Scg5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scg5
Entrez Gene ID	20394
Full Name	secretogranin V
Synonyms	7B2,AI325031,Sgne-1,Sgne1
General protein information	Preferred Names secretogranin V Names neuroendocrine protein 7B2 secretogranin-5 secretory granule endocrine protein I secretory granule neuroendocrine protein 1, 7B2 protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 E4\|2 57.45 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009162.3	NP_033188.3	neuroendocrine protein 7B2 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Scg5	NP_033188.3
Xenopus tropicalis (tropical clawed frog)	scg5	NP_001072162.2
Homo sapiens (human)	SCG5	NP_001138229.1
Pan troglodytes (chimpanzee)	SCG5	NP_001092019.1
	SCG5	XP_001083853.1
Danio rerio (zebrafish)	LOC100330746	XP_002665782.1
Gallus gallus (chicken)	SCG5	XP_004941787.1
Danio rerio (zebrafish)	scg5	NP_957020.1
Rattus norvegicus (Norway rat)	Scg5	NP_037307.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse.
Stauber M, Weidemann M, Dittrich-Breiholz O, Lobschat K, Alten L, Mai M, Beckers A, Kracht M, Gossler A
Developmental biology423(2)170-188(2017 03)

?linc1 encodes a long noncoding RNA that regulates islet ?-cell formation and function.
Arnes L, Akerman I, Balderes DA, Ferrer J, Sussel L
Genes & development30(5)502-7(2016 Mar)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.
Kanaya T, Hase K, Takahashi D, Fukuda S, Hoshino K, Sasaki I, Hemmi H, Knoop KA, Kumar N, Sato M, Katsuno T, Yokosuka O, Toyooka K, Nakai K, Sakamoto A, Kitahara Y, Jinnohara T, McSorley SJ, Kaisho T, Williams IR, Ohno H
Nature immunology13(8)729-36(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein has a preferential effect on glucagon synthesis
Title: Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein: preferential effect on glucagon synthesis.

7B2 possesses chaperone activity that blocks partially unfolded pro-PC2 forms from losing catalytic competence and then aggregating.
Title: 7B2 prevents unfolding and aggregation of prohormone convertase 2.

a role for Scg5 in the modulation of body weight
Title: Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice.

Differential expression of 7B2 may contribute to the difference between B6 and C3H mice not only in glucagon production and secretion but also in glucose tolerance.
Title: Differences of pancreatic expression of 7B2 between C57BL/6J and C3H/HeJ mice and genetic polymorphisms at its locus (Sgne1).

phosphorylation of 7B2 functionally inactivates this protein in a manner analogous to the phosphorylating inactivation of BiP, which impairs its ability to bind substrate
Title: Neuroendocrine protein 7B2 can be inactivated by phosphorylation within the secretory pathway.

The following Scg5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scg5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03639	NM_009162.3 Latest version!	Mus musculus secretogranin V (Scg5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scg5 ( NM_009162.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033188.3 Mus musculus secretogranin V (Scg5), mRNA.

