Plk2 cDNA ORF clone, Mus musculus(house mouse)

Polo-like kinase 2 modulates ?-synuclein protein levels by regulating its mRNA production.
Kofoed RH, Zheng J, Ferreira N, Lykke-Andersen S, Salvi M, Betzer C, Reimer L, Jensen TH, Fog K, Jensen PH
Neurobiology of disease10649-62(2017 Oct)

Polo-Like Kinase 2 is Dynamically Regulated to Coordinate Proliferation and Early Lineage Specification Downstream of Yes-Associated Protein 1 in Cardiac Progenitor Cells.
Mochizuki M, Lorenz V, Ivanek R, Della Verde G, Gaudiello E, Marsano A, Pfister O, Kuster GM
Journal of the American Heart Association6(10)(2017 Oct)

Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development.
Stopp S, Gr?ndl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S
Proceedings of the National Academy of Sciences of the United States of America114(30)8029-8034(2017 Jul)

MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression.
Deng S, Wang H, Jia C, Zhu S, Chu X, Ma Q, Wei J, Chen E, Zhu W, Macon CJ, Jayaweera DT, Dykxhoorn DM, Dong C
Arteriosclerosis, thrombosis, and vascular biology37(2)280-290(2017 Feb)

miR-146a regulates lineage negative bone marrow cell senescence and apoptosis by suppressing Plk2 expression that, in turn, activates p16Ink4a/p19Arf and p53 signaling.
Title: MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression.

PLK2, functional kinase and polo-box domains were required for interaction with PFV Gag. Fluorescently-tagged PFV Gag, through its chromatin tethering function, selectively relocalized ectopically expressed eGFP-tagged PLK proteins to mitotic chromosomes i
Title: Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.

In support of a tumor suppressor function for Plk2, loss of Plk2 increased the formation of lesions in multiparous glands. Collectively, these results demonstrate a novel role for Plk2 in regulating mammary gland development.
Title: Plk2 regulates mitotic spindle orientation and mammary gland development.

These results support a significant role for a PLK kinase in phosphorylating alpha-synuclein at Ser129 in the brain, and suggest that PLK2 is responsible for this activity under physiological conditions.
Title: In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 ?-synuclein phosphorylation in mouse brain.

PLK2 inhibition is a tractable CNS pharmacological target that does not cause genotoxicity at doses and exposures that engage the target in the sensory retina.
Title: Pharmacological inhibition of polo like kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei.