAT GACTACTCAT CTGTGATGCA TTATGGGAGA 
TTTGCCTTCA GCTGGCGTGG GCAGCCCACC ATCATACCAC TCTGGACCTC CAGTGTTCAC 
ATTGGCCAGC GATGGAACCT GAGTACCTCA GATATCACCC GGGTCTGCAG GCTGTATAAC 
TGCAGCCGGA GTGTCCCTGA CTCCCACGGG AGAGGGTTTG AGGCCCAGAG TGATGGAAGC 
AGCCTCACCC CTGCCTCTAT ATCACGTCTA CAAAGACTTC TCGAGGCACT GTCAGAGGAA 
TCTGGAAGCT CTGCCCCTAG TGGCTCCAGG ACTGGAGGCC AGAGTATTGC CGGGCTTGGT 
AACAGCCAGC AAGGATGGGA GCATCCTCCT CAGAGCACAT TCAGTGTGGG AGCCTTGGCA 
AGACCACCTC AGATGCTAGC CGATGCTTCA AAATCGGGGC CTGGAGCAGG TGCAGACAGC 
TTGTCTCTAG AGCAGTTCCA GCTAGCCCAG GCCCCCACTG TACCTCTTGC TCTATTTCCA 
GAAGCCAGAG ACAAGCCAGC ACCTATCCAA GATGCCTTTG AGAGGCTAGC TCCACTTCCA 
GGAGGCTGTG CACCTGGAAG TCACATTAGA GAGGTGCCCA GAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intracellular activation of ovastacin mediates pre-fertilization hardening of the zona pellucida.
Molecular human reproduction23(9)607-616(2017 Sep)
K?rschgen H,Kuske M,Karmilin K,Yiallouros I,Balbach M,Floehr J,Wachten D,Jahnen-Dechent W,St?cker W

A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice.
PLoS genetics13(1)e1006580(2017 Jan)
Xiong B,Zhao Y,Beall S,Sadusky AB,Dean J

Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy.
The Journal of cell biology197(1)37-44(2012 Apr)
Burkart AD,Xiong B,Baibakov B,Jim?nez-Movilla M,Dean J

Astacin-like metallo-endopeptidase is dynamically expressed in embryonic stem cells and embryonic epithelium during morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists241(3)574-82(2012 Mar)
Acloque H,Lavial F,Pain B

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Astl cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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