Il20rb cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il20rb
Entrez Gene ID	213208
Full Name	interleukin 20 receptor beta
Synonyms	AV228068,Fndc6,Gm186,Il20R2
General protein information	Preferred Names interleukin 20 receptor beta Names interleukin-20 receptor subunit beta fibronectin type III domain containing 6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 E3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033543.3	NP_001028715.2	interleukin-20 receptor subunit beta precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	IL20RB	XP_001154958.1
Bos taurus (cattle)	IL20RB	NP_001095645.1
Rattus norvegicus (Norway rat)	Il20rb	NP_001166909.1
Xenopus tropicalis (tropical clawed frog)	il20rb	XP_004917829.1
Homo sapiens (human)	IL20RB	NP_653318.2
Mus musculus (house mouse)	Il20rb	NP_001028715.2
Gallus gallus (chicken)	IL20RB	XP_001231360.2
	IL20RB	XP_001114770.1
Canis lupus familiaris (dog)	IL20RB	XP_005634529.1

Gene Ontology
Bibliography

Related articles in PubMed

Alternative splicing directs two IL-20R2 isoforms and is responsible for the incomplete gene knockout via the exon I ablation.
Zhou H, Liu X, Yu R, Long T, Zhao R, Liu H, Xu Y, Liang JG, Liang P
Genes and immunity17(4)220-7(2016 06)

Signaling via the IL-20 receptor inhibits cutaneous production of IL-1? and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus.
Myles IA, Fontecilla NM, Valdez PA, Vithayathil PJ, Naik S, Belkaid Y, Ouyang W, Datta SK
Nature immunology14(8)804-11(2013 Aug)

Detection of IL-20R1 and IL-20R2 mRNA in C57BL/6 mice astroglial cells and brain cortex following LPS stimulation.
Abd Nikfarjam B, Ebtekar M, Sabouni F, Pourpak Z, Kheirandish M
Iranian journal of immunology : IJI10(2)62-9(2013 Jun)

Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss.
Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, Chang MS
The Journal of experimental medicine208(9)1849-61(2011 Aug)

PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.
Kirchhof P, Kahr PC, Kaese S, Piccini I, Vokshi I, Scheld HH, Rotering H, Fortmueller L, Laakmann S, Verheule S, Schotten U, Fabritz L, Brown NA
Circulation. Cardiovascular genetics4(2)123-33(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IL-20R1 and IL-20R2 are constitutively express in the brain.
Title: Detection of IL-20R1 and IL-20R2 mRNA in C57BL/6 mice astroglial cells and brain cortex following LPS stimulation.

IL-20R2 regulates T cell activation directly and attenuates antigen-specific CD8 responses; IL-20R2 signaling directly regulates CD8 and CD4 T cell responses in vitro and in vivo.
Title: IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses.

IL-20R2 receptor subunit is up-regulated by LPS in the liver of normal mice.
Title: The murine liver is a potential target organ for IL-19, IL-20 and IL-24: Type I Interferons and LPS regulate the expression of IL-20R2.

The following Il20rb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il20rb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15118	NM_001033543.3 Latest version!	Mus musculus interleukin 20 receptor beta (Il20rb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il20rb ( NM_001033543.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001028715.2 Mus musculus interleukin 20 receptor beta (Il20rb), mRNA.

