Sftpa1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sftpa1
Entrez Gene ID	20387
Full Name	surfactant associated protein A1
Synonyms	SP-A,Sftp-1,Sftp1
General protein information	Preferred Names surfactant associated protein A1 Names pulmonary surfactant-associated protein A PSAP PSP-A surfactant pulmonary associated protein A1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14 B\|14 22.36 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_023134.5	NP_075623.2	pulmonary surfactant-associated protein A precursor
NM_023134.4	NP_075623.2	pulmonary surfactant-associated protein A precursor

Pathways from BioSystems

Homologies

	SFTPA1	XP_002805703.1
Canis lupus familiaris (dog)	LOC610540	XP_003434532.2
Bos taurus (cattle)	SFTPA1	NP_001071306.2
Gallus gallus (chicken)	LL	NP_001034255.1
Homo sapiens (human)	SFTPA1	NP_001087239.2
Rattus norvegicus (Norway rat)	Sftpa1	NP_001257574.1
Pan troglodytes (chimpanzee)	SFTPA1	XP_001152394.2
Mus musculus (house mouse)	Sftpa1	NP_075623.2

Gene Ontology
Bibliography

Related articles in PubMed

14-3-3? loss leads to neonatal lethality by microRNA-126 downregulation-mediated developmental defects in lung vasculature.
Yang J, Joshi S, Wang Q, Li P, Wang H, Xiong Y, Xiao Y, Wang J, Parker-Thornburg J, Behringer RR, Yu D
Cell & bioscience758(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In triple KO mice, the HO-induced lung injury was associated with decreased surfactant protein (SP) A and SPC but not SPB and SPD expression.
Title: Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.

Our study provides comprehensive information regarding spatial and temporal expression of collectins (SP-A, SP-D and MBL-A) and their cellular sources in murine testis. Positive regulation by testosterone and alteration in their level upon LPS challenge are clues relevant to suggest their involvement in testicular immune privilege.
Title: Testicular expression of SP-A, SP-D and MBL-A is positively regulated by testosterone and modulated by lipopolysaccharide.

The presence of SP-A and SP-D in the murine decidua is likely to play a protective role against intrauterine infection during pregnancy.
Title: Expression of surfactant proteins SP-A and SP-D in murine decidua and immunomodulatory effects on decidual macrophages.

Human and murine data together indicate that SP-A, SP-D and MBL are synthesized in early gestational tissues, and may contribute to regulation of immune response at the feto-maternal interface during pregnancy.
Title: Expression and localization of collectins in feto-maternal tissues of human first trimester spontaneous abortion and abortion prone mouse model.

SP-A/D double knock-out mice showed increased susceptibility to urinary tract infection
Title: Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli.

The following Sftpa1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sftpa1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu00200	NM_023134.5 Latest version!	Mus musculus surfactant associated protein A1 (Sftpa1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OMu00200	NM_023134.4	Mus musculus surfactant associated protein A1 (Sftpa1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sftpa1 ( NM_023134.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075623.2 Mus musculus surfactant associated protein A1 (Sftpa1), mRNA.

Price & Availability↑

CloneID	OMu00200
Clone ID Related Accession (Same CDS sequence)	NM_023134.5 , NM_023134.4
Accession Version	NM_023134.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Mus musculus(house mouse)
Product	pulmonary surfactant-associated protein A precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124400.4. On Jan 25, 2019 this sequence version replaced NM_023134.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK004788.1, AK004620.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

