Taldo1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Taldo1
Entrez Gene ID	21351
Full Name	transaldolase 1
General protein information	Preferred Names transaldolase 1 Names transaldolase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 F5
Summary	This gene encodes a key enzyme of the nonoxidative pentose phosphate pathway that provides ribose-5-phosphate for nucleic acid synthesis and nicotinamide adenine dinucleotide phosphate (NADPH) for lipid biosynthesis. The encoded protein is important for maintaining structure and function of mitochondria. Studies in knockout mice identify that deficiency of this gene product is a cause of sperm dysmotility and male infertility. Deficiency of this protein has also been identified as a cause of hepatocarcinogenesis in mice. Two related pseudogenes have been identified on chromosome 10. [provided by RefSeq, Mar 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_011528.4	NP_035658.1	transaldolase

Pathways from BioSystems

Homologies

Homo sapiens (human)	TALDO1	NP_006746.1
Canis lupus familiaris (dog)	TALDO1	XP_533146.1
Danio rerio (zebrafish)	taldo1	NP_955981.1
Drosophila melanogaster (fruit fly)	Tal	NP_523835.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011800	XP_320715.3
Oryza sativa (rice)	Os08g0154300	NP_001061014.1
	LOC720828	XP_001116705.1
Caenorhabditis elegans (roundworm)	Y24D9A.8	NP_741369.1
Saccharomyces cerevisiae (baker's yeast)	TAL1	NP_013458.1
Arabidopsis thaliana (thale cress)	AT1G12230	NP_563900.1
Xenopus tropicalis (tropical clawed frog)	taldo1	NP_001017131.1
Pan troglodytes (chimpanzee)	TALDO1	XP_001148375.1
Bos taurus (cattle)	TALDO1	NP_001030360.2
Mus musculus (house mouse)	Taldo1	NP_035658.1
Kluyveromyces lactis	KLLA0A02607g	XP_451115.1
Magnaporthe oryzae (rice blast fungus)	MGG_02624	XP_003721167.1
Neurospora crassa	NCU02136	XP_964294.1
Canis lupus familiaris (dog)	LOC100855463	XP_003639736.1
Rattus norvegicus (Norway rat)	Taldo1	NP_113999.2
Eremothecium gossypii	AGOS_ACL196W	NP_983208.2
Schizosaccharomyces pombe (fission yeast)	tal1	NP_587953.1
Gallus gallus (chicken)	TALDO1	NP_001026348.1

Gene Ontology
Bibliography

Related articles in PubMed

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A
Developmental cell40(4)331-341.e4(2017 02)

Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network.
Moriyama T, Tanaka S, Nakayama Y, Fukumoto M, Tsujimura K, Yamada K, Bamba T, Yoneda Y, Fukusaki E, Oka M
Scientific reports634648(2016 Oct)

Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.
Bowman CE, Zhao L, Hartung T, Wolfgang MJ
Molecular and cellular biology36(15)2089-104(2016 Aug)

Mitochondrial involvement and erythronic acid as a novel biomarker in transaldolase deficiency.
Engelke UF, Zijlstra FS, Mochel F, Valayannopoulos V, Rabier D, Kluijtmans LA, Perl A, Verhoeven-Duif NM, de Lonlay P, Wamelink MM, Jakobs C, Morava E, Wevers RA
Biochimica et biophysica acta1802(11)1028-35(2010 Nov)

Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine.
Hanczko R, Fernandez DR, Doherty E, Qian Y, Vas G, Niland B, Telarico T, Garba A, Banerjee S, Middleton FA, Barrett D, Barcza M, Banki K, Landas SK, Perl A
The Journal of clinical investigation119(6)1546-57(2009 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that erythronic acid was identified as a major abnormal metabolite in all patients and in knock-out TALDO mice implicating an as yet unknown biochemical pathway in this disease.
Title: Mitochondrial involvement and erythronic acid as a novel biomarker in transaldolase deficiency.

Reduced beta-catenin phosphorylation and enhanced c-Jun expression in Taldo1-/- livers reflected adaptation to oxidative stress
Title: Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine.

