Trib1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Trib1
Entrez Gene ID	211770
Full Name	tribbles pseudokinase 1
Synonyms	A530090O15Rik,TRB-1,Trb1
General protein information	Preferred Names tribbles pseudokinase 1 Names tribbles homolog 1 trib1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_144549.4	NP_653132.1	tribbles homolog 1

Pathways from BioSystems

Homologies

	TRIB1	XP_001082540.1
Mus musculus (house mouse)	Trib1	NP_653132.1
Gallus gallus (chicken)	LOC428386	XP_425946.4
Homo sapiens (human)	TRIB1	NP_079471.1
Canis lupus familiaris (dog)	TRIB1	XP_539160.2
Xenopus tropicalis (tropical clawed frog)	trib1	XP_002938707.1
Pan troglodytes (chimpanzee)	TRIB1	XP_519955.2
Rattus norvegicus (Norway rat)	Trib1	NP_076475.1
Bos taurus (cattle)	TRIB1	NP_001094575.1

Gene Ontology
Bibliography

Related articles in PubMed

IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice.
Shintani Y, Ito T, Fields L, Shiraishi M, Ichihara Y, Sato N, Podaru M, Kainuma S, Tanaka H, Suzuki K
Scientific reports7(1)6877(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The Liver Clock Controls Cholesterol Homeostasis through Trib1 Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR) Axis.
Title: The Liver Clock Controls Cholesterol Homeostasis through Trib1 Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR) Axis.

Deletion of hepatic Trib1 leads to increased C/EBPalpha binding near upregulated lipogenic genes, as well as Trib1 itself.
Title: Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBP?.

These data suggested that the modulation of TRIB1 expression affects hepatic lipogenesis and glycogenesis through multiple molecular interactions.
Title: TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions.

TRIB1 and TRIB3 are more strongly expressed than TRIB2 in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.
Title: Tribbles expression in cumulus cells is related to oocyte maturation and fatty acid metabolism.

These results indicate that COP1 and Trib1 act as an oncoprotein complex functioning upstream of C/EBPalpha, and its ligase activity is crucial for leukemogenesis.
Title: COP1 targets C/EBP? for degradation and induces acute myeloid leukemia via Trib1.

The following Trib1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trib1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19601	NM_144549.4 Latest version!	Mus musculus tribbles pseudokinase 1 (Trib1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Trib1 ( NM_144549.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_653132.1 Mus musculus tribbles pseudokinase 1 (Trib1), mRNA.

Price & Availability↑

CloneID	OMu19601
Clone ID Related Accession (Same CDS sequence)	NM_144549.4
Accession Version	NM_144549.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Mus musculus(house mouse)
Product	tribbles homolog 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC161172.4. On May 1, 2007 this sequence version replaced NM_144549.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK028626.1, AK162876.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCGGGTCG GTCCCGTGCG TTTTGCCCTG AGCGGCGCCT CGCAGCCCCG CGGTCCGGGT 
CTACTGTTTC CGGCTGCCCG GGGAACCCCG GCCAAACGCC TGCTGGACAC GGACGACGCG 
GGGGCAGTGG CGGCCAAGTG TCCGCGCCTC TCTGAGTGCT CGAGTCCCCC CGACTACCTC 
AGTCCCCCTG GCTCGCCCTG CAGCCCTCAG CCTCCGCCCT CCACGCAGGG GACCGGCGGC 
AGCTGTGTGA GCTCACCCGG GCCCAGCCGA ATCGCCGACT ACCTGCTGCT ACCCCTAGCT 
GAGCGCGAGC ATGTGTCCCG GGCACTGTGC ATCCACACCG GCCGCGAGCT GCGCTGCAAG 
GAATTCCCCA TTAAACACTA CCAGGACAAA ATCAGGCCTT ACATCCAGCT GCCGTCCCAT 
AGCAACATCA CTGGCATTGT GGAGGTGCTC CTTGGTGAGA GCAAGGCCTA CGTCTTCTTC 
GAGAAGGACT TTGGAGACAT GCACTCCTAT GTGCGGAGCC GAAAACGGCT TCGGGAAGAG 
GAGGCCGCTC GGCTCTTCAA GCAGATTGTT TCCGCCGTCG CCCACTGCCA CCAGTCGGCC 
ATCGTGCTGG GGGACCTGAA GCTCAGGAAG TTCGTCTTCT CCACCGAGGA GAGAACCCAG 
CTTAGACTGG AAAGCCTGGA AGATACTCAC ATCATTAAGG GTGAAGATGA TGCGCTGTCA 
GATAAACATG GCTGCCCAGC CTACGTGAGC CCCGAGATCC TCAACACTAC TGGGACCTAC 
TCTGGAAAGG CGGCGGACGT CTGGAGCCTC GGGGTGATGC TCTATACGCT TTTGGTCGGA 
CGATACCCCT TTCATGACTC AGATCCGAGT GCCCTTTTTT CCAAAATCCG CCGTGGACAG 
TTCTGCATTC CTGAGCACGT CTCCCCCAAA GCCAGGTGCC TCATCCGAAG CCTCCTAAGA 
CGAGAACCTT CTGAGAGACT CACAGCTCCT CAGATCTTAC TCCATCCCTG GTTCGAGTAT 
GTCTTGGAAC CGGGCTATGT TGACTCAGAA ATAGGAACTT CAGACCAGAT TGTTCCTGAG 
TACCAGGAGG ACAGTGACAT AAGTTCCTTC TTCTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653132.1
CDS	510..1628
Translation	MRVGPVRFALSGASQPRGPGLLFPAARGTPAKRLLDTDDAGAVAAKCPRLSECSSPPDYLSPPGSPCSPQPPPSTQGTGGSCVSSPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKEFPIKHYQDKIRPYIQLPSHSNITGIVEVLLGESKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIIKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHVSPKARCLIRSLLRREPSERLTAPQILLHPWFEYVLEPGYVDSEIGTSDQIVPEYQEDSDISSFFC

