Shc3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Shc3
Entrez Gene ID	20418
Full Name	src homology 2 domain-containing transforming protein C3
Synonyms	N-Shc,Rai,ShcC
General protein information	Preferred Names src homology 2 domain-containing transforming protein C3 Names SHC-transforming protein 3 SH2 domain protein C3 SHC-transforming protein C neuronal Shc
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 A5\|13 26.12 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009167.4	NP_033193.2	SHC-transforming protein 3
NM_009167.5	NP_033193.3	SHC-transforming protein 3
NM_009167.3	NP_033193.2	SHC-transforming protein 3

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SHC3	XP_002683725.2
Xenopus tropicalis (tropical clawed frog)	shc3	NP_001093734.1
Gallus gallus (chicken)	SHC3	XP_004949302.1
Danio rerio (zebrafish)	LOC100332111	XP_002665883.2
Canis lupus familiaris (dog)	SHC3	XP_533553.3
Rattus norvegicus (Norway rat)	Shc3	NP_001099213.1
Homo sapiens (human)	SHC3	NP_058544.3
Pan troglodytes (chimpanzee)	SHC3	XP_520118.2
	SHC3	XP_001089267.1
Mus musculus (house mouse)	Shc3	NP_033193.2

Gene Ontology
Bibliography

Related articles in PubMed

Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia.
Heng X, Guo Q, Leung AW, Li JY
eLife6(2017 May)

NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease.
Triaca V, Sposato V, Bolasco G, Ciotti MT, Pelicci P, Bruni AC, Cupidi C, Maletta R, Feligioni M, Nistic? R, Canu N, Calissano P
Aging cell15(4)661-72(2016 Aug)

The Adaptor Protein Rai/ShcC Promotes Astrocyte-Dependent Inflammation during Experimental Autoimmune Encephalomyelitis.
Ulivieri C, Savino MT, Luccarini I, Fanigliulo E, Aldinucci A, Bonechi E, Benagiano M, Ortensi B, Pelicci G, D'Elios MM, Ballerini C, Baldari CT
Journal of immunology (Baltimore, Md. : 1950)197(2)480-90(2016 07)

Canonical Notch signaling plays an instructive role in auditory supporting cell development.
Campbell DP, Chrysostomou E, Doetzlhofer A
Scientific reports619484(2016 Jan)

Integrated annotation and analysis of in situ hybridization images using the ImAnno system: application to the ear and sensory organs of the fetal mouse.
Romand R, Ripp R, Poidevin L, Boeglin M, Geffers L, Doll? P, Poch O
PloS one10(2)e0118024(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results provide evidence that Rai/ShcC plays opposite roles in Th17 cell differentiation and astrocyte activation
Title: The Adaptor Protein Rai/ShcC Promotes Astrocyte-Dependent Inflammation during Experimental Autoimmune Encephalomyelitis.

Deficit of p66ShcA restores redox-sensitive stress response program in cisplatin-induced acute kidney injury.
Title: Deficit of p66ShcA restores redox-sensitive stress response program in cisplatin-induced acute kidney injury.

Rai (ShcC/N-Shc), a member of the family of Shc-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells.
Title: Rai is a new regulator of neural progenitor migration and glioblastoma invasion.

Rai interferes with the TCR signaling cascade one of the earliest steps--recruitment of the initiating kinase ZAP-70 to the phosphorylated subunit of the TCR/CD3 complex.
Title: The Shc family protein adaptor, Rai, negatively regulates T cell antigen receptor signaling by inhibiting ZAP-70 recruitment and activation.

TrkB-mediated ERK1/2 activation is impaired in huntingtin knock-in striatal cells involves reduced p52/p46 Shc expression
Title: Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression.

The following Shc3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Shc3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu20275	NM_009167.4 Latest version!	Mus musculus src homology 2 domain-containing transforming protein C3 (Shc3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$279.30 $399.00
OMu84945	NM_009167.5 Latest version!	Mus musculus src homology 2 domain-containing transforming protein C3 (Shc3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OMu20275	NM_009167.3	Mus musculus src homology 2 domain-containing transforming protein C3 (Shc3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$279.30 $399.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Shc3 ( NM_009167.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033193.2 Mus musculus src homology 2 domain-containing transforming protein C3 (Shc3), mRNA.

