Sult2a1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sult2a1
Entrez Gene ID	20859
Full Name	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
Synonyms	ST2A1,Std,Sth1,mSTa1
General protein information	Preferred Names sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 Names bile salt sulfotransferase 1 ST hydroxysteroid sulfotransferase sulfotransferase 2A1 sulfotransferase, DHEA preferring sulfotransferase, hydroxysteroid preferring 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 A1\|7 8.02 cM
Summary	This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001111296.2	NP_001104766.1	bile salt sulfotransferase 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Sult2a6	NP_001074794.1
	SULT2A1	XP_001113439.1
Mus musculus (house mouse)	Sult2a5	NP_001171909.1
Homo sapiens (human)	SULT2A1	NP_003158.2
Bos taurus (cattle)	LOC514658	XP_005219518.1
Rattus norvegicus (Norway rat)	Sult2a1	NP_571978.1
Pan troglodytes (chimpanzee)	SULT2A1	XP_513004.4
Mus musculus (house mouse)	Sult2a3	NP_001095056.2
Rattus norvegicus (Norway rat)	Sult2a2	NP_001020302.1
Bos taurus (cattle)	SULT2A1	NP_001039818.1
Mus musculus (house mouse)	Sult2a1	NP_001104766.1
Mus musculus (house mouse)	Sult2a4	NP_001095004.1
Rattus norvegicus (Norway rat)	Sult2a6	NP_036827.3
Xenopus tropicalis (tropical clawed frog)	sult2a1	NP_001120025.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of murine hepatic hydroxysteroid sulfotransferase expression in hyposulfatemic mice and in a cell model of 3'-phosphoadenosine-5'-phosphosulfate deficiency.
Barrett KG, Fang H, Gargano MD, Markovich D, Kocarek TA, Runge-Morris M
Drug metabolism and disposition: the biological fate of chemicals41(8)1505-13(2013 Aug)

Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases.
Senggunprai L, Yoshinari K, Yamazoe Y
The Biochemical journal422(3)455-62(2009 Aug)

Age- and sex-dependent expression of multiple murine hepatic hydroxysteroid sulfotransferase (SULT2A) genes.
Kocarek TA, Duanmu Z, Fang HL, Runge-Morris M
Biochemical pharmacology76(8)1036-46(2008 Oct)

Conservation of the hydroxysteroid sulfotransferase SULT2B1 gene structure in the mouse: pre- and postnatal expression, kinetic analysis of isoforms, and comparison with prototypical SULT2A1.
Shimizu C, Fuda H, Yanai H, Strott CA
Endocrinology144(4)1186-93(2003 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

hyposulfatemia leads to hepatic phosphoadenosine-5'-phosphosulfate depletion, which causes loss of SULT2A1 activity and results in accumulation of nonsulfated bile acids and activated farnesoid X receptor activation.
Title: Regulation of murine hepatic hydroxysteroid sulfotransferase expression in hyposulfatemic mice and in a cell model of 3'-phosphoadenosine-5'-phosphosulfate deficiency.

Sult2A1 converts bile acids, steroids and a number of drugs to the corresponding sulfated metabolites in the livers of 4-month- and 20-month-old mice.
Title: Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: the role of a gene enhancer in the liver chromatin.

decreased levels or activities of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor during the acute-phase response could contribute to decreases in Sult2A1, resulting in decreased sulfation of DHEA
Title: Suppression of DHEA sulfotransferase (Sult2A1) during the acute-phase response.

Increased Sult2A1 expression appears to be an adaptive response to ensure optimal metabolism of Sult2A1 substrates at old age.
Title: Gene regulation for the senescence marker protein DHEA-sulfotransferase by the xenobiotic-activated nuclear pregnane X receptor (PXR).

and Sult2a1 participate in an integrated pathway mediating elimination of sulfated steroid and bile acid metabolites from the liver
Title: Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice.

The following Sult2a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sult2a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03479	NM_001111296.2 Latest version!	Mus musculus sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (Sult2a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sult2a1 ( NM_001111296.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001104766.1 Mus musculus sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (Sult2a1), mRNA.

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CloneID	OMu03479
Clone ID Related Accession (Same CDS sequence)	NM_001111296.2
Accession Version	NM_001111296.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-11
Organism	Mus musculus(house mouse)
Product	bile salt sulfotransferase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC157361.8. On May 27, 2010 this sequence version replaced NM_001111296.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC145167.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END##

