Sprr3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sprr3
Entrez Gene ID	20766
Full Name	small proline-rich protein 3
Synonyms	SPR3
General protein information	Preferred Names small proline-rich protein 3 Names small proline-rich protein 3 cornifin beta
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 F1\|3 40.14 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001204427.1	NP_001191356.1	small proline-rich protein 3
NM_011478.2	NP_035608.1	small proline-rich protein 3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Sprr3	NP_001101156.1
Mus musculus (house mouse)	Sprr3	NP_035608.1
Homo sapiens (human)	SPRR3	NP_005407.1
Canis lupus familiaris (dog)	LOC100685649	XP_005630895.1
Pan troglodytes (chimpanzee)	SPRR3	XP_003949601.1
	LOC713857	XP_001109921.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of small proline-rich repeat protein 3 as a novel atheroprotective factor that promotes adaptive Akt signaling in vascular smooth muscle cells.
Segedy AK, Pyle AL, Li B, Zhang Y, Babaev VR, Jat P, Fazio S, Atkinson JB, Linton MF, Young PP
Arteriosclerosis, thrombosis, and vascular biology34(12)2527-36(2014 Dec)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction.
Pyle AL, Atkinson JB, Pozzi A, Reese J, Eckes B, Davidson JM, Crimmins DL, Young PP
The American journal of pathology173(5)1577-88(2008 Nov)

Exogenous expression of Esophagin/SPRR3 attenuates the tumorigenicity of esophageal squamous cell carcinoma cells via promoting apoptosis.
Zhang Y, Feng YB, Shen XM, Chen BS, Du XL, Luo ML, Cai Y, Han YL, Xu X, Zhan QM, Wang MR
International journal of cancer122(2)260-6(2008 Jan)

Long-range comparison of human and mouse Sprr loci to identify conserved noncoding sequences involved in coordinate regulation.
Martin N, Patel S, Segre JA
Genome research14(12)2430-8(2004 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SPRR3 protects an atheroma lesion from vascular smooth muscle cell (VSMC) loss by promoting survival signaling in plaque VSMCs, thereby significantly decreasing atherosclerosis progression.
Title: Identification of small proline-rich repeat protein 3 as a novel atheroprotective factor that promotes adaptive Akt signaling in vascular smooth muscle cells.

These data suggest that SPRR3 may play a role in vascular smooth muscle cells adaptation to local biomechanical stress within the plaque microenvironment.
Title: Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction.

Esophagin/SPRR3 may play a role in the maintenance of normal esophageal epithelial homeostasis, and aberrant expression of Esophagin/SPRR3 may contribute to the tumorigenesis of esophageal squamous cell carcinoma
Title: Exogenous expression of Esophagin/SPRR3 attenuates the tumorigenicity of esophageal squamous cell carcinoma cells via promoting apoptosis.

The following Sprr3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sprr3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02595	NM_001204427.1 Latest version!	Mus musculus small proline-rich protein 3 (Sprr3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OMu02595	NM_011478.2 Latest version!	Mus musculus small proline-rich protein 3 (Sprr3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sprr3 ( NM_001204427.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001191356.1 Mus musculus small proline-rich protein 3 (Sprr3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu02595
Clone ID Related Accession (Same CDS sequence)	NM_001204427.1 , NM_011478.2
Accession Version	NM_001204427.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Mus musculus(house mouse)
Product	small proline-rich protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC127036.3. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB590101.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