Price & Availability↑

CloneID	OMu20275
Clone ID Related Accession (Same CDS sequence)	NM_009167.4 , NM_009167.3
Accession Version	NM_009167.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1425bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-27
Organism	Mus musculus(house mouse)
Product	SHC-transforming protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC159104.2. On Aug 30, 2018 this sequence version replaced NM_009167.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.111093.1, SRR1660815.88372.1 [ECO:0000332] ##Evidence-Data-END##

ATGAGTGCCA CCAGGAAGAG CCGGGCCGGC GACGAGCCAC TGCCCAGGCC CCCTCGGGGC 
GCGCCGCACA CCAGCGATCA GGTGCTGGGG CCGGGAGTCA CCTATGTGGT CAAGTACTTG 
GGCTGCATCG AAGTTCTGCG CTCAATGAGG TCTCTTGACT TCAGTACAAG AACTCAGGTT 
ACCAGGGAAG CCATCAGCCG TGTCTGCGAA GCTGTGCCAG GTGCCAAAGG AGCCCTCAAG 
AAGAGAAAGC CGCCGAGTAA GATGCTGTCC AGCATCCTGG GGAAGAGCAA CCTCCAGTTC 
GCAGGGATGA GCATCTCCCT GACCATCTCC ACCGCCAGCC TGAATCTGCG CACTCCTGAC 
TCCAAACAGA TCATAGCGAA CCATCATATG CGGTCTATCT CTTTTGCCTC AGGGGGAGAC 
CCGGACACAA CGGACTATGT TGCCTATGTC GCTAAGGACC CTGTCAATCG CAGAGCTTGC 
CACATTCTGG AATGCTGTGA CGGGCTAGCC CAAGATGTCA TTGGCTCCAT CGGACAAGCC 
TTTGAACTCC GGTTCAAACA GTATTTGCAG TGCCCTTCCA AGGTTCCTGC CCTCCAGGAC 
CGAATGCAGA GTCTGGATGA GCCATGGACT GAAGAAGAGG GAGATGGCCC TGATCACCCA 
TACTACAACA GCGTTCCCAC CAAGATGCCT CCCCCAGGGG GGTTTCTGGA TGCTCGATTG 
AAAGGCAGAC CCCACGCTCC TGAGGCAGCC CAGTTTGCAG GAAAAGAGCA AACTTATTAC 
CAGGGAAGAC ACTTAGGAGA TACATTTGGT GAAGACTGGC AGCGAGCACC CACCAGGCAA 
GGCTCCTTGG ACATCTATAG CACAGCAGAA GGGAAAACTC ACATGGTTCC TGTAGGAGAA 
ACACCAACCT ATGTCAACAC CCAGCCAGTC CCACCACAGG TGTGGCCAGC AGCAACCAGC 
AGCACTGAGA GCAGCCCACG GAAGGACCTC TTTGACATGA AGCCCTTTGA AGATGCCCTG 
AGAAACCAGC CCCTGGGCCC CATGTTGAGC AAAGCCGCGT CTGTGGAGTG CATCAGCCCG 
GTCACACCCA GAGCCCCGGA TGCCAGGATG CTGGAGGAGC TTAACGCTGA GCCCTGGTAC 
CAAGGAGAGA TGAGCAGGAA GGAGGCAGAG GCCCTGCTAC GGGAAGATGG AGACTTCCTA 
GTGAGGAAGA GTACCACCAA CCCCGGCTCC TTTGTCCTCA CAGGCATGCA CAATGGGCAG 
GCCAAGCACC TGCTGCTGGT GGACCCGGAA GGCACGATCC GGACGAAGGA CAGGGTCTTT 
GACAGCATCA GCCACCTCAT CAATTACCAC CTCGAGAGCA GCCTGCCCAT TGTCTCTGCC 
GGGAGTGAGC TTTGTCTCCA GCAACCAGTG GAGAGGAAAC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033193.2
CDS	44..1468
Translation	MSATRKSRAGDEPLPRPPRGAPHTSDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQVTREAISRVCEAVPGAKGALKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPSKVPALQDRMQSLDEPWTEEEGDGPDHPYYNSVPTKMPPPGGFLDARLKGRPHAPEAAQFAGKEQTYYQGRHLGDTFGEDWQRAPTRQGSLDIYSTAEGKTHMVPVGETPTYVNTQPVPPQVWPAATSSTESSPRKDLFDMKPFEDALRNQPLGPMLSKAASVECISPVTPRAPDARMLEELNAEPWYQGEMSRKEAEALLREDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLINYHLESSLPIVSAGSELCLQQPVERKP

