Sp3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sp3
Entrez Gene ID	20687
Full Name	trans-acting transcription factor 3
Synonyms	D130027J01Rik
General protein information	Preferred Names trans-acting transcription factor 3 Names transcription factor Sp3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 C3
Summary	This gene product belongs to a family of Sp1 related transcription factors, which regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses transcription of numerous genes. Alternative splicing results in transcript variants encoding different isoforms, and one variant initiates translation from a non-AUG (AUA) codon. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001018042.3	NP_001018052.1	transcription factor Sp3 isoform 1
NM_001098425.1	NP_001091895.1	transcription factor Sp3 isoform 2

Pathways from BioSystems

Homologies

	SP3	XP_001088331.2
Rattus norvegicus (Norway rat)	Sp3	XP_002729217.3
Danio rerio (zebrafish)	sp3a	NP_001082967.1
Gallus gallus (chicken)	SP3	NP_989934.1
Xenopus tropicalis (tropical clawed frog)	sp3	XP_002934651.1
Mus musculus (house mouse)	Sp3	NP_001018052.1
Homo sapiens (human)	SP3	NP_003102.1
Canis lupus familiaris (dog)	SP3	XP_005640384.1
Bos taurus (cattle)	SP3	XP_002685342.2

Gene Ontology
Bibliography

Related articles in PubMed

Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.
Bourke LM, Del Monte-Nieto G, Outhwaite JE, Bharti V, Pollock PM, Simmons DG, Adam A, Hur SS, Maghzal GJ, Whitelaw E, Stocker R, Suter CM, Harvey RP, Harten SK
Differentiation; research in biological diversity948-20(2017 Mar - Apr)

Sp3 controls fibroblast growth factor receptor 4 gene activity during myogenic differentiation.
Cavanaugh E, DiMario JX
Gene61724-31(2017 Jun)

Involvement of GATA1 and Sp3 in the activation of the murine STING gene promoter in NIH3T3 cells.
Xu YY, Jin R, Zhou GP, Xu HG
Scientific reports7(1)2090(2017 May)

Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.
Wegener A, K?spert M, Sock E, Philipsen S, Suske G, Wegner M
Journal of neurochemistry140(2)245-256(2017 Jan)

Transcription factors YY1, Sp1 and Sp3 modulate dystrophin Dp71 gene expression in hepatic cells.
Pe?uelas-Urquides K, Becerril-Esquivel C, Mendoza-de-Le?n LC, Silva-Ram?rez B, D?vila-Velderrain J, Cisneros B, de Le?n MB
The Biochemical journal473(13)1967-76(2016 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sp3 binds and activates the FGFR4 promoter.
Title: Sp3 controls fibroblast growth factor receptor 4 gene activity during myogenic differentiation.

This resulted in Sp1 displacement from the promoter and binding of Sp3 to it, leading to p300 recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3-mediated gene regulation that may apply to other genes
Title: Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms.

Dp71 expression in hepatic cells is carried out, in part, by YY1-, Sp1- and Sp3-mediated transcription from the Dp71 promoter.
Title: Transcription factors YY1, Sp1 and Sp3 modulate dystrophin Dp71 gene expression in hepatic cells.

Sp1/Sp3 transcription factors have roles in regulating hallmarks of megakaryocyte maturation and platelet formation and function
Title: Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function.

Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.
Title: Zinc finger independent genome-wide binding of Sp2 potentiates recruitment of histone-fold protein Nf-y distinguishing it from Sp1 and Sp3.

