Npb cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Npb
Entrez Gene ID	208990
Full Name	neuropeptide B
General protein information	Preferred Names neuropeptide B Names neuropeptide B mPPL7 preproneuropeptide B preproprotein L7
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 E2

mRNA and Protein(s)

mRNA	Protein	Name
NM_153288.3	NP_695020.1	neuropeptide B isoform 1 precursor
NM_001347617.1	NP_001334546.1	neuropeptide B isoform 3 precursor
NM_001347616.1	NP_001334545.1	neuropeptide B isoform 2 precursor

Pathways from BioSystems

Homologies

	NPB	XP_001112472.1
Bos taurus (cattle)	NPB	NP_776369.1
Mus musculus (house mouse)	Npb	NP_695020.1
Rattus norvegicus (Norway rat)	Npb	NP_695205.1
Homo sapiens (human)	NPB	NP_683694.1
Canis lupus familiaris (dog)	NPB	XP_003639281.1

Gene Ontology
Bibliography

Related articles in PubMed

Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain.
Kelly MA, Beuckmann CT, Williams SC, Sinton CM, Motoike T, Richardson JA, Hammer RE, Garry MG, Yanagisawa M
Proceedings of the National Academy of Sciences of the United States of America102(28)9942-7(2005 Jul)

Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity.
Ishii M, Fei H, Friedman JM
Proceedings of the National Academy of Sciences of the United States of America100(18)10540-5(2003 Sep)

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.
Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M
Proceedings of the National Academy of Sciences of the United States of America100(10)6251-6(2003 May)

Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7.
Fujii R, Yoshida H, Fukusumi S, Habata Y, Hosoya M, Kawamata Y, Yano T, Hinuma S, Kitada C, Asami T, Mori M, Fujisawa Y, Fujino M
The Journal of biological chemistry277(37)34010-6(2002 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NPB is a factor in the modulation of responses to inflammatory pain and body weight homeostasis.
Title: Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain.

role for GPR7 and its endogenous ligands, neuropeptide B and neuropeptide W, in regulating energy homeostasis.
Title: Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity.

identified a neuropeptide modified with bromine; an endogenous ligand for GPR7
Title: Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7.

The following Npb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Npb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu02014	NM_153288.3 Latest version!	Mus musculus neuropeptide B (Npb), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu83547	NM_001347617.1 Latest version!	Mus musculus neuropeptide B (Npb), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OMu83550	NM_001347616.1 Latest version!	Mus musculus neuropeptide B (Npb), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Npb ( NM_153288.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_695020.1 Mus musculus neuropeptide B (Npb), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu02014
Clone ID Related Accession (Same CDS sequence)	NM_153288.3
Accession Version	NM_153288.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-19
Organism	Mus musculus(house mouse)
Product	neuropeptide B isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK141698.1. On Apr 6, 2007 this sequence version replaced NM_153288.2. ##Evidence-Data-START## Transcript exon combination :: AK141698.1, BB442010.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGGT GTAGGACGCT GGTGGCCGCT GCCCTGGCGC TGCTCCTGCC GCCAGCCCTC 
GCGTGGTACA AGCCCGCGGC GGGACCCCAC CACTACTCGG TGGGCCGCGC CTCGGGGCTA 
CTGTCGAGTT TCCACAGGTT CCCGTCCACG CGACGCTCCG AGTCTCCAGC ACTCCGGGTG 
GGAACCGGAC CTCTGCGCAA TTTAGAGATG CGCCCCAGCG TAAGGAGCCT TGCCCTGTGT 
GTCAAAGATG TGACCCCGAA CCTGCAGAGC TGCCAGCGGC AACTCAACAG CCGAGGGACT 
TTCCAGTGTA AAGCGGACGT CTTCTTGTCG CTGCACGAGA CTGATTGCCA GAGCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_695020.1
CDS	33..392
Translation	MARCRTLVAAALALLLPPALAWYKPAAGPHHYSVGRASGLLSSFHRFPSTRRSESPALRVGTGPLRNLEMRPSVRSLALCVKDVTPNLQSCQRQLNSRGTFQCKADVFLSLHETDCQST

Target ORF information:

RefSeq Version	NM_153288.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus neuropeptide B (Npb), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153288.3

ORF Insert Sequence:

ATGGCCCGGT GTAGGACGCT GGTGGCCGCT GCCCTGGCGC TGCTCCTGCC GCCAGCCCTC 
GCGTGGTACA AGCCCGCGGC GGGACCCCAC CACTACTCGG TGGGCCGCGC CTCGGGGCTA 
CTGTCGAGTT TCCACAGGTT CCCGTCCACG CGACGCTCCG AGTCTCCAGC ACTCCGGGTG 
GGAACCGGAC CTCTGCGCAA TTTAGAGATG CGCCCCAGCG TAAGGAGCCT TGCCCTGTGT 
GTCAAAGATG TGACCCCGAA CCTGCAGAGC TGCCAGCGGC AACTCAACAG CCGAGGGACT 
TTCCAGTGTA AAGCGGACGT CTTCTTGTCG CTGCACGAGA CTGATTGCCA GAGCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Npb ( NM_001347617.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001334546.1 Mus musculus neuropeptide B (Npb), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu83547
Clone ID Related Accession (Same CDS sequence)	NM_001347617.1
Accession Version	NM_001347617.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 348bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Mus musculus(house mouse)
Product	neuropeptide B isoform 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK141698.1, BE648548.1 and AW123684.1. On Dec 2, 2016 this sequence version replaced XM_017314406.1. ##Evidence-Data-START## Transcript exon combination :: BE648548.1, BE956717.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGGT GTAGGACGCT GGTGGCCGCT GCCCTGGCGC TGCTCCTGCC GCCAGCCCTC 
GCGTGGTACA AGCCCGCGGC GGGACCCCAC CACTACTCGG TGGGCCGCGC CTCGGGGCTA 
CTGTCGAGTT TCCACAGGTT CCCGTCCACG CGACGCTCCG AGTCTCCAGC ACTCCGGGTG 
GGAACCGGAC CTCTGCGCAA TTTAGAGATG CGCCCCAGCG CCCTGTGTGT CAAAGATGTG 
ACCCCGAACC TGCAGAGCTG CCAGCGGCAA CTCAACAGCC GAGGGACTTT CCAGTGTAAA 
GCGGACGTCT TCTTGTCGCT GCACGAGACT GATTGCCAGA GCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001334546.1
CDS	33..380
Translation	MARCRTLVAAALALLLPPALAWYKPAAGPHHYSVGRASGLLSSFHRFPSTRRSESPALRVGTGPLRNLEMRPSALCVKDVTPNLQSCQRQLNSRGTFQCKADVFLSLHETDCQST

Target ORF information:

RefSeq Version	NM_001347617.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus neuropeptide B (Npb), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001347617.1

ORF Insert Sequence:

ATGGCCCGGT GTAGGACGCT GGTGGCCGCT GCCCTGGCGC TGCTCCTGCC GCCAGCCCTC 
GCGTGGTACA AGCCCGCGGC GGGACCCCAC CACTACTCGG TGGGCCGCGC CTCGGGGCTA 
CTGTCGAGTT TCCACAGGTT CCCGTCCACG CGACGCTCCG AGTCTCCAGC ACTCCGGGTG 
GGAACCGGAC CTCTGCGCAA TTTAGAGATG CGCCCCAGCG CCCTGTGTGT CAAAGATGTG 
ACCCCGAACC TGCAGAGCTG CCAGCGGCAA CTCAACAGCC GAGGGACTTT CCAGTGTAAA 
GCGGACGTCT TCTTGTCGCT GCACGAGACT GATTGCCAGA GCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Npb ( NM_001347616.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001334545.1 Mus musculus neuropeptide B (Npb), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu83550
Clone ID Related Accession (Same CDS sequence)	NM_001347616.1
Accession Version	NM_001347616.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Mus musculus(house mouse)
Product	neuropeptide B isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL663030.12 and AW123684.1. On Dec 2, 2016 this sequence version replaced XM_017314407.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AA016409.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGGT GTAGGACGCT GGTGGCCGCT GCCCTGGCGC TGCTCCTGCC GCCAGCCCTC 
GCGTGGTACA AGCCCGCGGC GGGACCCCAC CACTACTCGG TGGGCCGCGC CTCGGGGCTA 
CTGTCGAGTT TCCACAGGTT CCCGTCCACG CGACGCTCCG AGTCTCCAGC ACTCCGGGTG 
GGAACCGGAC CTCTGCGCAA TTTAGAGATG CGCCCCAGCG TAAGGAGCCT TAGCTGCCAG 
CGGCAACTCA ACAGCCGAGG GACTTTCCAG TGTAAAGCGG ACGTCTTCTT GTCGCTGCAC 
GAGACTGATT GCCAGAGCAC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001334545.1
CDS	33..356
Translation	MARCRTLVAAALALLLPPALAWYKPAAGPHHYSVGRASGLLSSFHRFPSTRRSESPALRVGTGPLRNLEMRPSVRSLSCQRQLNSRGTFQCKADVFLSLHETDCQST

Target ORF information:

RefSeq Version	NM_001347616.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus neuropeptide B (Npb), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001347616.1

ORF Insert Sequence:

ATGGCCCGGT GTAGGACGCT GGTGGCCGCT GCCCTGGCGC TGCTCCTGCC GCCAGCCCTC 
GCGTGGTACA AGCCCGCGGC GGGACCCCAC CACTACTCGG TGGGCCGCGC CTCGGGGCTA 
CTGTCGAGTT TCCACAGGTT CCCGTCCACG CGACGCTCCG AGTCTCCAGC ACTCCGGGTG 
GGAACCGGAC CTCTGCGCAA TTTAGAGATG CGCCCCAGCG TAAGGAGCCT TAGCTGCCAG 
CGGCAACTCA ACAGCCGAGG GACTTTCCAG TGTAAAGCGG ACGTCTTCTT GTCGCTGCAC 
GAGACTGATT GCCAGAGCAC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain.
Proceedings of the National Academy of Sciences of the United States of America102(28)9942-7(2005 Jul)
Kelly MA,Beuckmann CT,Williams SC,Sinton CM,Motoike T,Richardson JA,Hammer RE,Garry MG,Yanagisawa M

Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity.
Proceedings of the National Academy of Sciences of the United States of America100(18)10540-5(2003 Sep)
Ishii M,Fei H,Friedman JM

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.
Proceedings of the National Academy of Sciences of the United States of America100(10)6251-6(2003 May)
Tanaka H,Yoshida T,Miyamoto N,Motoike T,Kurosu H,Shibata K,Yamanaka A,Williams SC,Richardson JA,Tsujino N,Garry MG,Lerner MR,King DS,O'Dowd BF,Sakurai T,Yanagisawa M

Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7.
The Journal of biological chemistry277(37)34010-6(2002 Sep)
Fujii R,Yoshida H,Fukusumi S,Habata Y,Hosoya M,Kawamata Y,Yano T,Hinuma S,Kitada C,Asami T,Mori M,Fujisawa Y,Fujino M

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Npb cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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