ATGATGTCAG ACTATAATTG GTTTGAAGGC ATACCTTTTC CTGCCATATC ATATCAAAGA 
GAAATTTTGG AAGATATTCG TAATAAGTTT GTGGTGAAAG AAGAAGACTT GTTGATATTA 
ACTTACCCCA AGTCAGGAAC GAACTGGCTG ATTGAGATTG TATGCTTGAT TCAGACCAAG 
GGAGATCCGA AGTGGATCCA AACTGTGCCC ATTTGGAACC GCTCACCCTG GATAGAGACT 
GATATAGGAT ATTCTGCATT AATCAATAAG GAAGGACCAC GACTCATAAC CTCCCATCTT 
CCCATCCATC TCTTCTCCAA GTCTTTCTTC AGTTCCAAGG CCAAGGCGAT CTATCTCGTG 
AGAAATCCCA GAGATATTCT TGTGTCTGGT TACTTTTTCT GGGGTAACAC AAACCTTGTG 
AAGAATCCAG GGTCACTCGG AACTTATTTT GAATGGTTCC TCAAAGGAAA TGTTCTATTC 
GGATCATGGT TTGAGCATGT TCGTGGCTGG CTGTCCATGA GAGAATGGGA CAACTTTTTG 
GTACTGTACT ATGAAGACAT AAAAAAGGAT ACAAAGGGAA CCATAAAGAA GATCTGTGAC 
TTCCTAGGGA AAAATTTAGG GCCAGATGAG CTGGATCTCG TCCTCAAGTA CAGCTCTTTC 
CAAGCCATGA AAGAAAACAA CATGTCCAAT TTTAGTCTCA TTAAGGAAGA TCAGGTTACT 
AATGGCTTGA AGCTCATGAG AAAAGGCACA ATTGGGGACT GGAAGAATCA CTTCACAGTA 
GCCCAAGCTG AAGCCTTCGA TAAAGTTTTC CAGGAGAAAA TGGCTGGATT CCCCCCAGGG 
ATTTTCCCAT GGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001104766.1
CDS	55..912
Translation	MMSDYNWFEGIPFPAISYQREILEDIRNKFVVKEEDLLILTYPKSGTNWLIEIVCLIQTKGDPKWIQTVPIWNRSPWIETDIGYSALINKEGPRLITSHLPIHLFSKSFFSSKAKAIYLVRNPRDILVSGYFFWGNTNLVKNPGSLGTYFEWFLKGNVLFGSWFEHVRGWLSMREWDNFLVLYYEDIKKDTKGTIKKICDFLGKNLGPDELDLVLKYSSFQAMKENNMSNFSLIKEDQVTNGLKLMRKGTIGDWKNHFTVAQAEAFDKVFQEKMAGFPPGIFPWE

Target ORF information:

RefSeq Version	NM_001111296.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (Sult2a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001111296.2

ORF Insert Sequence:

ATGATGTCAG ACTATAATTG GTTTGAAGGC ATACCTTTTC CTGCCATATC ATATCAAAGA 
GAAATTTTGG AAGATATTCG TAATAAGTTT GTGGTGAAAG AAGAAGACTT GTTGATATTA 
ACTTACCCCA AGTCAGGAAC GAACTGGCTG ATTGAGATTG TATGCTTGAT TCAGACCAAG 
GGAGATCCGA AGTGGATCCA AACTGTGCCC ATTTGGAACC GCTCACCCTG GATAGAGACT 
GATATAGGAT ATTCTGCATT AATCAATAAG GAAGGACCAC GACTCATAAC CTCCCATCTT 
CCCATCCATC TCTTCTCCAA GTCTTTCTTC AGTTCCAAGG CCAAGGCGAT CTATCTCGTG 
AGAAATCCCA GAGATATTCT TGTGTCTGGT TACTTTTTCT GGGGTAACAC AAACCTTGTG 
AAGAATCCAG GGTCACTCGG AACTTATTTT GAATGGTTCC TCAAAGGAAA TGTTCTATTC 
GGATCATGGT TTGAGCATGT TCGTGGCTGG CTGTCCATGA GAGAATGGGA CAACTTTTTG 
GTACTGTACT ATGAAGACAT AAAAAAGGAT ACAAAGGGAA CCATAAAGAA GATCTGTGAC 
TTCCTAGGGA AAAATTTAGG GCCAGATGAG CTGGATCTCG TCCTCAAGTA CAGCTCTTTC 
CAAGCCATGA AAGAAAACAA CATGTCCAAT TTTAGTCTCA TTAAGGAAGA TCAGGTTACT 
AATGGCTTGA AGCTCATGAG AAAAGGCACA ATTGGGGACT GGAAGAATCA CTTCACAGTA 
GCCCAAGCTG AAGCCTTCGA TAAAGTTTTC CAGGAGAAAA TGGCTGGATT CCCCCCAGGG 
ATTTTCCCAT GGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of murine hepatic hydroxysteroid sulfotransferase expression in hyposulfatemic mice and in a cell model of 3'-phosphoadenosine-5'-phosphosulfate deficiency.
Drug metabolism and disposition: the biological fate of chemicals41(8)1505-13(2013 Aug)
Barrett KG,Fang H,Gargano MD,Markovich D,Kocarek TA,Runge-Morris M

Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases.
The Biochemical journal422(3)455-62(2009 Aug)
Senggunprai L,Yoshinari K,Yamazoe Y

Age- and sex-dependent expression of multiple murine hepatic hydroxysteroid sulfotransferase (SULT2A) genes.
Biochemical pharmacology76(8)1036-46(2008 Oct)
Kocarek TA,Duanmu Z,Fang HL,Runge-Morris M

Conservation of the hydroxysteroid sulfotransferase SULT2B1 gene structure in the mouse: pre- and postnatal expression, kinetic analysis of isoforms, and comparison with prototypical SULT2A1.
Endocrinology144(4)1186-93(2003 Apr)
Shimizu C,Fuda H,Yanai H,Strott CA

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Sult2a1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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