The following Sp3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sp3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11792	NM_001018042.3 Latest version!	Mus musculus trans-acting transcription factor 3 (Sp3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
OMu13097	NM_001098425.1 Latest version!	Mus musculus trans-acting transcription factor 3 (Sp3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$419.30 $599.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sp3 ( NM_001018042.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001018052.1 Mus musculus trans-acting transcription factor 3 (Sp3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu11792
Clone ID Related Accession (Same CDS sequence)	NM_001018042.3
Accession Version	NM_001018042.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2352bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	transcription factor Sp3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC079874.1. On Jun 1, 2007 this sequence version replaced NM_001018042.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC079874.1, SRR1660815.274705.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCGCTC CCGAAAAGCC CGTGAAACAA GAGGAAATGG CTGCCTTGGA CGTGGACGGC 
GGCGGAGGCG GCGGCGGCCA CGGCGAGTAT CTACAGCAGC AGCAGCAGCA ACAGCAGCAG 
CACGGAAACG GCGCGGCGGC GGCGGCGGCC CAGGACACTC AGCCGTCACC GCTCGCTCTG 
CTGGCCGCTA CCTGCAGCAA GATAGGGCCG CCATCGCCGG GCGACGACGA CGAGGAGGCG 
GCCGTTGCCG CCGCCGCCGG GGTCCCCGCC GCCGCCGCCG GAGCGACAGG TGATTTGGCT 
TCTGCACAGT TAGGAGGAGC ACCAAACCGA TGGGAGGTTT TGTCAGCTAC ACCTACAACT 
ATAAAAGATG AAGCTGGTAA TCTAGTACAG ATTCCAGGTG CTGCTACTTC AAGTGGGCAG 
TATGTCCTTC CCCTTCAGAA TTTGCAGAAT CAACAAATAT TTTCAGTTGC ACCAGGATCA 
GATTCATCAA ATGGCACAGT GTCCAATGTT CAGTATCAAG TAATACCACA AATTCAGTCA 
ACAGACGCTC AGCAGGTTCA GATTGGCTTC ACAGGCTCCT CAGATAATGG GGGCATAAAT 
CAAGAAAACA GCCAAATTCA GATCATTCCT GGCTCTAATC AAACCTTACT CGCCTCTGGA 
ACACCTCCTG CTAATATCCA GAATCTCATA CCACAGACTG GTCAAGTCCA GGTTCAGGGA 
GTTGCAATTG GTGGCTCATC ATTTCCTGGC CAAACTCAAG TAGTCGCTAA TGTGCCTCTT 
GGTCTGCCAG GAAATATTAC CTTTGTACCA ATCAATAGTG TCGATCTAGA TTCTTTGGGA 
CTCTCGGGAA GTTCTCAGAC AATGACTGCA GGCATTAATG CCGATGGACA TTTGATAAAC 
ACAGGACAAG CTATGGATAG TTCAGACAAT TCAGAAAGGA CTGGTGAGCG GGTTTCTCCT 
GATGTTAATG AAACTAATGC TGATACAGAT TTATTTGTGC CAACATCCTC TTCATCACAG 
TTGCCTGTTA CAATAGATAG TACAGGTATA TTACAGCAAA ACACAAATAG CTTGACTACT 
ACTAGTGGGC AAGTCCATTC TTCAGATCTT CAGGGAAATT ATATCCAGTC GCCTGTTTCT 
GAAGAGACAC AGGCTCAGAA TATTCAGGTT TCTACAGCAC AGCCTGTTGT ACAACATCTA 
CAACTTCAAG ATTCTCAGCA GCCAACCAGT CAAGCCCAAA TTGTGCAAGG TATTACACCA 
CAGACAATCC ATGGCGTGCA AGCCAGTGGT CAAAATATAT CACAACAGGC TTTGCAAAAC 
CTTCAGTTGC AGCTGAATCC TGGAACCTTT TTAATTCAGG CACAGACAGT GACCCCTTCT 
GGACAGATAA CTTGGCAAAC ATTTCAAGTA CAAGGGGTCC AGAACTTACA GAATTTGCAA 
ATACAAAATA CTGCTGCCCA ACAAATTACT TTGACGCCTG TTCAGACACT CACGCTTGGT 
CAAGTCGCAG CAGGTGGAGC CTTGACTTCA ACTCCAGTCA GTCTAAGCAC TGGTCAGTTG 
CCAAATCTAC AGACAGTTAC AGTAAATTCT ATAGATTCTA CTGGCATACA GCTACATCCA 
GGAGAGAATG CCGACAGTCC TGCAGATATT AGGATCAAGG AAGAGGAACC TGACCCTGAA 
GAATGGCAGC TCAGTGGTGA CTCTACACTG AACACCAATG ACCTAACACA TTTACGAGTA 
CAAGTGGTAG ATGAAGAAGG GGACCAACAA CATCAAGAAG GAAAAAGACT TCGGAGGGTA 
GCTTGCACCT GTCCCAACTG TAAAGAAGGT GGTGGGAGAG GTACCAATCT TGGGAAAAAG 
AAGCAACACA TTTGTCATAT ACCGGGATGT GGTAAAGTCT ATGGGAAGAC CTCACATCTG 
AGAGCACACC TGCGTTGGCA TTCGGGGGAG CGCCCTTTTA TTTGTAACTG GATGTTCTGT 
GGTAAAAGAT TTACACGAAG TGATGAATTA CAGAGGCACA GAAGAACACA TACAGGTGAG 
AAGAAGTTTG TTTGTCCAGA ATGTTCAAAA CGCTTTATGA GAAGTGACCA CCTTGCCAAA 
CATATTAAAA CACATCAAAA TAAAAAAGTC ATTCACTCTA GCAGTACAGT GCTCGCATCT 
GTGGAAGCTG GAAGAGATGA TGCCTTGATT ACTGCAGGAG GAACAACACT TATCCTTGCA 
AATATTCAAC AGGGGTCTGT GTCAGGGATA GGAACTGTCA ATACTTCTGC CACCAGCAAT 
CAAGACATCC TTACCAACAC TGAAATACCT TTACAGCTTG TCACAGTTTC TGGAAATGAG 
ACAATGGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001018052.1
CDS	191..2542
Translation	MTAPEKPVKQEEMAALDVDGGGGGGGHGEYLQQQQQQQQQHGNGAAAAAAQDTQPSPLALLAATCSKIGPPSPGDDDEEAAVAAAAGVPAAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPGAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSNVQYQVIPQIQSTDAQQVQIGFTGSSDNGGINQENSQIQIIPGSNQTLLASGTPPANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDVNETNADTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTTSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQDSQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQITWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGALTSTPVSLSTGQLPNLQTVTVNSIDSTGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKVIHSSSTVLASVEAGRDDALITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME

Target ORF information:

RefSeq Version	NM_001018042.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus trans-acting transcription factor 3 (Sp3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001018042.3

ORF Insert Sequence:

ATGACCGCTC CCGAAAAGCC CGTGAAACAA GAGGAAATGG CTGCCTTGGA CGTGGACGGC 
GGCGGAGGCG GCGGCGGCCA CGGCGAGTAT CTACAGCAGC AGCAGCAGCA ACAGCAGCAG 
CACGGAAACG GCGCGGCGGC GGCGGCGGCC CAGGACACTC AGCCGTCACC GCTCGCTCTG 
CTGGCCGCTA CCTGCAGCAA GATAGGGCCG CCATCGCCGG GCGACGACGA CGAGGAGGCG 
GCCGTTGCCG CCGCCGCCGG GGTCCCCGCC GCCGCCGCCG GAGCGACAGG TGATTTGGCT 
TCTGCACAGT TAGGAGGAGC ACCAAACCGA TGGGAGGTTT TGTCAGCTAC ACCTACAACT 
ATAAAAGATG AAGCTGGTAA TCTAGTACAG ATTCCAGGTG CTGCTACTTC AAGTGGGCAG 
TATGTCCTTC CCCTTCAGAA TTTGCAGAAT CAACAAATAT TTTCAGTTGC ACCAGGATCA 
GATTCATCAA ATGGCACAGT GTCCAATGTT CAGTATCAAG TAATACCACA AATTCAGTCA 
ACAGACGCTC AGCAGGTTCA GATTGGCTTC ACAGGCTCCT CAGATAATGG GGGCATAAAT 
CAAGAAAACA GCCAAATTCA GATCATTCCT GGCTCTAATC AAACCTTACT CGCCTCTGGA 
ACACCTCCTG CTAATATCCA GAATCTCATA CCACAGACTG GTCAAGTCCA GGTTCAGGGA 
GTTGCAATTG GTGGCTCATC ATTTCCTGGC CAAACTCAAG TAGTCGCTAA TGTGCCTCTT 
GGTCTGCCAG GAAATATTAC CTTTGTACCA ATCAATAGTG TCGATCTAGA TTCTTTGGGA 
CTCTCGGGAA GTTCTCAGAC AATGACTGCA GGCATTAATG CCGATGGACA TTTGATAAAC 
ACAGGACAAG CTATGGATAG TTCAGACAAT TCAGAAAGGA CTGGTGAGCG GGTTTCTCCT 
GATGTTAATG AAACTAATGC TGATACAGAT TTATTTGTGC CAACATCCTC TTCATCACAG 
TTGCCTGTTA CAATAGATAG TACAGGTATA TTACAGCAAA ACACAAATAG CTTGACTACT 
ACTAGTGGGC AAGTCCATTC TTCAGATCTT CAGGGAAATT ATATCCAGTC GCCTGTTTCT 
GAAGAGACAC AGGCTCAGAA TATTCAGGTT TCTACAGCAC AGCCTGTTGT ACAACATCTA 
CAACTTCAAG ATTCTCAGCA GCCAACCAGT CAAGCCCAAA TTGTGCAAGG TATTACACCA 
CAGACAATCC ATGGCGTGCA AGCCAGTGGT CAAAATATAT CACAACAGGC TTTGCAAAAC 
CTTCAGTTGC AGCTGAATCC TGGAACCTTT TTAATTCAGG CACAGACAGT GACCCCTTCT 
GGACAGATAA CTTGGCAAAC ATTTCAAGTA CAAGGGGTCC AGAACTTACA GAATTTGCAA 
ATACAAAATA CTGCTGCCCA ACAAATTACT TTGACGCCTG TTCAGACACT CACGCTTGGT 
CAAGTCGCAG CAGGTGGAGC CTTGACTTCA ACTCCAGTCA GTCTAAGCAC TGGTCAGTTG 
CCAAATCTAC AGACAGTTAC AGTAAATTCT ATAGATTCTA CTGGCATACA GCTACATCCA 
GGAGAGAATG CCGACAGTCC TGCAGATATT AGGATCAAGG AAGAGGAACC TGACCCTGAA 
GAATGGCAGC TCAGTGGTGA CTCTACACTG AACACCAATG ACCTAACACA TTTACGAGTA 
CAAGTGGTAG ATGAAGAAGG GGACCAACAA CATCAAGAAG GAAAAAGACT TCGGAGGGTA 
GCTTGCACCT GTCCCAACTG TAAAGAAGGT GGTGGGAGAG GTACCAATCT TGGGAAAAAG 