Target ORF information:

RefSeq Version	NM_009167.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus src homology 2 domain-containing transforming protein C3 (Shc3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009167.4

ORF Insert Sequence:

ATGAGTGCCA CCAGGAAGAG CCGGGCCGGC GACGAGCCAC TGCCCAGGCC CCCTCGGGGC 
GCGCCGCACA CCAGCGATCA GGTGCTGGGG CCGGGAGTCA CCTATGTGGT CAAGTACTTG 
GGCTGCATCG AAGTTCTGCG CTCAATGAGG TCTCTTGACT TCAGTACAAG AACTCAGGTT 
ACCAGGGAAG CCATCAGCCG TGTCTGCGAA GCTGTGCCAG GTGCCAAAGG AGCCCTCAAG 
AAGAGAAAGC CGCCGAGTAA GATGCTGTCC AGCATCCTGG GGAAGAGCAA CCTCCAGTTC 
GCAGGGATGA GCATCTCCCT GACCATCTCC ACCGCCAGCC TGAATCTGCG CACTCCTGAC 
TCCAAACAGA TCATAGCGAA CCATCATATG CGGTCTATCT CTTTTGCCTC AGGGGGAGAC 
CCGGACACAA CGGACTATGT TGCCTATGTC GCTAAGGACC CTGTCAATCG CAGAGCTTGC 
CACATTCTGG AATGCTGTGA CGGGCTAGCC CAAGATGTCA TTGGCTCCAT CGGACAAGCC 
TTTGAACTCC GGTTCAAACA GTATTTGCAG TGCCCTTCCA AGGTTCCTGC CCTCCAGGAC 
CGAATGCAGA GTCTGGATGA GCCATGGACT GAAGAAGAGG GAGATGGCCC TGATCACCCA 
TACTACAACA GCGTTCCCAC CAAGATGCCT CCCCCAGGGG GGTTTCTGGA TGCTCGATTG 
AAAGGCAGAC CCCACGCTCC TGAGGCAGCC CAGTTTGCAG GAAAAGAGCA AACTTATTAC 
CAGGGAAGAC ACTTAGGAGA TACATTTGGT GAAGACTGGC AGCGAGCACC CACCAGGCAA 
GGCTCCTTGG ACATCTATAG CACAGCAGAA GGGAAAACTC ACATGGTTCC TGTAGGAGAA 
ACACCAACCT ATGTCAACAC CCAGCCAGTC CCACCACAGG TGTGGCCAGC AGCAACCAGC 
AGCACTGAGA GCAGCCCACG GAAGGACCTC TTTGACATGA AGCCCTTTGA AGATGCCCTG 
AGAAACCAGC CCCTGGGCCC CATGTTGAGC AAAGCCGCGT CTGTGGAGTG CATCAGCCCG 
GTCACACCCA GAGCCCCGGA TGCCAGGATG CTGGAGGAGC TTAACGCTGA GCCCTGGTAC 
CAAGGAGAGA TGAGCAGGAA GGAGGCAGAG GCCCTGCTAC GGGAAGATGG AGACTTCCTA 
GTGAGGAAGA GTACCACCAA CCCCGGCTCC TTTGTCCTCA CAGGCATGCA CAATGGGCAG 
GCCAAGCACC TGCTGCTGGT GGACCCGGAA GGCACGATCC GGACGAAGGA CAGGGTCTTT 
GACAGCATCA GCCACCTCAT CAATTACCAC CTCGAGAGCA GCCTGCCCAT TGTCTCTGCC 
GGGAGTGAGC TTTGTCTCCA GCAACCAGTG GAGAGGAAAC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Shc3 ( NM_009167.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033193.2 Mus musculus src homology 2 domain-containing transforming protein C3 (Shc3), mRNA.