ATGAGTTCTT ACCAGCAAAA GCAGCCCTTT GTCCCACCTC CTCAGCCTGA ACAGCATCAA 
GTGAAGCAAC CTTGTCAGCC TCCACCACAA GGAAAATTTG TTCCCATAGC CACCTCTGAG 
CCATGCCACA CAGATGTTCC ACAACCAGGA AACACCAAGA TTCCAGAACC ATGCAGCACC 
AAAGTGCCTG AGCCAGGGAA CACTGTTGTT CTTGAGCCAG ATTATACTAC GATGCCTGGG 
CCATGTTCTA CAAACATCAC TGAGCCAGAT TATACCACAA TTCCTGGGCC ATGCTCTACC 
AACATCACAG AGCCAGATTA TACTACAATT CCTGGGCCAT GCTCTACCAA CATCCCTGGG 
CCAGATCGTA CCGTGGTTCC TGGATCATGC TCTACCAACA TCACAGAGCC AGATTATACC 
ACAATTCCTG GGCCATCCTC TACCAAAATC CCTGACCCAG GCTGTGCCAT GGTTCCTGGG 
CCCAGTCCTT CCAGTACTTC TGAGCCAAGC TCAGAACCAT GCTCTATCAA TGTTCGTGAA 
CCTGGCTACA TGAATGCCTC AGAGCCCACC CATGCCAAGG TTCCTGATCA GGGCTACACC 
AAGATACCTG ACCAGGGATC CTCTAAGGTA CCAGAGCCAT GCCAGTCCAG GGTTCCTGAG 
GTGTGCCCCC CAACTGTCAC CCCTGTATCA GCTAAGCAGA AGACCAAGCA GAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001191356.1
CDS	53..769
Translation	MSSYQQKQPFVPPPQPEQHQVKQPCQPPPQGKFVPIATSEPCHTDVPQPGNTKIPEPCSTKVPEPGNTVVLEPDYTTMPGPCSTNITEPDYTTIPGPCSTNITEPDYTTIPGPCSTNIPGPDRTVVPGSCSTNITEPDYTTIPGPSSTKIPDPGCAMVPGPSPSSTSEPSSEPCSINVREPGYMNASEPTHAKVPDQGYTKIPDQGSSKVPEPCQSRVPEVCPPTVTPVSAKQKTKQK

Target ORF information:

RefSeq Version	NM_001204427.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus small proline-rich protein 3 (Sprr3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001204427.1

ORF Insert Sequence:

ATGAGTTCTT ACCAGCAAAA GCAGCCCTTT GTCCCACCTC CTCAGCCTGA ACAGCATCAA 
GTGAAGCAAC CTTGTCAGCC TCCACCACAA GGAAAATTTG TTCCCATAGC CACCTCTGAG 
CCATGCCACA CAGATGTTCC ACAACCAGGA AACACCAAGA TTCCAGAACC ATGCAGCACC 
AAAGTGCCTG AGCCAGGGAA CACTGTTGTT CTTGAGCCAG ATTATACTAC GATGCCTGGG 
CCATGTTCTA CAAACATCAC TGAGCCAGAT TATACCACAA TTCCTGGGCC ATGCTCTACC 
AACATCACAG AGCCAGATTA TACTACAATT CCTGGGCCAT GCTCTACCAA CATCCCTGGG 
CCAGATCGTA CCGTGGTTCC TGGATCATGC TCTACCAACA TCACAGAGCC AGATTATACC 
ACAATTCCTG GGCCATCCTC TACCAAAATC CCTGACCCAG GCTGTGCCAT GGTTCCTGGG 
CCCAGTCCTT CCAGTACTTC TGAGCCAAGC TCAGAACCAT GCTCTATCAA TGTTCGTGAA 
CCTGGCTACA TGAATGCCTC AGAGCCCACC CATGCCAAGG TTCCTGATCA GGGCTACACC 
AAGATACCTG ACCAGGGATC CTCTAAGGTA CCAGAGCCAT GCCAGTCCAG GGTTCCTGAG 
GTGTGCCCCC CAACTGTCAC CCCTGTATCA GCTAAGCAGA AGACCAAGCA GAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sprr3 ( NM_011478.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035608.1 Mus musculus small proline-rich protein 3 (Sprr3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu02595
Clone ID Related Accession (Same CDS sequence)	NM_001204427.1 , NM_011478.2
Accession Version	NM_011478.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Mus musculus(house mouse)
Product	small proline-rich protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY709657.1, BC125629.1 and EH099911.1. On Mar 3, 2011 this sequence version replaced NM_011478.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BY709657.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849387 [ECO:0000348] ##Evidence-Data-END##