Price & Availability↑

CloneID	OMu03639
Clone ID Related Accession (Same CDS sequence)	NM_009162.3
Accession Version	NM_009162.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	neuroendocrine protein 7B2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK019337.1, AK161556.1 and BB025018.1. On Nov 13, 2006 this sequence version replaced NM_009162.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK161579.1, AK017481.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164136 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTCAA GGCTGGTCTC TGCTATGCTA TCTGGCCTTT TGTTTTGGTT GATGTTTGAG 
TGGAATCCAG CATTCGCTTA TAGTCCACGG ACCCCTGACC GGGTCTCAGA GACAGACATC 
CAGAGGCTGC TTCATGGGGT TATGGAGCAG CTGGGCATTG CCAGGCCACG CGTGGAGTAC 
CCGGCTCACC AGGCCATGAA TCTTGTTGGG CCACAGAGCA TCGAAGGGGG AGCTCACGAG 
GGTCTTCAGC ATCTGGGTCC TTTTGGCAAC ATCCCCAACA TAGTGGCAGA GTTGACTGGT 
GACAACATTC CTAAGGACTT CAGTGAGGAT CAAGGCTACC CAGACCCTCC AAATCCCTGT 
CCTCTTGGGA AAACTGCTGA TGATGGATGT CTAGAAAACG CCCCCGACAC TGCAGAGTTC 
AGCCGAGAAT TCCAGTTAGA CCAGCACCTT TTTGATCCAG AACATGACTA CCCAGGTTTG 
GGCAAGTGGA ACAAGAAACT CCTTTATGAG AAAATGAAGG GAGGACAGAG GCGGAAGCGG 
AGGAGTGTCA ATCCCTATCT ACAAGGAAAG AGGTTGGACA ATGTTGTGGC AAAGAAATCT 
GTCCCCCACT TCTCAGAAGA GGAGAAGGAA GCAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033188.3
CDS	101..739
Translation	MASRLVSAMLSGLLFWLMFEWNPAFAYSPRTPDRVSETDIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDFSEDQGYPDPPNPCPLGKTADDGCLENAPDTAEFSREFQLDQHLFDPEHDYPGLGKWNKKLLYEKMKGGQRRKRRSVNPYLQGKRLDNVVAKKSVPHFSEEEKEAE

Target ORF information:

RefSeq Version	NM_009162.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus secretogranin V (Scg5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009162.3

ORF Insert Sequence:

ATGGCCTCAA GGCTGGTCTC TGCTATGCTA TCTGGCCTTT TGTTTTGGTT GATGTTTGAG 
TGGAATCCAG CATTCGCTTA TAGTCCACGG ACCCCTGACC GGGTCTCAGA GACAGACATC 
CAGAGGCTGC TTCATGGGGT TATGGAGCAG CTGGGCATTG CCAGGCCACG CGTGGAGTAC 
CCGGCTCACC AGGCCATGAA TCTTGTTGGG CCACAGAGCA TCGAAGGGGG AGCTCACGAG 
GGTCTTCAGC ATCTGGGTCC TTTTGGCAAC ATCCCCAACA TAGTGGCAGA GTTGACTGGT 
GACAACATTC CTAAGGACTT CAGTGAGGAT CAAGGCTACC CAGACCCTCC AAATCCCTGT 
CCTCTTGGGA AAACTGCTGA TGATGGATGT CTAGAAAACG CCCCCGACAC TGCAGAGTTC 
AGCCGAGAAT TCCAGTTAGA CCAGCACCTT TTTGATCCAG AACATGACTA CCCAGGTTTG 
GGCAAGTGGA ACAAGAAACT CCTTTATGAG AAAATGAAGG GAGGACAGAG GCGGAAGCGG 
AGGAGTGTCA ATCCCTATCT ACAAGGAAAG AGGTTGGACA ATGTTGTGGC AAAGAAATCT 
GTCCCCCACT TCTCAGAAGA GGAGAAGGAA GCAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse.
Developmental biology423(2)170-188(2017 03)
Stauber M,Weidemann M,Dittrich-Breiholz O,Lobschat K,Alten L,Mai M,Beckers A,Kracht M,Gossler A

?linc1 encodes a long noncoding RNA that regulates islet ?-cell formation and function.
Genes & development30(5)502-7(2016 Mar)
Arnes L,Akerman I,Balderes DA,Ferrer J,Sussel L

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.
Nature immunology13(8)729-36(2012 Jun)
Kanaya T,Hase K,Takahashi D,Fukuda S,Hoshino K,Sasaki I,Hemmi H,Knoop KA,Kumar N,Sato M,Katsuno T,Yokosuka O,Toyooka K,Nakai K,Sakamoto A,Kitahara Y,Jinnohara T,McSorley SJ,Kaisho T,Williams IR,Ohno H

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Scg5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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