ATGTCACTAG GCTCTTTGGC CTTCACCCTC TTCTTGACTG TTGTTGCTGG CATCAAGTGC 
AATGGGACAG AAGTTTGTGC CGGAAGCCCT GGGATCCCTG GCACTCCCGG AAACCATGGT 
TTGCCCGGCA GAGATGGGAG AGATGGTATC AAAGGAGACC CTGGACCTCC AGGTCCCATG 
GGCCCTCCTG GAGGAATGCC AGGTCTTCCT GGGCGCGATG GGCTGCCTGG AGCCCCTGGT 
GCACCTGGAG AACATGGAGA CAAGGGAGAG CCTGGAGAAA GGGGGCTTCC AGGGTTTCCA 
GCTTACCTGG ATGAGGAGCT TCAGACTGCA CTCTACGAGA TCAAACATCA GATTCTGCAA 
ACAATGGGAG TCCTCAGCTT GCAAGGATCC ATGCTGTCAG TGGGGGATAA AGTCTTTTCC 
ACCAATGGGC AGTCAGTCAA CTTTGATACC ATTAGAGAGA TGTGTACCAG AGCCGGTGGC 
CACATTGCTG CCCCGAGGAA TCCTGAGGAG AACGAGGCCA TCGCAAGCAT TACAAAGAAG 
TACAACACCT ATCCCTACTT AGGTGTGATT GAAGGCCAGA CTCCTGGAGA CTTCCACTAC 
CTGGATGGGG CTTCTGTGAA CTACACCAAC TGGTACCCAG GAGAGCCCAG GGGTCGGGGC 
AAAGAGAAAT GTGTAGAAAT GTATACAGAT GGGAAATGGA ATGATAAGGG CTGCCTGCAG 
TACCGGCTGG CCATTTGTGA ATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075623.2
CDS	102..848
Translation	MSLGSLAFTLFLTVVAGIKCNGTEVCAGSPGIPGTPGNHGLPGRDGRDGIKGDPGPPGPMGPPGGMPGLPGRDGLPGAPGAPGEHGDKGEPGERGLPGFPAYLDEELQTALYEIKHQILQTMGVLSLQGSMLSVGDKVFSTNGQSVNFDTIREMCTRAGGHIAAPRNPEENEAIASITKKYNTYPYLGVIEGQTPGDFHYLDGASVNYTNWYPGEPRGRGKEKCVEMYTDGKWNDKGCLQYRLAICEF

Target ORF information:

RefSeq Version	NM_023134.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus surfactant associated protein A1 (Sftpa1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023134.5

ORF Insert Sequence:

ATGTCACTAG GCTCTTTGGC CTTCACCCTC TTCTTGACTG TTGTTGCTGG CATCAAGTGC 
AATGGGACAG AAGTTTGTGC CGGAAGCCCT GGGATCCCTG GCACTCCCGG AAACCATGGT 
TTGCCCGGCA GAGATGGGAG AGATGGTATC AAAGGAGACC CTGGACCTCC AGGTCCCATG 
GGCCCTCCTG GAGGAATGCC AGGTCTTCCT GGGCGCGATG GGCTGCCTGG AGCCCCTGGT 
GCACCTGGAG AACATGGAGA CAAGGGAGAG CCTGGAGAAA GGGGGCTTCC AGGGTTTCCA 
GCTTACCTGG ATGAGGAGCT TCAGACTGCA CTCTACGAGA TCAAACATCA GATTCTGCAA 
ACAATGGGAG TCCTCAGCTT GCAAGGATCC ATGCTGTCAG TGGGGGATAA AGTCTTTTCC 
ACCAATGGGC AGTCAGTCAA CTTTGATACC ATTAGAGAGA TGTGTACCAG AGCCGGTGGC 
CACATTGCTG CCCCGAGGAA TCCTGAGGAG AACGAGGCCA TCGCAAGCAT TACAAAGAAG 
TACAACACCT ATCCCTACTT AGGTGTGATT GAAGGCCAGA CTCCTGGAGA CTTCCACTAC 
CTGGATGGGG CTTCTGTGAA CTACACCAAC TGGTACCCAG GAGAGCCCAG GGGTCGGGGC 
AAAGAGAAAT GTGTAGAAAT GTATACAGAT GGGAAATGGA ATGATAAGGG CTGCCTGCAG 
TACCGGCTGG CCATTTGTGA ATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sftpa1 ( NM_023134.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075623.2 Mus musculus surfactant associated protein A1 (Sftpa1), mRNA.

Price & Availability↑

CloneID	OMu00200
Clone ID Related Accession (Same CDS sequence)	NM_023134.5 , NM_023134.4
Accession Version	NM_023134.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-22
Organism	Mus musculus(house mouse)
Product	pulmonary surfactant-associated protein A precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK004788.1. On Apr 17, 2007 this sequence version replaced NM_023134.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK004788.1, AK075702.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

