Gan cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gan
Entrez Gene ID	209239
Full Name	giant axonal neuropathy
Synonyms	A330045G18,gigaxonin
General protein information	Preferred Names giant axonal neuropathy Names gigaxonin gan
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001081151.2	NP_001074620.1	gigaxonin
NM_001081151.1	NP_001074620.1	gigaxonin

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gan	NP_001100904.1
Gallus gallus (chicken)	GAN	XP_428110.3
Pan troglodytes (chimpanzee)	GAN	XP_001142931.2
	GAN	XP_001111517.1
Bos taurus (cattle)	GAN	NP_001092485.1
Xenopus tropicalis (tropical clawed frog)	gan	NP_001016530.1
Homo sapiens (human)	GAN	NP_071324.1
Canis lupus familiaris (dog)	GAN	XP_546814.1
Mus musculus (house mouse)	Gan	NP_001074620.1
Danio rerio (zebrafish)	LOC100537435	XP_003200482.2

Gene Ontology
Bibliography

Related articles in PubMed

Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy.
Israeli E, Dryanovski DI, Schumacker PT, Chandel NS, Singer JD, Julien JP, Goldman RD, Opal P
Human molecular genetics25(11)2143-2157(2016 06)

Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation.
Mahammad S, Murthy SN, Didonna A, Grin B, Israeli E, Perrot R, Bomont P, Julien JP, Kuczmarski E, Opal P, Goldman RD
The Journal of clinical investigation123(5)1964-75(2013 May)

Gigaxonin mutation analysis in patients with NIFID.
Dequen F, Cairns NJ, Bigio EH, Julien JP
Neurobiology of aging32(8)1528-9(2011 Aug)

Modest loss of peripheral axons, muscle atrophy and formation of brain inclusions in mice with targeted deletion of gigaxonin exon 1.
Dequen F, Bomont P, Gowing G, Cleveland DW, Julien JP
Journal of neurochemistry107(1)253-64(2008 Oct)

Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport.
Ding J, Allen E, Wang W, Valle A, Wu C, Nardine T, Cui B, Yi J, Taylor A, Jeon NL, Chu S, So Y, Vogel H, Tolwani R, Mobley W, Yang Y
Human molecular genetics15(9)1451-63(2006 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We demonstrate that gigaxonin is crucial for ubiquitin-proteasomal degradation of neuronal Intermediate filaments. Moreover,Intermediate filaments accumulation impairs mitochondrial motility and is associated with metabolic and oxidative stress
Title: Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy.

gigaxonin is a major factor in the degradation of cytoskeletal intermediate filaments
Title: Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation.

GAN variants are identified in brain sections of mutant mice with giant axonal neuropathy.
Title: Gigaxonin mutation analysis in patients with NIFID.

At 6 months of age the Gigaxonin-knockout(Deltaexon1;Deltaexon1) mice exhibit a modest hind limb muscle atrophy, a 10% decrease of muscle innervation and a 27% axonal loss in the L5 ventral roots.
Title: Modest loss of peripheral axons, muscle atrophy and formation of brain inclusions in mice with targeted deletion of gigaxonin exon 1.

Disruption of gigaxonin results in an impaired ubiquitin-proteasome system leading to a substantial accumulation of toxic microtubule-associated protein MAP8 in the null mutants.
Title: Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport.

The following Gan gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gan cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu01778	NM_001081151.2 Latest version!	Mus musculus giant axonal neuropathy (Gan), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OMu01778	NM_001081151.1	Mus musculus giant axonal neuropathy (Gan), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gan ( NM_001081151.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001074620.1 Mus musculus giant axonal neuropathy (Gan), mRNA.

