Mchr1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mchr1
Entrez Gene ID	207911
Full Name	melanin-concentrating hormone receptor 1
Synonyms	AW049955,Gpr24,Mch1r
General protein information	Preferred Names melanin-concentrating hormone receptor 1 Names melanin-concentrating hormone receptor 1 G protein coupled receptor 24 Gpr24-9 protein coupled receptor MCH receptor 1 MCHR SLC-1 somatostatin receptor-like protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_145132.2	NP_660114.1	melanin-concentrating hormone receptor 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	MCHR1	NP_005288.3
Pan troglodytes (chimpanzee)	MCHR1	NP_001012440.1
Canis lupus familiaris (dog)	MCHR1	NP_001003038.1
Bos taurus (cattle)	MCHR1	NP_001096762.1
Rattus norvegicus (Norway rat)	Mchr1	NP_113946.1
Xenopus tropicalis (tropical clawed frog)	mchr1.2	NP_001072243.1
Danio rerio (zebrafish)	mchr1b	XP_692413.3
Danio rerio (zebrafish)	mchr1a	XP_001343144.1
	MCHR1	NP_001028057.1
Mus musculus (house mouse)	Mchr1	NP_660114.1
Gallus gallus (chicken)	LOC100859572	XP_004946431.1

Gene Ontology
Bibliography

Related articles in PubMed

Melanin concentrating hormone modulates oxytocin-mediated marble burying.
Sanathara NM, Garau C, Alachkar A, Wang L, Wang Z, Nishimori K, Xu X, Civelli O
Neuropharmacology12822-32(2018 Jan)

Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice.
Jang JH, Park JY, Oh JY, Bae SJ, Jang H, Jeon S, Kim J, Park HJ
Scientific reports8(1)707(2018 Jan)

Neurochemical Heterogeneity Among Lateral Hypothalamic Hypocretin/Orexin and Melanin-Concentrating Hormone Neurons Identified Through Single-Cell Gene Expression Analysis.
Mickelsen LE, Kolling FW 4th, Chimileski BR, Fujita A, Norris C, Chen K, Nelson CE, Jackson AC
eNeuro4(5)(2017 Sep-Oct)

Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII.
Feng S, Xing C, Shen T, Qiao Y, Wang R, Chen J, Liao J, Lu Z, Yang X, Abd-Allah SM, Li J, Jing N, Tang K
Scientific reports7(1)5282(2017 Jul)

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
Badgandi HB, Hwang SH, Shimada IS, Loriot E, Mukhopadhyay S
The Journal of cell biology216(3)743-760(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study showed that KO of mchr1 mice had significantly higher levels of both punished and non-punished food maintained responding.
Title: Consequences of constitutive deletion of melanin-concentrating hormone-1 receptors for feeding and foraging behaviors of mice.

MCH1-Rs regulate the rewarding properties of alcohol through interactions with signaling cascades in the nucleus accumbens shell.
Title: The melanin-concentrating hormone-1 receptor modulates alcohol-induced reward and DARPP-32 phosphorylation.

The present work is the first study to systematically compare the effects of MCH signaling on behavioral and metabolic phenotypes.[Meta-analysis]
Title: Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes.

This study demonistrated that lack of MCH receptor provoked a ventricular size increase and beat frequency of ependymal cilia.
Title: Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume.

This study supports the use of the Mchr1-cre mouse for outlining the neuroanatomical distribution and neurochemical phenotype of MCHR1 neurons.
Title: Neurochemical characterization of neurons expressing melanin-concentrating hormone receptor 1 in the mouse hypothalamus.

The following Mchr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mchr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11322	NM_145132.2 Latest version!	Mus musculus melanin-concentrating hormone receptor 1 (Mchr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mchr1 ( NM_145132.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_660114.1 Mus musculus melanin-concentrating hormone receptor 1 (Mchr1), mRNA.

Price & Availability↑

CloneID	OMu11322
Clone ID Related Accession (Same CDS sequence)	NM_145132.2
Accession Version	NM_145132.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	melanin-concentrating hormone receptor 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY279235.1, AK134867.1 and AW049955.1. On Apr 16, 2010 this sequence version replaced NM_145132.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BY276741.1, AK134867.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATCTGC AAGCCTCGTT GCTGTCCACT GGCCCCAATG CCAGCAACAT CTCCGATGGC 
CAGGATAATT TCACATTGGC GGGGCCACCT CCTCGCACAA GGAGTGTCTC CTACATCAAC 
ATCATCATGC CTTCAGTGTT TGGTACCATC TGTCTCCTGG GCATTGTGGG AAACTCCACA 
GTCATTTTTG CCGTGGTGAA GAAATCCAAG CTGCACTGGT GCAGCAACGT CCCTGACATC 
TTCATCATCA ACCTCTCTGT GGTGGATCTG CTTTTCCTGC TGGGCATGCC TTTCATGATC 
CACCAGCTCA TGGGTAATGG TGTCTGGCAC TTTGGGGAAA CCATGTGCAC CCTCATCACA 
GCCATGGACG CCAACAGTCA GTTCACCAGC ACCTACATCC TGACTGCTAT GGCCATTGAC 
CGCTACTTGG CCACCGTCCA TCCCATCTCC TCCACCAAGT TCCGGAAGCC CTCCATGGCC 
ACCCTGGTGA TCTGCCTCCT GTGGGCTCTC TCGTTCATTA GCATCACTCC TGTGTGGCTC 
TATGCCAGGC TTATCCCCTT CCCAGGGGGT GCTGTGGGCT GTGGCATCCG CCTACCAAAC 
CCAGATACTG ATCTTTACTG GTTCACTCTG TATCAGTTTT TCCTGGCCTT CGCCCTTCCG 
TTTGTGGTCA TCACTGCTGC GTACGTGAAA ATACTACAGC GCATGACGTC TTCGGTGGCC 
CCAGCCTCTC AACGCAGCAT CCGGCTTCGG ACAAAGAGGG TGACCCGCAC AGCCATTGCC 
ATCTGTCTGG TCTTCTTTGT GTGCTGGGCG CCCTACTACG TGCTGCAGCT GACCCAGTTG 
TCCATCAGCC GCCCGACCCT CACATTCGTC TACCTGTACA ATGCGGCTAT CAGCTTGGGC 
TATGCCAACA GCTGCCTCAA TCCCTTTGTG TACATAGTAC TCTGTGAGAC CTTTCGAAAA 
CGCTTGGTGC TGTCGGTGAA GCCCGCGGCC CAGGGGCAGC TTCGCACGGT CAGCAATGCT 
CAGACAGCTG ACGAGGAGAG GACAGAAAGC AAAGGCACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_660114.1
CDS	276..1337
Translation	MDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT

Target ORF information:

RefSeq Version	NM_145132.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus melanin-concentrating hormone receptor 1 (Mchr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145132.2

ORF Insert Sequence:

ATGGATCTGC AAGCCTCGTT GCTGTCCACT GGCCCCAATG CCAGCAACAT CTCCGATGGC 
CAGGATAATT TCACATTGGC GGGGCCACCT CCTCGCACAA GGAGTGTCTC CTACATCAAC 
ATCATCATGC CTTCAGTGTT TGGTACCATC TGTCTCCTGG GCATTGTGGG AAACTCCACA 
GTCATTTTTG CCGTGGTGAA GAAATCCAAG CTGCACTGGT GCAGCAACGT CCCTGACATC 
TTCATCATCA ACCTCTCTGT GGTGGATCTG CTTTTCCTGC TGGGCATGCC TTTCATGATC 
CACCAGCTCA TGGGTAATGG TGTCTGGCAC TTTGGGGAAA CCATGTGCAC CCTCATCACA 
GCCATGGACG CCAACAGTCA GTTCACCAGC ACCTACATCC TGACTGCTAT GGCCATTGAC 
CGCTACTTGG CCACCGTCCA TCCCATCTCC TCCACCAAGT TCCGGAAGCC CTCCATGGCC 
ACCCTGGTGA TCTGCCTCCT GTGGGCTCTC TCGTTCATTA GCATCACTCC TGTGTGGCTC 
TATGCCAGGC TTATCCCCTT CCCAGGGGGT GCTGTGGGCT GTGGCATCCG CCTACCAAAC 
CCAGATACTG ATCTTTACTG GTTCACTCTG TATCAGTTTT TCCTGGCCTT CGCCCTTCCG 
TTTGTGGTCA TCACTGCTGC GTACGTGAAA ATACTACAGC GCATGACGTC TTCGGTGGCC 
CCAGCCTCTC AACGCAGCAT CCGGCTTCGG ACAAAGAGGG TGACCCGCAC AGCCATTGCC 
ATCTGTCTGG TCTTCTTTGT GTGCTGGGCG CCCTACTACG TGCTGCAGCT GACCCAGTTG 
TCCATCAGCC GCCCGACCCT CACATTCGTC TACCTGTACA ATGCGGCTAT CAGCTTGGGC 
TATGCCAACA GCTGCCTCAA TCCCTTTGTG TACATAGTAC TCTGTGAGAC CTTTCGAAAA 
CGCTTGGTGC TGTCGGTGAA GCCCGCGGCC CAGGGGCAGC TTCGCACGGT CAGCAATGCT 
CAGACAGCTG ACGAGGAGAG GACAGAAAGC AAAGGCACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Melanin concentrating hormone modulates oxytocin-mediated marble burying.
Neuropharmacology12822-32(2018 Jan)
Sanathara NM,Garau C,Alachkar A,Wang L,Wang Z,Nishimori K,Xu X,Civelli O

Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice.
Scientific reports8(1)707(2018 Jan)
Jang JH,Park JY,Oh JY,Bae SJ,Jang H,Jeon S,Kim J,Park HJ

Neurochemical Heterogeneity Among Lateral Hypothalamic Hypocretin/Orexin and Melanin-Concentrating Hormone Neurons Identified Through Single-Cell Gene Expression Analysis.
eNeuro4(5)(2017 Sep-Oct)
Mickelsen LE,Kolling FW 4th,Chimileski BR,Fujita A,Norris C,Chen K,Nelson CE,Jackson AC

Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII.
Scientific reports7(1)5282(2017 Jul)
Feng S,Xing C,Shen T,Qiao Y,Wang R,Chen J,Liao J,Lu Z,Yang X,Abd-Allah SM,Li J,Jing N,Tang K

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
The Journal of cell biology216(3)743-760(2017 Mar)
Badgandi HB,Hwang SH,Shimada IS,Loriot E,Mukhopadhyay S

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Mchr1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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