Serpina1a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Serpina1a
Entrez Gene ID	20700
Full Name	serine (or cysteine) peptidase inhibitor, clade A, member 1A
Synonyms	Aat-2,Aat2,Dom1,PI1,Spi1-1,Spi1-3
General protein information	Preferred Names serine (or cysteine) peptidase inhibitor, clade A, member 1A Names alpha-1-antitrypsin 1-1 AAT alpha-1 protease inhibitor 1 alpha-1-antiproteinase alpha-1-antitrypsin 2 serine (or cysteine) proteinase inhibitor, clade A, member 1a serine protease inhibitor 1-1 serine protease inhibitor A1a serpin A1a
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12 E\|12 52.98 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001252569.1	NP_001239498.1	alpha-1-antitrypsin 1-1 isoform 2
NM_009243.4	NP_033269.1	alpha-1-antitrypsin 1-1 isoform 1 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Serpina1	NP_071964.2
Gallus gallus (chicken)	SERPINA4	NP_001264421.1
Gallus gallus (chicken)	SERPINA5	XP_004941954.1
Xenopus tropicalis (tropical clawed frog)	serpina1	XP_002936109.1
Pan troglodytes (chimpanzee)	SERPINA1	XP_522938.2
Mus musculus (house mouse)	Serpina1e	NP_033273.1
Gallus gallus (chicken)	SERPINA1	NP_001264422.1
Danio rerio (zebrafish)	serpina1l	NP_001013277.3
Canis lupus familiaris (dog)	SERPINA1	NP_001073578.1
Mus musculus (house mouse)	Serpina1d	NP_033272.1
Xenopus tropicalis (tropical clawed frog)	serpina3k	XP_002936116.2
Mus musculus (house mouse)	Serpina1c	NP_033271.1
Gallus gallus (chicken)	SERPINA9	XP_004941955.1
Xenopus tropicalis (tropical clawed frog)	LOC100488834	XP_002936115.2
Homo sapiens (human)	SERPINA1	NP_001002236.1
	SERPINA1	XP_001099255.1
Bos taurus (cattle)	SERPINA1	NP_776307.1
Mus musculus (house mouse)	Serpina1a	NP_033269.1
Mus musculus (house mouse)	Serpina1b	NP_033270.3
Danio rerio (zebrafish)	serpina1	NP_001071226.1

Gene Ontology
Bibliography

Related articles in PubMed

Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/?-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy.
Feng L, Zhang J, Zhu N, Ding Q, Zhang X, Yu J, Qiang W, Zhang Z, Ma Y, Huang D, Shen Y, Fang S, Yu Y, Wang H, Shen Y
Autophagy13(4)686-702(2017 Apr)

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)

Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation.
Di Francesco A, Di Germanio C, Panda AC, Huynh P, Peaden R, Navas-Enamorado I, Bastian P, Lehrmann E, Diaz-Ruiz A, Ross D, Siegel D, Martindale JL, Bernier M, Gorospe M, Abdelmohsen K, de Cabo R
Free radical biology & medicine99225-233(2016 10)

Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus.
Elshikha AS, Lu Y, Chen MJ, Akbar M, Zeumer L, Ritter A, Elghamry H, Mahdi MA, Morel L, Song S
PloS one11(5)e0156583(2016)

FBG1 Is the Final Arbitrator of A1AT-Z Degradation.
Wen JH, Wen H, Gibson-Corley KN, Glenn KA
PloS one10(8)e0135591(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study proved that SYVN1 enhances SERPINA1(E342K)/ATZ degradation through SQSTM1-dependent autophagy and attenuates SERPINA1(E342K)/ATZ cytotoxicity.
Title: Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/?-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy.

Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation.
Title: Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation.

hAAT inhibits DC activation and function, and it also attenuates autoimmunity and renal damage in the MRL/lpr lupus model
Title: Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus.

Data indicate that the scFv4B12 intrabody increased the secretion of Z alpha1-antitrypsin that retained inhibitory activity against neutrophil elastase.
Title: A single-chain variable fragment intrabody prevents intracellular polymerization of Z ?1-antitrypsin while allowing its antiproteinase activity.