Price & Availability↑

CloneID	OMu01778
Clone ID Related Accession (Same CDS sequence)	NM_001081151.2 , NM_001081151.1
Accession Version	NM_001081151.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1794bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-14
Organism	Mus musculus(house mouse)
Product	gigaxonin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC121116.7. On Jun 15, 2018 this sequence version replaced NM_001081151.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK039455.1, BC112432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAGG GCAGCGCTGT GTCCGACCCT CAGCACGCCG CGCGCCTGCT GCGGGCGCTC 
AGCTCGTTCC GGGAGGAGGC GCGTTTCTGC GACGCGCATC TGGTCCTCGA CGGCGAGGAG 
ATCCCGGTGC AGAAGAACAT CCTGGCGGCG GCCAGCCCGT ACATCAGGAC AAAGTTAAAC 
TATAATCCTC CAAAAGATGA CGGATCCACT TATAAGATTG AACTTGAAGG GATATCGGTA 
ATGGTGATGA GAGAGATCCT GGATTACATC TTCAGTGGGC AGATCAGGTT AAATGAAGAT 
ACAATCCAGG ATGTTGTGCA GGCAGCCGAC CTGCTGCTGC TGACGGACCT GAAAACGCTG 
TGCTGTGAGT TCCTGGAGGG CTGCATAGCG GCGGAGAACT GCATTGGCAT CCGGGACTTT 
GCGCTGCACT ACTGCCTGCA CCACGTGCAT TACCTGGCCA CTGAGTACCT GGAGACCCAC 
TTCCGAGACG TCAGCAGCAC AGAGGAGTTC CTGGAGCTGA GTCCACAGAA ACTCAAAGAA 
GTGATCTCTC TCGAGAAGCT GAACGTTGGC AACGAGAGAT ACGTGTTCGA GGCAGTGATT 
CGGTGGATAG CACACGATGT AGAGATGAGA AAGGTCCACA TGAAGGATGT CATGTCAGCG 
CTGTGGGTCT CGGGGCTGGA CTCCAGCTAC CTGCGCGAGC AGATGCTGAA TGAACCCTTG 
GTGCGAGAAA TCGTCAAAGA GTGCAGCAAC ATCCCGCTCA GCCAGCCGCA GCAGGGGGAG 
GCCATGCTGG CCAGCTTCAA GCCCAGGGGC TACTCAGAGT GCATAGTGAC CATCGGAGGG 
GAGGAGAGAG TGTCACGGAA ACCCACAGCG GCCATGCGAT GTATGTGCCC TCTCTACGAC 
CCTAACCGGC AGCTGTGGAT TGAACTGGCT CCTCTGAGCA TGCCGAGAAT TAACCATGGA 
GTTCTTTCAG CAGAAGGATT TCTGTTTGTG TTGGGGGGCC AAGATGAAAA CAAGCAGACG 
CTGAGCTCAG GAGAGAAGTA TGACCCAGAC GCTAACACGT GGACTGCGCT CCCACCCATG 
CATGAGGCAA GACACAACTT TGGGATCGTG GAGATAGACG GGATGCTCTA CATCCTTGGA 
GGGGAGGATG GCGATCGAGA GCTCATTTCC ATGGAGTGTT ATGATATTTA TTCCAAAACC 
TGGACGAAGC AGCCCGACTT GACCATGGTT AGGAAGATTG GCTGCTATGC AGCTATGAAA 
AAGAAAATCT ATGCCATGGG CGGAGGCTCG TATGGAAAAC TGTTTGAGTC TGTGGAGTGT 
TACGACCCAC GGACCCAGCA ATGGACTGCC ATATGCCCAC TGAAAGAGAG GAGGTTTGGA 
GCAGTGGCCT GTGGTGTTGC CATGGAGCTG TATGTGTTTG GAGGCGTCCG AAGTCGAGAG 
GACATCCAGG GCAGCGAGAT GGTCACCTGC AAGTCCGAGT TCTATCATGA CGAGTTTAAG 
AGGTGGATCT ACCTTAACGA TCAGAACCTA TGCATCCCTG CCAGCTCCTC CTTTGTCTAC 
GGAGCGGTCC CCATAGGAGC CAGTATTTAT GTTATCGGAG ACCTGGACAC AGGTACCAAC 
TACGACTACG TGCGGGAGTT TAAGAGAAGC ACGGGCACCT GGCACCACAC AAAGCCACTC 
CTGCCATCTG ACCTTCGGCG CACAGGCTGT GCAGCCCTGC GCATAGCCAA CTGCAAGCTC 
TTCCGCCTGC AGCTGCAACA AGGCTTGTTC CGCATCCGGG TCCATTCCCC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001074620.1
CDS	155..1948
Translation	MAEGSAVSDPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSNIPLSQPQQGEAMLASFKPRGYSECIVTIGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVLGGQDENKQTLSSGEKYDPDANTWTALPPMHEARHNFGIVEIDGMLYILGGEDGDRELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDIQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRIANCKLFRLQLQQGLFRIRVHSP