Target ORF information:

RefSeq Version	NM_144549.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus tribbles pseudokinase 1 (Trib1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144549.4

ORF Insert Sequence:

ATGCGGGTCG GTCCCGTGCG TTTTGCCCTG AGCGGCGCCT CGCAGCCCCG CGGTCCGGGT 
CTACTGTTTC CGGCTGCCCG GGGAACCCCG GCCAAACGCC TGCTGGACAC GGACGACGCG 
GGGGCAGTGG CGGCCAAGTG TCCGCGCCTC TCTGAGTGCT CGAGTCCCCC CGACTACCTC 
AGTCCCCCTG GCTCGCCCTG CAGCCCTCAG CCTCCGCCCT CCACGCAGGG GACCGGCGGC 
AGCTGTGTGA GCTCACCCGG GCCCAGCCGA ATCGCCGACT ACCTGCTGCT ACCCCTAGCT 
GAGCGCGAGC ATGTGTCCCG GGCACTGTGC ATCCACACCG GCCGCGAGCT GCGCTGCAAG 
GAATTCCCCA TTAAACACTA CCAGGACAAA ATCAGGCCTT ACATCCAGCT GCCGTCCCAT 
AGCAACATCA CTGGCATTGT GGAGGTGCTC CTTGGTGAGA GCAAGGCCTA CGTCTTCTTC 
GAGAAGGACT TTGGAGACAT GCACTCCTAT GTGCGGAGCC GAAAACGGCT TCGGGAAGAG 
GAGGCCGCTC GGCTCTTCAA GCAGATTGTT TCCGCCGTCG CCCACTGCCA CCAGTCGGCC 
ATCGTGCTGG GGGACCTGAA GCTCAGGAAG TTCGTCTTCT CCACCGAGGA GAGAACCCAG 
CTTAGACTGG AAAGCCTGGA AGATACTCAC ATCATTAAGG GTGAAGATGA TGCGCTGTCA 
GATAAACATG GCTGCCCAGC CTACGTGAGC CCCGAGATCC TCAACACTAC TGGGACCTAC 
TCTGGAAAGG CGGCGGACGT CTGGAGCCTC GGGGTGATGC TCTATACGCT TTTGGTCGGA 
CGATACCCCT TTCATGACTC AGATCCGAGT GCCCTTTTTT CCAAAATCCG CCGTGGACAG 
TTCTGCATTC CTGAGCACGT CTCCCCCAAA GCCAGGTGCC TCATCCGAAG CCTCCTAAGA 
CGAGAACCTT CTGAGAGACT CACAGCTCCT CAGATCTTAC TCCATCCCTG GTTCGAGTAT 
GTCTTGGAAC CGGGCTATGT TGACTCAGAA ATAGGAACTT CAGACCAGAT TGTTCCTGAG 
TACCAGGAGG ACAGTGACAT AAGTTCCTTC TTCTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice.
Scientific reports7(1)6877(2017 Jul)
Shintani Y,Ito T,Fields L,Shiraishi M,Ichihara Y,Sato N,Podaru M,Kainuma S,Tanaka H,Suzuki K

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Trib1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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