Sos1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sos1
Entrez Gene ID	20662
Full Name	SOS Ras/Rac guanine nucleotide exchange factor 1
Synonyms	4430401P03Rik,9630010N06,AI449023
General protein information	Preferred Names SOS Ras/Rac guanine nucleotide exchange factor 1 Names son of sevenless homolog 1 guanine nucleotide releasing factor ras guanine exchange factor son-of-sevenless 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 E3\|17 50.67 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009231.2	NP_033257.2	son of sevenless homolog 1

Pathways from BioSystems

Homologies

	SOS1	XP_001103238.2
Drosophila melanogaster (fruit fly)	Sos	NP_476597.2
Canis lupus familiaris (dog)	SOS1	XP_005630658.1
Mus musculus (house mouse)	Sos1	NP_033257.2
Caenorhabditis elegans (roundworm)	sos-1	NP_504235.2
Xenopus tropicalis (tropical clawed frog)	sos1	XP_004914729.1
Pan troglodytes (chimpanzee)	SOS1	XP_515425.3
Bos taurus (cattle)	SOS1	XP_002691287.2
Gallus gallus (chicken)	SOS1	XP_003640979.2
Homo sapiens (human)	SOS1	NP_005624.2
Rattus norvegicus (Norway rat)	Sos1	NP_001094186.1

Gene Ontology
Bibliography

Related articles in PubMed

Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs.
Liceras-Boillos P, Garc?a-Navas R, Ginel-Picardo A, Anta B, P?rez-Andr?s M, Lillo C, G?mez C, Jimeno D, Fern?ndez-Medarde A, Baltan?s FC, Santos E
Oncogene35(50)6389-6402(2016 Dec)

Sos1 Regulates Macrophage Podosome Assembly and Macrophage Invasive Capacity.
Baruzzi A, Remelli S, Lorenzetto E, Sega M, Chignola R, Berton G
Journal of immunology (Baltimore, Md. : 1950)195(10)4900-12(2015 Nov)

Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T?cells leads to PI3K pathway activation and defects in migration.
Guittard G, Kortum RL, Balagopalan L, ?uburu N, Nguyen P, Sommers CL, Samelson LE
European journal of immunology45(8)2389-95(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a direct mechanistic link between Sos1 and control of intracellular oxidative stress, and demonstrate functional prevalence of Sos1 over Sos2 with regards to cellular proliferation and viability.
Title: Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs.

findings suggest that targeting the Src/Abl/Sos1/Rac pathway may represent a double-edged sword to control both cancer-invasive capacities and cancer-related inflammation.
Title: Sos1 Regulates Macrophage Podosome Assembly and Macrophage Invasive Capacity.

The increased activity of the PI3K/AKT pathway led to downregulation of the surface receptor CD62L in Sos-1/2dKO T cells and a subsequent impairment in T-cell migration.
Title: Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T?cells leads to PI3K pathway activation and defects in migration.

Data suggest that interactions between Sos1 (Son of Sevenless homolog 1) and Crk (proto-oncogene proteins c-crk) involve electrostatic interactions at binding sites.
Title: Role of electrostatic interactions in binding of peptides and intrinsically disordered proteins to their folded targets. 1. NMR and MD characterization of the complex between the c-Crk N-SH3 domain and the peptide Sos.

ROS1 kinase activity and MEK1/2-ERK1/2 signaling regulates epithelial differentiation in the epididymis.
Title: ROS1 signaling regulates epithelial differentiation in the epididymis.

The following Sos1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sos1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22344	NM_009231.2 Latest version!	Mus musculus SOS Ras/Rac guanine nucleotide exchange factor 1 (Sos1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$776.30 $1109.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sos1 ( NM_009231.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033257.2 Mus musculus SOS Ras/Rac guanine nucleotide exchange factor 1 (Sos1), mRNA.