Price & Availability↑

CloneID	OMu20275
Clone ID Related Accession (Same CDS sequence)	NM_009167.4 , NM_009167.3
Accession Version	NM_009167.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1425bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-26
Organism	Mus musculus(house mouse)
Product	SHC-transforming protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U46854.1, BC105644.1 and BB274049.1. On Jan 15, 2008 this sequence version replaced NM_009167.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC103612.1, SRR1660813.111093.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGAGTGCCA CCAGGAAGAG CCGGGCCGGC GACGAGCCAC TGCCCAGGCC CCCTCGGGGC 
GCGCCGCACA CCAGCGATCA GGTGCTGGGG CCGGGAGTCA CCTATGTGGT CAAGTACTTG 
GGCTGCATCG AAGTTCTGCG CTCAATGAGG TCTCTTGACT TCAGTACAAG AACTCAGGTT 
ACCAGGGAAG CCATCAGCCG TGTCTGCGAA GCTGTGCCAG GTGCCAAAGG AGCCCTCAAG 
AAGAGAAAGC CGCCGAGTAA GATGCTGTCC AGCATCCTGG GGAAGAGCAA CCTCCAGTTC 
GCAGGGATGA GCATCTCCCT GACCATCTCC ACCGCCAGCC TGAATCTGCG CACTCCTGAC 
TCCAAACAGA TCATAGCGAA CCATCATATG CGGTCTATCT CTTTTGCCTC AGGGGGAGAC 
CCGGACACAA CGGACTATGT TGCCTATGTC GCTAAGGACC CTGTCAATCG CAGAGCTTGC 
CACATTCTGG AATGCTGTGA CGGGCTAGCC CAAGATGTCA TTGGCTCCAT CGGACAAGCC 
TTTGAACTCC GGTTCAAACA GTATTTGCAG TGCCCTTCCA AGGTTCCTGC CCTCCAGGAC 
CGAATGCAGA GTCTGGATGA GCCATGGACT GAAGAAGAGG GAGATGGCCC TGATCACCCA 
TACTACAACA GCGTTCCCAC CAAGATGCCT CCCCCAGGGG GGTTTCTGGA TGCTCGATTG 
AAAGGCAGAC CCCACGCTCC TGAGGCAGCC CAGTTTGCAG GAAAAGAGCA AACTTATTAC 
CAGGGAAGAC ACTTAGGAGA TACATTTGGT GAAGACTGGC AGCGAGCACC CACCAGGCAA 
GGCTCCTTGG ACATCTATAG CACAGCAGAA GGGAAAACTC ACATGGTTCC TGTAGGAGAA 
ACACCAACCT ATGTCAACAC CCAGCCAGTC CCACCACAGG TGTGGCCAGC AGCAACCAGC 
AGCACTGAGA GCAGCCCACG GAAGGACCTC TTTGACATGA AGCCCTTTGA AGATGCCCTG 
AGAAACCAGC CCCTGGGCCC CATGTTGAGC AAAGCCGCGT CTGTGGAGTG CATCAGCCCG 
GTCACACCCA GAGCCCCGGA TGCCAGGATG CTGGAGGAGC TTAACGCTGA GCCCTGGTAC 
CAAGGAGAGA TGAGCAGGAA GGAGGCAGAG GCCCTGCTAC GGGAAGATGG AGACTTCCTA 
GTGAGGAAGA GTACCACCAA CCCCGGCTCC TTTGTCCTCA CAGGCATGCA CAATGGGCAG 
GCCAAGCACC TGCTGCTGGT GGACCCGGAA GGCACGATCC GGACGAAGGA CAGGGTCTTT 
GACAGCATCA GCCACCTCAT CAATTACCAC CTCGAGAGCA GCCTGCCCAT TGTCTCTGCC 
GGGAGTGAGC TTTGTCTCCA GCAACCAGTG GAGAGGAAAC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033193.2
CDS	4..1428
Translation	MSATRKSRAGDEPLPRPPRGAPHTSDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQVTREAISRVCEAVPGAKGALKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPSKVPALQDRMQSLDEPWTEEEGDGPDHPYYNSVPTKMPPPGGFLDARLKGRPHAPEAAQFAGKEQTYYQGRHLGDTFGEDWQRAPTRQGSLDIYSTAEGKTHMVPVGETPTYVNTQPVPPQVWPAATSSTESSPRKDLFDMKPFEDALRNQPLGPMLSKAASVECISPVTPRAPDARMLEELNAEPWYQGEMSRKEAEALLREDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLINYHLESSLPIVSAGSELCLQQPVERKP

