Serpina3k cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Serpina3k
Entrez Gene ID	20714
Full Name	serine (or cysteine) peptidase inhibitor, clade A, member 3K
Synonyms	1300001I07Rik,D12Rp54,MMCM2,MMSpi2,RP54,Spi-2,Spi2,contrapsin
General protein information	Preferred Names serine (or cysteine) peptidase inhibitor, clade A, member 3K Names serine protease inhibitor A3K alpha-1 antiproteinase serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3K serine (or cysteine) proteinase inhibitor, clade A, member 3K serine protease inhibitor 2 serpin A3K
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12 E\|12 53.99 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011458.2	NP_035588.2	serine protease inhibitor A3K precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SERPINA3-7	NP_001012283.2
Bos taurus (cattle)	LOC784932	XP_002696874.1
Bos taurus (cattle)	SERPINA3	XP_005222351.1
Mus musculus (house mouse)	Serpina3n	NP_033278.2
Homo sapiens (human)	SERPINA3	NP_001076.2
Bos taurus (cattle)	SERPINA3-1	NP_777193.2
Bos taurus (cattle)	SERPINA3-3	NP_001033293.1
Mus musculus (house mouse)	Serpina3c	NP_032484.1
Pan troglodytes (chimpanzee)	SERPINA3	XP_510145.2
Mus musculus (house mouse)	Serpina3k	NP_035588.2
Mus musculus (house mouse)	Serpina3m	NP_033279.2
Rattus norvegicus (Norway rat)	Serpina3n	NP_113719.1
	SERPINA3	XP_001096947.2
Canis lupus familiaris (dog)	SERPINA3	XP_005623829.1
Bos taurus (cattle)	SERPINA3-8	NP_001075181.1

Gene Ontology
Bibliography

Related articles in PubMed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)

The circadian Clock gene regulates acrosin activity of sperm through serine protease inhibitor A3K.
Cheng S, Liang X, Wang Y, Jiang Z, Liu Y, Hou W, Li S, Zhang J, Wang Z
Experimental biology and medicine (Maywood, N.J.)241(2)205-15(2016 Jan)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

Update of the human and mouse SERPIN gene superfamily.
Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V
Human genomics722(2013 Oct)

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.
Lo JC, Jamsai D, O'Connor AE, Borg C, Clark BJ, Whisstock JC, Field MC, Adams V, Ishikawa T, Aitken RJ, Whittle B, Goodnow CC, Ormandy CJ, O'Bryan MK
PLoS genetics8(10)e1002969(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SERPINA3K is involved in the Clock gene-mediated male fertility by regulating acrosin activity and provide the first evidence that SERPINA3K could be regulated by Clock gene via retinoic acid-related orphan receptor response elements.
Title: The circadian Clock gene regulates acrosin activity of sperm through serine protease inhibitor A3K.

structural analysis of the murine orthologue of human antichymotrypsin
Title: The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins.

The following Serpina3k gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpina3k cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08195	NM_011458.2 Latest version!	Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 3K (Serpina3k), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Serpina3k ( NM_011458.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035588.2 Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 3K (Serpina3k), mRNA.

Price & Availability↑

CloneID	OMu08195
Clone ID Related Accession (Same CDS sequence)	NM_011458.2
Accession Version	NM_011458.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Mus musculus(house mouse)
Product	serine protease inhibitor A3K precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK149436.1. On Jun 10, 2007 this sequence version replaced NM_011458.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149436.1, X56786.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTTCA TTGTAGCTAT GGGGATGATT TTAATGGCTG GAATCTGTCC TGCTGTCCTA 
TGCTTCCCAG ATGGCACAAA GGAAATGGAC ATTGTATTCC ATGAACACCA AGACAATGGG 
ACACAAGATG ACAGTCTCAC ATTGGCCTCC GTCAACACTG ACTTTGCCTT CAGTCTGTAC 
AAGAAGCTGG CTTTGAAGAA TCAAGATAAA AATATTGTCT TCTCCCCACT TAGCATCTCA 
GCTGCCTTGG CCCTCGTGTC CCTGGGAGCA AAGGGCAAGA CCATGGAAGA GATTTTAGAA 
GGCCTCAAGT TCAATCTCAC AGAGACCCCT GAAGCAGACA TCCACCAGGG CTTTGGCAAC 
CTCCTACAGA GTCTCAGCCA GCCAGAAGAC CAGGATCAGA TAAACATAGG CAATGCCATG 
TTTATTGAAA AGGACCTGCA GATCCTGGCA GAATTCCATG AGAAGACAAG GGCTCTGTAC 
CAGACTGAGG CCTTCACAGC AGACTTCCAG CAGCCTACTG AGGCCAAAAA CCTCATCAAT 
GACTATGTGA GCAATCAGAC CCAGGGGATG ATCAAGAAAC TGATCTCAGA ACTGGATGAT 
GGGACATTGA TGGTGCTGGT GAATTACATC TACTTTAAAG GCAAATGGAA GATATCCTTT 
GACCCCCAGG ACACATTTGA GTCTGAGTTC TACTTGGATG AGAAGAGATC TGTGAAGGTT 
CCCATGATGA AAATGAAGTT ACTGACTGCA CGCCACTTCC GTGATGAGGA GCTATCGTGC 
TCTGTGTTGG AGCTGAAGTA CACAGGAAAT GCCAGTGCCC TGCTCATCCT CCCTGACCAA 
GGCAGGATGC AGCAGGTGGA AGCCAGCTTA CAACCAGAGA CCCTGAGGAA ATGGAGGAAA 
ACTTTGTTTT CCAGCCAAAT AGAGGAGCTA AACCTGCCCA AGTTCTCCAT CGCTAGTGAC 
TACAGGCTGG AAGAGGATGT CCTTCCAGAA ATGGGGATTA AGGAAGTCTT CACAGAACAA 
GCTGACCTAT CTGGGATCAC AGAAGCCAAG AAACTGAGTG TGTCTCAGGT GGTCCACAAG 
GCTGTGCTGG ATGTGGCTGA GACAGGCACA GAAGCAGCTG CTGCCACAGG GGTTATTGGT 
GGCATTCGTA AGGCCGTATT ACCAGCTGTG TGTTTCAACA GGCCATTCCT GATTGTTATC 
TATCACACAA GTGCTCAGAG TATCCTCTTT ATGGCCAAAG TCAATAACCC CAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035588.2
CDS	78..1334
Translation	MAFIVAMGMILMAGICPAVLCFPDGTKEMDIVFHEHQDNGTQDDSLTLASVNTDFAFSLYKKLALKNQDKNIVFSPLSISAALALVSLGAKGKTMEEILEGLKFNLTETPEADIHQGFGNLLQSLSQPEDQDQINIGNAMFIEKDLQILAEFHEKTRALYQTEAFTADFQQPTEAKNLINDYVSNQTQGMIKKLISELDDGTLMVLVNYIYFKGKWKISFDPQDTFESEFYLDEKRSVKVPMMKMKLLTARHFRDEELSCSVLELKYTGNASALLILPDQGRMQQVEASLQPETLRKWRKTLFSSQIEELNLPKFSIASDYRLEEDVLPEMGIKEVFTEQADLSGITEAKKLSVSQVVHKAVLDVAETGTEAAAATGVIGGIRKAVLPAVCFNRPFLIVIYHTSAQSILFMAKVNNPK