Price & Availability↑

CloneID	OMu22344
Clone ID Related Accession (Same CDS sequence)	NM_009231.2
Accession Version	NM_009231.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3960bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-20
Organism	Mus musculus(house mouse)
Product	son of sevenless homolog 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK140310.1, CB521016.1 and AC161447.6. On Nov 3, 2006 this sequence version replaced NM_009231.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGCAGGCGC AGCAGCTGCC TTACGAGTTT TTCAGCGAGG AGAACGCGCC CAAGTGGCGG 
GGGCTGCTGG TGCCTGCGCT GAAAAAGGTT CAGGGGCAAG TTCACCCTAC TCTTGAGTCT 
AATGATGATG CTCTTCAGTA TGTTGAAGAA TTAATTTTGC AATTACTAAA TATGCTATGC 
CAAGCTCAGC CCCGGAGTGC TTCAGATGTG GAGGAACGTG TTCAAAAGAG TTTTCCTCAT 
CCAATTGATA AGTGGGCAAT AGCTGATGCC CAATCAGCCA TTGAAAAGAG GAAGAGACGA 
AATCCTTTAT CGCTGCCAGC AGAAAGAATT CATCATTTAT TAAGGGAGGT CCTCGGTTAT 
AAAATTGACC ACCAGGTTTC TGTTTACATA GTAGCAGTAT TAGAATACAT TTCTGCAGAT 
ATTTTAAAGC TCGTGGGGAA TTATGTAAGA AATATACGGC ATTATGAAAT TACAAAACAA 
GACATTAAAG TGGCAATGTG TGCTGATAAG GTATTGATGG ATATGTTTCA TCAAGATGTA 
GAAGATATAA ATATCTTATC TTTAACTGAT GAAGAGCCTT CCACCTCAGG AGAACAAACT 
TATTATGATT TGGTAAAAGC ATTCATGGCA GAAATTCGAC AGTATATAAG AGAATTAAAT 
CTAATTATAA AAGTTTTTCG AGAGCCCTTT GTCTCTAATT CCAAATTGTT TTCATCTAAT 
GATGTAGAAA ACATATTCAG TCGTATAGTA GATATACATG AACTTAGTGT AAAGTTACTG 
GGCCATATAG AAGATACTGT AGAAATGACA GATGAAGGCA GTCCCCACCC ATTAGTAGGA 
AGCTGTTTTG AAGACTTAGC AGAAGAACTG GCATTTGACC CGTATGAGTC ATATGCTCGG 
GATATTTTAC GACCCGGATT CCATGGCCAT TTTCTTAGTC AGTTATCAAA GCCTGGGGCA 
GCACTTTATT TGCAGTCCAT AGGCGAAGGC TTCAAAGAAG CTGTCCAGTA CGTCCTGCCC 
CGGCTGCTGC TTGCCCCTGT GTACCACTGT CTGCATTACT TTGAACTTCT GAAGCAGTTA 
GAAGAAAAGA GTGAAGATCA AGAAGACAAG GAGTGTATGA AGCAAGCAAT AACAGCCCTG 
CTTAATGTCC AAAGTGGCAT GGAAAAAATT TGCTCCAAAA GTCTTGCAAA ACGAAGACTA 
AGTGAGTCTG CATGTCGGTT TTACAGCCAG CAGATGAAGG GGAAACAGCT AGCCATCAAG 
AAGATGAACG AGATCCAGAA GAACATTGAT GGCTGGGAGG GGAAGGACAT TGGACAGTGT 