Target ORF information:

RefSeq Version	NM_001081151.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus giant axonal neuropathy (Gan), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001081151.2

ORF Insert Sequence:

ATGGCCGAGG GCAGCGCTGT GTCCGACCCT CAGCACGCCG CGCGCCTGCT GCGGGCGCTC 
AGCTCGTTCC GGGAGGAGGC GCGTTTCTGC GACGCGCATC TGGTCCTCGA CGGCGAGGAG 
ATCCCGGTGC AGAAGAACAT CCTGGCGGCG GCCAGCCCGT ACATCAGGAC AAAGTTAAAC 
TATAATCCTC CAAAAGATGA CGGATCCACT TATAAGATTG AACTTGAAGG GATATCGGTA 
ATGGTGATGA GAGAGATCCT GGATTACATC TTCAGTGGGC AGATCAGGTT AAATGAAGAT 
ACAATCCAGG ATGTTGTGCA GGCAGCCGAC CTGCTGCTGC TGACGGACCT GAAAACGCTG 
TGCTGTGAGT TCCTGGAGGG CTGCATAGCG GCGGAGAACT GCATTGGCAT CCGGGACTTT 
GCGCTGCACT ACTGCCTGCA CCACGTGCAT TACCTGGCCA CTGAGTACCT GGAGACCCAC 
TTCCGAGACG TCAGCAGCAC AGAGGAGTTC CTGGAGCTGA GTCCACAGAA ACTCAAAGAA 
GTGATCTCTC TCGAGAAGCT GAACGTTGGC AACGAGAGAT ACGTGTTCGA GGCAGTGATT 
CGGTGGATAG CACACGATGT AGAGATGAGA AAGGTCCACA TGAAGGATGT CATGTCAGCG 
CTGTGGGTCT CGGGGCTGGA CTCCAGCTAC CTGCGCGAGC AGATGCTGAA TGAACCCTTG 
GTGCGAGAAA TCGTCAAAGA GTGCAGCAAC ATCCCGCTCA GCCAGCCGCA GCAGGGGGAG 
GCCATGCTGG CCAGCTTCAA GCCCAGGGGC TACTCAGAGT GCATAGTGAC CATCGGAGGG 
GAGGAGAGAG TGTCACGGAA ACCCACAGCG GCCATGCGAT GTATGTGCCC TCTCTACGAC 
CCTAACCGGC AGCTGTGGAT TGAACTGGCT CCTCTGAGCA TGCCGAGAAT TAACCATGGA 
GTTCTTTCAG CAGAAGGATT TCTGTTTGTG TTGGGGGGCC AAGATGAAAA CAAGCAGACG 
CTGAGCTCAG GAGAGAAGTA TGACCCAGAC GCTAACACGT GGACTGCGCT CCCACCCATG 
CATGAGGCAA GACACAACTT TGGGATCGTG GAGATAGACG GGATGCTCTA CATCCTTGGA 
GGGGAGGATG GCGATCGAGA GCTCATTTCC ATGGAGTGTT ATGATATTTA TTCCAAAACC 
TGGACGAAGC AGCCCGACTT GACCATGGTT AGGAAGATTG GCTGCTATGC AGCTATGAAA 
AAGAAAATCT ATGCCATGGG CGGAGGCTCG TATGGAAAAC TGTTTGAGTC TGTGGAGTGT 
TACGACCCAC GGACCCAGCA ATGGACTGCC ATATGCCCAC TGAAAGAGAG GAGGTTTGGA 
GCAGTGGCCT GTGGTGTTGC CATGGAGCTG TATGTGTTTG GAGGCGTCCG AAGTCGAGAG 
GACATCCAGG GCAGCGAGAT GGTCACCTGC AAGTCCGAGT TCTATCATGA CGAGTTTAAG 
AGGTGGATCT ACCTTAACGA TCAGAACCTA TGCATCCCTG CCAGCTCCTC CTTTGTCTAC 
GGAGCGGTCC CCATAGGAGC CAGTATTTAT GTTATCGGAG ACCTGGACAC AGGTACCAAC 
TACGACTACG TGCGGGAGTT TAAGAGAAGC ACGGGCACCT GGCACCACAC AAAGCCACTC 
CTGCCATCTG ACCTTCGGCG CACAGGCTGT GCAGCCCTGC GCATAGCCAA CTGCAAGCTC 
TTCCGCCTGC AGCTGCAACA AGGCTTGTTC CGCATCCGGG TCCATTCCCC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gan ( NM_001081151.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001074620.1 Mus musculus giant axonal neuropathy (Gan), mRNA.