FBG1 degrades A1AT-Z through a Beclin1-dependent arm of autophagy.
Title: FBG1 Is the Final Arbitrator of A1AT-Z Degradation.

The following Serpina1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpina1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05265	NM_001252569.1 Latest version!	Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 1A (Serpina1a), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu03778	NM_009243.4 Latest version!	Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 1A (Serpina1a), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Serpina1a ( NM_001252569.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001239498.1 Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 1A (Serpina1a), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu05265
Clone ID Related Accession (Same CDS sequence)	NM_001252569.1
Accession Version	NM_001252569.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1311bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	alpha-1-antitrypsin 1-1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC134902.7 and AC098741.2. Transcript Variant: This variant (2) has an additional exon in the 5' region, which includes an upstream in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGTACTGTG CAATCCGTGT TCGGCTCTCC AGATTATTTA CAGTGAAAGG GCAGAAAGCA 
CGGTGGAAAA TGACTCCCTC CATCTCATGG GGTCTACTGC TTCTGGCAGG CCTGTGTTGC 
CTGGTCCCCA GCTTTCTGGC TGAGGATGTT CAGGAGACAG ACACCTCCCA GAAGGATCAG 
TCCCCAGCCT CCCATGAGAT CGCTACAAAC CTGGGAGACT TTGCAATCAG CCTATACCGG 
GAGCTGGTCC ATCAGTCCAA CACTTCCAAC ATCTTCTTCT CCCCAGTGAG CATTGCCACA 
GCCTTTGCTA TGCTCTCCCT AGGGAGCAAG GGTGACACTC ACACGCAGAT CCTAGAGGGC 
CTGCAGTTCA ACCTCACACA AACATCGGAG GCTGACATCC ACAAGTCCTT CCAACACCTC 
CTCCAAACCC TCAACAGACC AGACAGTGAG CTGCAGCTGA GCACAGGCAA TGGCCTCTTT 
GTCAACAATG ACCTGAAGCT GGTGGAGAAG TTTCTGGAAG AGGCCAAGAA CCATTATCAG 
GCAGAAGTCT TCTCTGTCAA CTTTGCAGAG TCAGAGGAGG CCAAGAAAGT GATTAATGAT 
TTTGTGGAGA AGGGAACCCA AGGAAAGATA GCTGAGGCGG TGAAAAAACT GGACCAAGAC 
ACAGTTTTCG CCCTGGCAAA TTACATTCTC TTTAAAGGCA AATGGAAGAA GCCATTCGAT 
CCTGAGAACA CTGAGGAAGC TGAGTTCCAC GTGGACGAGT CCACCACGGT GAAGGTGCCC 
ATGATGACCC TCTCGGGCAT GCTTCATGTG CACCATTGCA GCACGCTGTC CAGCTGGGTG 
CTGCTGATGG ATTATGCAGG CAATGCCACT GCTGTCTTCC TTCTGCCCGA TGATGGGAAG 
ATGCAGCATC TGGAGCAAAC TCTCAGCAAG GAGCTCATCT CTAAGTTCCT GCTAAACAGG 
CGCAGAAGGT TAGCCCAGAT CCACTTCCCC AGACTGTCCA TCTCTGGAGA ATATAACTTG 
AAGACACTCA TGAGTCCACT GGGCATCACC CGGATCTTCA ACAATGGGGC TGACCTCTCC 
GGAATCACAG AGGAAAATGC TCCCCTGAAG CTCAGCCAGG CTGTGCATAA GGCTGTGCTG 
ACCATCGATG AGACAGGAAC AGAAGCTGCA GCAGTTACAG TCTTACAAAT GGTTCCTATG 
TCTATGCCCC CTATCCTGCG CTTCGACCAC CCTTTCCTTT TCATAATATT TGAAGAACAC 
ACTCAGAGCC CCATCTTTTT GGGAAAAGTG GTAGATCCCA CACATAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001239498.1
CDS	249..1559
Translation	MYCAIRVRLSRLFTVKGQKARWKMTPSISWGLLLLAGLCCLVPSFLAEDVQETDTSQKDQSPASHEIATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIAEAVKKLDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDESTTVKVPMMTLSGMLHVHHCSTLSSWVLLMDYAGNATAVFLLPDDGKMQHLEQTLSKELISKFLLNRRRRLAQIHFPRLSISGEYNLKTLMSPLGITRIFNNGADLSGITEENAPLKLSQAVHKAVLTIDETGTEAAAVTVLQMVPMSMPPILRFDHPFLFIIFEEHTQSPIFLGKVVDPTHK