AAGCAACACA TTTGTCATAT ACCGGGATGT GGTAAAGTCT ATGGGAAGAC CTCACATCTG 
AGAGCACACC TGCGTTGGCA TTCGGGGGAG CGCCCTTTTA TTTGTAACTG GATGTTCTGT 
GGTAAAAGAT TTACACGAAG TGATGAATTA CAGAGGCACA GAAGAACACA TACAGGTGAG 
AAGAAGTTTG TTTGTCCAGA ATGTTCAAAA CGCTTTATGA GAAGTGACCA CCTTGCCAAA 
CATATTAAAA CACATCAAAA TAAAAAAGTC ATTCACTCTA GCAGTACAGT GCTCGCATCT 
GTGGAAGCTG GAAGAGATGA TGCCTTGATT ACTGCAGGAG GAACAACACT TATCCTTGCA 
AATATTCAAC AGGGGTCTGT GTCAGGGATA GGAACTGTCA ATACTTCTGC CACCAGCAAT 
CAAGACATCC TTACCAACAC TGAAATACCT TTACAGCTTG TCACAGTTTC TGGAAATGAG 
ACAATGGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sp3 ( NM_001098425.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001091895.1 Mus musculus trans-acting transcription factor 3 (Sp3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu13097
Clone ID Related Accession (Same CDS sequence)	NM_001098425.1
Accession Version	NM_001098425.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2151bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	transcription factor Sp3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA328978.1, CJ167744.1 and BC079874.1. Transcript Variant: This variant (2) is missing 2 exons from the 5' end compared to transcript variant 1, and it initiates translation from an in-frame, downstream non-AUG (AUA) codon, resulting in an isoform (2) with a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK088238.1, SRR1660817.302014.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATAGGGCCGC CATCGCCGGG CGACGACGAC GAGGAGGCGG CCGTTGCCGC CGCCGCCGGG 
GTCCCCGCCG CCGCCGCCGG AGCGACAGGT GATTTGGCTT CTGCACAGTT AGGAGGAGCA 
CCAAACCGAT GGGAGGTTTT GTCAGCTACA CCTACAACTA TAAAAGATGA AGCTGGTAAT 
CTAGTACAGA TTCCAGGTGC TGCTACTTCA AGTGGGCAGT ATGTCCTTCC CCTTCAGAAT 
TTGCAGAATC AACAAATATT TTCAGTTGCA CCAGGATCAG ATTCATCAAA TGGCACAGTG 
TCCAATGTTC AGTATCAAGT AATACCACAA ATTCAGTCAA CAGACGCTCA GCAGGTTCAG 
ATTGGCTTCA CAGGCTCCTC AGATAATGGG GGCATAAATC AAGAAAACAG CCAAATTCAG 
ATCATTCCTG GCTCTAATCA AACCTTACTC GCCTCTGGAA CACCTCCTGC TAATATCCAG 
AATCTCATAC CACAGACTGG TCAAGTCCAG GTTCAGGGAG TTGCAATTGG TGGCTCATCA 
TTTCCTGGCC AAACTCAAGT AGTCGCTAAT GTGCCTCTTG GTCTGCCAGG AAATATTACC 
TTTGTACCAA TCAATAGTGT CGATCTAGAT TCTTTGGGAC TCTCGGGAAG TTCTCAGACA 
ATGACTGCAG GCATTAATGC CGATGGACAT TTGATAAACA CAGGACAAGC TATGGATAGT 
