Slc22a1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc22a1
Entrez Gene ID	20517
Full Name	solute carrier family 22 (organic cation transporter), member 1
Synonyms	Lx1,Oct1,Orct,Orct1
General protein information	Preferred Names solute carrier family 22 (organic cation transporter), member 1 Names solute carrier family 22 member 1 mOCT1 organic cation transporter 1 solute carrier family 22, member 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 A1\|17 8.63 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009202.5	NP_033228.2	solute carrier family 22 member 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC22A1	NP_003048.1
Pan troglodytes (chimpanzee)	SLC22A1	XP_001151564.2
Bos taurus (cattle)	SLC22A1	NP_001094568.1
Rattus norvegicus (Norway rat)	Slc22a1	NP_036829.1
	LOC703449	XP_001099030.2
Canis lupus familiaris (dog)	SLC22A1	XP_005615754.1
Mus musculus (house mouse)	Slc22a1	NP_033228.2

Gene Ontology
Bibliography

Related articles in PubMed

A phosphotyrosine switch regulates organic cation transporters.
Sprowl JA, Ong SS, Gibson AA, Hu S, Du G, Lin W, Li L, Bharill S, Ness RA, Stecula A, Offer SM, Diasio RB, Nies AT, Schwab M, Cavaletti G, Schlatter E, Ciarimboli G, Schellens JH, Isacoff EY, Sali A, Chen T, Baker SD, Sparreboom A, Pabla N
Nature communications710880(2016 Mar)

Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions.
Pabla N, Gibson AA, Buege M, Ong SS, Li L, Hu S, Du G, Sprowl JA, Vasilyeva A, Janke LJ, Schlatter E, Chen T, Ciarimboli G, Sparreboom A
Proceedings of the National Academy of Sciences of the United States of America112(16)5231-6(2015 Apr)

Mouse organic cation transporter 1 determines properties and regulation of basolateral organic cation transport in renal proximal tubules.
Schlatter E, Klassen P, Massmann V, Holle SK, Guckel D, Edemir B, Pavenst?dt H, Ciarimboli G
Pflugers Archiv : European journal of physiology466(8)1581-9(2014 Aug)

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM
Proceedings of the National Academy of Sciences of the United States of America111(27)9983-8(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we unraveled substrate affinities and modulation of transport activity by acute regulation by protein kinases on mOCT1 and mOCT2
Title: Mouse organic cation transporter 1 determines properties and regulation of basolateral organic cation transport in renal proximal tubules.

Data indicate that the expression of the organic cation transporters Slc22a1, Slc22a2 and Slc22a3 essential for the cellular uptake of metformin was highly suppressed in Tsc1+/-renal tumours.
Title: Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin.

Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen.
Title: Luminal cholinergic signalling in airway lining fluid: a novel mechanism for activating chloride secretion via Ca??-dependent Cl? and K? channels.

The influence of organic cation transporters 1, 2, and 3 (OCT1, OCT2, and OCT3) and their genetic variants on cellular uptake of picoplatin and on the individual components of the ensuing cytotoxicity such as DNA adduct formation, was determined.
Title: Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.

the interaction of glucocorticoid receptor with Oct-1 on the beta-casein gene promoter
Title: Oct-1 functions as a transactivator in the hormonal induction of beta-casein gene expression.

The following Slc22a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc22a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03710	NM_009202.5 Latest version!	Mus musculus solute carrier family 22 (organic cation transporter), member 1 (Slc22a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$328.30 $469.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc22a1 ( NM_009202.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033228.2 Mus musculus solute carrier family 22 (organic cation transporter), member 1 (Slc22a1), mRNA.

Price & Availability↑

CloneID	OMu03710
Clone ID Related Accession (Same CDS sequence)	NM_009202.5
Accession Version	NM_009202.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1671bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	solute carrier family 22 member 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC167817.4. On Oct 19, 2007 this sequence version replaced NM_009202.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC021651.1, AF010259.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END##