Target ORF information:

RefSeq Version	NM_011458.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 3K (Serpina3k), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011458.2

ORF Insert Sequence:

ATGGCCTTCA TTGTAGCTAT GGGGATGATT TTAATGGCTG GAATCTGTCC TGCTGTCCTA 
TGCTTCCCAG ATGGCACAAA GGAAATGGAC ATTGTATTCC ATGAACACCA AGACAATGGG 
ACACAAGATG ACAGTCTCAC ATTGGCCTCC GTCAACACTG ACTTTGCCTT CAGTCTGTAC 
AAGAAGCTGG CTTTGAAGAA TCAAGATAAA AATATTGTCT TCTCCCCACT TAGCATCTCA 
GCTGCCTTGG CCCTCGTGTC CCTGGGAGCA AAGGGCAAGA CCATGGAAGA GATTTTAGAA 
GGCCTCAAGT TCAATCTCAC AGAGACCCCT GAAGCAGACA TCCACCAGGG CTTTGGCAAC 
CTCCTACAGA GTCTCAGCCA GCCAGAAGAC CAGGATCAGA TAAACATAGG CAATGCCATG 
TTTATTGAAA AGGACCTGCA GATCCTGGCA GAATTCCATG AGAAGACAAG GGCTCTGTAC 
CAGACTGAGG CCTTCACAGC AGACTTCCAG CAGCCTACTG AGGCCAAAAA CCTCATCAAT 
GACTATGTGA GCAATCAGAC CCAGGGGATG ATCAAGAAAC TGATCTCAGA ACTGGATGAT 
GGGACATTGA TGGTGCTGGT GAATTACATC TACTTTAAAG GCAAATGGAA GATATCCTTT 
GACCCCCAGG ACACATTTGA GTCTGAGTTC TACTTGGATG AGAAGAGATC TGTGAAGGTT 
CCCATGATGA AAATGAAGTT ACTGACTGCA CGCCACTTCC GTGATGAGGA GCTATCGTGC 
TCTGTGTTGG AGCTGAAGTA CACAGGAAAT GCCAGTGCCC TGCTCATCCT CCCTGACCAA 
GGCAGGATGC AGCAGGTGGA AGCCAGCTTA CAACCAGAGA CCCTGAGGAA ATGGAGGAAA 
ACTTTGTTTT CCAGCCAAAT AGAGGAGCTA AACCTGCCCA AGTTCTCCAT CGCTAGTGAC 
TACAGGCTGG AAGAGGATGT CCTTCCAGAA ATGGGGATTA AGGAAGTCTT CACAGAACAA 
GCTGACCTAT CTGGGATCAC AGAAGCCAAG AAACTGAGTG TGTCTCAGGT GGTCCACAAG 
GCTGTGCTGG ATGTGGCTGA GACAGGCACA GAAGCAGCTG CTGCCACAGG GGTTATTGGT 
GGCATTCGTA AGGCCGTATT ACCAGCTGTG TGTTTCAACA GGCCATTCCT GATTGTTATC 
TATCACACAA GTGCTCAGAG TATCCTCTTT ATGGCCAAAG TCAATAACCC CAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Scientific reports740495(2017 Jan)
Naba A,Clauser KR,Mani DR,Carr SA,Hynes RO

The circadian Clock gene regulates acrosin activity of sperm through serine protease inhibitor A3K.
Experimental biology and medicine (Maywood, N.J.)241(2)205-15(2016 Jan)
Cheng S,Liang X,Wang Y,Jiang Z,Liu Y,Hou W,Li S,Zhang J,Wang Z

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

Update of the human and mouse SERPIN gene superfamily.
Human genomics722(2013 Oct)
Heit C,Jackson BC,McAndrews M,Wright MW,Thompson DC,Silverman GA,Nebert DW,Vasiliou V

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.
PLoS genetics8(10)e1002969(2012)
Lo JC,Jamsai D,O'Connor AE,Borg C,Clark BJ,Whisstock JC,Field MC,Adams V,Ishikawa T,Aitken RJ,Whittle B,Goodnow CC,Ormandy CJ,O'Bryan MK

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Serpina3k cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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