EIF5A2 cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	EIF5A2
Entrez Gene ID	208691
Full Name	eukaryotic translation initiation factor 5A2
Synonyms	9630038B20,eIF5AII
General protein information	Preferred Names eukaryotic translation initiation factor 5A2 Names eukaryotic translation initiation factor 5A-2 eukaryotic initiation factor 5A
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 3 Map Location: 3\|3 A3

mRNA and Protein(s)

mRNA	Protein	Name
XM_017319514.2	XP_017175003.2	eukaryotic translation initiation factor 5A-2 isoform X1
XM_017319514.1	XP_017175003.1	eukaryotic translation initiation factor 5A-2 isoform X1
NM_177586.6	NP_808254.1	eukaryotic translation initiation factor 5A-2
NM_177586.5	NP_808254.1	eukaryotic translation initiation factor 5A-2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Eif5a2	NP_001094167.1
Pan troglodytes (chimpanzee)	EIF5A2	XP_001163733.1
Bos taurus (cattle)	EIF5A2	NP_001179018.1
Gallus gallus (chicken)	EIF5A2	NP_990863.1
Homo sapiens (human)	EIF5A2	NP_065123.1
	EIF5A2	XP_002802971.1
Canis lupus familiaris (dog)	EIF5A2	XP_005639970.1
Mus musculus (house mouse)	Eif5a2	NP_808254.1

Gene Ontology
Bibliography

Related articles in PubMed

Biological Relevance and Therapeutic Potential of the Hypusine Modification System.
P?llmann N, Braig M, Sievert H, Preukschas M, Hermans-Borgmeyer I, Schweizer M, Nagel CH, Neumann M, Wild P, Haralambieva E, Hagel C, Bokemeyer C, Hauber J, Balabanov S
The Journal of biological chemistry290(30)18343-60(2015 Jul)

Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability.
Chen M, Huang JD, Deng HK, Dong S, Deng W, Tsang SL, Huen MS, Chen L, Zan T, Zhu GX, Guan XY
BMC cancer11199(2011 May)

A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, N?rnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Doll? P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS biology9(1)e1000582(2011 Jan)

Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media.
Parkinson N, Hardisty-Hughes RE, Tateossian H, Tsai HT, Brooker D, Morse S, Lalane Z, MacKenzie F, Fray M, Glenister P, Woodward AM, Polley S, Barbaric I, Dear N, Hough TA, Hunter AJ, Cheeseman MT, Brown SD
PLoS genetics2(10)e149(2006 Oct)

Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression.
Jenkins ZA, H??g PG, Johansson HE
Genomics71(1)101-9(2001 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

activation of eIF-5A2 repressed p19 level and therefore destabilized p53 in transgenic mouse embryo fibroblast (MEF) cells. This subsequently allowed for the accumulation of chromosomal instability.
Title: Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability.

Eukaryotic initiation factor 5A (eIF5A) (eIF-4D, eIF-5A) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys 50. Mouse EIF5A1 and EIF5A2 encode two isoforms: eIF5AI and eIF5AII.
Title: Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression.

The following EIF5A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EIF5A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu06470	NM_177586.6 Latest version!	Mus musculus eukaryotic translation initiation factor 5A2 (Eif5a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu80580	XM_017319514.1 Latest version!	Mus musculus eukaryotic translation initiation factor 5A2 (Eif5a2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OMu88189	XM_017319514.2 Latest version!	Mus musculus eukaryotic translation initiation factor 5A2 (Eif5a2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu06470	NM_177586.5	Mus musculus eukaryotic translation initiation factor 5A2 (Eif5a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EIF5A2 ( NM_177586.6 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_808254.1 Mus musculus eukaryotic translation initiation factor 5A2 (Eif5a2), mRNA.

