Gtf2h3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gtf2h3
Entrez Gene ID	209357
Full Name	general transcription factor IIH, polypeptide 3
Synonyms	34kDa,5033417D07Rik,BTF2,BTF2 p34,C730029A10,D5Ertd679e,TFIIH
General protein information	Preferred Names general transcription factor IIH, polypeptide 3 Names general transcription factor IIH subunit 3 BTF2-p34 TFIIH basal transcription factor complex p34 subunit basic transcription factor 2 34 kDa subunit general transcription factor IIH, polypeptide 3, 34kDa
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 F\|5 63.67 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_181410.3	NP_852075.1	general transcription factor IIH subunit 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	GTF2H3	NP_001507.2
Bos taurus (cattle)	GTF2H3	NP_001073057.1
Rattus norvegicus (Norway rat)	Gtf2h3	NP_001019407.1
Danio rerio (zebrafish)	gtf2h3	NP_001002564.1
Eremothecium gossypii	AGOS_ADL323C	NP_983773.1
Arabidopsis thaliana (thale cress)	AT1G18340	NP_564050.1
Danio rerio (zebrafish)	gtf2h3-2	NP_001121894.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008522	XP_316918.4
Neurospora crassa	NCU01580	XP_956217.1
Oryza sativa (rice)	Os02g0125800	NP_001045748.1
Canis lupus familiaris (dog)	GTF2H3	XP_534644.1
Drosophila melanogaster (fruit fly)	Tfb4	NP_608574.2
Saccharomyces cerevisiae (baker's yeast)	TFB4	NP_015381.1
Schizosaccharomyces pombe (fission yeast)	tfb4	NP_595532.1
Pan troglodytes (chimpanzee)	GTF2H3	XP_001170519.1
Magnaporthe oryzae (rice blast fungus)	MGG_03877	XP_003720002.1
Xenopus tropicalis (tropical clawed frog)	gtf2h3	NP_001120625.1
Mus musculus (house mouse)	Gtf2h3	NP_852075.1
Gallus gallus (chicken)	GTF2H3	NP_001264448.1
Kluyveromyces lactis	KLLA0B08569g	XP_451910.1

Gene Ontology
Bibliography

Related articles in PubMed

Dynamic partnership between TFIIH, PGC-1? and SIRT1 is impaired in trichothiodystrophy.
Traboulsi H, Davoli S, Catez P, Egly JM, Compe E
PLoS genetics10(10)e1004732(2014 Oct)

Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing.
Nonnekens J, Perez-Fernandez J, Theil AF, Gadal O, Bonnart C, Giglia-Mari G
Human molecular genetics22(14)2881-93(2013 Jul)

Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.
Kamileri I, Karakasilioti I, Sideri A, Kosteas T, Tatarakis A, Talianidis I, Garinis GA
Proceedings of the National Academy of Sciences of the United States of America109(8)2995-3000(2012 Feb)

B2 RNA represses TFIIH phosphorylation of RNA polymerase II.
Yakovchuk P, Goodrich JA, Kugel JF
Transcription2(1)45-9(2011 Jan-Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

extensive molecular analyses unveiled that wild-type TFIIH cooperated in an ATP-dependent manner with PGC1-alpha as well as with the deacetylase SIRT1, thereby contributing to the PGC1-a deacetylation by SIRT1
Title: Dynamic partnership between TFIIH, PGC-1? and SIRT1 is impaired in trichothiodystrophy.

Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing.
Title: Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing.

Data show that that B2 RNA, when present with Pol II in promoter-bound complexes, specifically represses CTD phosphorylation by TFIIH.
Title: B2 RNA represses TFIIH phosphorylation of RNA polymerase II.

Molecular analyses performed on the mice brain tissue demonstrate that TFIIH is required for the stabilization of thyroid hormone receptors (TR) to their DNA-responsive elements.
Title: Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH.

The following Gtf2h3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gtf2h3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16065	NM_181410.3 Latest version!	Mus musculus general transcription factor IIH, polypeptide 3 (Gtf2h3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gtf2h3 ( NM_181410.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_852075.1 Mus musculus general transcription factor IIH, polypeptide 3 (Gtf2h3), mRNA.

