Tcap cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tcap
Entrez Gene ID	21393
Full Name	titin-cap
Synonyms	AI503981,AJ223855
General protein information	Preferred Names titin-cap Names telethonin titin cap protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_011540.2	NP_035670.2	telethonin

Pathways from BioSystems

Homologies

Bos taurus (cattle)	TCAP	NP_001014915.1
Danio rerio (zebrafish)	tcap	XP_684103.1
Pan troglodytes (chimpanzee)	TCAP	XP_511458.3
Homo sapiens (human)	TCAP	NP_003664.1
	TCAP	XP_001089621.1
Mus musculus (house mouse)	Tcap	NP_035670.2
Xenopus tropicalis (tropical clawed frog)	tcap	XP_002940414.1
Canis lupus familiaris (dog)	TCAP	NP_001128597.1

Gene Ontology
Bibliography

Related articles in PubMed

Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes.
Candasamy AJ, Haworth RS, Cuello F, Ibrahim M, Aravamudhan S, Kr?ger M, Holt MR, Terracciano CM, Mayr M, Gautel M, Avkiran M
The Journal of biological chemistry289(3)1282-93(2014 Jan)

Circadian regulation of myocardial sarcomeric Titin-cap (Tcap, telethonin): identification of cardiac clock-controlled genes using open access bioinformatics data.
Podobed PS, Alibhai FJ, Chow CW, Martino TA
PloS one9(8)e104907(2014)

A critical role for Telethonin in regulating t-tubule structure and function in the mammalian heart.
Ibrahim M, Siedlecka U, Buyandelger B, Harada M, Rao C, Moshkov A, Bhargava A, Schneider M, Yacoub MH, Gorelik J, Kn?ll R, Terracciano CM
Human molecular genetics22(2)372-83(2013 Jan)

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.
Richard AF, Demignon J, Sakakibara I, Pujol J, Favier M, Strochlic L, Le Grand F, Sgarioto N, Guernec A, Schmitt A, Cagnard N, Huang R, Legay C, Guillet-Deniau I, Maire P
Developmental biology359(2)303-20(2011 Nov)

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.
Kn?ll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Sch?fer K, Kn?ll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didi? M, Quentin T, Maier LS, Teucher N, Uns?ld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR
Circulation research109(7)758-69(2011 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

cardiac telethonin is constitutively bis-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2+) transients.
Title: Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes.

Tcap is a critical, load-sensitive regulator of t-tubule structure and function.
Title: A critical role for Telethonin in regulating t-tubule structure and function in the mammalian heart.

Telethonin knockout mice develop heart failure following biomechanical stress, owing at least in part to apoptosis of cardiomyocytes, an effect that may also play a role in human heart failure.
Title: Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.

Whereas both promotor E boxes in Tcap are required for full activation by MyoD or myogenin in NIH3T3 cells, the promoter proximal E box has a greater contribution to activation in C2C12 cells and to activation by MyoD in NIH3T3 cells.
Title: Transcriptional analysis of the titin cap gene.

Findings suggest that TCAP knockdown with RNA interference alters normal muscle cell differentiation.
Title: TCAP knockdown by RNA interference inhibits myoblast differentiation in cultured skeletal muscle cells.

The following Tcap gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tcap cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14781	NM_011540.2 Latest version!	Mus musculus titin-cap (Tcap), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tcap ( NM_011540.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035670.2 Mus musculus titin-cap (Tcap), mRNA.

