Sh2d1a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sh2d1a
Entrez Gene ID	20400
Full Name	SH2 domain containing 1A
Synonyms	Gm686,SAP
General protein information	Preferred Names SH2 domain containing 1A Names SH2 domain-containing protein 1A Duncan disease homolog SH2 domain protein 1A SLAM-associated protein isoform SAP-2 T-cell signal transduction molecule SAP signaling lymphocytic activation molecule-associated protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X A4

mRNA and Protein(s)

mRNA	Protein	Name
NM_001313691.1	NP_001300620.1	SH2 domain-containing protein 1A isoform 4
NM_001313689.1	NP_001300618.1	SH2 domain-containing protein 1A isoform 3
XM_017318440.1	XP_017173929.1	SH2 domain-containing protein 1A isoform X1
NM_011364.4	NP_035494.1	SH2 domain-containing protein 1A isoform 2
NM_001313688.1	NP_001300617.1	SH2 domain-containing protein 1A isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SH2D1A	NP_001029905.1
Mus musculus (house mouse)	Sh2d1a	NP_035494.1
Xenopus tropicalis (tropical clawed frog)	sh2d1a	XP_002931832.1
Homo sapiens (human)	SH2D1A	NP_002342.1
	SH2D1A	NP_001028009.1
Canis lupus familiaris (dog)	SH2D1A	XP_852122.1
Rattus norvegicus (Norway rat)	Sh2d1a	NP_001102783.2
Danio rerio (zebrafish)	sh2d1ab	XP_001920648.3
Gallus gallus (chicken)	LOC100857869	XP_003641167.1

Gene Ontology
Bibliography

Related articles in PubMed

Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor.
Peled M, Tocheva AS, Sandigursky S, Nayak S, Philips EA, Nichols KE, Strazza M, Azoulay-Alfaguter I, Askenazi M, Neel BG, Pelzek AJ, Ueberheide B, Mor A
Proceedings of the National Academy of Sciences of the United States of America115(3)E468-E477(2018 Jan)

The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells.
Xu L, Huang Q, Wang H, Hao Y, Bai Q, Hu J, Li Y, Wang P, Chen X, He R, Li B, Yang X, Zhao T, Zhang Y, Wang Y, Ou J, Liang H, Wu Y, Zhou X, Ye L
Immunity47(3)538-551.e5(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

naive T cells regulate B cell survival in a SAP-dependent manner
Title: T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP.

SAP-dependent activating SFR signaling is essential for NKT cell selection.
Title: Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity.

SAP differentially regulates the late-stage lineage decisions of iNKT cell subsets. These results also provide evidence that iNKT1, iNKT2, and iNKT17 cells are differentially regulated by SAP. SAP-dependent signals are essential for the fate decisions that drive the differentiation of iNKT2 but not iNKT1 and NKT17 cells.
Title: SLAM-associated protein favors the development of iNKT2 over iNKT17 cells.

In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.
Title: A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.

SAP is an essential molecule for autoimmune antibody production.
Title: The Role of Follicular Helper T Cell Molecules and Environmental Influences in Autoantibody Production and Progression to Inflammatory Arthritis in Mice.

The following Sh2d1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sh2d1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu68675	NM_001313689.1 Latest version!	Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu68676	NM_001313691.1 Latest version!	Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu68677	NM_001313688.1 Latest version!	Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu68676	XM_017318440.1 Latest version!	Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu18688	NM_011364.4 Latest version!	Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sh2d1a ( NM_001313689.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001300618.1 Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu68675
Clone ID Related Accession (Same CDS sequence)	NM_001313689.1
Accession Version	NM_001313689.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	SH2 domain-containing protein 1A isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL831716.7 and AF097632.1. Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 3' end of the first exon and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF097632.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

ATGGATGCAG TGACTGTGTA CCACGGCAAA ATCAGCAGGG AGACCGGGGA GAAGCTCTTA 
CTCGCTACCG GGCTGGATGG AAGCTATCTG CTGCGAGACA GCGAGAGTGT CCCTGGCGTG 
TACTGCCTGT ATCAAGGTTA CATCTACACA TATCGAGTGT CCCAGACAGA AACAGGTTCT 
TGGAGTGCCG AGACAGCACC TGGAGTACAT AAAAGATTTT TCCGGAAAGT AAAAAATCTC 
ATCTCAGCGT TTCAGAAGCC GGATCAAGGC ATCGTGACGC CTCTGCAGTA TCCAGTTGAA 
AAGTCCTCTG GCAGGGGCCC ACAAGCTCCC ACAGGGAGAA GAGATTCTGA TATCTGCCTG 
AATGCACCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001300618.1
CDS	159..530
Translation	MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDICLNAP

Target ORF information:

RefSeq Version	NM_001313689.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001313689.1

ORF Insert Sequence:

ATGGATGCAG TGACTGTGTA CCACGGCAAA ATCAGCAGGG AGACCGGGGA GAAGCTCTTA 
CTCGCTACCG GGCTGGATGG AAGCTATCTG CTGCGAGACA GCGAGAGTGT CCCTGGCGTG 
TACTGCCTGT ATCAAGGTTA CATCTACACA TATCGAGTGT CCCAGACAGA AACAGGTTCT 
TGGAGTGCCG AGACAGCACC TGGAGTACAT AAAAGATTTT TCCGGAAAGT AAAAAATCTC 
ATCTCAGCGT TTCAGAAGCC GGATCAAGGC ATCGTGACGC CTCTGCAGTA TCCAGTTGAA 
AAGTCCTCTG GCAGGGGCCC ACAAGCTCCC ACAGGGAGAA GAGATTCTGA TATCTGCCTG 
AATGCACCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sh2d1a ( NM_001313691.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001300620.1 Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu68676
Clone ID Related Accession (Same CDS sequence)	NM_001313691.1 , XM_017318440.1
Accession Version	NM_001313691.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 246bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	SH2 domain-containing protein 1A isoform 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF019627.1 and AF097632.1. Transcript Variant: This variant (4) contains an alternate first exon and lacks an internal exon compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF019627.1, BC147807.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGTATCAAG GTTACATCTA CACATATCGA GTGTCCCAGA CAGAAACAGG TTCTTGGAGT 
GCCGAGACAG CACCTGGAGT ACATAAAAGA TTTTTCCGGA AAGTAAAAAA TCTCATCTCA 
GCGTTTCAGA AGCCGGATCA AGGCATCGTG ACGCCTCTGC AGTATCCAGT TGAAAAGTCC 
TCTGGCAGGG GCCCACAAGC TCCCACAGGG AGAAGAGATT CTGATATCTG CCTGAATGCA 
CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001300620.1
CDS	25..270
Translation	MYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDICLNAP

Target ORF information:

RefSeq Version	NM_001313691.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001313691.1

ORF Insert Sequence:

ATGTATCAAG GTTACATCTA CACATATCGA GTGTCCCAGA CAGAAACAGG TTCTTGGAGT 
GCCGAGACAG CACCTGGAGT ACATAAAAGA TTTTTCCGGA AAGTAAAAAA TCTCATCTCA 
GCGTTTCAGA AGCCGGATCA AGGCATCGTG ACGCCTCTGC AGTATCCAGT TGAAAAGTCC 
TCTGGCAGGG GCCCACAAGC TCCCACAGGG AGAAGAGATT CTGATATCTG CCTGAATGCA 
CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sh2d1a ( NM_001313688.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001300617.1 Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu68677
Clone ID Related Accession (Same CDS sequence)	NM_001313688.1
Accession Version	NM_001313688.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	SH2 domain-containing protein 1A isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL831716.7, KF811030.1 and AF097632.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: KF811030.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

ATGGATGCAG TGACTGTGTA CCACGGCAAA ATCAGCAGGG AGACCGGGGA GAAGCTCTTA 
CTCGCTACCG GGCTGGATGG AAGCTATCTG CTGCGAGACA GCGAGAGTGT CCCTGGCGTG 
TACTGCCTGT GTGTTTTTGT GCATAGCGCC TTCCAGCACT ATGGATTAGC CTATGTAGAT 
GAAGCTTCCA GGTATCAAGG TTACATCTAC ACATATCGAG TGTCCCAGAC AGAAACAGGT 
TCTTGGAGTG CCGAGACAGC ACCTGGAGTA CATAAAAGAT TTTTCCGGAA AGTAAAAAAT 
CTCATCTCAG CGTTTCAGAA GCCGGATCAA GGCATCGTGA CGCCTCTGCA GTATCCAGTT 
GAAAAGTCCT CTGGCAGGGG CCCACAAGCT CCCACAGGGA GAAGAGATTC TGATATCTGC 
CTGAATGCAC CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001300617.1
CDS	159..593
Translation	MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVFVHSAFQHYGLAYVDEASRYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDICLNAP

Target ORF information:

RefSeq Version	NM_001313688.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001313688.1

ORF Insert Sequence:

ATGGATGCAG TGACTGTGTA CCACGGCAAA ATCAGCAGGG AGACCGGGGA GAAGCTCTTA 
CTCGCTACCG GGCTGGATGG AAGCTATCTG CTGCGAGACA GCGAGAGTGT CCCTGGCGTG 
TACTGCCTGT GTGTTTTTGT GCATAGCGCC TTCCAGCACT ATGGATTAGC CTATGTAGAT 
GAAGCTTCCA GGTATCAAGG TTACATCTAC ACATATCGAG TGTCCCAGAC AGAAACAGGT 
TCTTGGAGTG CCGAGACAGC ACCTGGAGTA CATAAAAGAT TTTTCCGGAA AGTAAAAAAT 
CTCATCTCAG CGTTTCAGAA GCCGGATCAA GGCATCGTGA CGCCTCTGCA GTATCCAGTT 
GAAAAGTCCT CTGGCAGGGG CCCACAAGCT CCCACAGGGA GAAGAGATTC TGATATCTGC 
CTGAATGCAC CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sh2d1a ( XM_017318440.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017173929.1 Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu68676
Clone ID Related Accession (Same CDS sequence)	NM_001313691.1 , XM_017318440.1
Accession Version	XM_017318440.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 246bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	SH2 domain-containing protein 1A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTATCAAG GTTACATCTA CACATATCGA GTGTCCCAGA CAGAAACAGG TTCTTGGAGT 
GCCGAGACAG CACCTGGAGT ACATAAAAGA TTTTTCCGGA AAGTAAAAAA TCTCATCTCA 
GCGTTTCAGA AGCCGGATCA AGGCATCGTG ACGCCTCTGC AGTATCCAGT TGAAAAGTCC 
TCTGGCAGGG GCCCACAAGC TCCCACAGGG AGAAGAGATT CTGATATCTG CCTGAATGCA 
CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017173929.1
CDS	137..382
Translation	MYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDICLNAP

Target ORF information:

RefSeq Version	XM_017318440.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017318440.1

ORF Insert Sequence:

ATGTATCAAG GTTACATCTA CACATATCGA GTGTCCCAGA CAGAAACAGG TTCTTGGAGT 
GCCGAGACAG CACCTGGAGT ACATAAAAGA TTTTTCCGGA AAGTAAAAAA TCTCATCTCA 
GCGTTTCAGA AGCCGGATCA AGGCATCGTG ACGCCTCTGC AGTATCCAGT TGAAAAGTCC 
TCTGGCAGGG GCCCACAAGC TCCCACAGGG AGAAGAGATT CTGATATCTG CCTGAATGCA 
CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sh2d1a ( NM_011364.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035494.1 Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu18688
Clone ID Related Accession (Same CDS sequence)	NM_011364.4
Accession Version	NM_011364.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	SH2 domain-containing protein 1A isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL831716.7, AK040076.1 and AF097632.1. On Aug 25, 2015 this sequence version replaced NM_011364.3. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF072903.1, AK040076.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGGATGCAG TGACTGTGTA CCACGGCAAA ATCAGCAGGG AGACCGGGGA GAAGCTCTTA 
CTCGCTACCG GGCTGGATGG AAGCTATCTG CTGCGAGACA GCGAGAGTGT CCCTGGCGTG 
TACTGCCTGT GTGTTTTGTA TCAAGGTTAC ATCTACACAT ATCGAGTGTC CCAGACAGAA 
ACAGGTTCTT GGAGTGCCGA GACAGCACCT GGAGTACATA AAAGATTTTT CCGGAAAGTA 
AAAAATCTCA TCTCAGCGTT TCAGAAGCCG GATCAAGGCA TCGTGACGCC TCTGCAGTAT 
CCAGTTGAAA AGTCCTCTGG CAGGGGCCCA CAAGCTCCCA CAGGGAGAAG AGATTCTGAT 
ATCTGCCTGA ATGCACCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035494.1
CDS	159..539
Translation	MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDICLNAP

Target ORF information:

RefSeq Version	NM_011364.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus SH2 domain containing 1A (Sh2d1a), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011364.4

ORF Insert Sequence:

ATGGATGCAG TGACTGTGTA CCACGGCAAA ATCAGCAGGG AGACCGGGGA GAAGCTCTTA 
CTCGCTACCG GGCTGGATGG AAGCTATCTG CTGCGAGACA GCGAGAGTGT CCCTGGCGTG 
TACTGCCTGT GTGTTTTGTA TCAAGGTTAC ATCTACACAT ATCGAGTGTC CCAGACAGAA 
ACAGGTTCTT GGAGTGCCGA GACAGCACCT GGAGTACATA AAAGATTTTT CCGGAAAGTA 
AAAAATCTCA TCTCAGCGTT TCAGAAGCCG GATCAAGGCA TCGTGACGCC TCTGCAGTAT 
CCAGTTGAAA AGTCCTCTGG CAGGGGCCCA CAAGCTCCCA CAGGGAGAAG AGATTCTGAT 
ATCTGCCTGA ATGCACCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor.
Proceedings of the National Academy of Sciences of the United States of America115(3)E468-E477(2018 Jan)
Peled M,Tocheva AS,Sandigursky S,Nayak S,Philips EA,Nichols KE,Strazza M,Azoulay-Alfaguter I,Askenazi M,Neel BG,Pelzek AJ,Ueberheide B,Mor A

The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells.
Immunity47(3)538-551.e5(2017 Sep)
Xu L,Huang Q,Wang H,Hao Y,Bai Q,Hu J,Li Y,Wang P,Chen X,He R,Li B,Yang X,Zhao T,Zhang Y,Wang Y,Ou J,Liang H,Wu Y,Zhou X,Ye L

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Sh2d1a cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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