Price & Availability↑

CloneID	OMu01778
Clone ID Related Accession (Same CDS sequence)	NM_001081151.2 , NM_001081151.1
Accession Version	NM_001081151.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1794bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Mus musculus(house mouse)
Product	gigaxonin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC121116.7. On Feb 6, 2007 this sequence version replaced XM_146539.8. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK039455.1, BC112432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGAGG GCAGCGCTGT GTCCGACCCT CAGCACGCCG CGCGCCTGCT GCGGGCGCTC 
AGCTCGTTCC GGGAGGAGGC GCGTTTCTGC GACGCGCATC TGGTCCTCGA CGGCGAGGAG 
ATCCCGGTGC AGAAGAACAT CCTGGCGGCG GCCAGCCCGT ACATCAGGAC AAAGTTAAAC 
TATAATCCTC CAAAAGATGA CGGATCCACT TATAAGATTG AACTTGAAGG GATATCGGTA 
ATGGTGATGA GAGAGATCCT GGATTACATC TTCAGTGGGC AGATCAGGTT AAATGAAGAT 
ACAATCCAGG ATGTTGTGCA GGCAGCCGAC CTGCTGCTGC TGACGGACCT GAAAACGCTG 
TGCTGTGAGT TCCTGGAGGG CTGCATAGCG GCGGAGAACT GCATTGGCAT CCGGGACTTT 
GCGCTGCACT ACTGCCTGCA CCACGTGCAT TACCTGGCCA CTGAGTACCT GGAGACCCAC 
TTCCGAGACG TCAGCAGCAC AGAGGAGTTC CTGGAGCTGA GTCCACAGAA ACTCAAAGAA 
GTGATCTCTC TCGAGAAGCT GAACGTTGGC AACGAGAGAT ACGTGTTCGA GGCAGTGATT 
CGGTGGATAG CACACGATGT AGAGATGAGA AAGGTCCACA TGAAGGATGT CATGTCAGCG 
CTGTGGGTCT CGGGGCTGGA CTCCAGCTAC CTGCGCGAGC AGATGCTGAA TGAACCCTTG 
GTGCGAGAAA TCGTCAAAGA GTGCAGCAAC ATCCCGCTCA GCCAGCCGCA GCAGGGGGAG 
GCCATGCTGG CCAGCTTCAA GCCCAGGGGC TACTCAGAGT GCATAGTGAC CATCGGAGGG 
GAGGAGAGAG TGTCACGGAA ACCCACAGCG GCCATGCGAT GTATGTGCCC TCTCTACGAC 
CCTAACCGGC AGCTGTGGAT TGAACTGGCT CCTCTGAGCA TGCCGAGAAT TAACCATGGA 
GTTCTTTCAG CAGAAGGATT TCTGTTTGTG TTGGGGGGCC AAGATGAAAA CAAGCAGACG 
CTGAGCTCAG GAGAGAAGTA TGACCCAGAC GCTAACACGT GGACTGCGCT CCCACCCATG 
CATGAGGCAA GACACAACTT TGGGATCGTG GAGATAGACG GGATGCTCTA CATCCTTGGA 
GGGGAGGATG GCGATCGAGA GCTCATTTCC ATGGAGTGTT ATGATATTTA TTCCAAAACC 
TGGACGAAGC AGCCCGACTT GACCATGGTT AGGAAGATTG GCTGCTATGC AGCTATGAAA 
AAGAAAATCT ATGCCATGGG CGGAGGCTCG TATGGAAAAC TGTTTGAGTC TGTGGAGTGT 
TACGACCCAC GGACCCAGCA ATGGACTGCC ATATGCCCAC TGAAAGAGAG GAGGTTTGGA 
GCAGTGGCCT GTGGTGTTGC CATGGAGCTG TATGTGTTTG GAGGCGTCCG AAGTCGAGAG 
GACATCCAGG GCAGCGAGAT GGTCACCTGC AAGTCCGAGT TCTATCATGA CGAGTTTAAG 
AGGTGGATCT ACCTTAACGA TCAGAACCTA TGCATCCCTG CCAGCTCCTC CTTTGTCTAC 
GGAGCGGTCC CCATAGGAGC CAGTATTTAT GTTATCGGAG ACCTGGACAC AGGTACCAAC 
TACGACTACG TGCGGGAGTT TAAGAGAAGC ACGGGCACCT GGCACCACAC AAAGCCACTC 
CTGCCATCTG ACCTTCGGCG CACAGGCTGT GCAGCCCTGC GCATAGCCAA CTGCAAGCTC 
TTCCGCCTGC AGCTGCAACA AGGCTTGTTC CGCATCCGGG TCCATTCCCC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001074620.1
CDS	1..1794
Translation	MAEGSAVSDPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSNIPLSQPQQGEAMLASFKPRGYSECIVTIGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVLGGQDENKQTLSSGEKYDPDANTWTALPPMHEARHNFGIVEIDGMLYILGGEDGDRELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDIQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRIANCKLFRLQLQQGLFRIRVHSP