Target ORF information:

RefSeq Version	NM_001252569.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 1A (Serpina1a), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001252569.1

ORF Insert Sequence:

ATGTACTGTG CAATCCGTGT TCGGCTCTCC AGATTATTTA CAGTGAAAGG GCAGAAAGCA 
CGGTGGAAAA TGACTCCCTC CATCTCATGG GGTCTACTGC TTCTGGCAGG CCTGTGTTGC 
CTGGTCCCCA GCTTTCTGGC TGAGGATGTT CAGGAGACAG ACACCTCCCA GAAGGATCAG 
TCCCCAGCCT CCCATGAGAT CGCTACAAAC CTGGGAGACT TTGCAATCAG CCTATACCGG 
GAGCTGGTCC ATCAGTCCAA CACTTCCAAC ATCTTCTTCT CCCCAGTGAG CATTGCCACA 
GCCTTTGCTA TGCTCTCCCT AGGGAGCAAG GGTGACACTC ACACGCAGAT CCTAGAGGGC 
CTGCAGTTCA ACCTCACACA AACATCGGAG GCTGACATCC ACAAGTCCTT CCAACACCTC 
CTCCAAACCC TCAACAGACC AGACAGTGAG CTGCAGCTGA GCACAGGCAA TGGCCTCTTT 
GTCAACAATG ACCTGAAGCT GGTGGAGAAG TTTCTGGAAG AGGCCAAGAA CCATTATCAG 
GCAGAAGTCT TCTCTGTCAA CTTTGCAGAG TCAGAGGAGG CCAAGAAAGT GATTAATGAT 
TTTGTGGAGA AGGGAACCCA AGGAAAGATA GCTGAGGCGG TGAAAAAACT GGACCAAGAC 
ACAGTTTTCG CCCTGGCAAA TTACATTCTC TTTAAAGGCA AATGGAAGAA GCCATTCGAT 
CCTGAGAACA CTGAGGAAGC TGAGTTCCAC GTGGACGAGT CCACCACGGT GAAGGTGCCC 
ATGATGACCC TCTCGGGCAT GCTTCATGTG CACCATTGCA GCACGCTGTC CAGCTGGGTG 
CTGCTGATGG ATTATGCAGG CAATGCCACT GCTGTCTTCC TTCTGCCCGA TGATGGGAAG 
ATGCAGCATC TGGAGCAAAC TCTCAGCAAG GAGCTCATCT CTAAGTTCCT GCTAAACAGG 
CGCAGAAGGT TAGCCCAGAT CCACTTCCCC AGACTGTCCA TCTCTGGAGA ATATAACTTG 
AAGACACTCA TGAGTCCACT GGGCATCACC CGGATCTTCA ACAATGGGGC TGACCTCTCC 
GGAATCACAG AGGAAAATGC TCCCCTGAAG CTCAGCCAGG CTGTGCATAA GGCTGTGCTG 
ACCATCGATG AGACAGGAAC AGAAGCTGCA GCAGTTACAG TCTTACAAAT GGTTCCTATG 
TCTATGCCCC CTATCCTGCG CTTCGACCAC CCTTTCCTTT TCATAATATT TGAAGAACAC 
ACTCAGAGCC CCATCTTTTT GGGAAAAGTG GTAGATCCCA CACATAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Serpina1a ( NM_009243.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033269.1 Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 1A (Serpina1a), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu03778
Clone ID Related Accession (Same CDS sequence)	NM_009243.4