These data reveal an essential role of transaldolase in sperm-cell mitochondrial function and, thus, male fertility.
Title: Transaldolase is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa.

The following Taldo1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Taldo1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16274	NM_011528.4 Latest version!	Mus musculus transaldolase 1 (Taldo1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Taldo1 ( NM_011528.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035658.1 Mus musculus transaldolase 1 (Taldo1), mRNA.

Price & Availability↑

CloneID	OMu16274
Clone ID Related Accession (Same CDS sequence)	NM_011528.4
Accession Version	NM_011528.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Mus musculus(house mouse)
Product	transaldolase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC163434.5. On Mar 20, 2010 this sequence version replaced NM_011528.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK003092.1, AK142030.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGGGT CCCCGGTAAA GCGCCAGAGG ATGGAGTCCG CCTTGGACCA GCTCAAGCAG 
TTCACCACCG TGGTGGCCGA CACGGGTGAT TTCAATGCCA TCGATGAATA CAAGCCCCAA 
GATGCCACCA CCAACCCATC CCTGATCCTG GCTGCAGCCC AGATGCCTGC CTACCAAGAG 
CTGGTAGAGG AGGCCATTGC CTACGGCAAG AAGCTGGGTG GGCCTCAAGA GGAGCAGATT 
AAAAATGCCA TTGACAAACT TTTTGTGCTG TTTGGAGCAG AAATATTAAA GAAGATTCCA 
GGCCGTGTAT CCACAGAAGT TGATGCAAGG CTTTCCTTTG ATAAGGATGC CATGGTGGCC 
CGAGCCAGGC GCCTCATCGA GCTTTACAAA GAAGCTGGGG TCGGCAAGGA CAGAATTCTC 
ATCAAGTTAT CATCAACCTG GGAGGGGATT CAGGCTGGAA AGGAGCTGGA GGAACAGCAT 
GGCATCCACT GCAACATGAC ACTGCTTTTC TCCTTCGCCC AGGCTGTGGC CTGTGCTGAG 
GCGGGCGTGA CGCTCATCTC TCCCTTTGTG GGGCGCATCC TTGATTGGCA TGTGGCAAAC 
ACAGACAAGA AATCCTATGA ACCCCAGGAG GACCCTGGGG TCAAGAGTGT CACCAAAATC 
TACAACTACT ACAAGAAGTT CGGCTACAAG ACCATTGTCA TGGGCGCCTC CTTCCGCAAC 
ACGGGCGAGA TCAAAGCACT GGCGGGCTGT GACTTCCTCA CCATCTCCCC GAAGCTCCTG 
GGGGAGCTGC TCAAGGATAA CAGCAAGCTG GCGCCTGCGC TCTCTGTCAA GGCGGCCCAG 
ACCAGTGACT CGGAGAAGAT ACATCTGGAC GAGAAGGCCT TCCGTTGGCT GCACAACGAA 
GACCAAATGG CCGTGGAGAA GCTCTCCGAC GGCATCCGCA AATTTGCTGC TGATGCCATA 
AAGTTGGAGC GGATGCTCAC GGAACGAATG TTCAGCGCTG AGAACGGGAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035658.1
CDS	63..1076
Translation	MSGSPVKRQRMESALDQLKQFTTVVADTGDFNAIDEYKPQDATTNPSLILAAAQMPAYQELVEEAIAYGKKLGGPQEEQIKNAIDKLFVLFGAEILKKIPGRVSTEVDARLSFDKDAMVARARRLIELYKEAGVGKDRILIKLSSTWEGIQAGKELEEQHGIHCNMTLLFSFAQAVACAEAGVTLISPFVGRILDWHVANTDKKSYEPQEDPGVKSVTKIYNYYKKFGYKTIVMGASFRNTGEIKALAGCDFLTISPKLLGELLKDNSKLAPALSVKAAQTSDSEKIHLDEKAFRWLHNEDQMAVEKLSDGIRKFAADAIKLERMLTERMFSAENGK