TGCAATGAGT TCATAATGGA AGGAACTCTT ACACGTGTAG GAGCCAAACA CGAGAGACAC 
ATATTTCTCT TCGATGGCTT AATGATTTGC TGTAAATCAA ACCATGGGCA GCCAAGACTC 
CCTGGTGCTA GCAGTGCAGA ATACCGGCTT AAAGAAAAGT TTTTTATGCG AAAGGTACAG 
ATTAATGATA AAGATGACAC CAGTGAGTAC AAGCATGCTT TTGAAATCAT TCTGAAAGAT 
GGCAATAGTG TTATATTTTC TGCCAAGTCA GCTGAAGAGA AAAACAACTG GATGGCAGCA 
CTGATCTCTT TGCAGTACCG CAGCACCCTG GAGAGGATGC TGGACGTAAC GGTGCTGCAG 
GAGGAGAAGG AGGAGCAGAT GAGGCTGCCC AGTGCTGAAG TGTACAGGTT TGCAGAACCT 
GACTCCGAGG AGAATATTCT ATTCGAAGAG AATGTGCAGC CCAAAGCTGG GATCCCCATT 
ATCAAGGCAG GGACAGTGCT TAAGCTCATT GAGAGGCTTA CCTACCACAT GTACGCAGAT 
CCAAATTTTG TTCGGACGTT TCTTACAACA TACAGGTCCT TTTGCAGACC TCAAGAACTA 
CTGAGTCTTC TGATAGAAAG ATTTGAAATT CCAGAGCCTG AGCCAACAGA AGCTGATCGC 
ATAGCTATAG AGAATGGAGA TCAGCCCCTG AGTGCAGAGC TGAAGAGGTT TAGAAAGGAA 
TATATTCAGC CTGTGCAGTT GAGGGTGTTA AATGTGTGTC GGCACTGGGT GGAGCACCAT 
TTCTATGACT TTGAAAGAGA TGCAGACCTT TTACAGAGAA TGGAGGAATT TATTGGAACA 
GTAAGAGGTA AAGCAATGAA AAAATGGGTC GAATCCATCA CTAAGATAAT CCAAAGGAAA 
AAAATTGCAA GAGACAATGG CCCAGGTCAT AACATTACAT TTCAGAGCTC ACCTCCCACA 
GTTGAGTGGC ACATAAGCAG ACCTGGGCAC ATAGAGACTT TTGACTTGCT CACCTTACAC 
CCAATAGAAA TTGCTCGGCA ACTCACTTTA CTTGAATCAG ATCTATACCG GGCTGTGCAG 
CCATCAGAAT TAGTTGGAAG TGTGTGGACA AAAGAAGATA AAGAAATTAA TTCTCCCAAC 
CTTCTGAAGA TGATTCGGCA CACCACTAAC CTCACTTTGT GGTTTGAGAA ATGTATTGTA 
GAAACAGAAA ACTTAGAAGA AAGAGTAGCT GTAGTAAGTC GGATAATTGA GATTCTACAA 
GTCTTTCAAG AGCTGAACAA CTTCAATGGT GTCCTGGAAG TTGTCAGTGC TATGAACTCG 
TCACCTGTTT ACAGACTAGA CCACACATTT GAGCAAATAC CAAGCAGACA AAAGAAAATT 
TTAGAAGAAG CTCATGAATT GAGTGAAGAT CACTATAAGA AATATTTGGC AAAACTCAGG 
TCTATTAATC CACCGTGTGT GCCTTTCTTT GGAATTTATC TCACAAATAT CCTGAAGACA 
GAAGAGGGCA ACCCTGAGGT CCTGAGGAGA CACGGGAAAG AGCTTATTAA CTTCAGCAAG 
AGGAGGAGAG TGGCCGAGAT CACAGGCGAG ATCCAGCAGT ACCAGAACCA GCCCTACTGC 
TTACGGGTGG AGCCGGACAT CAAGAGGTTC TTTGAAAACT TGAATCCAAT GGGAAACAGC 
ATGGAGAAAG AATTTACAGA CTATCTGTTC AACAAATCCC TAGAAATAGA ACCCCGGCAC 
CCTAAGCCTC TTCCGAGATT CCCAAAAAAA TACAGCTATC CCCTAAAATC TCCTGGTGTT 
CGTCCATCAA ATCCAAGACC AGGAACCATG AGACATCCCA CACCTCTGCA GCAGGAGCCA 
AGAAAAATTA GCTACAGTCG GATTCCTGAA AGTGAGACGG AAAGCACAGC ATCTGCACCA 
AACTCCCCTC GGACCCCACT GACGCCGCCC CCTGCATCTG GCACCTCCAG CAACACAGAT 
GTTTGCAGCG TGTTCGATTC TGACCACTCG GCAAGCCCTT TTCATTCAAG ATCTGCTTCA 
GTCTCATCTA TAAGTTTATC CAAGGGCACT GATGAAGTGC CTGTCCCCCC TCCTGTACCC 
CCTCGAAGAC GTCCAGAGTC TGCCCCAGCT GAATCCTCCC CATCCAAGAT TATGTCTAAG 
CACTTGGACA GCCCCCCAGC TATTCCTCCT AGGCAACCCA CATCCAAAGC CTATTCACCA 
CGCTATTCAA TATCAGATCG GACCTCTATA TCAGATCCTC CTGAAAGCCC TCCCTTGTTA 
CCACCACGGG AACCTGTGAG GACACCTGAT GTTTTCTCAA GCTCACCATT ACATCTCCAA 
CCTCCTCCTT TGGGCAAAAA GAGTGATCAT GGCAACGCCT TCTTCCCAAA CAGCCCATCC 
CCTTTTACAC CGCCACCCCC CCAAACCCCC TCTCCTCATG GCACGAGAAG GCATCTGCCA 
TCACCACCAC TGACACAGGA GATGGACCTC CATTCCATTG CTGGGCCTCC TGTTCCTCCA 
CGACAAAGCA CTTCTCAACT TATCCCCAAA CTCCCTCCAA AAACTTACAA AAGGGAGCAC 
ACACACCCAT CCATGCATAG AGATGGACCA CCACTGCTGG AGAATGCCCA TTCTTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033257.2
CDS	531..4490
Translation	MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPAERIHHLLREVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSSNDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDILRPGFHGHFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECMKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASSAEYRLKEKFFMRKVQINDKDDTSEYKHAFEIILKDGNSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTVLQEEKEEQMRLPSAEVYRFAEPDSEENILFEENVQPKAGIPIIKAGTVLKLIERLTYHMYADPNFVRTFLTTYRSFCRPQELLSLLIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDADLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLRRHGKELINFSKRRRVAEITGEIQQYQNQPYCLRVEPDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRHPKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAPNSPRTPLTPPPASGTSSNTDVCSVFDSDHSASPFHSRSASVSSISLSKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISDRTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPPPQTPSPHGTRRHLPSPPLTQEMDLHSIAGPPVPPRQSTSQLIPKLPPKTYKREHTHPSMHRDGPPLLENAHSS

