Stxbp3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Stxbp3
Entrez Gene ID	20912
Full Name	syntaxin binding protein 3
Synonyms	Munc-18c,Stxbp3a,Sxtbp3,Unc18-3
General protein information	Preferred Names syntaxin binding protein 3 Names syntaxin-binding protein 3 MUNC-18-3 mammalian homolog of Unc-18c protein unc-18 homolog 3 protein unc-18 homolog C syntaxin binding protein 3A unc-18 homolog 3 unc-18C
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 F3

mRNA and Protein(s)

mRNA	Protein	Name
NM_011504.1	NP_035634.1	syntaxin-binding protein 3

Pathways from BioSystems

Homologies

	STXBP3	XP_001087621.2
Rattus norvegicus (Norway rat)	Stxbp3	NP_446089.1
Pan troglodytes (chimpanzee)	STXBP3	XP_001145368.1
Canis lupus familiaris (dog)	STXBP3	XP_547249.2
Mus musculus (house mouse)	Stxbp3a	NP_035634.1
Danio rerio (zebrafish)	stxbp3	NP_998636.1
Xenopus tropicalis (tropical clawed frog)	stxbp3	NP_001015972.1
Homo sapiens (human)	STXBP3	NP_009200.2
Bos taurus (cattle)	STXBP3	NP_001076884.1
Gallus gallus (chicken)	STXBP3	NP_001073202.1

Gene Ontology
Bibliography

Related articles in PubMed

Munc18c depletion attenuates caerulein hyperstimulation induced pancreatitis.
Dolai S, Liang T, Orabi AI, Xie L, Holmyard D, Javed TA, Fernandez NA, Xie H, Cattral MS, Thurmond DC, Thorn P, Gaisano HY
The Journal of biological chemistry(2017 Dec)

Insulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanism.
Kioumourtzoglou D, Gould GW, Bryant NJ
Molecular and cellular biology34(7)1271-9(2014 Apr)

Milligram quantities of homogeneous recombinant full-length mouse Munc18c from Escherichia coli cultures.
Rehman A, Jarrott RJ, Whitten AE, King GJ, Hu SH, Christie MP, Collins BM, Martin JL
PloS one8(12)e83499(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PTP1B is the first known tyrosine phosphatase for Munc18c and a regulator of its phosphorylation and function in adipocytes.
Title: Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B.

Ectopic expression of syntaxin3 affects behaviors of B16 melanoma by controlling actin dynamics.
Title: Ectopic expression of syntaxin3 affects behaviors of B16 melanoma by controlling actin dynamics.

Investigated the use of Escherichia coli as an expression host for Munc18c. Three N-terminal His-tagged constructs were engineered, two with a tobacco etch virus (TEV) or thrombin protease cleavage site to enable removal of the fusion tag.
Title: Milligram quantities of homogeneous recombinant full-length mouse Munc18c from Escherichia coli cultures.

Munc18c provides stimulus-specific regulation of GLUT4 trafficking, but not FA transporter trafficking
Title: Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle.

The Using 3T3-L1 adipocytes subjected to small interfering ribonucleic acid reduction of Munc18c as a model of impaired insulin-stimulated GLUT4 vesicle exocytosis.
Title: Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis.

The following Stxbp3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Stxbp3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08291	NM_011504.1 Latest version!	Mus musculus syntaxin binding protein 3 (Stxbp3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Stxbp3 ( NM_011504.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035634.1 Mus musculus syntaxin binding protein 3 (Stxbp3), mRNA.