Price & Availability↑

CloneID	OMu15118
Clone ID Related Accession (Same CDS sequence)	NM_001033543.3
Accession Version	NM_001033543.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-09
Organism	Mus musculus(house mouse)
Product	interleukin-20 receptor subunit beta precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY772000.1, CK331954.1, AC134590.5 and BE852308.1. On Oct 18, 2007 this sequence version replaced NM_001033543.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATTTCCC AGGGAGTCTG GACAAGTCCG TTCATGTGGT TTTTCTACAG CATGACCTCA 
GGTTTTCTCA CGGATGCAGT GTCCGTTTTA CCTGCCCCTC AGAACCTCTC TGTACAGTCA 
ACCAACATGA AGCATCTCTT GATGTGGAAC CCAGTGACCC AGCCGGGGGA GACGGTGCTC 
TATTGTGTGG AGTATCAGGG GGAGTACGAG AGCCTGTACA TGAGCCACAT CTGGATCCCC 
AGCAGTCAAT GCTCACCGAC CAAAAGTCTG GAGTGTGATG TCACCGATGA CATAACCGCC 
ACAGTGCCAT ATAACTTCAG GGTCAAGGCC ATGCTGGGCT CACAGACTTC AGCCTGGAGC 
AACCTGGAGC ACCCCTTTAA CCGAAATGCA ACTGTCCTCA CCCCACCCAG GATGGAGGTC 
ACTGAACATG GGCTGCATCT GGTTATTGAG CTGGAAGACC TGGGGCCCCA GTTTGAGTTC 
CTTGTGGTCT ACTGGAGGAG GGAGCCTGGC GCCGCGGAAC ATGTTAAGAT GGTGAGGAGT 
GGGGACATTC CGGTGCACCT AGAAACCATG GAACCGGGGG CCATGTACTG TGTGAAGGCG 
CAGGCACTGG TGAAAGCCAT CGGGAGGCAC AGTGCCTTCA GCCAGCCTAC GTGTGTGGAG 
ATGCAAGGAG AGTCTCTTCC GCTGGCACTA GCTCTGTTTG CGTTTGTTGG CTTCATGCTG 
ATTCTCGTGG TTGTACTACT CTCCGTCTGG AAGATGGGCC AGCTGCTCCG GTATTCTTGC 
TGCCCCGCCG TTGTCCTCCC AGACACCTTG AAAATAACCA GTTCGTCTCA GAAGCTGATC 
AGCTGCAGGA AGGAGGAGGT GGACGCCTGT GCTGTGGCTG TGCTGTCCTC GGAGCATCTC 
TTTGGGGTCT GGATCTCACA GACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028715.2
CDS	146..1072
Translation	MISQGVWTSPFMWFFYSMTSGFLTDAVSVLPAPQNLSVQSTNMKHLLMWNPVTQPGETVLYCVEYQGEYESLYMSHIWIPSSQCSPTKSLECDVTDDITATVPYNFRVKAMLGSQTSAWSNLEHPFNRNATVLTPPRMEVTEHGLHLVIELEDLGPQFEFLVVYWRREPGAAEHVKMVRSGDIPVHLETMEPGAMYCVKAQALVKAIGRHSAFSQPTCVEMQGESLPLALALFAFVGFMLILVVVLLSVWKMGQLLRYSCCPAVVLPDTLKITSSSQKLISCRKEEVDACAVAVLSSEHLFGVWISQT

Target ORF information:

RefSeq Version	NM_001033543.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 20 receptor beta (Il20rb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033543.3

ORF Insert Sequence:

ATGATTTCCC AGGGAGTCTG GACAAGTCCG TTCATGTGGT TTTTCTACAG CATGACCTCA 
GGTTTTCTCA CGGATGCAGT GTCCGTTTTA CCTGCCCCTC AGAACCTCTC TGTACAGTCA 
ACCAACATGA AGCATCTCTT GATGTGGAAC CCAGTGACCC AGCCGGGGGA GACGGTGCTC 
TATTGTGTGG AGTATCAGGG GGAGTACGAG AGCCTGTACA TGAGCCACAT CTGGATCCCC 
AGCAGTCAAT GCTCACCGAC CAAAAGTCTG GAGTGTGATG TCACCGATGA CATAACCGCC 
ACAGTGCCAT ATAACTTCAG GGTCAAGGCC ATGCTGGGCT CACAGACTTC AGCCTGGAGC 
AACCTGGAGC ACCCCTTTAA CCGAAATGCA ACTGTCCTCA CCCCACCCAG GATGGAGGTC 
ACTGAACATG GGCTGCATCT GGTTATTGAG CTGGAAGACC TGGGGCCCCA GTTTGAGTTC 
CTTGTGGTCT ACTGGAGGAG GGAGCCTGGC GCCGCGGAAC ATGTTAAGAT GGTGAGGAGT 
GGGGACATTC CGGTGCACCT AGAAACCATG GAACCGGGGG CCATGTACTG TGTGAAGGCG 
CAGGCACTGG TGAAAGCCAT CGGGAGGCAC AGTGCCTTCA GCCAGCCTAC GTGTGTGGAG 
ATGCAAGGAG AGTCTCTTCC GCTGGCACTA GCTCTGTTTG CGTTTGTTGG CTTCATGCTG 
ATTCTCGTGG TTGTACTACT CTCCGTCTGG AAGATGGGCC AGCTGCTCCG GTATTCTTGC 
TGCCCCGCCG TTGTCCTCCC AGACACCTTG AAAATAACCA GTTCGTCTCA GAAGCTGATC 
AGCTGCAGGA AGGAGGAGGT GGACGCCTGT GCTGTGGCTG TGCTGTCCTC GGAGCATCTC 
TTTGGGGTCT GGATCTCACA GACTTGA