ATGCCCACCG TGGACGATGT CCTGGAGCAC GTTGGAGAGT TTGGCTGGTT CCAGAAGCAA 
GCCTTCCTGT TGCTATGCCT GATCTCAGCT TCTTTAGCTC CCATCTACGT GGGCATCGTT 
TTCCTGGGCT TCACCCCCGA CCACCACTGC CGGAGTCCTG GAGTGGCCGA GCTGAGCCAG 
CGGTGTGGCT GGAGCCCGGC AGAGGAGCTG AACTACACCG TGCCGGGCCT GGGGTCTGCG 
GGTGAGGCCT CCTTCCTCAG CCAATGCATG AAGTATGAGG TGGACTGGAA CCAGAGCACC 
CTTGACTGTG TGGACCCACT GTCCAGCCTG GCTGCCAACA GGAGCCACTT GCCACTGAGC 
CCCTGCGAGC ATGGCTGGGT GTACGACACT CCCGGCTCCT CCATCGTCAC TGAGTTTAAC 
CTGGTGTGTG GAGACGCCTG GAAAGTGGAC CTTTTTCAGT CCTGTGTGAA CTTGGGCTTC 
TTCCTGGGCT CCCTGGTTGT GGGTTACATT GCAGACAGGT TTGGCCGTAA GCTCTGCCTC 
CTGGTGACCA CTCTGGTCAC CTCCCTGTCT GGCGTGTTAA CAGCGGTGGC CCCAGACTAT 
ACATCCATGT TGCTCTTTCG CCTTCTGCAA GGCATGGTCA GCAAAGGCAG CTGGGTGTCT 
GGCTACACCT TGATCACAGA GTTTGTCGGC TCTGGCTACA GGAGAACGAC AGCCATCTTG 
TACCAGGTGG CCTTCACAGT GGGGCTAGTG GGGCTTGCTG GGGTGGCCTA TGCCATTCCA 
GACTGGCGCT GGCTCCAGCT GGCGGTGTCC CTGCCCACCT TCCTCTTCCT GCTGTATTAC 
TGGTTTGTCC CAGAATCCCC CCGGTGGCTG TTGTCTCAGA AGAGAACCAC TCAAGCGGTA 
AGGATAATGG AGCAAATTGC ACAGAAGAAC AGGAAGGTGC CCCCTGCTGA CCTGAAGATG 
ATGTGCCTTG AGGAAGATGC CTCAGAGAGG CGGAGTCCTT CGTTTGCAGA CCTGTTCCGC 
ACCCCCAGCC TGAGGAAGCA CACCCTCATC CTGATGTATC TATGGTTCTC TTGTGCTGTG 
CTGTACCAGG GCCTCATCAT GCATGTGGGA GCCACAGGGG CCAACCTCTA CCTGGACTTC 
TTTTATTCTT CTCTAGTGGA ATTCCCTGCG GCCTTTATCA TCCTTGTCAC CATTGACCGC 
ATTGGCCGCA TCTACCCAAT AGCGGCATCA AATCTGGTGG CGGGGGCAGC CTGCCTCCTC 
ATGATCTTTA TCCCACATGA GCTGCATTGG TTGAATGTGA CCCTCGCTTG TCTTGGCCGT 
ATGGGAGCCA CCATTGTGTT GCAGATGGTC TGCCTAGTGA ACGCTGAGCT GTACCCTACA 
TTCATCAGGA ATCTCGGGAT GATGGTGTGC TCTGCCCTGT GTGACCTAGG TGGGATCTTC 
ACCCCCTTCA TGGTGTTCAG GCTGATGGAA GTTTGGCAAG CCCTGCCCCT CATTTTGTTT 
GGGGTTTTGG GCCTGAGTGC TGGGGCTGTG ACCCTTCTAC TTCCGGAGAC CAAGGGCGTG 
GCTCTGCCTG AGACTATTGA AGAAGCGGAG AACCTGGGAA GGAGGAAATC AAAGGCCAAA 
GAAAACACGA TTTACCTTCA GGTCCAAACA GGCAAATCCC CACATACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033228.2
CDS	180..1850
Translation	MPTVDDVLEHVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPDHHCRSPGVAELSQRCGWSPAEELNYTVPGLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCEHGWVYDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSLSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQVAFTVGLVGLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKNRKVPPADLKMMCLEEDASERRSPSFADLFRTPSLRKHTLILMYLWFSCAVLYQGLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIPHELHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLSAGAVTLLLPETKGVALPETIEEAENLGRRKSKAKENTIYLQVQTGKSPHT

Target ORF information:

RefSeq Version	NM_009202.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 22 (organic cation transporter), member 1 (Slc22a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009202.5

ORF Insert Sequence:

ATGCCCACCG TGGACGATGT CCTGGAGCAC GTTGGAGAGT TTGGCTGGTT CCAGAAGCAA 
GCCTTCCTGT TGCTATGCCT GATCTCAGCT TCTTTAGCTC CCATCTACGT GGGCATCGTT 
TTCCTGGGCT TCACCCCCGA CCACCACTGC CGGAGTCCTG GAGTGGCCGA GCTGAGCCAG 
CGGTGTGGCT GGAGCCCGGC AGAGGAGCTG AACTACACCG TGCCGGGCCT GGGGTCTGCG 
GGTGAGGCCT CCTTCCTCAG CCAATGCATG AAGTATGAGG TGGACTGGAA CCAGAGCACC 
CTTGACTGTG TGGACCCACT GTCCAGCCTG GCTGCCAACA GGAGCCACTT GCCACTGAGC 
CCCTGCGAGC ATGGCTGGGT GTACGACACT CCCGGCTCCT CCATCGTCAC TGAGTTTAAC 
CTGGTGTGTG GAGACGCCTG GAAAGTGGAC CTTTTTCAGT CCTGTGTGAA CTTGGGCTTC 
TTCCTGGGCT CCCTGGTTGT GGGTTACATT GCAGACAGGT TTGGCCGTAA GCTCTGCCTC 
CTGGTGACCA CTCTGGTCAC CTCCCTGTCT GGCGTGTTAA CAGCGGTGGC CCCAGACTAT 
ACATCCATGT TGCTCTTTCG CCTTCTGCAA GGCATGGTCA GCAAAGGCAG CTGGGTGTCT 
GGCTACACCT TGATCACAGA GTTTGTCGGC TCTGGCTACA GGAGAACGAC AGCCATCTTG 
TACCAGGTGG CCTTCACAGT GGGGCTAGTG GGGCTTGCTG GGGTGGCCTA TGCCATTCCA 
GACTGGCGCT GGCTCCAGCT GGCGGTGTCC CTGCCCACCT TCCTCTTCCT GCTGTATTAC 
TGGTTTGTCC CAGAATCCCC CCGGTGGCTG TTGTCTCAGA AGAGAACCAC TCAAGCGGTA 
AGGATAATGG AGCAAATTGC ACAGAAGAAC AGGAAGGTGC CCCCTGCTGA CCTGAAGATG 
ATGTGCCTTG AGGAAGATGC CTCAGAGAGG CGGAGTCCTT CGTTTGCAGA CCTGTTCCGC 
ACCCCCAGCC TGAGGAAGCA CACCCTCATC CTGATGTATC TATGGTTCTC TTGTGCTGTG 
CTGTACCAGG GCCTCATCAT GCATGTGGGA GCCACAGGGG CCAACCTCTA CCTGGACTTC 
TTTTATTCTT CTCTAGTGGA ATTCCCTGCG GCCTTTATCA TCCTTGTCAC CATTGACCGC 
ATTGGCCGCA TCTACCCAAT AGCGGCATCA AATCTGGTGG CGGGGGCAGC CTGCCTCCTC 
ATGATCTTTA TCCCACATGA GCTGCATTGG TTGAATGTGA CCCTCGCTTG TCTTGGCCGT 
ATGGGAGCCA CCATTGTGTT GCAGATGGTC TGCCTAGTGA ACGCTGAGCT GTACCCTACA 
TTCATCAGGA ATCTCGGGAT GATGGTGTGC TCTGCCCTGT GTGACCTAGG TGGGATCTTC 
ACCCCCTTCA TGGTGTTCAG GCTGATGGAA GTTTGGCAAG CCCTGCCCCT CATTTTGTTT 
GGGGTTTTGG GCCTGAGTGC TGGGGCTGTG ACCCTTCTAC TTCCGGAGAC CAAGGGCGTG 
GCTCTGCCTG AGACTATTGA AGAAGCGGAG AACCTGGGAA GGAGGAAATC AAAGGCCAAA 
GAAAACACGA TTTACCTTCA GGTCCAAACA GGCAAATCCC CACATACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A phosphotyrosine switch regulates organic cation transporters.
Nature communications710880(2016 Mar)
Sprowl JA,Ong SS,Gibson AA,Hu S,Du G,Lin W,Li L,Bharill S,Ness RA,Stecula A,Offer SM,Diasio RB,Nies AT,Schwab M,Cavaletti G,Schlatter E,Ciarimboli G,Schellens JH,Isacoff EY,Sali A,Chen T,Baker SD,Sparreboom A,Pabla N

Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions.
Proceedings of the National Academy of Sciences of the United States of America112(16)5231-6(2015 Apr)
Pabla N,Gibson AA,Buege M,Ong SS,Li L,Hu S,Du G,Sprowl JA,Vasilyeva A,Janke LJ,Schlatter E,Chen T,Ciarimboli G,Sparreboom A

Mouse organic cation transporter 1 determines properties and regulation of basolateral organic cation transport in renal proximal tubules.
Pflugers Archiv : European journal of physiology466(8)1581-9(2014 Aug)
Schlatter E,Klassen P,Massmann V,Holle SK,Guckel D,Edemir B,Pavenst?dt H,Ciarimboli G

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Proceedings of the National Academy of Sciences of the United States of America111(27)9983-8(2014 Jul)
Chen L,Shu Y,Liang X,Chen EC,Yee SW,Zur AA,Li S,Xu L,Keshari KR,Lin MJ,Chien HC,Zhang Y,Morrissey KM,Liu J,Ostrem J,Younger NS,Kurhanewicz J,Shokat KM,Ashrafi K,Giacomini KM

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Slc22a1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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