Price & Availability↑

CloneID	OMu08291
Clone ID Related Accession (Same CDS sequence)	NM_011504.1
Accession Version	NM_011504.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1779bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-11
Organism	Mus musculus(house mouse)
Product	syntaxin-binding protein 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D30798.1. On Dec 7, 2005 this sequence version replaced XM_910404.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK155133.1, BC062901.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGCGCCGC CGGTATCGGA GCGGGGACTG AAGAGCGTCG TGTGGCGGAA GATAAAAACA 
GCCGTGTTCG ATGACTGCCG GAAAGAAGGC GAATGGAAGA TAATGCTGTT AGATGAGTTT 
ACCACCAAAC TTTTGTCGTC ATGCTGCAAA ATGACAGACC TTCTAGAGGA GGGCATAACT 
GTTATAGAGA ATATTTATAA GAATCGTGAA CCTGTCAGAC AAATGAAAGC TCTTTATTTC 
ATCTCTCCAA CACCAAAATC TGTAGATTGT TTCTTGAGAG ATTTTGGAAG TAAATCTGAG 
AAAAAATACA AAGCAGCGTA TATATACTTC ACTGACTTTT GTCCTGACAG TCTCTTTAAC 
AAGATTAAAG CATCTTGCTC CAAGTCAATA AGAAGATGTA AGGAAATAAA CATTTCCTTC 
ATTCCACAGG AATCTCAGGT TTATACTCTT GATGTACCGG ACGCATTCTA TTACTGTTAC 
AGTCCAGACC CTAGTAACGC CAGCAGGAAA GAAGTGGTCA TGGAGGCAAT GGCTGAGCAG 
ATTGTGACAG TGTGTGCCAC TCTGGATGAA AACCCTGGAG TGAGGTACAA GAGTAAACCT 
CTAGATAATG CCAGTAAGCT TGCACAGCTG GTTGAGAAAA AGCTTGAAGA CTACTACAAA 
ATTGATGAAA AAGGCCTAAT AAAGGGTAAA ACTCAGTCCC AGCTCTTAAT AATTGACCGT 
GGCTTTGACC CTGTGTCCAC TGTCCTGCAT GAACTGACCT TTCAGGCAAT GGCATATGAT 
CTACTACCAA TTGAGAATGA TACATACAAG TACAAAACAG ATGGAAAAGA GAAGGAGGCA 
GTTCTTGAAG AAGACGACGA CCTGTGGGTG CGGGTTCGAC ACCGGCACAT CGCGGTTGTG 
TTGGAGGAAA TTCCAAAGCT TATGAAGGAA ATTTCATCAA CAAAGAAAGC TACAGAGGGG 
AAGACATCAC TTAGCGCTCT TACCCAGCTG ATGAAAAAGA TGCCGCACTT CCGAAAGCAG 
ATCTCGAAGC AAGTAGTCCA TCTTAACTTA GCTGAAGACT GCATGAATAA GTTTAAGCTG 
AATATTGAGA AGCTCTGCAA AACTGAGCAG GACCTGGCAC TTGGAACAGA TGCTGAAGGC 
CAGCGGGTGA AGGACTCCAT GCTGGTGCTC CTCCCAGTGC TGCTCAACAA AAACCATGAC 
AACTGCGACA AAATACGGGC AGTCCTGCTC TACATCTTCG GGATTAATGG AACCACTGAA 
GAAAATCTGG ACAGACTGAT CCACAATGTA AAGATAGAAG ATGATAGTGA TATGATTCGT 
AACTGGAGCC ACCTTGGTGT TCCCATTGTT CCCCCATCCC AGCAAGCCAA ACCACTGAGA 
AAGGATCGGT CTGCAGAAGA GACTTTTCAG CTTTCTCGAT GGACACCTTT TATCAAAGAT 
ATCATGGAGG ATGCCATTGA TAATAGATTA GATTCCAAAG AGTGGCCGTA TTGTTCCCGG 
TGCCCAGCAG TGTGGAATGG CTCTGGAGCT GTGAGTGCTC GCCAGAAACC CAGAACTAAC 
TACTTAGAGC TGGACCGGAA AAATGGGTCA AGGCTGATTA TTTTTGTAAT TGGAGGAATT 
ACGTACTCTG AGATGCGGTG TGCTTATGAA GTTTCCCAGG CACATAAATC CTGTGAGGTT 
ATTATTGGTT CCACACATAT TTTAACACCC AGAAAGCTCC TGGATGATAT AAAAATGCTG 
AATAAATCAA AGGATAAAGT TTCCTTTAAG GATGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035634.1
CDS	35..1813
Translation	MAPPVSERGLKSVVWRKIKTAVFDDCRKEGEWKIMLLDEFTTKLLSSCCKMTDLLEEGITVIENIYKNREPVRQMKALYFISPTPKSVDCFLRDFGSKSEKKYKAAYIYFTDFCPDSLFNKIKASCSKSIRRCKEINISFIPQESQVYTLDVPDAFYYCYSPDPSNASRKEVVMEAMAEQIVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDEKGLIKGKTQSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYKYKTDGKEKEAVLEEDDDLWVRVRHRHIAVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKMPHFRKQISKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDAEGQRVKDSMLVLLPVLLNKNHDNCDKIRAVLLYIFGINGTTEENLDRLIHNVKIEDDSDMIRNWSHLGVPIVPPSQQAKPLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSRCPAVWNGSGAVSARQKPRTNYLELDRKNGSRLIIFVIGGITYSEMRCAYEVSQAHKSCEVIIGSTHILTPRKLLDDIKMLNKSKDKVSFKDE

Target ORF information:

RefSeq Version	NM_011504.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus syntaxin binding protein 3 (Stxbp3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011504.1

ORF Insert Sequence:

ATGGCGCCGC CGGTATCGGA GCGGGGACTG AAGAGCGTCG TGTGGCGGAA GATAAAAACA 
GCCGTGTTCG ATGACTGCCG GAAAGAAGGC GAATGGAAGA TAATGCTGTT AGATGAGTTT 
ACCACCAAAC TTTTGTCGTC ATGCTGCAAA ATGACAGACC TTCTAGAGGA GGGCATAACT 
GTTATAGAGA ATATTTATAA GAATCGTGAA CCTGTCAGAC AAATGAAAGC TCTTTATTTC 
ATCTCTCCAA CACCAAAATC TGTAGATTGT TTCTTGAGAG ATTTTGGAAG TAAATCTGAG 
AAAAAATACA AAGCAGCGTA TATATACTTC ACTGACTTTT GTCCTGACAG TCTCTTTAAC 
AAGATTAAAG CATCTTGCTC CAAGTCAATA AGAAGATGTA AGGAAATAAA CATTTCCTTC 
ATTCCACAGG AATCTCAGGT TTATACTCTT GATGTACCGG ACGCATTCTA TTACTGTTAC 
AGTCCAGACC CTAGTAACGC CAGCAGGAAA GAAGTGGTCA TGGAGGCAAT GGCTGAGCAG 
ATTGTGACAG TGTGTGCCAC TCTGGATGAA AACCCTGGAG TGAGGTACAA GAGTAAACCT 
CTAGATAATG CCAGTAAGCT TGCACAGCTG GTTGAGAAAA AGCTTGAAGA CTACTACAAA 
ATTGATGAAA AAGGCCTAAT AAAGGGTAAA ACTCAGTCCC AGCTCTTAAT AATTGACCGT 
GGCTTTGACC CTGTGTCCAC TGTCCTGCAT GAACTGACCT TTCAGGCAAT GGCATATGAT 
CTACTACCAA TTGAGAATGA TACATACAAG TACAAAACAG ATGGAAAAGA GAAGGAGGCA 
GTTCTTGAAG AAGACGACGA CCTGTGGGTG CGGGTTCGAC ACCGGCACAT CGCGGTTGTG 
TTGGAGGAAA TTCCAAAGCT TATGAAGGAA ATTTCATCAA CAAAGAAAGC TACAGAGGGG 
AAGACATCAC TTAGCGCTCT TACCCAGCTG ATGAAAAAGA TGCCGCACTT CCGAAAGCAG 
ATCTCGAAGC AAGTAGTCCA TCTTAACTTA GCTGAAGACT GCATGAATAA GTTTAAGCTG 
AATATTGAGA AGCTCTGCAA AACTGAGCAG GACCTGGCAC TTGGAACAGA TGCTGAAGGC 
CAGCGGGTGA AGGACTCCAT GCTGGTGCTC CTCCCAGTGC TGCTCAACAA AAACCATGAC 
AACTGCGACA AAATACGGGC AGTCCTGCTC TACATCTTCG GGATTAATGG AACCACTGAA 
GAAAATCTGG ACAGACTGAT CCACAATGTA AAGATAGAAG ATGATAGTGA TATGATTCGT 
AACTGGAGCC ACCTTGGTGT TCCCATTGTT CCCCCATCCC AGCAAGCCAA ACCACTGAGA 
AAGGATCGGT CTGCAGAAGA GACTTTTCAG CTTTCTCGAT GGACACCTTT TATCAAAGAT 
ATCATGGAGG ATGCCATTGA TAATAGATTA GATTCCAAAG AGTGGCCGTA TTGTTCCCGG 
TGCCCAGCAG TGTGGAATGG CTCTGGAGCT GTGAGTGCTC GCCAGAAACC CAGAACTAAC 
TACTTAGAGC TGGACCGGAA AAATGGGTCA AGGCTGATTA TTTTTGTAAT TGGAGGAATT 
ACGTACTCTG AGATGCGGTG TGCTTATGAA GTTTCCCAGG CACATAAATC CTGTGAGGTT 
ATTATTGGTT CCACACATAT TTTAACACCC AGAAAGCTCC TGGATGATAT AAAAATGCTG 
AATAAATCAA AGGATAAAGT TTCCTTTAAG GATGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Munc18c depletion attenuates caerulein hyperstimulation induced pancreatitis.
The Journal of biological chemistry(2017 Dec)
Dolai S,Liang T,Orabi AI,Xie L,Holmyard D,Javed TA,Fernandez NA,Xie H,Cattral MS,Thurmond DC,Thorn P,Gaisano HY

Insulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanism.
Molecular and cellular biology34(7)1271-9(2014 Apr)
Kioumourtzoglou D,Gould GW,Bryant NJ

Milligram quantities of homogeneous recombinant full-length mouse Munc18c from Escherichia coli cultures.
PloS one8(12)e83499(2013)
Rehman A,Jarrott RJ,Whitten AE,King GJ,Hu SH,Christie MP,Collins BM,Martin JL