Price & Availability↑

CloneID	OMu06470
Clone ID Related Accession (Same CDS sequence)	NM_177586.6 , NM_177586.5
Accession Version	NM_177586.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-29
Organism	Mus musculus(house mouse)
Product	eukaryotic translation initiation factor 5A-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC122490.3. On Oct 4, 2017 this sequence version replaced NM_177586.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AY205265.1, AK082214.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGACG AAATTGATTT CACTACTGGA GATGCAGGGG CTTCCAGCAC TTATCCTATG 
CAGTGCTCAG CCCTGCGCAA AAACGGCTTC GTCGTGCTCA AAGGGCGACC ATGCAAAATC 
GTGGAGATGT CAACTTCCAA GACTGGGAAG CATGGTCATG CCAAGGTACA CCTTGTTGGA 
ATTGACATTT TCACTGGCAA AAAATATGAA GACATTTGTC CTTCTACTCA CAACATGGAT 
GTTCCAAATA TTAAGAGAAA CGATTATCAA CTCATATGCA TTCAGGATGG TTACCTTTCC 
CTGCTGACAG AAACTGGCGA AGTCCGTGAA GATCTTAAGC TGCCAGAAGG TGAACTGGGC 
AAAGAAATAG AAGGGAAATA CAATGCAGGT GAAGATGTGC AGGTGTCTGT CATGTGTGCC 
ATGAGTGAAG AATACGCTGT AGCCATAAAG CCCTGCAAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808254.1
CDS	174..635
Translation	MADEIDFTTGDAGASSTYPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDYQLICIQDGYLSLLTETGEVREDLKLPEGELGKEIEGKYNAGEDVQVSVMCAMSEEYAVAIKPCK

Target ORF information:

RefSeq Version	NM_177586.6
Organism	Mus musculus(house mouse)
Definition	Mus musculus eukaryotic translation initiation factor 5A2 (Eif5a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177586.6

ORF Insert Sequence:

ATGGCAGACG AAATTGATTT CACTACTGGA GATGCAGGGG CTTCCAGCAC TTATCCTATG 
CAGTGCTCAG CCCTGCGCAA AAACGGCTTC GTCGTGCTCA AAGGGCGACC ATGCAAAATC 
GTGGAGATGT CAACTTCCAA GACTGGGAAG CATGGTCATG CCAAGGTACA CCTTGTTGGA 
ATTGACATTT TCACTGGCAA AAAATATGAA GACATTTGTC CTTCTACTCA CAACATGGAT 
GTTCCAAATA TTAAGAGAAA CGATTATCAA CTCATATGCA TTCAGGATGG TTACCTTTCC 
CTGCTGACAG AAACTGGCGA AGTCCGTGAA GATCTTAAGC TGCCAGAAGG TGAACTGGGC 
AAAGAAATAG AAGGGAAATA CAATGCAGGT GAAGATGTGC AGGTGTCTGT CATGTGTGCC 
ATGAGTGAAG AATACGCTGT AGCCATAAAG CCCTGCAAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF5A2 ( NM_177586.5 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_808254.1 Mus musculus eukaryotic translation initiation factor 5A2 (Eif5a2), mRNA.

Price & Availability↑

CloneID	OMu06470
Clone ID Related Accession (Same CDS sequence)	NM_177586.6 , NM_177586.5
Accession Version	NM_177586.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	eukaryotic translation initiation factor 5A-2
Comment	PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC122490.3. On Nov 17, 2006 this sequence version replaced NM_177586.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AY205265.1, AK082214.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGACG AAATTGATTT CACTACTGGA GATGCAGGGG CTTCCAGCAC TTATCCTATG 
CAGTGCTCAG CCCTGCGCAA AAACGGCTTC GTCGTGCTCA AAGGGCGACC ATGCAAAATC 
GTGGAGATGT CAACTTCCAA GACTGGGAAG CATGGTCATG CCAAGGTACA CCTTGTTGGA 
ATTGACATTT TCACTGGCAA AAAATATGAA GACATTTGTC CTTCTACTCA CAACATGGAT 
GTTCCAAATA TTAAGAGAAA CGATTATCAA CTCATATGCA TTCAGGATGG TTACCTTTCC 
CTGCTGACAG AAACTGGCGA AGTCCGTGAA GATCTTAAGC TGCCAGAAGG TGAACTGGGC 
AAAGAAATAG AAGGGAAATA CAATGCAGGT GAAGATGTGC AGGTGTCTGT CATGTGTGCC 
ATGAGTGAAG AATACGCTGT AGCCATAAAG CCCTGCAAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808254.1
CDS	140..601
Translation	MADEIDFTTGDAGASSTYPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDYQLICIQDGYLSLLTETGEVREDLKLPEGELGKEIEGKYNAGEDVQVSVMCAMSEEYAVAIKPCK