Target ORF information:

RefSeq Version	NM_009167.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus src homology 2 domain-containing transforming protein C3 (Shc3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009167.3

ORF Insert Sequence:

ATGAGTGCCA CCAGGAAGAG CCGGGCCGGC GACGAGCCAC TGCCCAGGCC CCCTCGGGGC 
GCGCCGCACA CCAGCGATCA GGTGCTGGGG CCGGGAGTCA CCTATGTGGT CAAGTACTTG 
GGCTGCATCG AAGTTCTGCG CTCAATGAGG TCTCTTGACT TCAGTACAAG AACTCAGGTT 
ACCAGGGAAG CCATCAGCCG TGTCTGCGAA GCTGTGCCAG GTGCCAAAGG AGCCCTCAAG 
AAGAGAAAGC CGCCGAGTAA GATGCTGTCC AGCATCCTGG GGAAGAGCAA CCTCCAGTTC 
GCAGGGATGA GCATCTCCCT GACCATCTCC ACCGCCAGCC TGAATCTGCG CACTCCTGAC 
TCCAAACAGA TCATAGCGAA CCATCATATG CGGTCTATCT CTTTTGCCTC AGGGGGAGAC 
CCGGACACAA CGGACTATGT TGCCTATGTC GCTAAGGACC CTGTCAATCG CAGAGCTTGC 
CACATTCTGG AATGCTGTGA CGGGCTAGCC CAAGATGTCA TTGGCTCCAT CGGACAAGCC 
TTTGAACTCC GGTTCAAACA GTATTTGCAG TGCCCTTCCA AGGTTCCTGC CCTCCAGGAC 
CGAATGCAGA GTCTGGATGA GCCATGGACT GAAGAAGAGG GAGATGGCCC TGATCACCCA 
TACTACAACA GCGTTCCCAC CAAGATGCCT CCCCCAGGGG GGTTTCTGGA TGCTCGATTG 
AAAGGCAGAC CCCACGCTCC TGAGGCAGCC CAGTTTGCAG GAAAAGAGCA AACTTATTAC 
CAGGGAAGAC ACTTAGGAGA TACATTTGGT GAAGACTGGC AGCGAGCACC CACCAGGCAA 
GGCTCCTTGG ACATCTATAG CACAGCAGAA GGGAAAACTC ACATGGTTCC TGTAGGAGAA 
ACACCAACCT ATGTCAACAC CCAGCCAGTC CCACCACAGG TGTGGCCAGC AGCAACCAGC 
AGCACTGAGA GCAGCCCACG GAAGGACCTC TTTGACATGA AGCCCTTTGA AGATGCCCTG 
AGAAACCAGC CCCTGGGCCC CATGTTGAGC AAAGCCGCGT CTGTGGAGTG CATCAGCCCG 
GTCACACCCA GAGCCCCGGA TGCCAGGATG CTGGAGGAGC TTAACGCTGA GCCCTGGTAC 
CAAGGAGAGA TGAGCAGGAA GGAGGCAGAG GCCCTGCTAC GGGAAGATGG AGACTTCCTA 
GTGAGGAAGA GTACCACCAA CCCCGGCTCC TTTGTCCTCA CAGGCATGCA CAATGGGCAG 
GCCAAGCACC TGCTGCTGGT GGACCCGGAA GGCACGATCC GGACGAAGGA CAGGGTCTTT 
GACAGCATCA GCCACCTCAT CAATTACCAC CTCGAGAGCA GCCTGCCCAT TGTCTCTGCC 
GGGAGTGAGC TTTGTCTCCA GCAACCAGTG GAGAGGAAAC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Shc3 ( NM_009167.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033193.3 Mus musculus src homology 2 domain-containing transforming protein C3 (Shc3), mRNA.