Target ORF information:

RefSeq Version	NM_001081151.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus giant axonal neuropathy (Gan), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001081151.1

ORF Insert Sequence:

ATGGCCGAGG GCAGCGCTGT GTCCGACCCT CAGCACGCCG CGCGCCTGCT GCGGGCGCTC 
AGCTCGTTCC GGGAGGAGGC GCGTTTCTGC GACGCGCATC TGGTCCTCGA CGGCGAGGAG 
ATCCCGGTGC AGAAGAACAT CCTGGCGGCG GCCAGCCCGT ACATCAGGAC AAAGTTAAAC 
TATAATCCTC CAAAAGATGA CGGATCCACT TATAAGATTG AACTTGAAGG GATATCGGTA 
ATGGTGATGA GAGAGATCCT GGATTACATC TTCAGTGGGC AGATCAGGTT AAATGAAGAT 
ACAATCCAGG ATGTTGTGCA GGCAGCCGAC CTGCTGCTGC TGACGGACCT GAAAACGCTG 
TGCTGTGAGT TCCTGGAGGG CTGCATAGCG GCGGAGAACT GCATTGGCAT CCGGGACTTT 
GCGCTGCACT ACTGCCTGCA CCACGTGCAT TACCTGGCCA CTGAGTACCT GGAGACCCAC 
TTCCGAGACG TCAGCAGCAC AGAGGAGTTC CTGGAGCTGA GTCCACAGAA ACTCAAAGAA 
GTGATCTCTC TCGAGAAGCT GAACGTTGGC AACGAGAGAT ACGTGTTCGA GGCAGTGATT 
CGGTGGATAG CACACGATGT AGAGATGAGA AAGGTCCACA TGAAGGATGT CATGTCAGCG 
CTGTGGGTCT CGGGGCTGGA CTCCAGCTAC CTGCGCGAGC AGATGCTGAA TGAACCCTTG 
GTGCGAGAAA TCGTCAAAGA GTGCAGCAAC ATCCCGCTCA GCCAGCCGCA GCAGGGGGAG 
GCCATGCTGG CCAGCTTCAA GCCCAGGGGC TACTCAGAGT GCATAGTGAC CATCGGAGGG 
GAGGAGAGAG TGTCACGGAA ACCCACAGCG GCCATGCGAT GTATGTGCCC TCTCTACGAC 
CCTAACCGGC AGCTGTGGAT TGAACTGGCT CCTCTGAGCA TGCCGAGAAT TAACCATGGA 
GTTCTTTCAG CAGAAGGATT TCTGTTTGTG TTGGGGGGCC AAGATGAAAA CAAGCAGACG 
CTGAGCTCAG GAGAGAAGTA TGACCCAGAC GCTAACACGT GGACTGCGCT CCCACCCATG 
CATGAGGCAA GACACAACTT TGGGATCGTG GAGATAGACG GGATGCTCTA CATCCTTGGA 
GGGGAGGATG GCGATCGAGA GCTCATTTCC ATGGAGTGTT ATGATATTTA TTCCAAAACC 
TGGACGAAGC AGCCCGACTT GACCATGGTT AGGAAGATTG GCTGCTATGC AGCTATGAAA 
AAGAAAATCT ATGCCATGGG CGGAGGCTCG TATGGAAAAC TGTTTGAGTC TGTGGAGTGT 