Price & Availability↑

CloneID	OMu14781
Clone ID Related Accession (Same CDS sequence)	NM_011540.2
Accession Version	NM_011540.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	telethonin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ223854.1. On Jan 27, 2007 this sequence version replaced NM_011540.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ223854.1, AK010167.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCCACTT CAGAGCTGAG CTGCCAAGTG TCTGAGGAGA ACCAGGAACG CAGGGAAGCC 
TTCTGGGCTG AGTGGAAAGA CCTGACTCTG TCTACCCGGC CGGAAGAGGG ATGCTCCTTG 
CACGAGGAGG ATACACAGAG GCATGAGACC TACCACCGGC AGGGACAGTG TCAGGCGGTG 
GTACAGCGCT CACCATGGCT GGTGATGCGC CTGGGTATCC TCGGCCGTGG GCTACAGGAA 
TACCAGCTGC CGTACCAGCG GGTGCTGCCC CTACCCATCT TCACGCCCAC CAAGGTGGGG 
GCCTCCAAGG AGGAGCGCGA GGAGACCCCC ATCCAGCTTC GGGAGCTGCT GGCCCTGGAG 
ACGGCCCTGG GCGGCCAGTG CGTGGAGCGC CAGGACGTGG CTGAGATCAC AAAGCAGCTT 
CCCCCTGTGG TGCCAGTCAG CAAACCCGGG CCCCTGCGCC GTACCCTGTC TCGATCCATG 
TCTCAGGAAG CTCAGAGAGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035670.2
CDS	37..540
Translation	MATSELSCQVSEENQERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHRQGQCQAVVQRSPWLVMRLGILGRGLQEYQLPYQRVLPLPIFTPTKVGASKEEREETPIQLRELLALETALGGQCVERQDVAEITKQLPPVVPVSKPGPLRRTLSRSMSQEAQRG

Target ORF information:

RefSeq Version	NM_011540.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus titin-cap (Tcap), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011540.2

ORF Insert Sequence:

ATGGCCACTT CAGAGCTGAG CTGCCAAGTG TCTGAGGAGA ACCAGGAACG CAGGGAAGCC 
TTCTGGGCTG AGTGGAAAGA CCTGACTCTG TCTACCCGGC CGGAAGAGGG ATGCTCCTTG 
CACGAGGAGG ATACACAGAG GCATGAGACC TACCACCGGC AGGGACAGTG TCAGGCGGTG 
GTACAGCGCT CACCATGGCT GGTGATGCGC CTGGGTATCC TCGGCCGTGG GCTACAGGAA 
TACCAGCTGC CGTACCAGCG GGTGCTGCCC CTACCCATCT TCACGCCCAC CAAGGTGGGG 
GCCTCCAAGG AGGAGCGCGA GGAGACCCCC ATCCAGCTTC GGGAGCTGCT GGCCCTGGAG 
ACGGCCCTGG GCGGCCAGTG CGTGGAGCGC CAGGACGTGG CTGAGATCAC AAAGCAGCTT 
CCCCCTGTGG TGCCAGTCAG CAAACCCGGG CCCCTGCGCC GTACCCTGTC TCGATCCATG 
TCTCAGGAAG CTCAGAGAGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes.
The Journal of biological chemistry289(3)1282-93(2014 Jan)
Candasamy AJ,Haworth RS,Cuello F,Ibrahim M,Aravamudhan S,Kr?ger M,Holt MR,Terracciano CM,Mayr M,Gautel M,Avkiran M

Circadian regulation of myocardial sarcomeric Titin-cap (Tcap, telethonin): identification of cardiac clock-controlled genes using open access bioinformatics data.
PloS one9(8)e104907(2014)
Podobed PS,Alibhai FJ,Chow CW,Martino TA

A critical role for Telethonin in regulating t-tubule structure and function in the mammalian heart.
Human molecular genetics22(2)372-83(2013 Jan)
Ibrahim M,Siedlecka U,Buyandelger B,Harada M,Rao C,Moshkov A,Bhargava A,Schneider M,Yacoub MH,Gorelik J,Kn?ll R,Terracciano CM

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.
Developmental biology359(2)303-20(2011 Nov)
Richard AF,Demignon J,Sakakibara I,Pujol J,Favier M,Strochlic L,Le Grand F,Sgarioto N,Guernec A,Schmitt A,Cagnard N,Huang R,Legay C,Guillet-Deniau I,Maire P

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.
Circulation research109(7)758-69(2011 Sep)
Kn?ll R,Linke WA,Zou P,Miocic S,Kostin S,Buyandelger B,Ku CH,Neef S,Bug M,Sch?fer K,Kn?ll G,Felkin LE,Wessels J,Toischer K,Hagn F,Kessler H,Didi? M,Quentin T,Maier LS,Teucher N,Uns?ld B,Schmidt A,Birks EJ,Gunkel S,Lang P,Granzier H,Zimmermann WH,Field LJ,Faulkner G,Dobbelstein M,Barton PJ,Sattler M,Wilmanns M,Chien KR

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Tcap cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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