Target ORF information:

RefSeq Version	NM_011528.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus transaldolase 1 (Taldo1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011528.4

ORF Insert Sequence:

ATGTCGGGGT CCCCGGTAAA GCGCCAGAGG ATGGAGTCCG CCTTGGACCA GCTCAAGCAG 
TTCACCACCG TGGTGGCCGA CACGGGTGAT TTCAATGCCA TCGATGAATA CAAGCCCCAA 
GATGCCACCA CCAACCCATC CCTGATCCTG GCTGCAGCCC AGATGCCTGC CTACCAAGAG 
CTGGTAGAGG AGGCCATTGC CTACGGCAAG AAGCTGGGTG GGCCTCAAGA GGAGCAGATT 
AAAAATGCCA TTGACAAACT TTTTGTGCTG TTTGGAGCAG AAATATTAAA GAAGATTCCA 
GGCCGTGTAT CCACAGAAGT TGATGCAAGG CTTTCCTTTG ATAAGGATGC CATGGTGGCC 
CGAGCCAGGC GCCTCATCGA GCTTTACAAA GAAGCTGGGG TCGGCAAGGA CAGAATTCTC 
ATCAAGTTAT CATCAACCTG GGAGGGGATT CAGGCTGGAA AGGAGCTGGA GGAACAGCAT 
GGCATCCACT GCAACATGAC ACTGCTTTTC TCCTTCGCCC AGGCTGTGGC CTGTGCTGAG 
GCGGGCGTGA CGCTCATCTC TCCCTTTGTG GGGCGCATCC TTGATTGGCA TGTGGCAAAC 
ACAGACAAGA AATCCTATGA ACCCCAGGAG GACCCTGGGG TCAAGAGTGT CACCAAAATC 
TACAACTACT ACAAGAAGTT CGGCTACAAG ACCATTGTCA TGGGCGCCTC CTTCCGCAAC 
ACGGGCGAGA TCAAAGCACT GGCGGGCTGT GACTTCCTCA CCATCTCCCC GAAGCTCCTG 
GGGGAGCTGC TCAAGGATAA CAGCAAGCTG GCGCCTGCGC TCTCTGTCAA GGCGGCCCAG 
ACCAGTGACT CGGAGAAGAT ACATCTGGAC GAGAAGGCCT TCCGTTGGCT GCACAACGAA 
GACCAAATGG CCGTGGAGAA GCTCTCCGAC GGCATCCGCA AATTTGCTGC TGATGCCATA 
AAGTTGGAGC GGATGCTCAC GGAACGAATG TTCAGCGCTG AGAACGGGAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Developmental cell40(4)331-341.e4(2017 02)
Bulusu V,Prior N,Snaebjornsson MT,Kuehne A,Sonnen KF,Kress J,Stein F,Schultz C,Sauer U,Aulehla A

Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network.
Scientific reports634648(2016 Oct)
Moriyama T,Tanaka S,Nakayama Y,Fukumoto M,Tsujimura K,Yamada K,Bamba T,Yoneda Y,Fukusaki E,Oka M

Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.
Molecular and cellular biology36(15)2089-104(2016 Aug)
Bowman CE,Zhao L,Hartung T,Wolfgang MJ

Mitochondrial involvement and erythronic acid as a novel biomarker in transaldolase deficiency.
Biochimica et biophysica acta1802(11)1028-35(2010 Nov)
Engelke UF,Zijlstra FS,Mochel F,Valayannopoulos V,Rabier D,Kluijtmans LA,Perl A,Verhoeven-Duif NM,de Lonlay P,Wamelink MM,Jakobs C,Morava E,Wevers RA

Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine.
The Journal of clinical investigation119(6)1546-57(2009 Jun)
Hanczko R,Fernandez DR,Doherty E,Qian Y,Vas G,Niland B,Telarico T,Garba A,Banerjee S,Middleton FA,Barrett D,Barcza M,Banki K,Landas SK,Perl A

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Taldo1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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