ATGTCACTAG GCTCTTTGGC CTTCACCCTC TTCTTGACTG TTGTTGCTGG CATCAAGTGC 
AATGGGACAG AAGTTTGTGC CGGAAGCCCT GGGATCCCTG GCACTCCCGG AAACCATGGT 
TTGCCCGGCA GAGATGGGAG AGATGGTATC AAAGGAGACC CTGGACCTCC AGGTCCCATG 
GGCCCTCCTG GAGGAATGCC AGGTCTTCCT GGGCGCGATG GGCTGCCTGG AGCCCCTGGT 
GCACCTGGAG AACATGGAGA CAAGGGAGAG CCTGGAGAAA GGGGGCTTCC AGGGTTTCCA 
GCTTACCTGG ATGAGGAGCT TCAGACTGCA CTCTACGAGA TCAAACATCA GATTCTGCAA 
ACAATGGGAG TCCTCAGCTT GCAAGGATCC ATGCTGTCAG TGGGGGATAA AGTCTTTTCC 
ACCAATGGGC AGTCAGTCAA CTTTGATACC ATTAGAGAGA TGTGTACCAG AGCCGGTGGC 
CACATTGCTG CCCCGAGGAA TCCTGAGGAG AACGAGGCCA TCGCAAGCAT TACAAAGAAG 
TACAACACCT ATCCCTACTT AGGTGTGATT GAAGGCCAGA CTCCTGGAGA CTTCCACTAC 
CTGGATGGGG CTTCTGTGAA CTACACCAAC TGGTACCCAG GAGAGCCCAG GGGTCGGGGC 
AAAGAGAAAT GTGTAGAAAT GTATACAGAT GGGAAATGGA ATGATAAGGG CTGCCTGCAG 
TACCGGCTGG CCATTTGTGA ATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075623.2
CDS	102..848
Translation	MSLGSLAFTLFLTVVAGIKCNGTEVCAGSPGIPGTPGNHGLPGRDGRDGIKGDPGPPGPMGPPGGMPGLPGRDGLPGAPGAPGEHGDKGEPGERGLPGFPAYLDEELQTALYEIKHQILQTMGVLSLQGSMLSVGDKVFSTNGQSVNFDTIREMCTRAGGHIAAPRNPEENEAIASITKKYNTYPYLGVIEGQTPGDFHYLDGASVNYTNWYPGEPRGRGKEKCVEMYTDGKWNDKGCLQYRLAICEF

Target ORF information:

RefSeq Version	NM_023134.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus surfactant associated protein A1 (Sftpa1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023134.4

ORF Insert Sequence:

ATGTCACTAG GCTCTTTGGC CTTCACCCTC TTCTTGACTG TTGTTGCTGG CATCAAGTGC 
AATGGGACAG AAGTTTGTGC CGGAAGCCCT GGGATCCCTG GCACTCCCGG AAACCATGGT 
TTGCCCGGCA GAGATGGGAG AGATGGTATC AAAGGAGACC CTGGACCTCC AGGTCCCATG 
GGCCCTCCTG GAGGAATGCC AGGTCTTCCT GGGCGCGATG GGCTGCCTGG AGCCCCTGGT 
GCACCTGGAG AACATGGAGA CAAGGGAGAG CCTGGAGAAA GGGGGCTTCC AGGGTTTCCA 
GCTTACCTGG ATGAGGAGCT TCAGACTGCA CTCTACGAGA TCAAACATCA GATTCTGCAA 
ACAATGGGAG TCCTCAGCTT GCAAGGATCC ATGCTGTCAG TGGGGGATAA AGTCTTTTCC 
ACCAATGGGC AGTCAGTCAA CTTTGATACC ATTAGAGAGA TGTGTACCAG AGCCGGTGGC 
CACATTGCTG CCCCGAGGAA TCCTGAGGAG AACGAGGCCA TCGCAAGCAT TACAAAGAAG 
TACAACACCT ATCCCTACTT AGGTGTGATT GAAGGCCAGA CTCCTGGAGA CTTCCACTAC 
CTGGATGGGG CTTCTGTGAA CTACACCAAC TGGTACCCAG GAGAGCCCAG GGGTCGGGGC 
AAAGAGAAAT GTGTAGAAAT GTATACAGAT GGGAAATGGA ATGATAAGGG CTGCCTGCAG 
TACCGGCTGG CCATTTGTGA ATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

14-3-3? loss leads to neonatal lethality by microRNA-126 downregulation-mediated developmental defects in lung vasculature.
Cell & bioscience758(2017)
Yang J,Joshi S,Wang Q,Li P,Wang H,Xiong Y,Xiao Y,Wang J,Parker-Thornburg J,Behringer RR,Yu D

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Sftpa1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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