Price & Availability↑

CloneID	OMu84945
Clone ID Related Accession (Same CDS sequence)	NM_009167.5
Accession Version	NM_009167.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1785bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Mus musculus(house mouse)
Product	SHC-transforming protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC159104.2. On Apr 15, 2019 this sequence version replaced NM_009167.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.88372.1, SRR7974084.26428.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGCTTCCAC GCACCAAGTA CAACCGCTTC AGGAATGACT CGGTGACATC GGTCGATGAC 
CTTCTCCACA GCCTGTCGGT GAGCGGCAGC GGCGGCAAGG TCTCGGCGGA GCCCGCGGCG 
AGCCCCTACC TGGTGTCGGG CGAGGCGCTG CGCAAGGCGC CGGACGATGG GCCCGGCAGC 
CTGGGCCACC TGCTCCACAA GGTGTCCCAC TTGAAACTCT CCAGCTCCGG CCTGCGTGGC 
CTGTCGTCGG CCGCCCGGGA GCGGGCAGGA GCGCGGCTCT CGGGCAGCTG CAGCGCGCCC 
AGCCTGGCGG CCCCGGACGG CGGCAGCGCG ACCCCCGGGT CCCGCGCCCC GGCCGCCAGC 
ATGAGTGCCA CCAGGAAGAG CCGGGCCGGC GACGAGCCAC TGCCCAGGCC CCCTCGGGGC 
GCGCCGCACA CCAGCGATCA GGTGCTGGGG CCGGGAGTCA CCTATGTGGT CAAGTACTTG 
GGCTGCATCG AAGTTCTGCG CTCAATGAGG TCTCTTGACT TCAGTACAAG AACTCAGGTT 
ACCAGGGAAG CCATCAGCCG TGTCTGCGAA GCTGTGCCAG GTGCCAAAGG AGCCCTCAAG 
AAGAGAAAGC CGCCGAGTAA GATGCTGTCC AGCATCCTGG GGAAGAGCAA CCTCCAGTTC 
GCAGGGATGA GCATCTCCCT GACCATCTCC ACCGCCAGCC TGAATCTGCG CACTCCTGAC 
TCCAAACAGA TCATAGCGAA CCATCATATG CGGTCTATCT CTTTTGCCTC AGGGGGAGAC 
CCGGACACAA CGGACTATGT TGCCTATGTC GCTAAGGACC CTGTCAATCG CAGAGCTTGC 
CACATTCTGG AATGCTGTGA CGGGCTAGCC CAAGATGTCA TTGGCTCCAT CGGACAAGCC 
TTTGAACTCC GGTTCAAACA GTATTTGCAG TGCCCTTCCA AGGTTCCTGC CCTCCAGGAC 
CGAATGCAGA GTCTGGATGA GCCATGGACT GAAGAAGAGG GAGATGGCCC TGATCACCCA 
TACTACAACA GCGTTCCCAC CAAGATGCCT CCCCCAGGGG GGTTTCTGGA TGCTCGATTG 
AAAGGCAGAC CCCACGCTCC TGAGGCAGCC CAGTTTGCAG GAAAAGAGCA AACTTATTAC 
CAGGGAAGAC ACTTAGGAGA TACATTTGGT GAAGACTGGC AGCGAGCACC CACCAGGCAA 
GGCTCCTTGG ACATCTATAG CACAGCAGAA GGGAAAACTC ACATGGTTCC TGTAGGAGAA 
ACACCAACCT ATGTCAACAC CCAGCCAGTC CCACCACAGG TGTGGCCAGC AGCAACCAGC 
AGCACTGAGA GCAGCCCACG GAAGGACCTC TTTGACATGA AGCCCTTTGA AGATGCCCTG 
AGAAACCAGC CCCTGGGCCC CATGTTGAGC AAAGCCGCGT CTGTGGAGTG CATCAGCCCG 
GTCACACCCA GAGCCCCGGA TGCCAGGATG CTGGAGGAGC TTAACGCTGA GCCCTGGTAC 
CAAGGAGAGA TGAGCAGGAA GGAGGCAGAG GCCCTGCTAC GGGAAGATGG AGACTTCCTA 
GTGAGGAAGA GTACCACCAA CCCCGGCTCC TTTGTCCTCA CAGGCATGCA CAATGGGCAG 
GCCAAGCACC TGCTGCTGGT GGACCCGGAA GGCACGATCC GGACGAAGGA CAGGGTCTTT 
GACAGCATCA GCCACCTCAT CAATTACCAC CTCGAGAGCA GCCTGCCCAT TGTCTCTGCC 
GGGAGTGAGC TTTGTCTCCA GCAACCAGTG GAGAGGAAAC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033193.3
CDS	2008..3792
Translation	MLPRTKYNRFRNDSVTSVDDLLHSLSVSGSGGKVSAEPAASPYLVSGEALRKAPDDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGGSATPGSRAPAASMSATRKSRAGDEPLPRPPRGAPHTSDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQVTREAISRVCEAVPGAKGALKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPSKVPALQDRMQSLDEPWTEEEGDGPDHPYYNSVPTKMPPPGGFLDARLKGRPHAPEAAQFAGKEQTYYQGRHLGDTFGEDWQRAPTRQGSLDIYSTAEGKTHMVPVGETPTYVNTQPVPPQVWPAATSSTESSPRKDLFDMKPFEDALRNQPLGPMLSKAASVECISPVTPRAPDARMLEELNAEPWYQGEMSRKEAEALLREDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLINYHLESSLPIVSAGSELCLQQPVERKP