TACGACCCAC GGACCCAGCA ATGGACTGCC ATATGCCCAC TGAAAGAGAG GAGGTTTGGA 
GCAGTGGCCT GTGGTGTTGC CATGGAGCTG TATGTGTTTG GAGGCGTCCG AAGTCGAGAG 
GACATCCAGG GCAGCGAGAT GGTCACCTGC AAGTCCGAGT TCTATCATGA CGAGTTTAAG 
AGGTGGATCT ACCTTAACGA TCAGAACCTA TGCATCCCTG CCAGCTCCTC CTTTGTCTAC 
GGAGCGGTCC CCATAGGAGC CAGTATTTAT GTTATCGGAG ACCTGGACAC AGGTACCAAC 
TACGACTACG TGCGGGAGTT TAAGAGAAGC ACGGGCACCT GGCACCACAC AAAGCCACTC 
CTGCCATCTG ACCTTCGGCG CACAGGCTGT GCAGCCCTGC GCATAGCCAA CTGCAAGCTC 
TTCCGCCTGC AGCTGCAACA AGGCTTGTTC CGCATCCGGG TCCATTCCCC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy.
Human molecular genetics25(11)2143-2157(2016 06)
Israeli E,Dryanovski DI,Schumacker PT,Chandel NS,Singer JD,Julien JP,Goldman RD,Opal P

Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation.
The Journal of clinical investigation123(5)1964-75(2013 May)
Mahammad S,Murthy SN,Didonna A,Grin B,Israeli E,Perrot R,Bomont P,Julien JP,Kuczmarski E,Opal P,Goldman RD

Gigaxonin mutation analysis in patients with NIFID.
Neurobiology of aging32(8)1528-9(2011 Aug)
Dequen F,Cairns NJ,Bigio EH,Julien JP

Modest loss of peripheral axons, muscle atrophy and formation of brain inclusions in mice with targeted deletion of gigaxonin exon 1.
Journal of neurochemistry107(1)253-64(2008 Oct)
Dequen F,Bomont P,Gowing G,Cleveland DW,Julien JP

Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport.
Human molecular genetics15(9)1451-63(2006 May)
Ding J,Allen E,Wang W,Valle A,Wu C,Nardine T,Cui B,Yi J,Taylor A,Jeon NL,Chu S,So Y,Vogel H,Tolwani R,Mobley W,Yang Y

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Gan cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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