Target ORF information:

RefSeq Version	NM_009231.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus SOS Ras/Rac guanine nucleotide exchange factor 1 (Sos1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009231.2

ORF Insert Sequence:

ATGCAGGCGC AGCAGCTGCC TTACGAGTTT TTCAGCGAGG AGAACGCGCC CAAGTGGCGG 
GGGCTGCTGG TGCCTGCGCT GAAAAAGGTT CAGGGGCAAG TTCACCCTAC TCTTGAGTCT 
AATGATGATG CTCTTCAGTA TGTTGAAGAA TTAATTTTGC AATTACTAAA TATGCTATGC 
CAAGCTCAGC CCCGGAGTGC TTCAGATGTG GAGGAACGTG TTCAAAAGAG TTTTCCTCAT 
CCAATTGATA AGTGGGCAAT AGCTGATGCC CAATCAGCCA TTGAAAAGAG GAAGAGACGA 
AATCCTTTAT CGCTGCCAGC AGAAAGAATT CATCATTTAT TAAGGGAGGT CCTCGGTTAT 
AAAATTGACC ACCAGGTTTC TGTTTACATA GTAGCAGTAT TAGAATACAT TTCTGCAGAT 
ATTTTAAAGC TCGTGGGGAA TTATGTAAGA AATATACGGC ATTATGAAAT TACAAAACAA 
GACATTAAAG TGGCAATGTG TGCTGATAAG GTATTGATGG ATATGTTTCA TCAAGATGTA 
GAAGATATAA ATATCTTATC TTTAACTGAT GAAGAGCCTT CCACCTCAGG AGAACAAACT 
TATTATGATT TGGTAAAAGC ATTCATGGCA GAAATTCGAC AGTATATAAG AGAATTAAAT 
CTAATTATAA AAGTTTTTCG AGAGCCCTTT GTCTCTAATT CCAAATTGTT TTCATCTAAT 
GATGTAGAAA ACATATTCAG TCGTATAGTA GATATACATG AACTTAGTGT AAAGTTACTG 
GGCCATATAG AAGATACTGT AGAAATGACA GATGAAGGCA GTCCCCACCC ATTAGTAGGA 
AGCTGTTTTG AAGACTTAGC AGAAGAACTG GCATTTGACC CGTATGAGTC ATATGCTCGG 
GATATTTTAC GACCCGGATT CCATGGCCAT TTTCTTAGTC AGTTATCAAA GCCTGGGGCA 
GCACTTTATT TGCAGTCCAT AGGCGAAGGC TTCAAAGAAG CTGTCCAGTA CGTCCTGCCC 
CGGCTGCTGC TTGCCCCTGT GTACCACTGT CTGCATTACT TTGAACTTCT GAAGCAGTTA 
GAAGAAAAGA GTGAAGATCA AGAAGACAAG GAGTGTATGA AGCAAGCAAT AACAGCCCTG 
CTTAATGTCC AAAGTGGCAT GGAAAAAATT TGCTCCAAAA GTCTTGCAAA ACGAAGACTA 
AGTGAGTCTG CATGTCGGTT TTACAGCCAG CAGATGAAGG GGAAACAGCT AGCCATCAAG 
AAGATGAACG AGATCCAGAA GAACATTGAT GGCTGGGAGG GGAAGGACAT TGGACAGTGT 
TGCAATGAGT TCATAATGGA AGGAACTCTT ACACGTGTAG GAGCCAAACA CGAGAGACAC 
ATATTTCTCT TCGATGGCTT AATGATTTGC TGTAAATCAA ACCATGGGCA GCCAAGACTC 
CCTGGTGCTA GCAGTGCAGA ATACCGGCTT AAAGAAAAGT TTTTTATGCG AAAGGTACAG 
ATTAATGATA AAGATGACAC CAGTGAGTAC AAGCATGCTT TTGAAATCAT TCTGAAAGAT 
GGCAATAGTG TTATATTTTC TGCCAAGTCA GCTGAAGAGA AAAACAACTG GATGGCAGCA 
CTGATCTCTT TGCAGTACCG CAGCACCCTG GAGAGGATGC TGGACGTAAC GGTGCTGCAG 
GAGGAGAAGG AGGAGCAGAT GAGGCTGCCC AGTGCTGAAG TGTACAGGTT TGCAGAACCT 
GACTCCGAGG AGAATATTCT ATTCGAAGAG AATGTGCAGC CCAAAGCTGG GATCCCCATT 
ATCAAGGCAG GGACAGTGCT TAAGCTCATT GAGAGGCTTA CCTACCACAT GTACGCAGAT 
CCAAATTTTG TTCGGACGTT TCTTACAACA TACAGGTCCT TTTGCAGACC TCAAGAACTA 
CTGAGTCTTC TGATAGAAAG ATTTGAAATT CCAGAGCCTG AGCCAACAGA AGCTGATCGC 
ATAGCTATAG AGAATGGAGA TCAGCCCCTG AGTGCAGAGC TGAAGAGGTT TAGAAAGGAA 
TATATTCAGC CTGTGCAGTT GAGGGTGTTA AATGTGTGTC GGCACTGGGT GGAGCACCAT 
TTCTATGACT TTGAAAGAGA TGCAGACCTT TTACAGAGAA TGGAGGAATT TATTGGAACA 
GTAAGAGGTA AAGCAATGAA AAAATGGGTC GAATCCATCA CTAAGATAAT CCAAAGGAAA 