TCAGACAATT CAGAAAGGAC TGGTGAGCGG GTTTCTCCTG ATGTTAATGA AACTAATGCT 
GATACAGATT TATTTGTGCC AACATCCTCT TCATCACAGT TGCCTGTTAC AATAGATAGT 
ACAGGTATAT TACAGCAAAA CACAAATAGC TTGACTACTA CTAGTGGGCA AGTCCATTCT 
TCAGATCTTC AGGGAAATTA TATCCAGTCG CCTGTTTCTG AAGAGACACA GGCTCAGAAT 
ATTCAGGTTT CTACAGCACA GCCTGTTGTA CAACATCTAC AACTTCAAGA TTCTCAGCAG 
CCAACCAGTC AAGCCCAAAT TGTGCAAGGT ATTACACCAC AGACAATCCA TGGCGTGCAA 
GCCAGTGGTC AAAATATATC ACAACAGGCT TTGCAAAACC TTCAGTTGCA GCTGAATCCT 
GGAACCTTTT TAATTCAGGC ACAGACAGTG ACCCCTTCTG GACAGATAAC TTGGCAAACA 
TTTCAAGTAC AAGGGGTCCA GAACTTACAG AATTTGCAAA TACAAAATAC TGCTGCCCAA 
CAAATTACTT TGACGCCTGT TCAGACACTC ACGCTTGGTC AAGTCGCAGC AGGTGGAGCC 
TTGACTTCAA CTCCAGTCAG TCTAAGCACT GGTCAGTTGC CAAATCTACA GACAGTTACA 
GTAAATTCTA TAGATTCTAC TGGCATACAG CTACATCCAG GAGAGAATGC CGACAGTCCT 
GCAGATATTA GGATCAAGGA AGAGGAACCT GACCCTGAAG AATGGCAGCT CAGTGGTGAC 
TCTACACTGA ACACCAATGA CCTAACACAT TTACGAGTAC AAGTGGTAGA TGAAGAAGGG 
GACCAACAAC ATCAAGAAGG AAAAAGACTT CGGAGGGTAG CTTGCACCTG TCCCAACTGT 
AAAGAAGGTG GTGGGAGAGG TACCAATCTT GGGAAAAAGA AGCAACACAT TTGTCATATA 
CCGGGATGTG GTAAAGTCTA TGGGAAGACC TCACATCTGA GAGCACACCT GCGTTGGCAT 
TCGGGGGAGC GCCCTTTTAT TTGTAACTGG ATGTTCTGTG GTAAAAGATT TACACGAAGT 
GATGAATTAC AGAGGCACAG AAGAACACAT ACAGGTGAGA AGAAGTTTGT TTGTCCAGAA 
TGTTCAAAAC GCTTTATGAG AAGTGACCAC CTTGCCAAAC ATATTAAAAC ACATCAAAAT 
AAAAAAGTCA TTCACTCTAG CAGTACAGTG CTCGCATCTG TGGAAGCTGG AAGAGATGAT 
GCCTTGATTA CTGCAGGAGG AACAACACTT ATCCTTGCAA ATATTCAACA GGGGTCTGTG 
TCAGGGATAG GAACTGTCAA TACTTCTGCC ACCAGCAATC AAGACATCCT TACCAACACT 
GAAATACCTT TACAGCTTGT CACAGTTTCT GGAAATGAGA CAATGGAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001091895.1
CDS	301..2451
Translation	IGPPSPGDDDEEAAVAAAAGVPAAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPGAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSNVQYQVIPQIQSTDAQQVQIGFTGSSDNGGINQENSQIQIIPGSNQTLLASGTPPANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDVNETNADTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTTSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQDSQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQITWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGALTSTPVSLSTGQLPNLQTVTVNSIDSTGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKVIHSSSTVLASVEAGRDDALITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME

Target ORF information:

RefSeq Version	NM_001098425.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus trans-acting transcription factor 3 (Sp3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001098425.1

ORF Insert Sequence:

ATAGGGCCGC CATCGCCGGG CGACGACGAC GAGGAGGCGG CCGTTGCCGC CGCCGCCGGG 
GTCCCCGCCG CCGCCGCCGG AGCGACAGGT GATTTGGCTT CTGCACAGTT AGGAGGAGCA 
CCAAACCGAT GGGAGGTTTT GTCAGCTACA CCTACAACTA TAAAAGATGA AGCTGGTAAT 
CTAGTACAGA TTCCAGGTGC TGCTACTTCA AGTGGGCAGT ATGTCCTTCC CCTTCAGAAT 
TTGCAGAATC AACAAATATT TTCAGTTGCA CCAGGATCAG ATTCATCAAA TGGCACAGTG 
TCCAATGTTC AGTATCAAGT AATACCACAA ATTCAGTCAA CAGACGCTCA GCAGGTTCAG 
ATTGGCTTCA CAGGCTCCTC AGATAATGGG GGCATAAATC AAGAAAACAG CCAAATTCAG 
ATCATTCCTG GCTCTAATCA AACCTTACTC GCCTCTGGAA CACCTCCTGC TAATATCCAG 
AATCTCATAC CACAGACTGG TCAAGTCCAG GTTCAGGGAG TTGCAATTGG TGGCTCATCA 
TTTCCTGGCC AAACTCAAGT AGTCGCTAAT GTGCCTCTTG GTCTGCCAGG AAATATTACC 
TTTGTACCAA TCAATAGTGT CGATCTAGAT TCTTTGGGAC TCTCGGGAAG TTCTCAGACA 
ATGACTGCAG GCATTAATGC CGATGGACAT TTGATAAACA CAGGACAAGC TATGGATAGT 
TCAGACAATT CAGAAAGGAC TGGTGAGCGG GTTTCTCCTG ATGTTAATGA AACTAATGCT 
GATACAGATT TATTTGTGCC AACATCCTCT TCATCACAGT TGCCTGTTAC AATAGATAGT 
ACAGGTATAT TACAGCAAAA CACAAATAGC TTGACTACTA CTAGTGGGCA AGTCCATTCT 
TCAGATCTTC AGGGAAATTA TATCCAGTCG CCTGTTTCTG AAGAGACACA GGCTCAGAAT 
ATTCAGGTTT CTACAGCACA GCCTGTTGTA CAACATCTAC AACTTCAAGA TTCTCAGCAG 
CCAACCAGTC AAGCCCAAAT TGTGCAAGGT ATTACACCAC AGACAATCCA TGGCGTGCAA 
GCCAGTGGTC AAAATATATC ACAACAGGCT TTGCAAAACC TTCAGTTGCA GCTGAATCCT 
GGAACCTTTT TAATTCAGGC ACAGACAGTG ACCCCTTCTG GACAGATAAC TTGGCAAACA 
TTTCAAGTAC AAGGGGTCCA GAACTTACAG AATTTGCAAA TACAAAATAC TGCTGCCCAA 
CAAATTACTT TGACGCCTGT TCAGACACTC ACGCTTGGTC AAGTCGCAGC AGGTGGAGCC 
TTGACTTCAA CTCCAGTCAG TCTAAGCACT GGTCAGTTGC CAAATCTACA GACAGTTACA 
GTAAATTCTA TAGATTCTAC TGGCATACAG CTACATCCAG GAGAGAATGC CGACAGTCCT 
GCAGATATTA GGATCAAGGA AGAGGAACCT GACCCTGAAG AATGGCAGCT CAGTGGTGAC 
TCTACACTGA ACACCAATGA CCTAACACAT TTACGAGTAC AAGTGGTAGA TGAAGAAGGG 
GACCAACAAC ATCAAGAAGG AAAAAGACTT CGGAGGGTAG CTTGCACCTG TCCCAACTGT 
AAAGAAGGTG GTGGGAGAGG TACCAATCTT GGGAAAAAGA AGCAACACAT TTGTCATATA 
CCGGGATGTG GTAAAGTCTA TGGGAAGACC TCACATCTGA GAGCACACCT GCGTTGGCAT 
TCGGGGGAGC GCCCTTTTAT TTGTAACTGG ATGTTCTGTG GTAAAAGATT TACACGAAGT 
GATGAATTAC AGAGGCACAG AAGAACACAT ACAGGTGAGA AGAAGTTTGT TTGTCCAGAA 
TGTTCAAAAC GCTTTATGAG AAGTGACCAC CTTGCCAAAC ATATTAAAAC ACATCAAAAT 
AAAAAAGTCA TTCACTCTAG CAGTACAGTG CTCGCATCTG TGGAAGCTGG AAGAGATGAT 
GCCTTGATTA CTGCAGGAGG AACAACACTT ATCCTTGCAA ATATTCAACA GGGGTCTGTG 
TCAGGGATAG GAACTGTCAA TACTTCTGCC ACCAGCAATC AAGACATCCT TACCAACACT 
GAAATACCTT TACAGCTTGT CACAGTTTCT GGAAATGAGA CAATGGAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.
Differentiation; research in biological diversity948-20(2017 Mar - Apr)
Bourke LM,Del Monte-Nieto G,Outhwaite JE,Bharti V,Pollock PM,Simmons DG,Adam A,Hur SS,Maghzal GJ,Whitelaw E,Stocker R,Suter CM,Harvey RP,Harten SK

Sp3 controls fibroblast growth factor receptor 4 gene activity during myogenic differentiation.
Gene61724-31(2017 Jun)
Cavanaugh E,DiMario JX

Involvement of GATA1 and Sp3 in the activation of the murine STING gene promoter in NIH3T3 cells.
Scientific reports7(1)2090(2017 May)
Xu YY,Jin R,Zhou GP,Xu HG

Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.
Journal of neurochemistry140(2)245-256(2017 Jan)
Wegener A,K?spert M,Sock E,Philipsen S,Suske G,Wegner M

Transcription factors YY1, Sp1 and Sp3 modulate dystrophin Dp71 gene expression in hepatic cells.
The Biochemical journal473(13)1967-76(2016 07)
Pe?uelas-Urquides K,Becerril-Esquivel C,Mendoza-de-Le?n LC,Silva-Ram?rez B,D?vila-Velderrain J,Cisneros B,de Le?n MB

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Sp3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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