The following Gan gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gan cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu01778 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001081151.2 , NM_001081151.1 | |
| Accession Version | NM_001081151.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1794bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-06-14 | |
| Organism | Mus musculus(house mouse) | |
| Product | gigaxonin | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC121116.7. On Jun 15, 2018 this sequence version replaced NM_001081151.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK039455.1, BC112432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCCGAGG GCAGCGCTGT GTCCGACCCT CAGCACGCCG CGCGCCTGCT GCGGGCGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001074620.1 |
| CDS | 155..1948 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001081151.2 |
1 | ATGGCCGAGG GCAGCGCTGT GTCCGACCCT CAGCACGCCG CGCGCCTGCT GCGGGCGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu01778 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001081151.2 , NM_001081151.1 | |
| Accession Version | NM_001081151.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1794bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-10-02 | |
| Organism | Mus musculus(house mouse) | |
| Product | gigaxonin | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC121116.7. On Feb 6, 2007 this sequence version replaced XM_146539.8. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK039455.1, BC112432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGCCGAGG GCAGCGCTGT GTCCGACCCT CAGCACGCCG CGCGCCTGCT GCGGGCGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001074620.1 |
| CDS | 1..1794 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001081151.1 |
1 | ATGGCCGAGG GCAGCGCTGT GTCCGACCCT CAGCACGCCG CGCGCCTGCT GCGGGCGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy. |
Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. |
Gigaxonin mutation analysis in patients with NIFID. |
Modest loss of peripheral axons, muscle atrophy and formation of brain inclusions in mice with targeted deletion of gigaxonin exon 1. |
Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport. |
