Slc31a2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc31a2
Entrez Gene ID	20530
Full Name	solute carrier family 31, member 2
Synonyms	AI604396,CTR2
General protein information	Preferred Names solute carrier family 31, member 2 Names probable low affinity copper uptake protein 2 copper transporter 2 solute carrier family 31 (copper transporters), member 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001290518.1	NP_001277447.1	probable low affinity copper uptake protein 2 isoform 2
XM_006537712.2	XP_006537775.1	probable low affinity copper uptake protein 2 isoform X1
NM_025286.3	NP_079562.1	probable low affinity copper uptake protein 2 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SLC31A2	XP_005626991.1
Rattus norvegicus (Norway rat)	Slc31a2	NP_001028865.2
Gallus gallus (chicken)	SLC31A2	NP_001264614.1
Xenopus tropicalis (tropical clawed frog)	slc31a2	XP_002937270.1
Mus musculus (house mouse)	Slc31a2	NP_079562.1
Danio rerio (zebrafish)	slc31a2	NP_001185678.1
Pan troglodytes (chimpanzee)	SLC31A2	XP_003951552.1
Bos taurus (cattle)	SLC31A2	NP_001029728.1
Homo sapiens (human)	SLC31A2	NP_001851.1
	SLC31A2	XP_001103504.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.
Logeman BL, Wood LK, Lee J, Thiele DJ
The Journal of biological chemistry292(27)11531-11546(2017 07)

Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans.
?hrvik H, Logeman B, Noguchi G, Eriksson I, Kjell?n L, Thiele DJ, Pejler G
Journal of immunology (Baltimore, Md. : 1950)195(8)3654-64(2015 Oct)

Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin.
Huang CP, Fofana M, Chan J, Chang CJ, Howell SB
Metallomics : integrated biometal science6(3)654-61(2014 Mar)

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.
?hrvik H, Nose Y, Wood LK, Kim BE, Gleber SC, Ralle M, Thiele DJ
Proceedings of the National Academy of Sciences of the United States of America110(46)E4279-88(2013 Nov)

Pancreatic islet and progenitor cell surface markers with cell sorting potential.
Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-R?nne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD
Diabetologia55(1)154-65(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2
Title: Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.

The increase in granular staining and heparin content is compatible with an impact of Ctr2 on mast cell maturation and, in support of this, the absence of Ctr2 resulted in markedly increased mRNA expression, storage, and enzymatic activity of tryptase.
Title: Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans.

In mouse embryo fibroblasts, reduction of CTR1 expression renders cells resistant to cisplatin whereas reduction of CTR2 makes them hypersensitive both in vitro and in vivo.
Title: Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin.

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.
Title: Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.

Copper transporter 2 regulates the transport of cisplatin through control of the rate of macropinocytosis.
Title: Copper transporter 2 regulates endocytosis and controls tumor growth and sensitivity to cisplatin in vivo.

The following Slc31a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc31a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu13919	NM_025286.3 Latest version!	Mus musculus solute carrier family 31, member 2 (Slc31a2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu16993	NM_001290518.1 Latest version!	Mus musculus solute carrier family 31, member 2 (Slc31a2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu16993	XM_006537712.2 Latest version!	Mus musculus solute carrier family 31, member 2 (Slc31a2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc31a2 ( NM_025286.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_079562.1 Mus musculus solute carrier family 31, member 2 (Slc31a2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13919
Clone ID Related Accession (Same CDS sequence)	NM_025286.3
Accession Version	NM_025286.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 432bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	probable low affinity copper uptake protein 2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB853212.1, BC029183.1 and BY482108.1. On Mar 14, 2014 this sequence version replaced NM_025286.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK008473.1, AK007579.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGATGC ATTTCATCTT CTCAGATGAG GCCGTGCTTC TCTTTGATTT CTGGAGGGTC 
CACAGCCCTA CAGGCATGGC TCTCTCAGTG CTGGTAGTCT TGCTCCTGGC AGTACTGTAT 
GAGGGCATCA AGGTTGGCAA AGCCAAATTG CTCCACAAGA CTCTGGAGAG CCTGCCTGCC 
ACCAACAGCC AGCAGTTCAT CTTGGGACCA GACCAGGATT CTACAGGCTC CAGATCAACT 
TCAGACAATA GGACCCGCCT CAGGTGGTTT TTGTGTTACT TTGGCCAGTC CCTAGTCCAT 
GTCATTCAGG TGGTAATTGG CTACTTTGTG ATGCTGGCTG TCATGTCCTA CAACACCTGG 
ATTTTCCTCG GTGTGGTCCT GGGCTCGGCT GTGGGCTACT ACCTAGCCTA CCCACTTCTC 
AACATGACTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079562.1
CDS	141..572
Translation	MPMHFIFSDEAVLLFDFWRVHSPTGMALSVLVVLLLAVLYEGIKVGKAKLLHKTLESLPATNSQQFILGPDQDSTGSRSTSDNRTRLRWFLCYFGQSLVHVIQVVIGYFVMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLNMT

Target ORF information:

RefSeq Version	NM_025286.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 31, member 2 (Slc31a2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025286.3

ORF Insert Sequence:

ATGCCGATGC ATTTCATCTT CTCAGATGAG GCCGTGCTTC TCTTTGATTT CTGGAGGGTC 
CACAGCCCTA CAGGCATGGC TCTCTCAGTG CTGGTAGTCT TGCTCCTGGC AGTACTGTAT 
GAGGGCATCA AGGTTGGCAA AGCCAAATTG CTCCACAAGA CTCTGGAGAG CCTGCCTGCC 
ACCAACAGCC AGCAGTTCAT CTTGGGACCA GACCAGGATT CTACAGGCTC CAGATCAACT 
TCAGACAATA GGACCCGCCT CAGGTGGTTT TTGTGTTACT TTGGCCAGTC CCTAGTCCAT 
GTCATTCAGG TGGTAATTGG CTACTTTGTG ATGCTGGCTG TCATGTCCTA CAACACCTGG 
ATTTTCCTCG GTGTGGTCCT GGGCTCGGCT GTGGGCTACT ACCTAGCCTA CCCACTTCTC 
AACATGACTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc31a2 ( NM_001290518.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001277447.1 Mus musculus solute carrier family 31, member 2 (Slc31a2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu16993
Clone ID Related Accession (Same CDS sequence)	NM_001290518.1 , XM_006537712.2
Accession Version	NM_001290518.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	probable low affinity copper uptake protein 2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK015878.1, BC029183.1 and BY482108.1. On Mar 14, 2014 this sequence version replaced XM_006537713.1. Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK015878.1, BY715432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCATTTCA TCTTCTCAGA TGAGGCCGTG CTTCTCTTTG ATTTCTGGAG GGTCCACAGC 
CCTACAGGCA TGGCTCTCTC AGTGCTGGTA GTCTTGCTCC TGGCAGTACT GTATGAGGGC 
ATCAAGGTTG GCAAAGCCAA ATTGCTCCAC AAGACTCTGG AGAGCCTGCC TGCCACCAAC 
AGCCAGCAGT TCATCTTGGG ACCAGACCAG GATTCTACAG GCTCCAGATC AACTTCAGAC 
AATAGGACCC GCCTCAGGTG GTTTTTGTGT TACTTTGGCC AGTCCCTAGT CCATGTCATT 
CAGGTGGTAA TTGGCTACTT TGTGATGCTG GCTGTCATGT CCTACAACAC CTGGATTTTC 
CTCGGTGTGG TCCTGGGCTC GGCTGTGGGC TACTACCTAG CCTACCCACT TCTCAACATG 
ACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277447.1
CDS	109..534
Translation	MHFIFSDEAVLLFDFWRVHSPTGMALSVLVVLLLAVLYEGIKVGKAKLLHKTLESLPATNSQQFILGPDQDSTGSRSTSDNRTRLRWFLCYFGQSLVHVIQVVIGYFVMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLNMT

Target ORF information:

RefSeq Version	NM_001290518.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 31, member 2 (Slc31a2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001290518.1

ORF Insert Sequence:

ATGCATTTCA TCTTCTCAGA TGAGGCCGTG CTTCTCTTTG ATTTCTGGAG GGTCCACAGC 
CCTACAGGCA TGGCTCTCTC AGTGCTGGTA GTCTTGCTCC TGGCAGTACT GTATGAGGGC 
ATCAAGGTTG GCAAAGCCAA ATTGCTCCAC AAGACTCTGG AGAGCCTGCC TGCCACCAAC 
AGCCAGCAGT TCATCTTGGG ACCAGACCAG GATTCTACAG GCTCCAGATC AACTTCAGAC 
AATAGGACCC GCCTCAGGTG GTTTTTGTGT TACTTTGGCC AGTCCCTAGT CCATGTCATT 
CAGGTGGTAA TTGGCTACTT TGTGATGCTG GCTGTCATGT CCTACAACAC CTGGATTTTC 
CTCGGTGTGG TCCTGGGCTC GGCTGTGGGC TACTACCTAG CCTACCCACT TCTCAACATG 
ACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc31a2 ( XM_006537712.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006537775.1 Mus musculus solute carrier family 31, member 2 (Slc31a2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu16993
Clone ID Related Accession (Same CDS sequence)	NM_001290518.1 , XM_006537712.2
Accession Version	XM_006537712.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	probable low affinity copper uptake protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006537712.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCATTTCA TCTTCTCAGA TGAGGCCGTG CTTCTCTTTG ATTTCTGGAG GGTCCACAGC 
CCTACAGGCA TGGCTCTCTC AGTGCTGGTA GTCTTGCTCC TGGCAGTACT GTATGAGGGC 
ATCAAGGTTG GCAAAGCCAA ATTGCTCCAC AAGACTCTGG AGAGCCTGCC TGCCACCAAC 
AGCCAGCAGT TCATCTTGGG ACCAGACCAG GATTCTACAG GCTCCAGATC AACTTCAGAC 
AATAGGACCC GCCTCAGGTG GTTTTTGTGT TACTTTGGCC AGTCCCTAGT CCATGTCATT 
CAGGTGGTAA TTGGCTACTT TGTGATGCTG GCTGTCATGT CCTACAACAC CTGGATTTTC 
CTCGGTGTGG TCCTGGGCTC GGCTGTGGGC TACTACCTAG CCTACCCACT TCTCAACATG 
ACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006537775.1
CDS	66..491
Translation	MHFIFSDEAVLLFDFWRVHSPTGMALSVLVVLLLAVLYEGIKVGKAKLLHKTLESLPATNSQQFILGPDQDSTGSRSTSDNRTRLRWFLCYFGQSLVHVIQVVIGYFVMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLNMT

Target ORF information:

RefSeq Version	XM_006537712.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 31, member 2 (Slc31a2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006537712.2

ORF Insert Sequence:

ATGCATTTCA TCTTCTCAGA TGAGGCCGTG CTTCTCTTTG ATTTCTGGAG GGTCCACAGC 
CCTACAGGCA TGGCTCTCTC AGTGCTGGTA GTCTTGCTCC TGGCAGTACT GTATGAGGGC 
ATCAAGGTTG GCAAAGCCAA ATTGCTCCAC AAGACTCTGG AGAGCCTGCC TGCCACCAAC 
AGCCAGCAGT TCATCTTGGG ACCAGACCAG GATTCTACAG GCTCCAGATC AACTTCAGAC 
AATAGGACCC GCCTCAGGTG GTTTTTGTGT TACTTTGGCC AGTCCCTAGT CCATGTCATT 
CAGGTGGTAA TTGGCTACTT TGTGATGCTG GCTGTCATGT CCTACAACAC CTGGATTTTC 
CTCGGTGTGG TCCTGGGCTC GGCTGTGGGC TACTACCTAG CCTACCCACT TCTCAACATG 
ACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.
The Journal of biological chemistry292(27)11531-11546(2017 07)
Logeman BL,Wood LK,Lee J,Thiele DJ

Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans.
Journal of immunology (Baltimore, Md. : 1950)195(8)3654-64(2015 Oct)
?hrvik H,Logeman B,Noguchi G,Eriksson I,Kjell?n L,Thiele DJ,Pejler G

Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin.
Metallomics : integrated biometal science6(3)654-61(2014 Mar)
Huang CP,Fofana M,Chan J,Chang CJ,Howell SB

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.
Proceedings of the National Academy of Sciences of the United States of America110(46)E4279-88(2013 Nov)
?hrvik H,Nose Y,Wood LK,Kim BE,Gleber SC,Ralle M,Thiele DJ

Pancreatic islet and progenitor cell surface markers with cell sorting potential.
Diabetologia55(1)154-65(2012 Jan)
Hald J,Galbo T,Rescan C,Radzikowski L,Sprinkel AE,Heimberg H,Ahnfelt-R?nne J,Jensen J,Scharfmann R,Gradwohl G,Kaestner KH,Stoeckert C Jr,Jensen JN,Madsen OD

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Slc31a2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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