ATGAGTTCTT ACCAGCAAAA GCAGCCCTTT GTCCCACCTC CTCAGCCTGA ACAGCATCAA 
GTGAAGCAAC CTTGTCAGCC TCCACCACAA GGAAAATTTG TTCCCATAGC CACCTCTGAG 
CCATGCCACA CAGATGTTCC ACAACCAGGA AACACCAAGA TTCCAGAACC ATGCAGCACC 
AAAGTGCCTG AGCCAGGGAA CACTGTTGTT CTTGAGCCAG ATTATACTAC GATGCCTGGG 
CCATGTTCTA CAAACATCAC TGAGCCAGAT TATACCACAA TTCCTGGGCC ATGCTCTACC 
AACATCACAG AGCCAGATTA TACTACAATT CCTGGGCCAT GCTCTACCAA CATCCCTGGG 
CCAGATCGTA CCGTGGTTCC TGGATCATGC TCTACCAACA TCACAGAGCC AGATTATACC 
ACAATTCCTG GGCCATCCTC TACCAAAATC CCTGACCCAG GCTGTGCCAT GGTTCCTGGG 
CCCAGTCCTT CCAGTACTTC TGAGCCAAGC TCAGAACCAT GCTCTATCAA TGTTCGTGAA 
CCTGGCTACA TGAATGCCTC AGAGCCCACC CATGCCAAGG TTCCTGATCA GGGCTACACC 
AAGATACCTG ACCAGGGATC CTCTAAGGTA CCAGAGCCAT GCCAGTCCAG GGTTCCTGAG 
GTGTGCCCCC CAACTGTCAC CCCTGTATCA GCTAAGCAGA AGACCAAGCA GAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035608.1
CDS	189..905
Translation	MSSYQQKQPFVPPPQPEQHQVKQPCQPPPQGKFVPIATSEPCHTDVPQPGNTKIPEPCSTKVPEPGNTVVLEPDYTTMPGPCSTNITEPDYTTIPGPCSTNITEPDYTTIPGPCSTNIPGPDRTVVPGSCSTNITEPDYTTIPGPSSTKIPDPGCAMVPGPSPSSTSEPSSEPCSINVREPGYMNASEPTHAKVPDQGYTKIPDQGSSKVPEPCQSRVPEVCPPTVTPVSAKQKTKQK

Target ORF information:

RefSeq Version	NM_011478.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus small proline-rich protein 3 (Sprr3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011478.2

ORF Insert Sequence:

ATGAGTTCTT ACCAGCAAAA GCAGCCCTTT GTCCCACCTC CTCAGCCTGA ACAGCATCAA 
GTGAAGCAAC CTTGTCAGCC TCCACCACAA GGAAAATTTG TTCCCATAGC CACCTCTGAG 
CCATGCCACA CAGATGTTCC ACAACCAGGA AACACCAAGA TTCCAGAACC ATGCAGCACC 
AAAGTGCCTG AGCCAGGGAA CACTGTTGTT CTTGAGCCAG ATTATACTAC GATGCCTGGG 
CCATGTTCTA CAAACATCAC TGAGCCAGAT TATACCACAA TTCCTGGGCC ATGCTCTACC 
AACATCACAG AGCCAGATTA TACTACAATT CCTGGGCCAT GCTCTACCAA CATCCCTGGG 
CCAGATCGTA CCGTGGTTCC TGGATCATGC TCTACCAACA TCACAGAGCC AGATTATACC 
ACAATTCCTG GGCCATCCTC TACCAAAATC CCTGACCCAG GCTGTGCCAT GGTTCCTGGG 
CCCAGTCCTT CCAGTACTTC TGAGCCAAGC TCAGAACCAT GCTCTATCAA TGTTCGTGAA 
CCTGGCTACA TGAATGCCTC AGAGCCCACC CATGCCAAGG TTCCTGATCA GGGCTACACC 
AAGATACCTG ACCAGGGATC CTCTAAGGTA CCAGAGCCAT GCCAGTCCAG GGTTCCTGAG 
GTGTGCCCCC CAACTGTCAC CCCTGTATCA GCTAAGCAGA AGACCAAGCA GAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of small proline-rich repeat protein 3 as a novel atheroprotective factor that promotes adaptive Akt signaling in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology34(12)2527-36(2014 Dec)
Segedy AK,Pyle AL,Li B,Zhang Y,Babaev VR,Jat P,Fazio S,Atkinson JB,Linton MF,Young PP

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction.
The American journal of pathology173(5)1577-88(2008 Nov)
Pyle AL,Atkinson JB,Pozzi A,Reese J,Eckes B,Davidson JM,Crimmins DL,Young PP

Exogenous expression of Esophagin/SPRR3 attenuates the tumorigenicity of esophageal squamous cell carcinoma cells via promoting apoptosis.
International journal of cancer122(2)260-6(2008 Jan)
Zhang Y,Feng YB,Shen XM,Chen BS,Du XL,Luo ML,Cai Y,Han YL,Xu X,Zhan QM,Wang MR

Long-range comparison of human and mouse Sprr loci to identify conserved noncoding sequences involved in coordinate regulation.
Genome research14(12)2430-8(2004 Dec)
Martin N,Patel S,Segre JA

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Sprr3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報