AAAATTGCAA GAGACAATGG CCCAGGTCAT AACATTACAT TTCAGAGCTC ACCTCCCACA 
GTTGAGTGGC ACATAAGCAG ACCTGGGCAC ATAGAGACTT TTGACTTGCT CACCTTACAC 
CCAATAGAAA TTGCTCGGCA ACTCACTTTA CTTGAATCAG ATCTATACCG GGCTGTGCAG 
CCATCAGAAT TAGTTGGAAG TGTGTGGACA AAAGAAGATA AAGAAATTAA TTCTCCCAAC 
CTTCTGAAGA TGATTCGGCA CACCACTAAC CTCACTTTGT GGTTTGAGAA ATGTATTGTA 
GAAACAGAAA ACTTAGAAGA AAGAGTAGCT GTAGTAAGTC GGATAATTGA GATTCTACAA 
GTCTTTCAAG AGCTGAACAA CTTCAATGGT GTCCTGGAAG TTGTCAGTGC TATGAACTCG 
TCACCTGTTT ACAGACTAGA CCACACATTT GAGCAAATAC CAAGCAGACA AAAGAAAATT 
TTAGAAGAAG CTCATGAATT GAGTGAAGAT CACTATAAGA AATATTTGGC AAAACTCAGG 
TCTATTAATC CACCGTGTGT GCCTTTCTTT GGAATTTATC TCACAAATAT CCTGAAGACA 
GAAGAGGGCA ACCCTGAGGT CCTGAGGAGA CACGGGAAAG AGCTTATTAA CTTCAGCAAG 
AGGAGGAGAG TGGCCGAGAT CACAGGCGAG ATCCAGCAGT ACCAGAACCA GCCCTACTGC 
TTACGGGTGG AGCCGGACAT CAAGAGGTTC TTTGAAAACT TGAATCCAAT GGGAAACAGC 
ATGGAGAAAG AATTTACAGA CTATCTGTTC AACAAATCCC TAGAAATAGA ACCCCGGCAC 
CCTAAGCCTC TTCCGAGATT CCCAAAAAAA TACAGCTATC CCCTAAAATC TCCTGGTGTT 
CGTCCATCAA ATCCAAGACC AGGAACCATG AGACATCCCA CACCTCTGCA GCAGGAGCCA 
AGAAAAATTA GCTACAGTCG GATTCCTGAA AGTGAGACGG AAAGCACAGC ATCTGCACCA 
AACTCCCCTC GGACCCCACT GACGCCGCCC CCTGCATCTG GCACCTCCAG CAACACAGAT 
GTTTGCAGCG TGTTCGATTC TGACCACTCG GCAAGCCCTT TTCATTCAAG ATCTGCTTCA 
GTCTCATCTA TAAGTTTATC CAAGGGCACT GATGAAGTGC CTGTCCCCCC TCCTGTACCC 
CCTCGAAGAC GTCCAGAGTC TGCCCCAGCT GAATCCTCCC CATCCAAGAT TATGTCTAAG 
CACTTGGACA GCCCCCCAGC TATTCCTCCT AGGCAACCCA CATCCAAAGC CTATTCACCA 
CGCTATTCAA TATCAGATCG GACCTCTATA TCAGATCCTC CTGAAAGCCC TCCCTTGTTA 
CCACCACGGG AACCTGTGAG GACACCTGAT GTTTTCTCAA GCTCACCATT ACATCTCCAA 
CCTCCTCCTT TGGGCAAAAA GAGTGATCAT GGCAACGCCT TCTTCCCAAA CAGCCCATCC 
CCTTTTACAC CGCCACCCCC CCAAACCCCC TCTCCTCATG GCACGAGAAG GCATCTGCCA 
TCACCACCAC TGACACAGGA GATGGACCTC CATTCCATTG CTGGGCCTCC TGTTCCTCCA 
CGACAAAGCA CTTCTCAACT TATCCCCAAA CTCCCTCCAA AAACTTACAA AAGGGAGCAC 
ACACACCCAT CCATGCATAG AGATGGACCA CCACTGCTGG AGAATGCCCA TTCTTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs.
Oncogene35(50)6389-6402(2016 Dec)
Liceras-Boillos P,Garc?a-Navas R,Ginel-Picardo A,Anta B,P?rez-Andr?s M,Lillo C,G?mez C,Jimeno D,Fern?ndez-Medarde A,Baltan?s FC,Santos E

Sos1 Regulates Macrophage Podosome Assembly and Macrophage Invasive Capacity.
Journal of immunology (Baltimore, Md. : 1950)195(10)4900-12(2015 Nov)
Baruzzi A,Remelli S,Lorenzetto E,Sega M,Chignola R,Berton G

Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T?cells leads to PI3K pathway activation and defects in migration.
European journal of immunology45(8)2389-95(2015 Aug)
Guittard G,Kortum RL,Balagopalan L,?uburu N,Nguyen P,Sommers CL,Samelson LE

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Sos1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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