Accession Version	NM_009243.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1242bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	alpha-1-antitrypsin 1-1 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC134902.7, AK146619.1, W82055.1 and CJ238440.1. On Nov 19, 2011 this sequence version replaced NM_009243.3. Transcript Variant: This variant (1) is the predominant transcript and encodes the shorter isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M75721.1, AK146619.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTCCCT CCATCTCATG GGGTCTACTG CTTCTGGCAG GCCTGTGTTG CCTGGTCCCC 
AGCTTTCTGG CTGAGGATGT TCAGGAGACA GACACCTCCC AGAAGGATCA GTCCCCAGCC 
TCCCATGAGA TCGCTACAAA CCTGGGAGAC TTTGCAATCA GCCTATACCG GGAGCTGGTC 
CATCAGTCCA ACACTTCCAA CATCTTCTTC TCCCCAGTGA GCATTGCCAC AGCCTTTGCT 
ATGCTCTCCC TAGGGAGCAA GGGTGACACT CACACGCAGA TCCTAGAGGG CCTGCAGTTC 
AACCTCACAC AAACATCGGA GGCTGACATC CACAAGTCCT TCCAACACCT CCTCCAAACC 
CTCAACAGAC CAGACAGTGA GCTGCAGCTG AGCACAGGCA ATGGCCTCTT TGTCAACAAT 
GACCTGAAGC TGGTGGAGAA GTTTCTGGAA GAGGCCAAGA ACCATTATCA GGCAGAAGTC 
TTCTCTGTCA ACTTTGCAGA GTCAGAGGAG GCCAAGAAAG TGATTAATGA TTTTGTGGAG 
AAGGGAACCC AAGGAAAGAT AGCTGAGGCG GTGAAAAAAC TGGACCAAGA CACAGTTTTC 
GCCCTGGCAA ATTACATTCT CTTTAAAGGC AAATGGAAGA AGCCATTCGA TCCTGAGAAC 
ACTGAGGAAG CTGAGTTCCA CGTGGACGAG TCCACCACGG TGAAGGTGCC CATGATGACC 
CTCTCGGGCA TGCTTCATGT GCACCATTGC AGCACGCTGT CCAGCTGGGT GCTGCTGATG 
GATTATGCAG GCAATGCCAC TGCTGTCTTC CTTCTGCCCG ATGATGGGAA GATGCAGCAT 
CTGGAGCAAA CTCTCAGCAA GGAGCTCATC TCTAAGTTCC TGCTAAACAG GCGCAGAAGG 
TTAGCCCAGA TCCACTTCCC CAGACTGTCC ATCTCTGGAG AATATAACTT GAAGACACTC 
ATGAGTCCAC TGGGCATCAC CCGGATCTTC AACAATGGGG CTGACCTCTC CGGAATCACA 
GAGGAAAATG CTCCCCTGAA GCTCAGCCAG GCTGTGCATA AGGCTGTGCT GACCATCGAT 
GAGACAGGAA CAGAAGCTGC AGCAGTTACA GTCTTACAAA TGGTTCCTAT GTCTATGCCC 
CCTATCCTGC GCTTCGACCA CCCTTTCCTT TTCATAATAT TTGAAGAACA CACTCAGAGC 
CCCATCTTTT TGGGAAAAGT GGTAGATCCC ACACATAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033269.1
CDS	103..1344
Translation	MTPSISWGLLLLAGLCCLVPSFLAEDVQETDTSQKDQSPASHEIATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIAEAVKKLDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDESTTVKVPMMTLSGMLHVHHCSTLSSWVLLMDYAGNATAVFLLPDDGKMQHLEQTLSKELISKFLLNRRRRLAQIHFPRLSISGEYNLKTLMSPLGITRIFNNGADLSGITEENAPLKLSQAVHKAVLTIDETGTEAAAVTVLQMVPMSMPPILRFDHPFLFIIFEEHTQSPIFLGKVVDPTHK

Target ORF information:

RefSeq Version	NM_009243.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 1A (Serpina1a), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009243.4

ORF Insert Sequence:

ATGACTCCCT CCATCTCATG GGGTCTACTG CTTCTGGCAG GCCTGTGTTG CCTGGTCCCC 
AGCTTTCTGG CTGAGGATGT TCAGGAGACA GACACCTCCC AGAAGGATCA GTCCCCAGCC 
TCCCATGAGA TCGCTACAAA CCTGGGAGAC TTTGCAATCA GCCTATACCG GGAGCTGGTC 
CATCAGTCCA ACACTTCCAA CATCTTCTTC TCCCCAGTGA GCATTGCCAC AGCCTTTGCT 
ATGCTCTCCC TAGGGAGCAA GGGTGACACT CACACGCAGA TCCTAGAGGG CCTGCAGTTC 
AACCTCACAC AAACATCGGA GGCTGACATC CACAAGTCCT TCCAACACCT CCTCCAAACC 
CTCAACAGAC CAGACAGTGA GCTGCAGCTG AGCACAGGCA ATGGCCTCTT TGTCAACAAT 
GACCTGAAGC TGGTGGAGAA GTTTCTGGAA GAGGCCAAGA ACCATTATCA GGCAGAAGTC 
TTCTCTGTCA ACTTTGCAGA GTCAGAGGAG GCCAAGAAAG TGATTAATGA TTTTGTGGAG 
AAGGGAACCC AAGGAAAGAT AGCTGAGGCG GTGAAAAAAC TGGACCAAGA CACAGTTTTC 
GCCCTGGCAA ATTACATTCT CTTTAAAGGC AAATGGAAGA AGCCATTCGA TCCTGAGAAC 
ACTGAGGAAG CTGAGTTCCA CGTGGACGAG TCCACCACGG TGAAGGTGCC CATGATGACC 
CTCTCGGGCA TGCTTCATGT GCACCATTGC AGCACGCTGT CCAGCTGGGT GCTGCTGATG 
GATTATGCAG GCAATGCCAC TGCTGTCTTC CTTCTGCCCG ATGATGGGAA GATGCAGCAT 
CTGGAGCAAA CTCTCAGCAA GGAGCTCATC TCTAAGTTCC TGCTAAACAG GCGCAGAAGG 
TTAGCCCAGA TCCACTTCCC CAGACTGTCC ATCTCTGGAG AATATAACTT GAAGACACTC 
ATGAGTCCAC TGGGCATCAC CCGGATCTTC AACAATGGGG CTGACCTCTC CGGAATCACA 
GAGGAAAATG CTCCCCTGAA GCTCAGCCAG GCTGTGCATA AGGCTGTGCT GACCATCGAT 
GAGACAGGAA CAGAAGCTGC AGCAGTTACA GTCTTACAAA TGGTTCCTAT GTCTATGCCC 
CCTATCCTGC GCTTCGACCA CCCTTTCCTT TTCATAATAT TTGAAGAACA CACTCAGAGC 
CCCATCTTTT TGGGAAAAGT GGTAGATCCC ACACATAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/?-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy.
Autophagy13(4)686-702(2017 Apr)
Feng L,Zhang J,Zhu N,Ding Q,Zhang X,Yu J,Qiang W,Zhang Z,Ma Y,Huang D,Shen Y,Fang S,Yu Y,Wang H,Shen Y

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Scientific reports740495(2017 Jan)
Naba A,Clauser KR,Mani DR,Carr SA,Hynes RO

Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation.
Free radical biology & medicine99225-233(2016 10)
Di Francesco A,Di Germanio C,Panda AC,Huynh P,Peaden R,Navas-Enamorado I,Bastian P,Lehrmann E,Diaz-Ruiz A,Ross D,Siegel D,Martindale JL,Bernier M,Gorospe M,Abdelmohsen K,de Cabo R

Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus.
PloS one11(5)e0156583(2016)
Elshikha AS,Lu Y,Chen MJ,Akbar M,Zeumer L,Ritter A,Elghamry H,Mahdi MA,Morel L,Song S

FBG1 Is the Final Arbitrator of A1AT-Z Degradation.
PloS one10(8)e0135591(2015)
Wen JH,Wen H,Gibson-Corley KN,Glenn KA

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Serpina1a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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