Price & Availability↑

CloneID	OMu16065
Clone ID Related Accession (Same CDS sequence)	NM_181410.3
Accession Version	NM_181410.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	general transcription factor IIH subunit 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB637936.1, AK133941.1 and AK050227.1. On Sep 19, 2009 this sequence version replaced NM_181410.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017515.1, AK133941.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849379, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGCTG ACGAAGATGA GTTGAACCTT CTGGTGATCA TAGTTGACAC CAACCCGATT 
TGGTGGGGAA AGCAAGCATT AAAGGAATCT CAGTTTACTT TATCCAAATG CATGGATGCA 
GTGATGGTGC TGGCGAATTC TCACCTGTTC ATGAACCGCT CCAACCAGCT GGCTGTCATC 
GCCAGTCACA TTCAGGAAAG CCGGCTCTTA TACCCGGGGA AGAACGGTGG ACTTGGAGAC 
TTCTTCGGAG ACCCTGGCAA TGCGCTCCCC GACTGTAACC CCTCTGGGAG TAAAGATGGG 
AAATACGAGC TGTTGACAGT TGCAAACGAG GTGATCGCTG AGGAGATCAA GGATCTGATG 
ACCAAGAGTG ACATCAAGGG CCAGCATACG GAGACACTAC TGGCAGGATC CCTGGCCAAA 
GCTCTGTGCT ACATTCACAG AGTGAACAAG GCAGTTAAAG ATAATCAGGA GATGAAATCA 
AGGATTTTGG TGATCAAGGC TGCAGAGGAC AGCGCACTGC AGTACATGAA CTTCATGAAC 
GTCATCTTTG CTGCTCAGAA GCAGAATATC CTCATCGACG CCTGCGTGCT GGACTCGGAT 
TCAGGGCTCC TCCAGCAGGC TTGTGACATC ACTGGGGGAC TGTACCTGAA GGTGCCTCAG 
ATGCCTTCTC TCCTGCAGTA CTTACTGTGG GTTTTTCTTC CGGACCAAGA TCAGCGGTCT 
CAGCTAATCC TCCCACCCCC GATCCACGTG GACTACAGGG CTGCCTGCTT CTGTCATCGC 
AGTCTCATTG AGATTGGCTA TGTCTGCTCT GTGTGTCTGT CTATTTTCTG CAATTTCAGC 
CCCATCTGCA CCACGTGCGA GACAGCTTTT AAGATCTCCC TCCCTCCTGT GCTGAAGGCC 
AAGAAGAAGA AACAGAAGGT GTCCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852075.1
CDS	42..971
Translation	MAADEDELNLLVIIVDTNPIWWGKQALKESQFTLSKCMDAVMVLANSHLFMNRSNQLAVIASHIQESRLLYPGKNGGLGDFFGDPGNALPDCNPSGSKDGKYELLTVANEVIAEEIKDLMTKSDIKGQHTETLLAGSLAKALCYIHRVNKAVKDNQEMKSRILVIKAAEDSALQYMNFMNVIFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQLILPPPIHVDYRAACFCHRSLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAKKKKQKVSL

Target ORF information:

RefSeq Version	NM_181410.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus general transcription factor IIH, polypeptide 3 (Gtf2h3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181410.3

ORF Insert Sequence:

ATGGCCGCTG ACGAAGATGA GTTGAACCTT CTGGTGATCA TAGTTGACAC CAACCCGATT 
TGGTGGGGAA AGCAAGCATT AAAGGAATCT CAGTTTACTT TATCCAAATG CATGGATGCA 
GTGATGGTGC TGGCGAATTC TCACCTGTTC ATGAACCGCT CCAACCAGCT GGCTGTCATC 
GCCAGTCACA TTCAGGAAAG CCGGCTCTTA TACCCGGGGA AGAACGGTGG ACTTGGAGAC 
TTCTTCGGAG ACCCTGGCAA TGCGCTCCCC GACTGTAACC CCTCTGGGAG TAAAGATGGG 
AAATACGAGC TGTTGACAGT TGCAAACGAG GTGATCGCTG AGGAGATCAA GGATCTGATG 
ACCAAGAGTG ACATCAAGGG CCAGCATACG GAGACACTAC TGGCAGGATC CCTGGCCAAA 
GCTCTGTGCT ACATTCACAG AGTGAACAAG GCAGTTAAAG ATAATCAGGA GATGAAATCA 
AGGATTTTGG TGATCAAGGC TGCAGAGGAC AGCGCACTGC AGTACATGAA CTTCATGAAC 
GTCATCTTTG CTGCTCAGAA GCAGAATATC CTCATCGACG CCTGCGTGCT GGACTCGGAT 
TCAGGGCTCC TCCAGCAGGC TTGTGACATC ACTGGGGGAC TGTACCTGAA GGTGCCTCAG 
ATGCCTTCTC TCCTGCAGTA CTTACTGTGG GTTTTTCTTC CGGACCAAGA TCAGCGGTCT 
CAGCTAATCC TCCCACCCCC GATCCACGTG GACTACAGGG CTGCCTGCTT CTGTCATCGC 
AGTCTCATTG AGATTGGCTA TGTCTGCTCT GTGTGTCTGT CTATTTTCTG CAATTTCAGC 
CCCATCTGCA CCACGTGCGA GACAGCTTTT AAGATCTCCC TCCCTCCTGT GCTGAAGGCC 
AAGAAGAAGA AACAGAAGGT GTCCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dynamic partnership between TFIIH, PGC-1? and SIRT1 is impaired in trichothiodystrophy.
PLoS genetics10(10)e1004732(2014 Oct)
Traboulsi H,Davoli S,Catez P,Egly JM,Compe E

Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing.
Human molecular genetics22(14)2881-93(2013 Jul)
Nonnekens J,Perez-Fernandez J,Theil AF,Gadal O,Bonnart C,Giglia-Mari G

Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.
Proceedings of the National Academy of Sciences of the United States of America109(8)2995-3000(2012 Feb)
Kamileri I,Karakasilioti I,Sideri A,Kosteas T,Tatarakis A,Talianidis I,Garinis GA

B2 RNA represses TFIIH phosphorylation of RNA polymerase II.
Transcription2(1)45-9(2011 Jan-Feb)
Yakovchuk P,Goodrich JA,Kugel JF

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Gtf2h3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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