Target ORF information:

RefSeq Version	NM_177586.5
Organism	Mus musculus(House mouse)
Definition	Mus musculus eukaryotic translation initiation factor 5A2 (Eif5a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177586.5

ORF Insert Sequence:

ATGGCAGACG AAATTGATTT CACTACTGGA GATGCAGGGG CTTCCAGCAC TTATCCTATG 
CAGTGCTCAG CCCTGCGCAA AAACGGCTTC GTCGTGCTCA AAGGGCGACC ATGCAAAATC 
GTGGAGATGT CAACTTCCAA GACTGGGAAG CATGGTCATG CCAAGGTACA CCTTGTTGGA 
ATTGACATTT TCACTGGCAA AAAATATGAA GACATTTGTC CTTCTACTCA CAACATGGAT 
GTTCCAAATA TTAAGAGAAA CGATTATCAA CTCATATGCA TTCAGGATGG TTACCTTTCC 
CTGCTGACAG AAACTGGCGA AGTCCGTGAA GATCTTAAGC TGCCAGAAGG TGAACTGGGC 
AAAGAAATAG AAGGGAAATA CAATGCAGGT GAAGATGTGC AGGTGTCTGT CATGTGTGCC 
ATGAGTGAAG AATACGCTGT AGCCATAAAG CCCTGCAAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF5A2 ( XM_017319514.1 ) cDNA ORF clone, Mus musculus(House mouse) -> XP_017175003.1 Mus musculus eukaryotic translation initiation factor 5A2 (Eif5a2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu80580
Clone ID Related Accession (Same CDS sequence)	XM_017319514.1
Accession Version	XM_017319514.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	eukaryotic translation initiation factor 5A-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGACG AAATTGATTT CACTACTGGA GATGCAGGGG CTTCCAGCAC TTATCCTATG 
CAGTGCTCAG CCCTGCGCAA AAACGGCTTC GTCGTGCTCA AAGGGCGACC ATGCAAAATC 
GTGGAGATGT CAACTTCCAA GACTGGGAAG CATGGTCATG CCAAGGTACA CCTTGTTGGA 
ATTGACATTT TCACTGGCAA AAAATATGAA GACATTTGTC CTTCTACTCA CAACATGGAT 
GTTCCAAATA TTAAGAGAAA CGATTATCAA CTCATATGCA TTCAGGATGG TTACCTTTCC 
CTGCTGACAG AAACTGGCGA AGTCCGTGAA GATCTTAAGC TGCCAGAAGG TGAACTGGGC 
AAAGAAATAG AAGGGAAATA CAATGCAGGT GAAGATGTGC AGGTAAGGCT CATAGTAGGC 
TGTGTATGTG TGTGTGTGTG TGTGTGTGTG TGTGTGTGTG TGCGCGTGTG TGTGAACTAT 
TGCATAAACC TTGGCCCTGA ACCCGTTAGC ATGAAAGACT GTGCGCAGAC TTCAGCGTCC 
CAGTGCCCGC TACTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017175003.1
CDS	178..735
Translation	MADEIDFTTGDAGASSTYPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDYQLICIQDGYLSLLTETGEVREDLKLPEGELGKEIEGKYNAGEDVQVRLIVGCVCVCVCVCVCVCVRVCVNYCINLGPEPVSMKDCAQTSASQCPLL

Target ORF information:

RefSeq Version	XM_017319514.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus eukaryotic translation initiation factor 5A2 (Eif5a2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017319514.1

ORF Insert Sequence:

ATGGCAGACG AAATTGATTT CACTACTGGA GATGCAGGGG CTTCCAGCAC TTATCCTATG 
CAGTGCTCAG CCCTGCGCAA AAACGGCTTC GTCGTGCTCA AAGGGCGACC ATGCAAAATC 
GTGGAGATGT CAACTTCCAA GACTGGGAAG CATGGTCATG CCAAGGTACA CCTTGTTGGA 
ATTGACATTT TCACTGGCAA AAAATATGAA GACATTTGTC CTTCTACTCA CAACATGGAT 
GTTCCAAATA TTAAGAGAAA CGATTATCAA CTCATATGCA TTCAGGATGG TTACCTTTCC 
CTGCTGACAG AAACTGGCGA AGTCCGTGAA GATCTTAAGC TGCCAGAAGG TGAACTGGGC 
AAAGAAATAG AAGGGAAATA CAATGCAGGT GAAGATGTGC AGGTAAGGCT CATAGTAGGC 
TGTGTATGTG TGTGTGTGTG TGTGTGTGTG TGTGTGTGTG TGCGCGTGTG TGTGAACTAT 
TGCATAAACC TTGGCCCTGA ACCCGTTAGC ATGAAAGACT GTGCGCAGAC TTCAGCGTCC 
CAGTGCCCGC TACTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF5A2 ( XM_017319514.2 ) cDNA ORF clone, Mus musculus(House mouse) -> XP_017175003.2 Mus musculus eukaryotic translation initiation factor 5A2 (Eif5a2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu88189
Clone ID Related Accession (Same CDS sequence)	XM_017319514.2
Accession Version	XM_017319514.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	eukaryotic translation initiation factor 5A-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017319514.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGATGC ATCTCGCCCG GGAACACTGC GAAGCTTCAA ACAGTCGACT GCAGGCAGCT 
CTGCACGCCG GAAGTGCACT AATCCGCAGC ACGTGGGGTT GCCAGGGCGA GCTTCACGTG 
ACGGGGCGGG ACCTCGGGAA GCTTCGAGCC AATGGGCGAC CTGGAGGCGG GGCCTGTGGC 
GCGCCGGGGC CTATCCCGGA AGTGTGGTCG CGGCGGGGCG GGCCCGGGCT GGGCGGGCCG 
GGGCGGGGAG CCGGGTGTGG GAAGCGTGGC GGCCCCGCCC CGTCTCCTGG ACCAGCCGCG 
GCCGCCAGCG CCGCCGCAGC CGCAGGGACC GGCGGACGCA GCAAAGGCGT GCGGTGCGGG 
GCCGGAAGTT CCCTCAGAAA AACCGCACAT CTCCCCAGTC CACCATGGCA GACGAAATTG 
ATTTCACTAC TGGAGATGCA GGGGCTTCCA GCACTTATCC TATGCAGTGC TCAGCCCTGC 
GCAAAAACGG CTTCGTCGTG CTCAAAGGGC GACCATGCAA AATCGTGGAG ATGTCAACTT 
CCAAGACTGG GAAGCATGGT CATGCCAAGG TACACCTTGT TGGAATTGAC ATTTTCACTG 
GCAAAAAATA TGAAGACATT TGTCCTTCTA CTCACAACAT GGATGTTCCA AATATTAAGA 
GAAACGATTA TCAACTCATA TGCATTCAGG ATGGTTACCT TTCCCTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017175003.2
CDS	15..725
Translation	MRMHLAREHCEASNSRLQAALHAGSALIRSTWGCQGELHVTGRDLGKLRANGRPGGGACGAPGPIPEVWSRRGGPGLGGPGRGAGCGKRGGPAPSPGPAAAASAAAAAGTGGRSKGVRCGAGSSLRKTAHLPSPPWQTKLISLLEMQGLPALILCSAQPCAKTASSCSKGDHAKSWRCQLPRLGSMVMPRYTLLELTFSLAKNMKTFVLLLTTWMFQILRETIINSYAFRMVTFPC

Target ORF information:

RefSeq Version	XM_017319514.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus eukaryotic translation initiation factor 5A2 (Eif5a2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017319514.2

ORF Insert Sequence:

ATGAGGATGC ATCTCGCCCG GGAACACTGC GAAGCTTCAA ACAGTCGACT GCAGGCAGCT 
CTGCACGCCG GAAGTGCACT AATCCGCAGC ACGTGGGGTT GCCAGGGCGA GCTTCACGTG 
ACGGGGCGGG ACCTCGGGAA GCTTCGAGCC AATGGGCGAC CTGGAGGCGG GGCCTGTGGC 
GCGCCGGGGC CTATCCCGGA AGTGTGGTCG CGGCGGGGCG GGCCCGGGCT GGGCGGGCCG 
GGGCGGGGAG CCGGGTGTGG GAAGCGTGGC GGCCCCGCCC CGTCTCCTGG ACCAGCCGCG 
GCCGCCAGCG CCGCCGCAGC CGCAGGGACC GGCGGACGCA GCAAAGGCGT GCGGTGCGGG 
GCCGGAAGTT CCCTCAGAAA AACCGCACAT CTCCCCAGTC CACCATGGCA GACGAAATTG 
ATTTCACTAC TGGAGATGCA GGGGCTTCCA GCACTTATCC TATGCAGTGC TCAGCCCTGC 
GCAAAAACGG CTTCGTCGTG CTCAAAGGGC GACCATGCAA AATCGTGGAG ATGTCAACTT 
CCAAGACTGG GAAGCATGGT CATGCCAAGG TACACCTTGT TGGAATTGAC ATTTTCACTG 
GCAAAAAATA TGAAGACATT TGTCCTTCTA CTCACAACAT GGATGTTCCA AATATTAAGA 
GAAACGATTA TCAACTCATA TGCATTCAGG ATGGTTACCT TTCCCTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Biological Relevance and Therapeutic Potential of the Hypusine Modification System.
The Journal of biological chemistry290(30)18343-60(2015 Jul)
P?llmann N,Braig M,Sievert H,Preukschas M,Hermans-Borgmeyer I,Schweizer M,Nagel CH,Neumann M,Wild P,Haralambieva E,Hagel C,Bokemeyer C,Hauber J,Balabanov S

Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability.
BMC cancer11199(2011 May)
Chen M,Huang JD,Deng HK,Dong S,Deng W,Tsang SL,Huen MS,Chen L,Zan T,Zhu GX,Guan XY

A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
PLoS biology9(1)e1000582(2011 Jan)
Diez-Roux G,Banfi S,Sultan M,Geffers L,Anand S,Rozado D,Magen A,Canidio E,Pagani M,Peluso I,Lin-Marq N,Koch M,Bilio M,Cantiello I,Verde R,De Masi C,Bianchi SA,Cicchini J,Perroud E,Mehmeti S,Dagand E,Schrinner S,N?rnberger A,Schmidt K,Metz K,Zwingmann C,Brieske N,Springer C,Hernandez AM,Herzog S,Grabbe F,Sieverding C,Fischer B,Schrader K,Brockmeyer M,Dettmer S,Helbig C,Alunni V,Battaini MA,Mura C,Henrichsen CN,Garcia-Lopez R,Echevarria D,Puelles E,Garcia-Calero E,Kruse S,Uhr M,Kauck C,Feng G,Milyaev N,Ong CK,Kumar L,Lam M,Semple CA,Gyenesei A,Mundlos S,Radelof U,Lehrach H,Sarmientos P,Reymond A,Davidson DR,Doll? P,Antonarakis SE,Yaspo ML,Martinez S,Baldock RA,Eichele G,Ballabio A

Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media.
PLoS genetics2(10)e149(2006 Oct)
Parkinson N,Hardisty-Hughes RE,Tateossian H,Tsai HT,Brooker D,Morse S,Lalane Z,MacKenzie F,Fray M,Glenister P,Woodward AM,Polley S,Barbaric I,Dear N,Hough TA,Hunter AJ,Cheeseman MT,Brown SD

Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression.
Genomics71(1)101-9(2001 Jan)
Jenkins ZA,H??g PG,Johansson HE

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EIF5A2 cDNA ORF clone, Mus musculus(House mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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