Target ORF information:

RefSeq Version	NM_009167.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus src homology 2 domain-containing transforming protein C3 (Shc3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009167.5

ORF Insert Sequence:

ATGCTTCCAC GCACCAAGTA CAACCGCTTC AGGAATGACT CGGTGACATC GGTCGATGAC 
CTTCTCCACA GCCTGTCGGT GAGCGGCAGC GGCGGCAAGG TCTCGGCGGA GCCCGCGGCG 
AGCCCCTACC TGGTGTCGGG CGAGGCGCTG CGCAAGGCGC CGGACGATGG GCCCGGCAGC 
CTGGGCCACC TGCTCCACAA GGTGTCCCAC TTGAAACTCT CCAGCTCCGG CCTGCGTGGC 
CTGTCGTCGG CCGCCCGGGA GCGGGCAGGA GCGCGGCTCT CGGGCAGCTG CAGCGCGCCC 
AGCCTGGCGG CCCCGGACGG CGGCAGCGCG ACCCCCGGGT CCCGCGCCCC GGCCGCCAGC 
ATGAGTGCCA CCAGGAAGAG CCGGGCCGGC GACGAGCCAC TGCCCAGGCC CCCTCGGGGC 
GCGCCGCACA CCAGCGATCA GGTGCTGGGG CCGGGAGTCA CCTATGTGGT CAAGTACTTG 
GGCTGCATCG AAGTTCTGCG CTCAATGAGG TCTCTTGACT TCAGTACAAG AACTCAGGTT 
ACCAGGGAAG CCATCAGCCG TGTCTGCGAA GCTGTGCCAG GTGCCAAAGG AGCCCTCAAG 
AAGAGAAAGC CGCCGAGTAA GATGCTGTCC AGCATCCTGG GGAAGAGCAA CCTCCAGTTC 
GCAGGGATGA GCATCTCCCT GACCATCTCC ACCGCCAGCC TGAATCTGCG CACTCCTGAC 
TCCAAACAGA TCATAGCGAA CCATCATATG CGGTCTATCT CTTTTGCCTC AGGGGGAGAC 
CCGGACACAA CGGACTATGT TGCCTATGTC GCTAAGGACC CTGTCAATCG CAGAGCTTGC 
CACATTCTGG AATGCTGTGA CGGGCTAGCC CAAGATGTCA TTGGCTCCAT CGGACAAGCC 
TTTGAACTCC GGTTCAAACA GTATTTGCAG TGCCCTTCCA AGGTTCCTGC CCTCCAGGAC 
CGAATGCAGA GTCTGGATGA GCCATGGACT GAAGAAGAGG GAGATGGCCC TGATCACCCA 
TACTACAACA GCGTTCCCAC CAAGATGCCT CCCCCAGGGG GGTTTCTGGA TGCTCGATTG 
AAAGGCAGAC CCCACGCTCC TGAGGCAGCC CAGTTTGCAG GAAAAGAGCA AACTTATTAC 
CAGGGAAGAC ACTTAGGAGA TACATTTGGT GAAGACTGGC AGCGAGCACC CACCAGGCAA 
GGCTCCTTGG ACATCTATAG CACAGCAGAA GGGAAAACTC ACATGGTTCC TGTAGGAGAA 
ACACCAACCT ATGTCAACAC CCAGCCAGTC CCACCACAGG TGTGGCCAGC AGCAACCAGC 
AGCACTGAGA GCAGCCCACG GAAGGACCTC TTTGACATGA AGCCCTTTGA AGATGCCCTG 
AGAAACCAGC CCCTGGGCCC CATGTTGAGC AAAGCCGCGT CTGTGGAGTG CATCAGCCCG 
GTCACACCCA GAGCCCCGGA TGCCAGGATG CTGGAGGAGC TTAACGCTGA GCCCTGGTAC 
CAAGGAGAGA TGAGCAGGAA GGAGGCAGAG GCCCTGCTAC GGGAAGATGG AGACTTCCTA 
GTGAGGAAGA GTACCACCAA CCCCGGCTCC TTTGTCCTCA CAGGCATGCA CAATGGGCAG 
GCCAAGCACC TGCTGCTGGT GGACCCGGAA GGCACGATCC GGACGAAGGA CAGGGTCTTT 
GACAGCATCA GCCACCTCAT CAATTACCAC CTCGAGAGCA GCCTGCCCAT TGTCTCTGCC 
GGGAGTGAGC TTTGTCTCCA GCAACCAGTG GAGAGGAAAC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia.
eLife6(2017 May)
Heng X,Guo Q,Leung AW,Li JY

NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease.
Aging cell15(4)661-72(2016 Aug)
Triaca V,Sposato V,Bolasco G,Ciotti MT,Pelicci P,Bruni AC,Cupidi C,Maletta R,Feligioni M,Nistic? R,Canu N,Calissano P

The Adaptor Protein Rai/ShcC Promotes Astrocyte-Dependent Inflammation during Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)197(2)480-90(2016 07)
Ulivieri C,Savino MT,Luccarini I,Fanigliulo E,Aldinucci A,Bonechi E,Benagiano M,Ortensi B,Pelicci G,D'Elios MM,Ballerini C,Baldari CT

Canonical Notch signaling plays an instructive role in auditory supporting cell development.
Scientific reports619484(2016 Jan)
Campbell DP,Chrysostomou E,Doetzlhofer A

Integrated annotation and analysis of in situ hybridization images using the ImAnno system: application to the ear and sensory organs of the fetal mouse.
PloS one10(2)e0118024(2015)
Romand R,Ripp R,Poidevin L,Boeglin M,Geffers L,Doll? P,Poch O

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Shc3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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